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All Journal Majalah Kedokteran Bandung Althea Medical Journal Medica Hospitalia Medika Kartika : Jurnal Kedokteran dan Kesehatan Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Jurnal Rumpun Ilmu Kesehatan Diagnosa: Jurnal Ilmu Kesehatan dan Keperawatan
Raja Iqbal Mulya Harahap
Departemen Patologi Klinik, Fakultas Kedokteran Universitas Padjadjaran/ Rumah Sakit Umum Pusat Dokter Hasan Sadikin Bandungathology, Faculty Of Medicine, Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Correlation Between Serum Ferritin and Testosterone Level in Adolescent Male with Transfusion Dependent Thalassemia Raja Iqbal Mulya Harahap; Nina Tristina; Delita Prihatni; Dewi Kartika Turbawaty
Majalah Kedokteran Bandung Vol 53, No 3 (2021)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v53n3.2389

Abstract

Transfusion-dependent thalassemia (TDT) is a type of beta-thalassemia that needs regular and long-term blood transfusions. Complications can occur due to the deposition of iron in TDT patients, including endocrine complications causing deficiency of testosterone that plays a role in the secondary sexual development in males. The objective of this study was to understand the correlation between ferritin and testosterone level in male adolescences with transfusion-dependent thalassemia. This cross-sectional observational correlative study was conducted from April to August 2019 on 74 males aged 12-18 years old who were presented to the Thalassemia Outpatient clinic, Dr. Hasan Sadikin General Hospital, Bandung. Blood was collected using phlebotomy for ferritin and total testosterone serum examination. Data were then analyzed using SPSS version 17.0. Low testosterone level (<3.0 ng/mL) was found in 63.5% of subjects. Results of the Spearmen correlation test demonstrated a negative correlation with r: -0,699 and p-value <0.001, showing a negative, strong, and significant correlation among those variables. The higher ferritin level in TDT patients indicates a high level of the free iron level in the body that can destroy the endocrine organs and cause deprivation of testosterone secretion, leading to hypogonadism in transfusion dependent thalassemia patients.
PREVALENSI HIPOKALEMIA DAN HIPONATREMIA PADA PASIEN TUBERKULOSIS MULTIDRUG RESISTANCE DI RS. HASAN SADIKIN BANDUNG Raja Iqbal Mulya Harahap; Nina Tristina; Tiene Rostini; Nida Suraya
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 5 No 1 (2022): Medika Kartika : Jurnal Kesehatan dan Kedokteran
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.396 KB)

Abstract

Tuberkulosis Multidrug Resistance (TB MDR) adalah infeksi M. tuberculosis yang resistenrifampisin, isoniazid, atau obat antituberkulosis lainnya. TB MDR dapat menyebabkanberbagai komplikasi baik lokal ataupun sistemik seperti electrolyte imbalance, termasukhiponatremia dan hipokalemia. Hiponatremia dan hipokalemia pada pasien TB MDRdisebabkan oleh berbagai faktor seperti invasi ke organ lain, Syndrome InappropriateAntidiuretic Hormone (SIADH), asupan rendah, serta efek samping pengobatan. Penelitian inibertujuan untuk mengetahui prevalensi hiponatremi dan hipokalemi pada penderita TB MDR.Penelitian adalah deskriptif retrospektif dengan data pasien baru TB MDR. Subjek adalah 115pasien yang berobat di Poliklinik TB MDR RSHS Bandung yang memeriksakan elektrolitnyadi laboratorium RSHS. Subjek penelitian laki-laki (54,8%) lebih banyak dibanding subjekpenelitian wanita (45,2%), dengan rerata usia pasien 38,06 ± 12,83 tahun. Rerata kadarnatrium adalah 136±4 mEq/L, 67% subjek memiliki kadar natrium normal, dan 33% subjekmemiliki kadar natrium di bawah normal. Rerata kadar kalium adalah 3,9±0,5 mEq/L, sebesar85,2% subjek memiliki kadar kalium normal, dan 14,8% subjek memiliki kadar kalium dibawah normal. Hiponatremia pada pasien MDR disebabkan asupan kurang, anoreksia danSIADH. Hipokalemia dapat disebabkan efek samping pengobatan TB sebelumnya, danpeningkatan katabolisme protein yang menyebabkan efluks kalium dari plasma. Hiponatremiapada pasien memiliki prevalensi sebesar 33%, dan Hipokalemia sebesar 14,8%. DOI : 10.35990/mk.v5n1.p12-20
Analysis of C-Peptide Levels Among Gynaecological Malignancies Patients Underwent Chemotherapy with Carboplatin Regiment Nina Tristina; Juandika Juandika; Leni Lismayanti; Adhi Kristianto Sugianli; Raja Iqbal Mulya Harahap
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 29, No 1 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i1.1967

