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All Journal Jurnal Edukasi dan Sains Biologi INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Ilmiah Manusia dan Kesehatan AVERROUS: Jurnal Kedokteran dan Kesehatan Malikussaleh GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh
Mulyati Sri Rahayu, Mulyati
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

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Effect of subacute toxicity of mosquito coil smoke inhalation on lung histology and blood hematology parameters in Wistar rats Sri Rahayu, Mulyati; Wahyuni, Sri
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.6046

Abstract

Mosquito coils are made from incense products and are designed to repel insects using pyrethrins and pyrethroids as their main active ingredients. However, the use of these coils poses significant public health and ecological risks due to the emitted toxic fumes. These fumes can have long-term damaging effects on humans and the environment. This study aimed to investigate the effects of various durations of subacute exposure to mosquito coil smoke (MCS) on lung histology and blood hematology in white male Wistar rats (Rattus norvegicus). Rats were divided into four groups (n = 6): control; P1, P2, and P3, exposed to MCS for 5, 7, and 9 h per day, respectively, for 21 days. Hematological blood analyses (red cell count (RBC), hemoglobin (Hb), and hematocrit (Hct)) were performed, and lung histopathology was evaluated using Manja Roenigk's criteria. The group exposed to MCS for 9 h/day showed a significant decrease in mean body weight (185.00 ± 9.59) (p = 0.008) compared with the control group. All treated groups had normal Hb and Hct levels and RBC indices, with no significant differences compared with the control group. The 9-hour exposure group had significantly lower lung weights than the control group (p<0.05), and all treatment groups showed significant differences in lung weight (p<0.05). Histopathological analysis revealed significant loss of alveolar septal integrity, leading to alveolar lumen rupture and development of emphysema. This study provides clear evidence of emphysema due to subacute allethrin-based MCS inhalation, although it did not affect hematological parameters in rats.
Co-Authors hasanah, Rizqi uswatun Husna Lubis, Rehani Julia Fitriany, Julia Maulana, Ary Fadhil Muhammad, Oktaduta Nora Maulina, Nora Nurmanda, Raudhatul Rahima, Yusriah Fitri Rizka, Adi Rizki Akbar, Rizki Sidrah Nadira, Cut Sri Wahyuni Utariningsih, Wheny Vina Fatmasyithah, Vina Wizar Putri Mellaratna Yuziani