Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal Jurnal Farmasi Sains dan Komunitas JRST (Jurnal Riset Sains dan Teknologi)
Pretty Falena Atmanda Kambira
Atma Jaya Catholic University of Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Engineering Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
COMBINATION UV-VIS SPECTROSCOPY AND PARTIAL LEAST SQUARE FOR DETECTING ADULTERATION PARACETAMOL AND PIROXICAM IN TRADITIONAL MEDICINES Pretty Falena Atmanda Kambira; Dion Notario; Untung Gunawan; Sherina Dhamayanti; Raymunanda Widya Kimla Ningrum; Sondang G.O. Ambarita; Grafty Polin
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 17, No 1 (2020)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (793.489 KB) | DOI: 10.24071/jpsc.002354

Abstract

An analytical method based on combination UV-Vis spectroscopy and chemometric was developed for detecting commonly listed adulterants such as paracetamol and piroxicam simultaneously in traditional medicines. No complex sample preparation and separation are required except grinding, dissolving, and filtering. The spectral interferences were resolved by multivariate techniques. Wavelengths selection and number of components optimization were performed by a combination of Genetic Algorithm and Partial Least Square (GA-PLS) followed by backward elimination through Jack-Knife Partial Least Square Regression (JK-PLSR). The capability PLSR model for quantitative analysis was assessed from the coefficient of determination (R2) and root mean square of error prediction/cross-validation (RMSEP/RMSECV) dan predicted residual sum of square (PRESS). Classification performance of PLS Discriminant Analysis (PLS-DA) was evaluated from the area under the receiver operating characteristic curve (AUROCC). For ensuring the sensitivity of the method, the detection limits from the two pseudo-univariate lines were estimated. The R2, RMSEP, RMSECV, AUROCC, and detection limit obtained from the selected models of paracetamol and piroxicam were 0.999, 0.25 mg/L, 0.15 mg/L, 100%, and 0.4 mg/L respectively. Therefore, the proposed method is suitable for the rapid screening of adulterated herbal medicine.
Antibacterial Property Evaluation of Ethanolic Extract of Plantago major L. and Its Fractions Deka Prismawan; Michael; Gwyneth Yovela Gunawan; Pretty Falena Atmanda Kambira
JRST (Jurnal Riset Sains dan Teknologi) Volume 10 No. 1, March 2026: JRST
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/jrst.v10i1.26388

Abstract

The escalating global health crisis of antibiotic resistance necessitates the search for novel antibacterial agents from natural sources. This study investigated the potential of Plantago major L., a plant used in traditional medicine, as a source of antibacterial compounds. It aimed to evaluate the antibacterial activity of its ethanol extract and its polarity-based fractions against Escherichia coli and Staphylococcus aureus. Dried P. major L. leaves were extracted with ethanol using maceration. The crude extract was then fractionated using a sequential liquid-liquid extraction with hexane, ethyl acetate, and n-butanol. The antibacterial activity of the extract and all fractions was tested against S. aureus (ATCC 25923) and E. coli (ATCC 25922) using the broth microdilution method to determine the Minimum Inhibitory Concentration (MIC). Results revealed distinct antibacterial profiles based on fraction polarity. The ethyl acetate fraction exhibited the strongest activity against S. aureus with an MIC of 0.104 mg/mL, indicating the presence of potent semi-polar compounds like flavonoids effective against gram-positive bacteria. Conversely, the n-butanol fraction was most effective against E. coli with an MIC of 3.3 mg/mL, suggesting the role of hydrophilic compounds such as saponins in disrupting the more complex gram-negative membrane. The crude ethanol extract showed lower activity, confirming the critical role of fractionation in concentrating the bioactive compounds. Plantago major L. possesses significant antibacterial potential, with its active compounds concentrated in specific polarity-based fractions. These findings validate its traditional use and support its further development as an alternative therapy in the face of growing antibiotic resistance.
Co-Authors Deka Prismawan Dion Notario Grafty Polin Gunawan, Untung Gwyneth Yovela Gunawan Michael Raymunanda Widya Kimla Ningrum Sherina Dhamayanti Sondang G.O. Ambarita