Abstract

 C-peptide is part of the, which its amounts were equal to endogenous insulin secreted by pancreatic β cells. Carboplatin is one of the chemotherapy regimens that are widely used to treat gynecological malignancies. Carboplatin may cause the damage of β-islets of Langerhans, which may cause defects in insulin synthesis leading to secondary diabetes mellitus or other types of diabetes mellitus. The purpose of this study was to determine the differences in C-peptide, (which reflects endogenous insulin levels) levels in patients with gynecologic malignancy who underwent carboplatin chemotherapy. This study was a comparative observational study with a cross-sectional design. There was a total of 42 subjects who met the inclusion criteria. Subjects with gynecological malignancy post-carboplatin chemotherapy regimens had lower serum C-peptide levels in group II compared to group I. Serum C-peptide levels can further be used to monitor side effects of carboplatin and can be used as a test to diagnose the other types of diabetes mellitus especially before starting the fourth cycle
KORELASI PENINGKATAN KADAR TROPONIN I DENGAN MORTALITAS PADA PASIEN DEWASA TERKONFIRMASI COVID-19 Nida Suraya; Lastri Supriatin; Delita Prihatni; Raja Iqbal Mulya Harahap
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 6 No 1 (2023): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

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Abstract

Jantung adalah organ kedua setelah paru-paru yang banyak dipengaruhi oleh Severe Acute Respiratory Syndrome Corona Virus-2 (SARS CoV-2), mengalami cedera akibat virus tersebut ditandai dengan peningkatan kadar troponin. Kadar troponin-I secara signifikan lebih tinggi pada pasien COVID-19 berat, mendapat perawatan intensif, dan meninggal. Penelitian ini bertujuan menganalisis hubungan kenaikan kadar troponin-I dengan mortalitas pasien dewasa terkonfirmasi Corona Virus Disease-19 (COVID-19). Penelitian ini bersifat deskriptif retrospektif dilakukan pada pasien COVID-19 rawat inap di RSUP Dr. Hasan Sadikin Bandung dari Desember 2020 hingga Maret 2021 sesuai kriteria inklusi dan eksklusi. Data kadar troponin-I dan karakteristik pasien diambil dari sistem informasi laboratorium dan rekam medis. Hubungan kenaikan kadar troponin I dengan mortalitas dianalisis dengan uji chi-square. Hasil penelitian menunjukkan bahwa dari 90 pasien usia 20-60 tahun sebanyak 48 orang (53,3%), pasien laki-laki sebanyak 57 orang (63,3%), dan pasien dengan komorbid sebanyak 64 orang (71,1%). Peningkatan kadar troponin-I terjadi pada 80% pasien berhubungan secara signifikan dengan mortalitas (p 0,0001) dengan Odds Ratio (OR) sebesar 6,40. Hal ini berarti pasien dengan kadar troponin I meningkat memiliki kemungkinan untuk meninggal 6,4 kali lebih besar daripada pasien dengan kadar troponin-I normal. Kondisi COVID-19 berat dapat menyebabkan kerusakan pada berbagai organ termasuk otot jantung. Pada penelitian ini, pasien COVID-19 dengan kenaikan kadar troponin-I pada masa perawatan memiliki risiko kematian lebih tinggi daripada pasien dengan kadar troponin-I yang normal. Untuk mengevaluasi apakah troponin-I merupakan faktor penyebab kematian yang kuat pada pasien COVID-19 dewasa diperlukan analisis multivariat. Kata kunci: COVID-19, mortalitas, troponin-I DOI : 10.35990/mk.v6n1.p34-43
Analysis of C-Peptide Levels Among Gynaecological Malignancies Patients Underwent Chemotherapy with Carboplatin Regiment Nina Tristina; Juandika Juandika; Leni Lismayanti; Adhi Kristianto Sugianli; Raja Iqbal Mulya Harahap
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol. 29 No. 1 (2022)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v29i1.1967

