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THE HIGH PLASMA RETINOL BINDING PROTEIN 4 LEVEL AS A RISK FACTOR CONSEQUENTLY OF TYPE 2 DIABETES MELLITUS OF ABDOMINAL OBESITY Budhitresna, AAG; Suastika, Ketut; Mantik Astawa, Nyoman; Santoso, Anwar
INDONESIAN JOURNAL OF BIOMEDICAL SCIENCES Vol. 5, No. 1 Januari 2011
Publisher : Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (149.463 KB)

Abdominal obesity (Ab-Ob) related to cardiometabolic risk, that is riskfactor constellation for succeeded cardiovasculer disease and type 2 DiabetesMellitus (DM). That factors such as atherogenic dislipidemia, hypertension,hyperglycemia, protrombotic state, and proinflammation state. Type 2 DMcharacterised by insulin resistance (IR). Plasma levels of retinol binding protein 4(RBP4) that is secreted by adipocytes are increased in insulin resistance (IR) state.Experiment in mice suggest that elevated RBP4 level cause IR. Although theunderlying mechanism is not clearly understood, RBP4 considered playimportance role consequently of type 2 DM in Ab-Ob.This research was carried out to determine the role of high plasma RBP4level as a risk factor consequently of type 2 DM in Ab-Ob. The research wasconducted by cross sectional analytic in 81 patients with Ab-Ob and case controlstudy with matching on 33 patients with Ab-Ob type 2 DM as cases and 33patients with Ab-Ob non type 2 DM as control. The plasma of TNF-?, sTNFR1,and RBP4 levels was measured by ELISA. IR status of the patients wasdetermined by HOMA-IR, whereas the ?-cell function was determined byHOMA-B. Ab-Ob was defined by using criteria for Asian peoples (male WC ? 90cm; female WC ? 80 cm). The result of 81 patients with Ab-Ob showed that bothplasma of TNF-? and sTNFR1 levels were significant positive correlated withplasma RBP4 level (coeficient correlation r = 0,294; p = 0,008 dan r = 0,458; p =<0,001 respectively). In addition, the plasma of RBP4 level significantly positivecorrelation with HOMA-IR (r = 0,450; p = 0,000) and significantly negativecorrelation with HOMA-B (r = -0,564; p = <0,001). In the matched case-controlstudy, it was shown that mean plasma of RBP4 level of type 2 DM group (76,08 ±16,84 ?g/ml) statistically higher than that without type 2 DM group (41,13 ±14,75 ?g/ml) (p = <0,001). The odds ratio higher plasma of RBP4 level was 5,426(CI 95%; 1,343 – 21, 928) statistically significant for increases risk type 2 DM (p= < 0,05). It has been proven that RBP4 was a dominant and consisten risk factor(66.9%, p = < 0.001) which influenced the incidence of type 2 DM in Ab-Ob. It can be concluded that high plasma of RBP4 level have a greater risk tosuffered from type 2 DM compared to low plasma of RBP4 in Ab-Ob. The highplasma of RBP4 level is most dominant and consistent risk factor consequently oftype 2 DM. These mechanism could behind the association between high plasmaof RBP4 level and type 2 DM.

Pemberdayaan Kelompok Ibu PKK Desa Bresela dalam Peningkatan Pengetahuan Gizi Seimbang untuk Pencegahan Stunting Anak Agung Gede Budhitresna; Sri Ratna Dewi; Ayu Savitri Siskayani; Kartika Sari
JURNAL SEWAKA BHAKTI Vol 8 No 1 (2022): Sewaka Bhakti
Publisher : UNHI Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/jsb.v8i1.2260

