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All Journal Journal of Islamic Medicine Science Midwifery Journal of Medical Studies
Putri Rahmadhanita
Universitas Islam Negeri Sulthan Thaha Saifuddin Jambi, Indonesia
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary Other

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The effect of ampk signaling in type 2 diabetes a literature review Putri Rahmadhanita; Mgs Irsan Saleh; Eddy Mart Salim
Science Midwifery Vol 11 No 2 (2023): June: Midwifery and Health Sciences
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v11i2.1286

Abstract

Diabetes is a metabolic syndrome characterized by inadequate blood glucose control and associated with reduced quality of life and various complications that significantly shorten life expectancy. Type 2 diabetes is caused by insulin resistance, in which insulin is well secreted but cells do not respond properly. Increasing evidence reveals the role of molecular pathways in the development of DM and its associated complications. The references of this literature review were collected from PubMed. Studies have attempted to identify signaling networks and therapeutic targeting in DM therapy. As the disease progresses, DM is followed by evidence of the existence of a molecular pathway in the form of AMPK signaling which can coordinate cell metabolism according to specific energy needs. AMPK is a master regulator of metabolism that functions to restore energy balance during metabolic stress at both a cellular and physiological level. Inducing AMPK signaling can provide blood glucose in DM which is important to improve hyperglycemia. The purpose of this literature review was to determine the effect of AMPK signaling on type 2 DM and gives an insight about agents that can enhances AMPK signaling to prevent the further impact of DM.
PERUBAHAN NILAI DARAH RUTIN PADA DARAH UMBILIKUS BAYI SETELAH PENYIMPANAN PERIODIK SAMPAI 28 HARI DI RSUD H. ABDUL MANAP KOTA JAMBI Putri Rahmadhanita; Hiratna; Armaidi Darmawan
Journal of Medical Studies Vol. 1 No. 2 (2021): Journal of Medical Studies
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/joms.v1i2.16566

Abstract

ABSTRACT Background: Umbilical cord blood can be used safely as a substitution for blood transfusion. The changes of cord blood hematology value occur during storage until the blood can be transfused. Objectives: Knowing storage time limit for cord blood that can be transfused. Methods: The study was performed with 37 umbilical cord blood of newborns after spontanous delivery at delivery room of H. Abdul Manap Hospital from February-March 2017. Each sample separated into 5 EDTA tubes contain 3 mL of umbilical cord blood, then complete blood count was performed at days 0, 3, 7, 14 and 28 with Swelab Alfa Hematology Analyzer. Umbilical cord blood stored at blood bank of clinical laboratory H. Abdul Manap Hospital at 2 – 6 ⁰C temperature. Results: The change in complete blood count considered significant (p<0,05) compared to day 0. Erithrocyte are stable up to 28 days, hemoglobin and hematocrit increase significantly in day-28, leukocyte decrease significantly in day-3, and platelets decrease significantly in day-14. Conclusions: Erythrocyte, hemoglobin and hematocrit can be transfused until day-28, while platelet can only be transfused until day-7 of storage. Keywords: Umbilical Cord Blood, Blood Bank, Hematology. ABSTRAK Latar Belakang: Darah tali pusat dapat digunakan dengan aman sebagai pengganti darah untuk transfusi. Selama proses penyimpanan hingga darah tersebut dapat ditransfusikan, terjadi perubahan nilai pada komponen darah tersebut. Tujuan: Mengetahui batas waktu penyimpanan darah tali pusat yang masih layak ditransfusikan. Metode: Sebanyak 37 sampel darah tali pusat diambil dari bayi lahir pervaginam di VK RSUD H. Abdul Manap Kota Jambi dari Februari-Maret 2017. Setiap sampel darah tali pusat dimasukkan ke dalam 5 tabung EDTA masing-masing sebanyak 3 mL, kemudian dilakukan pemeriksaan darah rutin pada hari ke-0, 3, 7, 14 dan 28 dengan menggunakan Swelab Alfa Hematology Analyzer. Darah disimpan dalam bank darah laboratorium RSUD H. Abdul Manap Kota Jambi dengan suhu 2 – 6 ⁰C. Hasil: Perubahan hasil darah rutin dianggap bermakna (p<0,05) dibandingkan dengan hari ke-0. Eritrosit stabil sampai 28 hari penyimpanan, hemoglobin dan hematokrit mengalami peningkatan bermakna pada hari ke-28, leukosit mengalami penurunan bermakna pada hari ke-3, dan trombosit mengalami penurunan bermakna pada hari ke-14 setelah penyimpanan. Kesimpulan: Eritrosit, hemoglobin dan hematokrit masih dapat digunakan untuk transfusi hingga penyimpanan hari ke-28 sedangkan trombosit hanya sampai penyimpanan hari ke-7. Kata Kunci: Darah Tali Pusat, Bank Darah, Hematologi
Neutrophil-to-Lymphocyte Ratio as a Prognostic Biomarker in Cervical Cancer: A Literature Review of Current Evidence Ariefani, Salsabila; Rahmadhanita, Putri; Finalita, Floera
Journal of Islamic Medicine Vol 10, No 1 (2026): Journal of Islamic Medicine
Publisher : Faculty of Medicine and Health Science, Universitas Islam Negeri Maulana Malik Ibrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jim.v10i1.41541