Abstract

 C-peptide is part of the, which its amounts were equal to endogenous insulin secreted by pancreatic β cells. Carboplatin is one of the chemotherapy regimens that are widely used to treat gynecological malignancies. Carboplatin may cause the damage of β-islets of Langerhans, which may cause defects in insulin synthesis leading to secondary diabetes mellitus or other types of diabetes mellitus. The purpose of this study was to determine the differences in C-peptide, (which reflects endogenous insulin levels) levels in patients with gynecologic malignancy who underwent carboplatin chemotherapy. This study was a comparative observational study with a cross-sectional design. There was a total of 42 subjects who met the inclusion criteria. Subjects with gynecological malignancy post-carboplatin chemotherapy regimens had lower serum C-peptide levels in group II compared to group I. Serum C-peptide levels can further be used to monitor side effects of carboplatin and can be used as a test to diagnose the other types of diabetes mellitus especially before starting the fourth cycle
Theoretical Study: Pengelolaan Work Life Balance Pada Tenaga Kesehatan Di Rumah Sakit Wijaya Johanes Chendra; Vip Paramarta; Giska Dianvayani; Raja Iqbal Mulya Harahap; M Hasyrul Muchtar
Jurnal Rumpun Ilmu Kesehatan Vol. 3 No. 2 (2023): Juli: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v3i2.1769

Abstract

Health workers have an important role to improve the maximum quality of health services to the community. It is also necessary for health workers to consider balanced work, one of which is the management of work life balance (WLB). Work Life Balance as an individual's ability to balance his responsibilities at work and things that are not related to work. The purpose of this theoretical study is to find out the management of work life balance in health workers in hospitals. The method used is a theoretical study by analyzing and comparing existing theories. It then learns more about a subject in theory or research and helps readers understand it better and with implications. The data that has been obtained is then analyzed and presented in narrative form in the form of diagrams or schematics whose contents discuss the results of the research analyzed from some of the literature. The result of this theoretical study is to arrange plans and schedules, control unnecessary things, filter between professional and personal, prevent burn out, and increase job attendance. It can be concluded that work life balance or balance of time in the context of working in a hospital, namely as health workers have the ability to balance between the time we provide as a professional in the workplace and the time we provide as a person outside where we work. Health workers who have a good work-life balance, then a person can be more productive and efficient at work. This also supports increasing satisfaction in doing work. It is hoped that the hospital and health workers will always conduct training to support increasing the professionalism of health workers and balancing their responsibilities at work and those that are not related to work. In addition, as a professionalism and performance appraisal that is assessed in terms of punctuality, discipline and altruism.
PERBANDINGAN BIAYA PEMERIKSAAN LABORATORIUM PADA PASIEN TUBERKULOSIS MULTIDRUG RESISTANCE (TB-MDR) DENGAN TUBERKULOSIS EXTENSIVE DRUG RESISTANCE (TB-XDR): STUDI PADA RUMAH SAKIT TERSIER DI BANDUNG Raja Iqbal Mulya Harahap; Juandika Juandika; Dety Mulyanti
DIAGNOSA: Jurnal Ilmu Kesehatan dan Keperawatan Vol. 1 No. 1 (2023): Februari : Jurnal Ilmu Kesehatan dan Keperawatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59581/diagnosa-widyakarya.v1i1.156