Stunting is a linear growth disorder caused by chronic nutrient intake malnutrition and or chronic or recurrent infectious diseases as indicated by a z-score for height for age (TB/U) less than -2 standard deviations (SD) based on World Health Organization standards (WHO). Stunting describes chronic undernutrition status during growth and development since early life. The prevalence of stunting in Gianyar Regency, Bali Province in 2013 was 40.99%. One of the 10 villages at the locus of stunting in Gianyar Regency is Bresela Village. The main factor causing stunting in Gianyar district based on data verification from the District Health Office. Gianyar, among others: smoking habits, personal hygiene in food preparation, level of adequacy of vitamin A, and availability of clean water. The problems that are often found are the lack of knowledge, attitudes, and behavior of the community regarding balanced nutrition and stunting in toddlers, therefore, together with partners, community empowerment is carried out through counseling about balanced nutrition as an effort to prevent stunting. Based on the pre and posttest evaluations, it was found that the knowledge of the PKM partners had increased from before and after the education had increased significantly (p value = 0.000).

Titer disparity of anti-Spike receptor binding domain SARS-CoV-2 antibody between vaccinated and naturally infected individuals Dewa P. Surawan; Duwi Sumohadi; Anak AG. Budhitresna; Putri P. Lestari; Kartika Dewi; Wasudewa Wikananda; Retenra P. Suwari; Md. Rabiul Islam; Haypheng Te; Ali A. Rabaan; Sri Masyeni
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.71

In conjunction with other health promotion strategies, vaccination of coronavirus disease 2019 (COVID-19) is a strategy to alleviate the burden of infection. The aim of this study was to determine the differences in antibody response strength between individuals who received COVID-19 vaccination and those who had a natural infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted among post-natural confirmed COVID-19 infection and immunized people in Bali, Indonesia. The vaccination was using Sinovac-CoronaVac with two-weeks interval between the two vaccine doses. To measure the level of anti-Spike receptor binding domain (SRBD) of SARS-CoV-2 antibody, we used Roche electro-chemiluminescence immunoassay (ECLIA) platform. Blood samples were obtained before and 28 days after first immunization in the vaccinated group, as well as two weeks after hospital discharge in the confirmed COVID-19 patients based on real-time reverse transcription polymerase chain reaction (RT-PCR). A total of 58 confirmed COVID-19 patients and 60 vaccinated individuals were included. On the 28th day after the initial vaccination, the seroconversion rate among vaccinated individuals was 91.67%. The mean titer of anti-SRBD SARS-CoV-2 antibody among vaccinated participants was 63.62±82.57 IU/mL (ranged between 0 IU/mL and 250 IU/mL). The mean titer among naturally infected group was 188.47±94.57 IU/mL (ranged between 4.25 IU/mL to 250 IU/mL) regardless the severity of COVID-19. Our data suggested that the titer of anti-SRBD SARS-CoV-2 antibody was significantly higher in naturally infected individuals compared to those who received COVID-19 vaccination (p<0.001). These data suggest that not all individuals vaccinated with Sinovac COVID-19 had protective level of anti-SRBD SARS-CoV-2 antibody and booster dose of heterologous vaccine maybe required.

Gambaran Tingkat Aktivitas Fisik dan Kejadian Obesitas pada Civitas Akademika Universitas Warmadewa, Bali Tjokorda Gde Agung Dariraditya Pemayun; Anak Agung Gede Budhitresna; Pande Ayu Naya Kasih Permatananda
Jurnal Pendidikan Tambusai Vol. 6 No. 2 (2022): Agustus 2022
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (365.537 KB)

