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All Journal Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Jurnal Kesehatan Islam : Islamic Health Journal
Dian Novita Wulandari
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Medicine & Pharmacology Public Health

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Skrining Potensi Essential Oil Cananga odorata dalam Penghambatannya Terhadap ACE II dan TMPRSS2 sebagai Anti Covid-19: Pendekatan In Silico Yoni Rina Bintari; Dian Novita Wulandari
Jurnal Ilmiah Biosaintropis (Bioscience-Tropic) Vol 8 No 2 (2023): Januari 2023
Publisher : Fakultas Matematika & Ilmu Pengetahuan Alam - Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/e-jbst.v8i2.508

Abstract

COVID-19 is a disease caused by viruses of the coronavirus class that are known to enter humans through the Angiotensin Coverting Enzyme (ACE II) receptor protein and transmembrane serine protease (TMPRSS 2). COVID-19 has become a pandemic, so it requires an agent that acts as an anti-Covid-19. Cananga odora is an herb that contains EO (Essential Oils) and is widely grown in Indonesia. EO are known to have antiviral potential.This study aims to explore the potential of EO from C.odora using a molecular docking approach by measuring its inhibition of ACE II (Q9BYF1) and TMPRSS2 (7MEQ). The inhibitory potential was calculated from the binding affinity using Pyrex Autodock Vina software. The docking results are then visualized using Biovia Discovery Studio and PyMOL. Prediction of physicochemical and pharmacokinetic profiles through pKCsm web. The docking results showed that geranyl acetate inhibited ACE II at Lys 562 with a gibs energy of -7.5 kcal. Thebest inhibition of TMPRSS2 by cedrole with energy gibs -6.2 kcal/mol via Pro 375. The active compound C. odorata has a different inhibitory mechanism from the control (chloroquine). The results of the in silico test predict the pharmacokinetic profile of EO from C.odora geranil asetat which has good absorption, distribution, metabolism and excretion values and is non-toxic, and cedrole can cross the blood brain barier.
POTENSI ANTIOKSIDAN FRAKSI n-HEKSANA DAUN UBI JALAR UNGU (Ipomoea batatas L.) Fina Dwi Saadah; Denis Mery Mirza; Dian Novita Wulandari
Jurnal Kesehatan Islam : Islamic Health Journal Vol. 13 No. 2 (2024): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v13i2.22844

Abstract

ABSTRAK Antioxidants are compounds that have the advantage of neutralizing free radicals and are found in many plants. Purple sweet potato leaves (Ipomoea batatas L.) belong to the Convolvulaceae family and have potential as antioxidants due to their compound content. The n-Hexane fraction of I. batatas leaves have non-polar active compounds that have the potential to act as antioxidants such as terpenoids and steroids. This study aims to determine the active substance content and antioxidant activity in the n-Hexane fraction of I. batatas leaves. I. batatas leaves were extracted using the ultrasonic-assisted extraction method with ethanol p.a. followed by liquid-liquid fractionation using n-Hexane solvent. Identification of active compounds used phytochemical screening methods and continued testing antioxidant activity using the 2,2-diphenyl-1-picryl-hydrazylhydrate (DPPH) method with ascorbic acid as standard. The data is expressed as percent inhibition and IC50 values calculated from the linear equation. The n-Hexane fraction of I. batatas was positive for containing terpenoid compounds and has antioxidant activity of the DPPH method is in the very weak category with an IC50 value of 278,27 µg/ml compared to ascorbic acid (IC50 8,90 µg/ml) in the very strong category. The n-Hexane fraction of I. batatas leaves contains terpenoid compounds and has antioxidant activity very weak antioxidant activity with an IC50 value of 278,27 µg/mL. Keywords: Antioxidant, DPPH, Faction, Leaf I. batatas.
Co-Authors Denis Mery Mirza Fina Dwi Saadah Yoni Rina Bintari