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All Journal Jurnal Veteriner Jurnal Ilmiah Mahasiswa Veteriner Jurnal Peternakan Lokal
Daniel Daniel
Laboratorium Farmakologi Fakultas Kedokteran Hewan Universitas Syiah Kuala, Banda Aceh
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Social Sciences Veterinary

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Skrining Senyawa Aktif Biji Pinang (Areca Catechu, L) Dalam Meningkatkan Sensitivitas Antikanker Doxorubicin Pada Kanker Payudara Secara In Silico Frengki Frengki; Andika Trihadi Septian; Daniel Daniel; Rosmaidar Rosmaidar; Hennivanda Hennivanda; T. Armansyah TR; Nazaruddin Nazaruddin; M. Hasan
JURNAL ILMIAH MAHASISWA VETERINER Vol 7, No 1 (2022): NOVEMBER-JANUARI
Publisher : JURNAL ILMIAH MAHASISWA VETERINER

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/jim vet..v7i1.23723

Abstract

ABSTRAK Doxorubicin merupakan kemoterapi golongan antrasiklin yang cukup ampuh dan masih digunakan dalam mengatasi kanker payudara. Selain efek kemoterapi yang diharapkan, penggunaan doxorubicin juga menimbulkan efek samping hingga memicu peristiwa autoresistensi doxorubicin melalui peningkatan ekspresi dan fungsi NFκβ. Salah satu upaya meningkatkan sensitivitas doxorubicin yaitu dengan menggunakan agen kemopreventif non-toksik sebagai bagian dari kombinasi agen kemoterapi. Tujuan penelitian ini adalah untuk membuktikan senyawa aktif yang terkandung dalam biji pinang (Areca catechu, L) yang berpotensi meningkatkan sensitivitas doxorubicin melalui inhibisi reseptor NFκβ. Penelitian ini dilakukan secara in silico melalui metode Moleculer Docking menggunakan software MOE. Bahan uji berupa data “canonical SMILES” 6 senyawa aktif biji pinang, senyawa deoxyelephantopin dan doxorubicin diunduh dari www.pubchem.org, sedangkan reseptor NFκβ (PDB id. 1VKX) diunduh dari www.rcsb.org.  Hasil docking menunjukkan bahwa senyawa aktif pilihan (protoanthocyanidin, arecaidine, arecoline, guvacoline, guvacine, dan isoguvacine) yang terkandung dalam biji pinang mampu meningkatkan sensitivitas antikanker doxorubicin melalui penekanan fungsi NFκβ dengan proanthocyanidin memiliki kemampuan inhibisi terbaik. Dengan demikian semua senyawa tersebut memiliki kemampuan meningkatkan sensitivitas antikanker doxorubicin sehingga dapat bekerja lebih optimal dalam mengatasi sel kanker payudara. Profil profil farmakokinetika dan toksisitas menunjukkan potensi proanthocyanidin sebagai kandidat obat antidiabetes hanya dapat diberikan secara parenteral.Kata Kunci : Doxorubicin, proanthocyanidin, moleculer docking.ABSTRACTDoxorubicin is an anthracycline class of chemotherapy that is quite effective and is still used in treating breast cancer. In addition to the expected chemotherapy effects, the use of doxorubicin also causes side effects that trigger doxorubicin autoresistance through increased expression and function of NFκβ. One effort to increase the sensitivity of doxorubicin is by using non-toxic chemopreventive agents as part of a combination of chemotherapeutic agents. The purpose of this study was to prove that the active compounds contained in areca nut (Areca catechu, L) seeds have the potential to increase doxorubicin sensitivity through inhibition of NFκβ receptors. This research was conducted in silico through the Molecular Docking method using MOE software. The test material in the form of "canonical SMILES" data for 6 active compounds in areca seed, deoxyelephantopin and doxorubicin compounds was downloaded from www.pubchem.org, while the NFκβ receptor (PDB id. 1VKX) was downloaded from www.rcsb.org. The docking results showed that selected active compounds (protoanthocyanidin, arecaidine, arecoline, guvacoline, guvacine, and isoguvacine) contained in areca nut seeds were able to increase the anticancer sensitivity of doxorubicin by suppressing NFκβ function with proanthocyanidin having the best inhibitory ability. Thus all these compounds have the ability to increase the anticancer sensitivity of doxorubicin so that they can work more optimally in treating breast cancer cells. The pharmacokinetic and toxicity profiles show the potential of proanthocyanidin as an antidiabetic drug candidate which can only be given parenterally.Keywords : Doxorubicin, proanthocyanidin, moleculer docking.
Pengaruh Lama Fermentasi Menggunakan Aspergillus Niger dan Urea Terhadap Kadar Nutrisi Ampas Sagu (Metroxylon sp) Daniel Daniel; Dedhi Yustendi; Fawwarahli Fawwarahli
Peternakan Lokal Vol 5 No 1 (2023): Jurnal Peternakan Lokal
Publisher : Program Studi Peternakan Universitas Muslim Maros

