Article Per Year (5 Year)
p-Index From 2020 - 2025
0.92
P-Index
This Author published in this journals
All Journal WMJ (Warmadewa Medical Journal) JURNAL PENDIDIKAN TAMBUSAI Medical and Health Science Journal Jurnal Sewaka Bhakti Narra J Aesculapius Medical Journal
Anak Agung Gede Budhitresna, Anak Agung Gede
Universitas Warmadewa
Biochemistry, Genetics & Molecular Biology Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Public Health Social Sciences Other

Published : 7 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 7 Documents
Search

 1 
Korelasi Kadar Angiopoietin-2 Plasma dan Petanda Inflamasi Dengan Resistensi Insulin Pada Penderita Obesitas Abdominal Budhitresna, Anak Agung Gede
WMJ (Warmadewa Medical Journal) Vol 1, No 1 (2016):
Publisher : Fakultas Kedokteran dan Ilmu Kesehatan Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Obesitas abdominal (Ob-Ab) merupakan komponen utama resistensi insulin (RI) yaitu kekutan pendorong utama untuk terjadinya diabetes mellitus (DM)  tipe-2. Kadar angiopoietin-2  (Ang-2) plasma dilaporkan mengalami peningkatan pada  penderita Ob-Ab dan diduga bahwa Ang-2 berpengaruh untuk terjadinya RI. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar Ang-2, Inflamasi dan RI pada penderita Ob-Ab. Dilakukan penelitian secara cross-sectional analitik pada 81 penderita dengan Ob-Ab. Kadar  TNF-α, sTNFR1 dan Ang-2 plasma diukur menggunakan metode ELISA. RI diukur menggunakan HOMA-IR. Analisis varian (ANOVA) dipergunakan untuk mengetahui persamaan variabel kontinyu. Analisis multivariat dipergunakan untuk mengetahui peran kadar TNF-α, s-TNFR-1, Ang-2 terhadap RI. Model analisis jalur (path analysis) dipergunakan untuk mengetahui pengaruh faktor risiko terjadinya RI. Hasil penelitian menunjukkan bahwa kadar TNF-α plasma tidak berkorelasi dengan HOMA-IR, sedangkan sTNFR-1 dan  Ang-2 plasma berkorelasi positif bermakna dengan HOMA-IR (masing-masing r=0,323; p=0.003 dan r = 0,641; p=<0,001). Pada analisis multivariat ditemukan Ang-2 merupakan faktor bebas berhubungan dengan HOMA-IR (p=<0,001). Kadar Ang-2 plasma yang tinggi merupakan faktor dominan (64,1%, p=< 0.001). Simpulan: pada penderita Ob-Ab kadar Ang-2 berkorelasi dengan terjadinya RI dan inflamasi. Kata kunci: Ang-2, resistensi insulin, inflamasi, obesitas abdominal.   [Correlation of Plasma Angiopoietin-2 and Inflammation Marker with Insulin Resistence in Patients with Central Obesity] Abdominal obesity (Ab-Ob) is a central component of insulin resistance (IR) and it is suggested that IR is a driving factor in the development of type 2 diabetes mellitus (T2DM).  Plasma Ang-2 levels have been reported to increase in the Ab-Ob and it has been hypothesized that Ang-2 plays important role in the occurrence of IR. We assessed the relationship between plasma Ang-2 levels, Inflammation and IR in Ab-Ob. A cross-sectional analytic study on 81 abdominally obese subjects was performed. The concentrations of TNF-α, sTNFR1 and Ang-2 plasma were measured using ELISA method. IR was measured using HOMA-IR. Analysis of variance (ANOVA) was used to test the equality of continuous variables. Multivariate analyses were performed to examine the influence of TNF-α, s-TNFR-1, and Ang-2 on IR. Path analysis models were performed to assess the influence of risk factors on occurrence of IR. Plasma of TNF-α was not correlated with HOMA-IR (r=160; p=0,154) whereasTNFR-1 and Ang-2 were significantly positive correlated with HOMA-IR (r=0.323, p = 0.003 and r = 0.641, p=<0.001, respectively).  The multivariate analysis showed Ang-2 was independently associated with HOMA-IR (p <0.001). It was found that high Ang-2 level was a dominant risk factor (64.1%, p=<0.001) for influencing IR in the abdominally obese subjects. It is concluded that plasma Ang-2 level is correlated with occurrence of IR and inflammation in abdominally obese subjects. Keywords: Ang-2, insulin resistance, inflammation, abdominal-obesity.
Korelasi Kadar Angiopoietin-2 Plasma dan Petanda Inflamasi Dengan Resistensi Insulin Pada Penderita Obesitas Abdominal Anak Agung Gede Budhitresna
WMJ (Warmadewa Medical Journal) Vol 1 No 1 (2016): Mei 2016
Publisher : Warmadewa University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wmj.1.1.5.10-16