Abstract

Background: The neutrophil-to-lymphocyte ratio (NLR) is a simple systemic inflammatory marker that reflects the balance between pro-tumor inflammation and anti-tumor immunity. Previous studies have shown that a high pre-treatment NLR is associated with poor survival outcomes and advanced clinical stage in cervical cancer. Objective: This review aims to evaluate the prognostic role of NLR and its impact on patient survival. Methods: A literature search was conducted for studies published between 2021-2026 using the PubMed/ MEDLINE database with predefined inclusion and exclusion criteria. A total of eight relevant articles were included in this review. Results: The included studies consistently demonstrated that a high pre-treatment NLR is an independent predictor of poor survival in patients with cervical cancer. Conclusion: NLR appears to be a promising prognostic biomarker for cervical cancer; however, the lack of standardized cut-off values limits its current clinical application.
The interplay of type I interferon, NLRP3 inflammasome, and self-antigen clearance in systemic lupus erythematosus progression Rahmadhanita, Putri; Finalita, Floera; Ariefani, Salsabila
Science Midwifery Vol 14 No 1 (2026): April: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v14i1.2317

Abstract

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease driven by impaired cellular debris clearance. While individual inflammatory pathways are well-documented, their synergistic interactions lack comprehensive synthesis, hindering the development of mechanism-based therapeutics. This literature review aims to elucidate the interconnected roles of specific cellular inflammatory pathways and their positive feedback loops in driving the clinical progression of SLE. A comprehensive literature review was conducted by analyzing 35 peer-reviewed scientific studies published between 2015 and 2025, sourced primarily from the PubMed database, focusing on SLE pathogenesis, cellular inflammation, and disease severity. SLE progression is propelled by a mutually reinforcing inflammatory cascade rather than isolated pathways. We identified three primary components establishing a pathological positive feedback loop: (1) Impaired self-antigen clearance, supplying a continuous source of Damage-Associated Molecular Patterns (DAMPs); (2) Type I Interferon (IFN-I) overactivation, acting as the systemic immune response conductor; and (3) The NLRP3 inflammasome, functioning as a local amplifier that induces direct tissue damage. The identification of this synergistic feedback loop demonstrates that single-target interventions may be insufficient. Comprehending this dynamic cascade necessitates a paradigm shift towards precision medicine. Future therapeutic strategies must prioritize multi-target combination therapies, stratifying patients based on their unique biological profiles to disrupt the pathogenic cycle effectively.
Co-Authors Armaidi Darmawan Eddy Mart Salim Finalita, Floera Hiratna Mgs Irsan Saleh Salsabila Ariefani