Abstract

Introduction. Tuberculosis (TB) is one of the oldest diseases known to attack humans, caused by the bacterium Mycobacterium tuberculosis. Multi-drug-resistant TB (MDR-TB) is a stage or condition in which Mycobacterium tuberculosis becomes minimally resistant to rifampicin administration and also insonicotinylhydrazine (INH). Extensive-drug-resistant TB (XDR-TB) is an MDR-TB with Mycobacterium tuberculosis immune characteristics against one of the fluoroquinolone class drugs and one of the second-line injection OAT (capreomycin, kanamycin, and amikacin). The aim of this study was to find out the description of variation in laboratory costs of MDR-TB/XDR patients on one treatment cycle. Method. The inclusion criteria were patients who had been diagnosed with MDR-TB/XDR and performed laboratory tests. The design of this study was a cross-sectional retrospective analytics using medical records of MDR-TB/XDR patients in MDR division. Results. There were 30 MDR-TB research subjects and 2 XDR-TB research subjects examined for laboratory examination. Comparison of laboratory mean of MDR-TB/XDR (p = 0,018). Discussion. There was a significant difference in the total cost of MDR-TB/XDR laboratory examinations in one treatment cycle. Conclusion. Laboratory examination of MDR-TB/XDR patients requires considerable cost, this is due to the side effects of OAT that require patient clinical monitoring.
Thawing Time Difference between Fresh Frozen Plasma Using Ziplock Plastic and non-Ziplock Plastic in Blood Transfusion Unit Dr. Hasan Sadikin General Hospital Bandung, Indonesia Rinanty, Rima; Lismayanti, Leni; Harahap, Raja Iqbal Mulya
Althea Medical Journal Vol 10, No 3 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v10n3.2795

Abstract

Background: The quality of fresh frozen plasma (FFP) in a clinical setting depends on thawing time. Thawing using a water bath is often used in blood transfusion units because it is easy to perform, affordable, and easy to look for. Protective plastics (Ziplock and non-Ziplock) are used to reduce the risk of contamination,. This study aimed to determine whether there is a difference in thawing time between FFP using Ziplock plastic and non-Ziplock plastic.Method: This experimental design was conducted in the Blood Bank Unit of Hasan Sadikin Hospital from June-August 2021. Samples were divided into two groups, namely thawing using Ziplock and non-Ziplock. Each group consisted of volume 160-200 ml and 201-240 ml.Results: The total samples were 24 FFP bags. In the group of the bag 160-200 ml, the median thawing time using Ziplock plastic was 8 minutes (8-16 minutes), non-Ziplock was 15 minutes (8-16 minutes) (p value 0,111), whereas in a group of bags with volume 201-240 ml, the median thawing time using Ziplock was 15 minutes (8-28 minutes), non-Ziplock was 20 minutes (14-30 minutes) (p- value 0,332). Although there was a time difference in both groups, the difference was non-significant.Conclusion: The thawing time between the small bag with a volume of 160-200 ml and the larger volume of 201-240 ml shows no difference. Ziplock plastic can be used to reduce the risk of contamination.
PENINGKATAN KADAR BILIRUBIN TOTAL SERUM DAN KAITANNYA DENGAN DERAJAT KLINIS PASIEN COVID-19: Elevation of Total Bilirubin Serum and Its Correlation with Clinical State of Covid-19 Patient Rostini, Tiene; Kurnia Pramono, Laila; Tjandrawati, Anna; Harahap, Raja Iqbal Mulya
Medica Hospitalia : Journal of Clinical Medicine Vol. 9 No. 2 (2022): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (273.579 KB) | DOI: 10.36408/mhjcm.v9i2.697