Abstract

Obesitas abdominal (Ob-Ab) merupakan komponen utama resistensi insulin (RI) yaitu kekutan pendorong utama untuk terjadinya diabetes mellitus (DM)  tipe-2. Kadar angiopoietin-2  (Ang-2) plasma dilaporkan mengalami peningkatan pada  penderita Ob-Ab dan diduga bahwa Ang-2 berpengaruh untuk terjadinya RI. Tujuan penelitian ini adalah untuk mengetahui korelasi kadar Ang-2, Inflamasi dan RI pada penderita Ob-Ab. Dilakukan penelitian secara cross-sectional analitik pada 81 penderita dengan Ob-Ab. Kadar  TNF-α, sTNFR1 dan Ang-2 plasma diukur menggunakan metode ELISA. RI diukur menggunakan HOMA-IR. Analisis varian (ANOVA) dipergunakan untuk mengetahui persamaan variabel kontinyu. Analisis multivariat dipergunakan untuk mengetahui peran kadar TNF-α, s-TNFR-1, Ang-2 terhadap RI. Model analisis jalur (path analysis) dipergunakan untuk mengetahui pengaruh faktor risiko terjadinya RI. Hasil penelitian menunjukkan bahwa kadar TNF-α plasma tidak berkorelasi dengan HOMA-IR, sedangkan sTNFR-1 dan  Ang-2 plasma berkorelasi positif bermakna dengan HOMA-IR (masing-masing r=0,323; p=0,003 dan r=0,641; p=<0,001). Pada analisis multivariat ditemukan Ang-2 merupakan faktor bebas berhubungan dengan HOMA-IR (p=<0,001). Kadar Ang-2 plasma yang tinggi merupakan faktor dominan (64,1%, p=<0,001). Simpulan: pada penderita Ob-Ab kadar Ang-2 berkorelasi dengan terjadinya RI dan inflamasi.Kata kunci: Ang-2, resistensi insulin, inflamasi, obesitas abdominal. [Correlation of Plasma Angiopoietin-2 and Inflammation Marker with Insulin Resistence in Patients with Central Obesity]Abdominal obesity (Ab-Ob) is a central component of insulin resistance (IR) and it is suggested that IR is a driving factor in the development of type 2 diabetes mellitus (T2DM).  Plasma Ang-2 levels have been reported to increase in the Ab-Ob and it has been hypothesized that Ang-2 plays important role in the occurrence of IR. We assessed the relationship between plasma Ang-2 levels, Inflammation and IR in Ab-Ob. A cross-sectional analytic study on 81 abdominally obese subjects was performed. The concentrations of TNF-α, sTNFR1 and Ang-2 plasma were measured using ELISA method. IR was measured using HOMA-IR. Analysis of variance (ANOVA) was used to test the equality of continuous variables. Multivariate analyses were performed to examine the influence of TNF-α, s-TNFR-1, and Ang-2 on IR. Path analysis models were performed to assess the influence of risk factors on occurrence of IR. Plasma of TNF-α was not correlated with HOMA-IR (r=160; p=0.154) whereasTNFR-1 and Ang-2 were significantly positive correlated with HOMA-IR (r=0.323, p=0.003 and r=0.641, p=<0.001, respectively).  The multivariate analysis showed Ang-2 was independently associated with HOMA-IR (p <0.001). It was found that high Ang-2 level was a dominant risk factor (64.1%, p=<0.001) for influencing IR in the abdominally obese subjects. It is concluded that plasma Ang-2 level is correlated with occurrence of IR and inflammation in abdominally obese subjects.Keywords: Ang-2, insulin resistance, inflammation, abdominal-obesity.
Pemberdayaan Kelompok Ibu PKK Desa Bresela dalam Peningkatan Pengetahuan Gizi Seimbang untuk Pencegahan Stunting Anak Agung Gede Budhitresna; Sri Ratna Dewi; Ayu Savitri Siskayani; Kartika Sari
JURNAL SEWAKA BHAKTI Vol 8 No 1 (2022): Sewaka Bhakti
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/jsb.v8i1.2260