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46918/peternakan.v5i1.1713

Abstract

This research was carried out aiming to improve the nutritional quality of dregs sago (Metroxylon sp) through a fermentation process by utilizing the fungus Aspergillus niger. The treatment applied was the storage time of fermented dregs sago which consisted of 4 treatments and 3 replications thats is, P0 (without storage), P1 (7 days of storage), P2 (14 days of storage) and P3 (21 days of storage). The researched variables consisted of the percentage of crude fiber, crude protein and ekstract ether. Laboratory analysis data for each treatment obtained were tabulated in a table and analyzed using analysis of variance (ANOVA) with the F test at the 5% level and continued with Duncan's test if parameters were found to be significantly different between treatments (Steel and Torrie, 1990). The results showed that there was a significant difference (P<0.05) in the percentage of crude fiber and ekstract ether, while the percentage of crude protein content did not show a significant difference (P>0.05). 0 days, 7 days, 14 days and 21 days affected the percentage of crude fiber and ekstract ether but did not affect the percentage of crude protein of fermented dregs sago.
Black Cumin Seed Extract Decrease Motility and Shortening Mortality Time of Ascaridia galli Worm In Vitro Henni Vanda; Ahmad Khairi Abadi; Muhammad Hambal; Farida Athaillah; Wahyu Eka Sari; Frengki Frengki; Daniel Daniel
Jurnal Veteriner Vol 24 No 1 (2023)
Publisher : Faculty of Veterinary Medicine, Udayana University and Published in collaboration with the Indonesia Veterinarian Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/jveteriner.2023.24.1.63

Abstract

Ascaridiasis caused by roundworm Ascaridia galli is one of important diseases in poultry industry in Indonesia. This disease can affect economic losses in the form of death, growth retardation, reduced egg production as well as trigger for secondary viral or bacteria infections. Control of this nematode requires a good strategy to avoid the risk of anthelmintic resistance, one of which is the use of herbal medicine such as black cumin seed (Nigella sativa). This study was aimed to determine the level of motility and mortality time of A. galli after treated with black cumin seed extract in vitro. In this study, black cumin seed was extracted using ethanol 96%, and then diluted to 15% (P1), 25% (P2), and 45% (P3) concentration. Pyrantel pamoate preparation was used as positive control (C1), and carboxymethyl cellulose (CMC) solution as negative control (C0). Observations were carried out every 15 minutes until all the treatment worms died. The results revealed that the motility and mortality time of A. galli were significantly different in some treatment groups. The mortality time of group C0, C1 , P1, P2, and P3 were 2592, 801, 1557, 1350, and 612 minutes, respectively. 45% of black cumin seed extract had the ability to decrease worm motility, and it showed the shortest mortality time compared to other treatment groups. It can be concluded that ethanolic extract of black cumin seeds had potential anthelmintics property on A. galli worms
Co-Authors Ahmad Khairi Abadi Andika Trihadi Septian Dedhi Yustendi Farida Athaillah Fawwarahli Fawwarahli FRENGKI FRENGKI Frengki Frengki Henni Vanda Hennivanda Hennivanda M. Hasan Muhammad Hambal Nazaruddin Nazaruddin Rosmaidar Rosmaidar T. Armansyah TR