Salsabila Ariefani
Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi, Indonesia

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TELAAH PUSTAKA : TANAMAN HERBAL YANG BERPOTENSI MEMILIKI EFEK ANTI KANKER PAYUDARA Salsabila Ariefani; Eko Fuji Ariyanto; Yohana Azhar
JURNAL KEDOKTERAN DAN KESEHATAN Vol 10, No 1 (2023)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/JKK.V10I1.19807

Abstract

Kanker payudara merupakan penyebab kematian terbanyak pada wanita. Kanker payudara dikategorikan berdasarkan reseptor homonal yaitu estrogen reseptor (ER), progesterone reseptor (PR) dan human epidermal growth factor receptor-2 (HER2). Efektivitas terapi kanker payudara saat ini masih menjadi tantangan dan pengobatan kanker payudara terus berkembang. Sejumlah penelitian telah menunjukkan efek antikanker dari beberapa tanaman herbal yang tersebar di seluruh dunia. Tujuan telaah pustaka ini untuk melihat efek dari tanaman herbal dan aktivitas senyawa bioaktifnya pada kanker payudara. Telaah pustaka didapatkan dari PubMed/MEDLINE yang membahas beberapa tanaman herbal yang banyak ditemukan dan telah diketahui dapat menghambat pertumbuhan dan metastasis sel kanker payudara. Senyawa aktif yang banyak ditemukan pada telaah literatur ini adalah flavonoid, alkaloid dan asam fenolik yang dapat menghambat proliferasi serta menginduksi apoptosis dari sel kanker. 
TELAAH PUSTAKA : TANAMAN HERBAL YANG BERPOTENSI MEMILIKI EFEK ANTI KANKER PAYUDARA Salsabila Ariefani; Eko Fuji Ariyanto; Yohana Azhar
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 10 No. 1 (2023): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v10i1.333

Abstract

Kanker payudara merupakan penyebab kematian terbanyak pada wanita. Kanker payudara dikategorikan berdasarkan reseptor homonal yaitu estrogen reseptor (ER), progesterone reseptor (PR) dan human epidermal growth factor receptor-2 (HER2). Efektivitas terapi kanker payudara saat ini masih menjadi tantangan dan pengobatan kanker payudara terus berkembang. Sejumlah penelitian telah menunjukkan efek antikanker dari beberapa tanaman herbal yang tersebar di seluruh dunia. Tujuan telaah pustaka ini untuk melihat efek dari tanaman herbal dan aktivitas senyawa bioaktifnya pada kanker payudara. Telaah pustaka didapatkan dari PubMed/MEDLINE yang membahas beberapa tanaman herbal yang banyak ditemukan dan telah diketahui dapat menghambat pertumbuhan dan metastasis sel kanker payudara. Senyawa aktif yang banyak ditemukan pada telaah literatur ini adalah flavonoid, alkaloid dan asam fenolik yang dapat menghambat proliferasi serta menginduksi apoptosis dari sel kanker.
Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker in Cervical Cancer: A Literature Review of Current Evidence Ariefani, Salsabila; Rahmadhanita, Putri; Finalita, Floera
Journal of Islamic Medicine Vol 10, No 1 (2026): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v10i1.41541

Abstract

Background: The neutrophil-to-lymphocyte ratio (NLR) is a simple systemic inflammatory marker that reflects the balance between pro-tumor inflammation and anti-tumor immunity. Previous studies have shown that a high pre-treatment NLR is associated with poor survival outcomes and advanced clinical stage in cervical cancer. Objective: This review aims to evaluate the prognostic role of NLR and its impact on patient survival. Methods: A literature search was conducted for studies published between 2021-2026 using the PubMed/ MEDLINE database with predefined inclusion and exclusion criteria. A total of eight relevant articles were included in this review. Results: The included studies consistently demonstrated that a high pre-treatment NLR is an independent predictor of poor survival in patients with cervical cancer. Conclusion: NLR appears to be a promising prognostic biomarker for cervical cancer; however, the lack of standardized cut-off values limits its current clinical application.
The interplay of type I interferon, NLRP3 inflammasome, and self-antigen clearance in systemic lupus erythematosus progression Rahmadhanita, Putri; Finalita, Floera; Ariefani, Salsabila
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2317

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease driven by impaired cellular debris clearance. While individual inflammatory pathways are well-documented, their synergistic interactions lack comprehensive synthesis, hindering the development of mechanism-based therapeutics. This literature review aims to elucidate the interconnected roles of specific cellular inflammatory pathways and their positive feedback loops in driving the clinical progression of SLE. A comprehensive literature review was conducted by analyzing 35 peer-reviewed scientific studies published between 2015 and 2025, sourced primarily from the PubMed database, focusing on SLE pathogenesis, cellular inflammation, and disease severity. SLE progression is propelled by a mutually reinforcing inflammatory cascade rather than isolated pathways. We identified three primary components establishing a pathological positive feedback loop: (1) Impaired self-antigen clearance, supplying a continuous source of Damage-Associated Molecular Patterns (DAMPs); (2) Type I Interferon (IFN-I) overactivation, acting as the systemic immune response conductor; and (3) The NLRP3 inflammasome, functioning as a local amplifier that induces direct tissue damage. The identification of this synergistic feedback loop demonstrates that single-target interventions may be insufficient. Comprehending this dynamic cascade necessitates a paradigm shift towards precision medicine. Future therapeutic strategies must prioritize multi-target combination therapies, stratifying patients based on their unique biological profiles to disrupt the pathogenic cycle effectively.