Abstract

Stunting is a linear growth disorder caused by chronic nutrient intake malnutrition and or chronic or recurrent infectious diseases as indicated by a z-score for height for age (TB/U) less than -2 standard deviations (SD) based on World Health Organization standards (WHO). Stunting describes chronic undernutrition status during growth and development since early life. The prevalence of stunting in Gianyar Regency, Bali Province in 2013 was 40.99%. One of the 10 villages at the locus of stunting in Gianyar Regency is Bresela Village. The main factor causing stunting in Gianyar district based on data verification from the District Health Office. Gianyar, among others: smoking habits, personal hygiene in food preparation, level of adequacy of vitamin A, and availability of clean water. The problems that are often found are the lack of knowledge, attitudes, and behavior of the community regarding balanced nutrition and stunting in toddlers, therefore, together with partners, community empowerment is carried out through counseling about balanced nutrition as an effort to prevent stunting. Based on the pre and posttest evaluations, it was found that the knowledge of the PKM partners had increased from before and after the education had increased significantly (p value = 0.000).
Titer disparity of anti-Spike receptor binding domain SARS-CoV-2 antibody between vaccinated and naturally infected individuals Dewa P. Surawan; Duwi Sumohadi; Anak AG. Budhitresna; Putri P. Lestari; Kartika Dewi; Wasudewa Wikananda; Retenra P. Suwari; Md. Rabiul Islam; Haypheng Te; Ali A. Rabaan; Sri Masyeni
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.71

Abstract

In conjunction with other health promotion strategies, vaccination of coronavirus disease 2019 (COVID-19) is a strategy to alleviate the burden of infection. The aim of this study was to determine the differences in antibody response strength between individuals who received COVID-19 vaccination and those who had a natural infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted among post-natural confirmed COVID-19 infection and immunized people in Bali, Indonesia. The vaccination was using Sinovac-CoronaVac with two-weeks interval between the two vaccine doses. To measure the level of anti-Spike receptor binding domain (SRBD) of SARS-CoV-2 antibody, we used Roche electro-chemiluminescence immunoassay (ECLIA) platform. Blood samples were obtained before and 28 days after first immunization in the vaccinated group, as well as two weeks after hospital discharge in the confirmed COVID-19 patients based on real-time reverse transcription polymerase chain reaction (RT-PCR). A total of 58 confirmed COVID-19 patients and 60 vaccinated individuals were included. On the 28th day after the initial vaccination, the seroconversion rate among vaccinated individuals was 91.67%. The mean titer of anti-SRBD SARS-CoV-2 antibody among vaccinated participants was 63.62±82.57 IU/mL (ranged between 0 IU/mL and 250 IU/mL). The mean titer among naturally infected group was 188.47±94.57 IU/mL (ranged between 4.25 IU/mL to 250 IU/mL) regardless the severity of COVID-19. Our data suggested that the titer of anti-SRBD SARS-CoV-2 antibody was significantly higher in naturally infected individuals compared to those who received COVID-19 vaccination (p<0.001). These data suggest that not all individuals vaccinated with Sinovac COVID-19 had protective level of anti-SRBD SARS-CoV-2 antibody and booster dose of heterologous vaccine maybe required.
Gambaran Tingkat Aktivitas Fisik dan Kejadian Obesitas pada Civitas Akademika Universitas Warmadewa, Bali Tjokorda Gde Agung Dariraditya Pemayun; Anak Agung Gede Budhitresna; Pande Ayu Naya Kasih Permatananda
Jurnal Pendidikan Tambusai Vol. 6 No. 2 (2022): Agustus 2022
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (365.537 KB)

Abstract

Obesitas merupakan penimbunan lemak yang berlebihan di seluruh jaringan tubuh secara merata yang mengakibatkan gangguan kesehatan dan menimbulkan berbagai penyakit seperti diabetes, hipertensi, serangan jantung dan menyebabkan kematian. Penyebab dari obesitas adalah tidak seimbangnya jumlah energi yang masuk dengan jumlah energi yang keluar. Orang yang obesitas cenderung memiliki gaya hidup yang tidak sehat dengan tingkat aktivitas fisik yang rendah dan sering terjadi pada orang dewasa berumur diatas 18 tahun. Penelitian ini bertujuan untuk mengetahui hubungan tingkat aktivitas fisik dengan kejadian obesitas pada civitas akademika Universitas Warmadewa. Penelitian ini menggunakan metode penelitian analitik dengan rancangan studi cross sectional dan menggunakan kuesionair IPAQ untuk mengetahui tingkat aktivitas fisik dan perhitungan IMT untuk mengetahui kejadian obesitas Sampel penelitian ini adalah civitas akademika Universitas Warmadewa yang obesitas. Data yang dikumpulkan akan dianalisis menggunakan uji korelasi spearman untuk melihat hubungan aktivitas fisik dengan kejadian obesitas pada civitas akademika Universitas Warmadewa. Hasil Penelitian ini menunjukkan tidak terdapat hubungan yang bermaknaantara aktivitas fisik dengan kejadian obesitas dengan nilai signifikansi 0,289
Hubungan Antara Status Gizi Dengan Menstruasi Dini Pada Siswi di SD Saraswati 3 Denpasar I Gusti Ayu Istri Pradnya Dewi; Anak Agung Gede Budhitresna; Desak Putu Citra Udiyani
Aesculapius Medical Journal Vol 4 No 1 (2024): February
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.4.1.2024.22-28

