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Rastria Meilanda
Institut Kesehatan Mitra Bunda
Agriculture, Biological Sciences & Forestry Chemistry Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Efek Penurunan Kadar Asam Urat Ekstrak Daun Kelor (Moringa Oleifera Lamk) pada Tikus Putih Jantan Galur Wistar (Rattus Norvegicus) Rastria Meilanda; Nyimas Nikmah Lanuari
SEHATMAS: Jurnal Ilmiah Kesehatan Masyarakat Vol. 2 No. 1 (2023): Januari 2023
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/sehatmas.v2i1.1012

Abstract

Gout is a disease of the residual metabolism of purine substances derived from the rest of the food we consumed. This study used Moringa oleifera Lamk as a treatment for gout. This study aims to know the effect of Moringa oleifera Lamk leaf extract on decreasing uric acid levels in male white rats wistar (Rattus norvegicus). This study used maceration method, using male white rats aged 2-3 months, weighing 100-150 grams. Rats were divided into 10 groups. Each group consisted of 3 rats. Induction given was chicken liver juice as much as 5 ml/200 gBB for 7 days orally.On the 7th day, measurement of uric acid was carried out 6 hours after the last induction. Giving group for negative control was given 1% CMC,for positive control Allopurinol was given, and for giving Moringa leaf extract on fresh and dry leaves dose 2,5 mg/gBB, 4,5 mg/gBB, 9 mg/gBB, 18 mg/gBB every day orally for 7 days. Measurement ofthe decrease in uric acid levels using the Easy Touch® GCU test strip on the 14th day in the 60th, 120th, and 180th minutes. The results showed that freshMoringa(Moringa oleifera Lamk) leaf extract was more effective in reducing uric acid levels in male whitewistar rats (Rattus norvegicus) and dosage which affects the decreasion of uric acid levels in male white rats wistar strain (Rattus norvegicus) is a dose of 18 mg/gBB in the 120th minutes.
ANTIBACTERIAL ACTIVITY OF SEA GRAPES (Caulerpa racemosa) AGAINST Streptococcusmutans AND Shigella dysenteriae Sri Hainil; Hesti Marliza; Maria Yunivista; Rastria Meilanda
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2471

Abstract

The Riau Islands are known as an island group in Indonesia that is famous for its wealth of marine plants. Among the prominent marine flora, sea grape (Caulerpa racemosa) is a marine plant that produces secondary metabolites including alkaloids, saponins, phenolics, and flavonoids which have been proven to have antibacterial properties. Previous research showed that 70% ethanol extract from sea grapes exhibited strong antibacterial activity. However, there is no detailed information regarding the ability of the n-hexane and ethyl acetate fractions of sea grapes as antibacterials. This study aims to examine the antibacterial effects of n-hexane and ethyl acetate fractions from sea grapes against Streptococcus mutans and Shigella dysenteriae. The sea grape extraction process is carried out through the maceration method using 95% ethanol solvent, followed by the fractionation stage using the liquid-liquid extraction method. This fractionation process involves the use of non-polar (n-hexane) and semi-polar (ethyl acetate) solvents. The test method used was disk paper diffusion with varying fraction concentrations: 500 μg/disc, 400 μg/disk, 300 μg/disc, and 200 μg/disk. The positive control for this study used 30 μg/disc of tetracycline, because tetracycline is known as a broad-spectrum antibiotic. Meanwhile, the negative control used 10% DMSO. Findings from the research stated that the n-hexane fraction could not stop the growth of Streptococcus mutans bacteria, while the ethyl acetate fraction was able to inhibit the development of these bacteria. The average diameter at a concentration of 500 μg/disk was 9.2 mm, 400 μg/disk is 8 mm, 300 μg/disc is 7.7 mm, and 200 μg/disc is 6.5 mm. However, neither the ethyl acetate nor n-hexane fractions showed an inhibition zone against Shigella dysenteriae bacteria
Co-Authors Diani Megasari Hasan, Nahrul Hesti Marliza Maria Yunivista Nyimas Nikmah Lanuari Sri Hainil Suhaera Suhaera