Obesitas merupakan penimbunan lemak yang berlebihan di seluruh jaringan tubuh secara merata yang mengakibatkan gangguan kesehatan dan menimbulkan berbagai penyakit seperti diabetes, hipertensi, serangan jantung dan menyebabkan kematian. Penyebab dari obesitas adalah tidak seimbangnya jumlah energi yang masuk dengan jumlah energi yang keluar. Orang yang obesitas cenderung memiliki gaya hidup yang tidak sehat dengan tingkat aktivitas fisik yang rendah dan sering terjadi pada orang dewasa berumur diatas 18 tahun. Penelitian ini bertujuan untuk mengetahui hubungan tingkat aktivitas fisik dengan kejadian obesitas pada civitas akademika Universitas Warmadewa. Penelitian ini menggunakan metode penelitian analitik dengan rancangan studi cross sectional dan menggunakan kuesionair IPAQ untuk mengetahui tingkat aktivitas fisik dan perhitungan IMT untuk mengetahui kejadian obesitas Sampel penelitian ini adalah civitas akademika Universitas Warmadewa yang obesitas. Data yang dikumpulkan akan dianalisis menggunakan uji korelasi spearman untuk melihat hubungan aktivitas fisik dengan kejadian obesitas pada civitas akademika Universitas Warmadewa. Hasil Penelitian ini menunjukkan tidak terdapat hubungan yang bermaknaantara aktivitas fisik dengan kejadian obesitas dengan nilai signifikansi 0,289

PENGABDIAN KEPADA MASYARAKAT: RUMAH SINGGAH SEHAT KREATIF MENOLAK CORONA Sri Ratna Dewi; Desak i Putu Oki Lestar; A, A.G. Budhitresna; Luh Made Ayu Pradnyadari
Dharma Bhakti Vol 1 No 1 (2023): Dharma Bhakti
Publisher : Universitas Hindu Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32795/dharmabhakti.v1i1.3813

Yayasan Peduli Kanker Anak Bali is one of the non-profit foundations that helps children with cancer who need a temporary house while being treated at Sanglah Hospital. The priority problem faced by our partners is that children suffering from cancer have a higher risk of being infected with COVID-19, but masks and hand sanitizers are increasingly expensive and scarce, besides that the economy is also feeling increasingly sluggish due to the outbreak of this COVID-19 infection. This dedication activity aims to increase their knowledge of a clean and healthy life program, training in making hand sanitizers, and masks. The method used is the method of counseling, training and mentoring, and evaluation will be carried out to monitor the success of the activity. Based on the pre and posttest evaluation, an increase in knowledge of as much as 81% about a clean and healthy life program and all partners can make hand sanitizers and masks. Keywords: COVID-19, cancer foundation, hand sanitizers, masks

Gambaran Tingkat Aktivitas Fisik dan Kejadian Obesitas pada Civitas Akademika Universitas Warmadewa, Bali Dariraditya Pemayun, Tjokorda Gde Agung; Gede Budhitresna, Anak Agung; Kasih Permatananda, Pande Ayu Naya
Jurnal Pendidikan Tambusai Vol. 6 No. 2 (2022): Agustus 2022
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai, Riau, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jptam.v6i2.3711

Obesitas merupakan penimbunan lemak yang berlebihan di seluruh jaringan tubuh secara merata yang mengakibatkan gangguan kesehatan dan menimbulkan berbagai penyakit seperti diabetes, hipertensi, serangan jantung dan menyebabkan kematian. Penyebab dari obesitas adalah tidak seimbangnya jumlah energi yang masuk dengan jumlah energi yang keluar. Orang yang obesitas cenderung memiliki gaya hidup yang tidak sehat dengan tingkat aktivitas fisik yang rendah dan sering terjadi pada orang dewasa berumur diatas 18 tahun. Penelitian ini bertujuan untuk mengetahui hubungan tingkat aktivitas fisik dengan kejadian obesitas pada civitas akademika Universitas Warmadewa. Penelitian ini menggunakan metode penelitian analitik dengan rancangan studi cross sectional dan menggunakan kuesionair IPAQ untuk mengetahui tingkat aktivitas fisik dan perhitungan IMT untuk mengetahui kejadian obesitas Sampel penelitian ini adalah civitas akademika Universitas Warmadewa yang obesitas. Data yang dikumpulkan akan dianalisis menggunakan uji korelasi spearman untuk melihat hubungan aktivitas fisik dengan kejadian obesitas pada civitas akademika Universitas Warmadewa. Hasil Penelitian ini menunjukkan tidak terdapat hubungan yang bermaknaantara aktivitas fisik dengan kejadian obesitas dengan nilai signifikansi 0,289