Abstract

[Relationship Between Nutritional Status and Early Menstruation in Students at SD Saraswati 3 Denpasar] Early menstruation is increasingly showing an increase throughout the world, including in Indonesia. Bali Province ranks second after DKI Jakarta Province in cases of early menstruation, especially Denpasar City, which has a relatively high prevalence of early menstruation, reaching 26.7%. In the preliminary study that the researchers conducted at SD Saraswati 3 Denpasar, the majority of early menstruation was 40%. Excess nutritional status is often associated with earlier menstruation. This study aims to determine the relationship between nutritional status and early menstruation in female students at SD Saraswati 3 Denpasar. This research method is an observational analytic study with a cross-sectional design. The research subjects were SD Saraswati 3 Denpasar students who met the inclusion criteria with a total sample of 180 people using the total sampling method. The independent variable in this study was nutritional status, and the dependent variable was early menstruation. Research data were analyzed statistically in two stages: univariate and correlation tests with Spearmen-Rho. The P value is considered significant when P <0.05. This study found that age was obtained with an average of 9,56±1,13 years. The highest normal BMI was received by 80 female students (44,4%). Menstrual status was experienced by 77 female students (42,7%). The age of first menstruation was at the age of 11, with as many as 30 female students (16,7%). Based on the statistical test results, a moderate correlation was obtained with the results r = 0.462 and p = <0.001 (p < 0.05). This study's results indicate a significant relationship between nutritional status and early menstruation in female students at SD Saraswati 3 Denpasar.
The Relationship between Body Mass Index and Blood Pressure Control in Hypertension Patients at the Sukawati I Community Health Center, Gianyar Regency Tjahyadi, I Gede Ketut Deny Patmantha Putra; Budhitresna, Anak Agung Gede; Suka Astini, Dewa Ayu Agung Alit
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.4580

Abstract

Background: Being overweight or obese is one of the factors that cause an increase in blood pressure. The bigger a person's body, the more blood is needed to supply nutrients and oxygen to other tissues and muscles. Bali Province, especially Gianyar Regency, has a relatively high number of hypertension sufferers. The highest estimate of hypertension sufferers is in the working area of the Sukawati I Public Health Center, with a prevalence of 8.55% of the total in Gianyar Regency of 17.35%. This research aims to determine the relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Methods: The research design used was analytic observational with a crosssectional approach. The number of research subjects, namely 83 people, was taken by consecutive sampling technique. Data analysis will be carried out univariately and bivariate using the chi-square test method with a confidence level of 95% (p < 0.05). Results: The results of the univariate analysis showed that the majority of study subjects were aged 51-60 years (60.2%), were female (66.3%), most had normal BMI (66.3%), and 66.3% of subjects with hypertension were classified as have controlled blood control. Based on the results of statistical tests, a value of p = 0.003 (p < 0.05) was obtained, which indicated a significant relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Conclusion: The results of this study indicate that the increasing BMI status of hypertensive patients will tend to have uncontrolled blood pressure.
Co-Authors Ali A. Rabaan Ayu Savitri Siskayani Desak Putu Citra Udiyani Dewa P. Surawan Duwi Sumohadi Haypheng Te I Gusti Ayu Istri Pradnya Dewi Kartika Dewi Md. Rabiul Islam Ni Luh Putu Eka Kartika Sari Pande Ayu Naya Kasih Permatananda Putri P. Lestari Retenra P. Suwari Sri Masyeni, Dewa Ayu Putri Sri Ratna Dewi Suka Astini, Dewa Ayu Agung Alit Tjahyadi, I Gede Ketut Deny Patmantha Putra Tjokorda Gde Agung Dariraditya Pemayun Wasudewa Wikananda