Abstract

Latar belakang : Reseptor utama SARS-CoV-2, yaitu Angiotensin Converting Enzyme-2 (ACE-2) diekspresikan secara luas pada tubuh manusia. Derajat klinis infeksi Coronavirus Disease 2019 (COVID-19) bervariasi, dan diklasifikasikan menjadi asimtomatik, sakit ringan, sakit sedang, sakit berat, dan kritis. Peningkatan kadar bilirubin total serum sering dihubungkan dengan derajat klinis penyakit serta mortalitas COVID-19. Penelitian ini bertujuan untuk mengetahui peningkatan kadar bilirubin total serum dan hubungannya dengan derajat klinis infeksi COVID-19 Metode : Desain penelitian adalah cross sectional dengan pengambilan data secara simple random sampling. Data yang dikumpulkan sebanyak 73 sampel yang berasal dari RSUP Dr. Hasan Sadikin dalam periode Mei–Desember 2020. Data bilirubin total dan derajat klinis infeksi COVID-19 dianalisis menggunakan Uji Mann-Whitney dan Uji Spearman untuk mendapatkan hubungan antara kedua variabel. Hasil : Hasil penelitian ini menunjukkan laki-laki lebih banyak dari perempuan, dengan dominasi subjek berusia 46–65 tahun, yaitu sebanyak 47,9% dari keseluruhan sampel. Median kadar bilirubin total serum pada infeksi COVID-19 derajat klinis berat-kritis lebih tinggi dibandingkan derajat klinis sedang (0,8 mg/dl vs 0,4 mg/dl), dengan koefisien r sebesar 0,463 (p<0,05). Simpulan : Peningkatan kadar bilirubin total serum berhubungan dengan derajat klinis infeksi COVID-19 di RSUP Dr. Hasan Sadikin Bandung. Penelitian lebih lanjut dapat dilakukan secara kohort prospektif yang mengukur kadar bilirubin total serum secara serial dan menilai outcome subjek penelitian.
Correlation Between Testosterone Level With HBA1C Level As Glycemic Control Marker Among Type 2 Diabetes Mellitus Patient Harahap, Raja Iqbal Mulya; Tristina, Nina; Nurhayati, Imas; Rachmayati, Sylvia
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.941

Abstract

BACKGROUND: Type 2 Diabetes Mellitus could cause various complications due to formation of advanced glycation end products (AGEs).  The AGEs could destroy many organs into cellular level, one of them is testis, then causing testosterone production deficiency, and hypogonadism. Meanwhile, the AGEs formation in vivo will depend on on mean glucose level in T2DM patient. HbA1C is one of the most common parameter used to asses glycemic control among T2DM patient. OBJECTIVE: This research was conducted to find out the correlation between serum total testosterone with HbA1C level among T2DM patient METHOD:Research subject was collected from Outpatient Polyclinic of Internal Medicine Departement Hasan Sadikin Hospital. HbA1C examination was conducted with turbidimetry method, meanwhile total testosterone level was performed with ELISA method. The examination of research parameter was done at Clinical Laboratory Installation of Hasan Sadikin Bandung   RESULT: During sample collection periode, 70 patients was collected and fulfilled the inclusion criteria, 18 of 70 subjects has low testosteron level with Mean (SD): 424, 48 (204,82) ng/mL. Correlationntesting between the variables showed r = -0,619 , and p-value <0.001, which means strong and significant correlation between total testosterone and HbA1C among T2DM patient.   CONCLUSION: There was strong and significant correlation between total testosterone with HbA1C level among T2DM patients, further research could be conducted with prospective cohort method or using free testosterone examination.
Co-Authors Adhi Kristianto Sugianli Anna Tjandrawati Delita Prihatni Dety Mulyanti Dewi Kartika Turbawaty Giska Dianvayani Juandika Juandika Juandika Juandika Kurnia Pramono, Laila Lastri Supriatin Leni Lismayanti M Hasyrul Muchtar Nida Suraya Nina Tristina Nina Tristina Nurhayati, Imas Rinanty, Rima Sylvia Rachmayati Tiene Rostini, Tiene Vip Paramarta Wijaya Johanes Chendra