Claim Missing Document
Check
Articles

Found 4 Documents
Search

ANTIOXIDANT EFFECTIVENESS TEST USING UV-VISIBLE SPECTROPHOTOMETRY IN FORMULATIONS ETHANOL EXTRACT OF KELUBI FRUIT FLESH (Eleiodoxa conferta (Griff.) Burret) MOISTURIZING CREAM PREPARATIONS Kanne Dachi; Sudewi Sudewi; Nilsya Febrika Zebua; Siti Salmiyah; Ika Julianti Tambunan
Jambura Journal of Health Sciences and Research Vol 5, No 1 (2023): JANUARI: JAMBURA JOURNAL OF HEALTH SCIENCES AND RESEARCH
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35971/jjhsr.v5i1.17617

Abstract

Buah kelubi (Eleiodoxa conferta (Griff.) Burret)  adalah tanaman buah yang mengandung senyawa flavonoid sangat bermanfaat untuk kulit. Kebaruan penelitian ini karena peneliti melakukan pengujian efektivitas antioksidan menggunakan spektrofotometri uv-visible pada formulasi ekstrak etanol daging buah kelubi dalam sediaan krim pelembab kulit. Tujuan penelitian untuk menganalisis ekstrak etanol daging buah kelubi yang diformulasikan kedalam sediaan krim pelembab pada beberapa variasi konsentrasi yang memiliki aktivitas sebagai antioksidan dan tidak menimbulkan iritasi pada kulit. Penelitian menggunakan metode deskriptif dan eksperimental dengan bahan uji daging buah kelubi yang di maserasi menggunakan penyari etanol 96% diformulasikan kedalam krim pelembab menggunakan konsentrasi 1,5%, 2,0%, 2,5% serta blanko. Hasil pengujian pada sediaan krim pelembab menunjukkan bahwa ekstrak etanol daging buah kelubi (Eleiodoxaconferta (Griff.) Burret) dapat diformulasikan dalam bentuk sediaan krim pelembab yang homogen dengan tipe emulsi M/A serta mempunyai nilai pH yang sesuai denga pH kulit fisiologis manusia yaitu nilai pH sediaan krim pelembab sesaat setelah dibuat adalah 6,1-6,5 dan pH sediaan krim pelembab setelah dilakukan Cycling test adalah 6,0-6,3. Sediaan krim pelembab dengan konsentrasi ekstrak etanol daging buah kelubi sebesar 2,5% adalah sediaan terbaik yang mampu memberikan kelembaban pada kulit sukarelawan dengan nilai 56 dimana nilai tersebut dikategorikan  “Hidrasi”, dengan persen pemulihan kelembapan pada kulit sebesar 28,04% selama 4 minggu pemakaian dengan kategori antioksidan sedang (IC50= 118,4903 ppm) dan blanko tergolong sebagai antioksidan yang sangat lemah (IC50= 243,0549 ppm). Kesimpulannya sediaan krim pelembab ekstrak etanol daging buah kelubi tidak menimbulakan efek mengiritasi kulit.Kata Kunci: Antioksidan; Ekstrak etanol; Buah kelubi; Krim pelembab.AbstractKelubi fruit (Eleiodoxa conferta (Griff.) Burret) is a fruit plant that contains flavonoid compounds that are very beneficial for the skin. The novelty of this study is that researchers tested the effectiveness of antioxidants using UV-visible spectrophotometry on the formulation of ethanol extract of kelubi fruit flesh in skin moisturizing cream preparations. The purpose of the study was to analyze ethanol extract of kelubi fruit flesh formulated into a moisturizing cream preparation at several concentration variations that have activity as antioxidants and do not cause irritation to the skin. The study used descriptive and experimental methods with test materials for kelubi fruit flesh which was macerated using 96% ethanol filtering formulated into a moisturizing cream utilizing a concentration of 1.5%, 2.0%, 2.5%, and blanks. The test results on moisturizing cream preparations showed that ethanol extract of kelubi fruit flesh (Eleiodoxaconferta (Griff.) Burret) can be formulated in the dosage form of a homogeneous moisturizing cream with an M / A emulsion type and has a pH value that is under the pH of human physiological skin, namely the pH value of the moisturizing cream preparation shortly after it is made is 6.1-6.5, and the pH of the moisturizing cream preparation after the cycling test is 6.0-6.3. A moisturizing cream preparation with a concentration of ethanol extract of kelubi fruit flesh 2.5% is the best preparation that can provide moisture to the skin of volunteers with a value of 56 where the value is categorized as "Hydration," with a moisture recovery percent on the skin of 28.04% for 4 weeks of use with a moderate antioxidant category (IC50 = 118.4903 ppm) and blanks classified as very weak antioxidants (IC50 = 243.0549 ppm). In conclusion, preparing the moisturizing cream of ethanol extract from kelubi fruit flesh does not cause an irritating effect on the skin.
Fermentasi Seduhan Kopi Arabika Dengan Bakteri Lactobacillus Casei Dan Ragi Saccharomyces Cerevisiae Dan Uji Toksisitas Nurul Afwa Yustika Sari; Sumardi; Salman; Ika Julianti Tambunan; Kanne Dachi; Siti Muliani Julianty
Jurnal Indah Sains dan Klinis Vol 2 No 3 (2021): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v2i3.32

