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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research Indonesian Journal of Biomedicine and Clinical Sciences
Hermawan Istiadi
Department of Anatomical Pathology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience

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The Effect of Apium graveolens (Linn) Extract on Reepithelialization of Incision Wounds: In Vivo Study Muhammad Avicenna Abdul Syukur; Endang Mahati; Vega Karlowee; Hermawan Istiadi; Indah Saraswati; Najatullah; Muflihatul Muniroh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.735

Abstract

Background: A wound is a disorder of the continuity of the epithelial layer of the skin or mucosa and can result from physical or thermal damage. Proliferation and remodeling processes are important phases in incision wound healing. Celery is believed to have the potential to regulate the inflammatory phase and accelerate the process of proliferation and remodeling of wound tissue. This study aims to evaluate the potency of celery extract (Apium graveolens (Linn)) on incision wound healing in vivo. Methods: This study was an in vivo experimental study. A total of 24 rats were used in this study and divided into 4 treatment groups (2 control and 2 treatment groups). Analysis of epithelial thickness ratio and epithelial length was performed using SPSS using univariate and bivariate. Results: The control group had the lowest epithelial thickness ratio, followed by 50% extract, 75% extract, and finally, the gentamicin group. The length of newly formed epithelium in wounds treated with Apium graveolens (Linn) extract group 70% (mean 1.461 mm) was similar to that treated with gentamicin 0.1% (mean 1.457 mm) and much better than those treated without extract (0.869 mm). Conclusion: Celery extract (Apium graveolens (Linn)) has the potential to accelerate the process of reepithelialization of incision wounds in vivo studies.
The Effect of Apium graveolens (Linn) Extract on Reepithelialization of Incision Wounds: In Vivo Study Muhammad Avicenna Abdul Syukur; Endang Mahati; Vega Karlowee; Hermawan Istiadi; Indah Saraswati; Najatullah; Muflihatul Muniroh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 18 (2023): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i18.735

Abstract

Background: A wound is a disorder of the continuity of the epithelial layer of the skin or mucosa and can result from physical or thermal damage. Proliferation and remodeling processes are important phases in incision wound healing. Celery is believed to have the potential to regulate the inflammatory phase and accelerate the process of proliferation and remodeling of wound tissue. This study aims to evaluate the potency of celery extract (Apium graveolens (Linn)) on incision wound healing in vivo. Methods: This study was an in vivo experimental study. A total of 24 rats were used in this study and divided into 4 treatment groups (2 control and 2 treatment groups). Analysis of epithelial thickness ratio and epithelial length was performed using SPSS using univariate and bivariate. Results: The control group had the lowest epithelial thickness ratio, followed by 50% extract, 75% extract, and finally, the gentamicin group. The length of newly formed epithelium in wounds treated with Apium graveolens (Linn) extract group 70% (mean 1.461 mm) was similar to that treated with gentamicin 0.1% (mean 1.457 mm) and much better than those treated without extract (0.869 mm). Conclusion: Celery extract (Apium graveolens (Linn)) has the potential to accelerate the process of reepithelialization of incision wounds in vivo studies.
In vivo assay of Gigantochloa apus shoot extract as biolarvicide for myiasis-causing fly larvae Aqsa Aufa Syauqi Sadana; Hermawan Istiadi; Ryan Halleyantoro; Muflihatul Muniroh
Indonesian Journal of Biomedicine and Clinical Sciences Vol 57 No 4 (2025)
Publisher : Published by Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/inajbcs.v57i4.16307

Abstract

The use of synthetic insecticides in treating myiasis is associated with adverse side effects and potential disruption of metabolic systems, prompting interest in natural alternatives. This study investigated the in vivo larvicidal efficacy of Gigantochloa apus bamboo shoot extract, formulated as a spray gel. Twenty-five Wistar rats were randomly divided into 5 groups: a negative control group, a positive control (ivermectin), and 3 treatment groups receiving of 1%, 3%, and 5% G. apus bamboo shoot extract. Myiasis was induced by introducing fly larvae into standardized wounds. Treatments were applied topically twice daily for 32 hr, and larval mortality was assessed every 8 hr. Phytochemical screening and GC-MS analysis revealed the presence of bioactive compounds, including alkaloids, flavonoids, tannins, saponins, and hydrogen cyanide, all of which are known for their larvicidal, neurotoxic, and antiproliferative properties. The 5% extract group showed the highest mortality rate (100%) at 32 hr. The LC50 and LC95 values were determined at 1.43% and 6.01%, respectively. Compared to the standard ivermectin treatment, the 5% extract demonstrated a shorter lethal time and more rapid larval death. Morphological examination revealed darker abdominal segments in the dead larvae, indicating a potential interaction with the digestive tract. These findings indicate that G. apus bamboo shoot extract has potential larvicidal activity and can be an effective natural alternative for treating myiasis.
Co-Authors Aqsa Aufa Syauqi Sadana Endang Mahati Indah Saraswati Muflihatul Muniroh Muhammad Avicenna Abdul Syukur Najatullah Ryan Halleyantoro Vega Karlowee