Abstract

Coffee drinks are one of the most popular drinks for people of all ages, especially adults. But now with the addition of flavor, most people are enjoying coffee drinks.The purpose of the study was to see the effect of fermentation on the taste and aroma of brewed Arabica coffee with Lactobacillus casei and yeast Saccharomyces cerevisiae isolates with the addition of grape juice and sucrose and the level of toxicity of the fermentation of brewed Arabica coffee with the Brine Shrimp Lethality Test (BSLT).This research is experimental, namely the fermentation of brewed Arabica coffee with Lactobacillus casei and yeast Saccharomyces cerevisiae isolates with the addition of grape juice and sucrose. Fermentation was carried out for 3 days at open room temperature under anaerobic conditions. The results of the fermentation were tested for Brine Shrimp Lethality Test (BSLT), alcohol content test and organoleptic test by 15 panelists. Furthermore, the data were tested using the hedonic test of analysis of variance.The results of the variance showed that the fermentation of roasted Arabica coffee and green beans on taste obtained F count < F table 1% showed no significant difference, for aroma obtained F count > F table 1% showed there was a significant difference, to the color of the steeped fermented sample Roasted Arabica coffee obtained F count < F table 1% shows there is no real difference while in green beans obtained F count > F table 1% shows there is a significant difference.
Optimasi Formula Minuman Kopi Kombinasi Ekstrak Jahe (Zingiber officinale) dan Temu Giring (Curcuma heyneana) sebagai Antioksidan Ika Julianti Tambunan; Ayuning Putri Julian; Siti Muliani Julianty; Kanne Dachi; Sumardi; Samran
Jurnal Indah Sains dan Klinis Vol 3 No 2 (2022): Jurnal Indah Sains dan Klinis
Publisher : Yayasan Penelitian dan Inovasi Sumatera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52622/jisk.v3i2.62

Abstract

Kopi mengandung polyphenol sebagai senyawa antioksidan. Kandungan yang terdapat pada temu giring adalah senyawa alkaloida, flavonoida, triterpenoida, saponin dan tanin sebagai antioksidan. Jahe mengandung gingerol, beta-caroten, asam mengandung gingerol, beta-caroten, asamkafeat, curc kafeat, curcumin sebagai antioksidan. Tujuan dari p umin sebagai antioksidan. Tujuan dari penelitian enelitian ini adalah untuk mengetahui apakah minuman kopi yang dikombinasikan dengan ekstrak jahe ( Zingiber officinale) dan ekstrak temu giring (Curcuma heyneana) memiliki kapasitas antioksidan dan disukai oleh sukarelawan. Penelitian ini secara eksperimental dalam menyiapkan minuman kopi yang menggabungk menggabungkan ekstrak jahe ekstrak jahe dan ekstrak temu ekstrak temu giring dan giring dan mendemonstrasi mendemonstrasikan penemuan simplisia, penemuan simplisia, produksi produksi ekstrak ekstrak jahe dan temu giring, giring, serta optimasi optimasi formula formula menggunaka menggunakan SLD ( simplex simplex lattice lattice design) dan melakukan survey survey responden responden pada setiap formula. Rendemen simplisia jahe 500 g dan temu giring 750 g giring 750 g dengan berat ekstrak jahe sebanya dengan berat ekstrak jahe sebanyak 88,8 g k 88,8 g dan berat ekstrak temu giring sebanyak 98, dan berat ekstrak temu giring sebanyak 98,2 g. Penentuan optimasi formula menggunakan SLD didasarkan pada aktivitas antioksidan formula yang optimal, yaitu rasio jahe : temu giring (1/4 : optimal, yaitu rasio jahe : temu giring (1/4 : 3/4) formula II dan hasil formula II dan hasil hedonist masing-masing formula adalah formula IV dengan rasio jahe : temu giring (3/4 : 1/4)
Formulation and Antioxidant Activity Test Of Body Lotion Preparation of Ethanol Extract of Sky Mustard Leaves (Cyanthillium cinereum (L) H.Rob) As A Moisturizer Ika Julianti Tambunan; Siti Muliani
Jurnal FARMASIMED (JFM) Vol 7 No 2 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/jfm.v7i2.2441

Abstract

The skin is the first protection to ward off free radicals. Cosmetics used on the skin throughout the body are body lotions. The content of the sky mustard leaves (Cyanthillium cinereum (L) H. Rob) are alkaloid compounds, phenols, saponins, steroids, tannins, and flavonoids that function as antioxidants. This study aims to determine the antioxidant activity of the formulation of body lotion preparations of ethanol extract of sky mustard leaves. This study was conducted using an experimental method. The method of maceration of sky mustard leaves (Cyanthillium cinereum (L) H. Rob) using 96% ethanol. The methods used include selecting a standard formula, making body lotion preparations in concentrations of 1%, 1.5%, 2% and blanks, as well as evaluating the physical quality of the preparations and testing antioxidant activity using the DPPH method. The results showed that the leaves of the sky mustard (Cyanthillium cinereum (L) H. Rob) can be formulated into a body lotion preparation. The preparation obtained was stable and homogeneous, an oil-in-water emulsion type, pH immediately after being made 5.6 - 6.0 and after the cycling test 6.0 - 6.05, with a viscosity value of 2,300-4750 mPa's. The body lotion preparation of the sky mustard leaves with a concentration of 2% was the best preparation with a recovery percentage of 57.53% and an IC50 value of 61.38 ppm, including the "strong" category. The extract of the sky mustard leaves had an IC50 value of 14.75 ppm, which was categorized as "very strong". The blank preparation had an IC50 value of 156.91 ppm, including the "moderate" category.