Titer disparity of anti-Spike receptor binding domain SARS-CoV-2 antibody between vaccinated and naturally infected individuals Surawan, Dewa P.; Sumohadi, Duwi; Budhitresna, Anak AG.; Lestari, Putri P.; Dewi, Kartika; Wikananda, Wasudewa; Suwari, Retenra P.; Islam, Md. Rabiul; Te, Haypheng; Rabaan, Ali A.; Masyeni, Sri
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.71

In conjunction with other health promotion strategies, vaccination of coronavirus disease 2019 (COVID-19) is a strategy to alleviate the burden of infection. The aim of this study was to determine the differences in antibody response strength between individuals who received COVID-19 vaccination and those who had a natural infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted among post-natural confirmed COVID-19 infection and immunized people in Bali, Indonesia. The vaccination was using Sinovac-CoronaVac with two-weeks interval between the two vaccine doses. To measure the level of anti-Spike receptor binding domain (SRBD) of SARS-CoV-2 antibody, we used Roche electro-chemiluminescence immunoassay (ECLIA) platform. Blood samples were obtained before and 28 days after first immunization in the vaccinated group, as well as two weeks after hospital discharge in the confirmed COVID-19 patients based on real-time reverse transcription polymerase chain reaction (RT-PCR). A total of 58 confirmed COVID-19 patients and 60 vaccinated individuals were included. On the 28th day after the initial vaccination, the seroconversion rate among vaccinated individuals was 91.67%. The mean titer of anti-SRBD SARS-CoV-2 antibody among vaccinated participants was 63.62±82.57 IU/mL (ranged between 0 IU/mL and 250 IU/mL). The mean titer among naturally infected group was 188.47±94.57 IU/mL (ranged between 4.25 IU/mL to 250 IU/mL) regardless the severity of COVID-19. Our data suggested that the titer of anti-SRBD SARS-CoV-2 antibody was significantly higher in naturally infected individuals compared to those who received COVID-19 vaccination (p<0.001). These data suggest that not all individuals vaccinated with Sinovac COVID-19 had protective level of anti-SRBD SARS-CoV-2 antibody and booster dose of heterologous vaccine maybe required.

The Relationship between Body Mass Index and Blood Pressure Control in Hypertension Patients at the Sukawati I Community Health Center, Gianyar Regency Tjahyadi, I Gede Ketut Deny Patmantha Putra; Budhitresna, Anak Agung Gede; Suka Astini, Dewa Ayu Agung Alit
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.4580

Background: Being overweight or obese is one of the factors that cause an increase in blood pressure. The bigger a person's body, the more blood is needed to supply nutrients and oxygen to other tissues and muscles. Bali Province, especially Gianyar Regency, has a relatively high number of hypertension sufferers. The highest estimate of hypertension sufferers is in the working area of the Sukawati I Public Health Center, with a prevalence of 8.55% of the total in Gianyar Regency of 17.35%. This research aims to determine the relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Methods: The research design used was analytic observational with a crosssectional approach. The number of research subjects, namely 83 people, was taken by consecutive sampling technique. Data analysis will be carried out univariately and bivariate using the chi-square test method with a confidence level of 95% (p < 0.05). Results: The results of the univariate analysis showed that the majority of study subjects were aged 51-60 years (60.2%), were female (66.3%), most had normal BMI (66.3%), and 66.3% of subjects with hypertension were classified as have controlled blood control. Based on the results of statistical tests, a value of p = 0.003 (p < 0.05) was obtained, which indicated a significant relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Conclusion: The results of this study indicate that the increasing BMI status of hypertensive patients will tend to have uncontrolled blood pressure.

Hubungan Lama Menjalani Hemodialisis Dengan Status Gizi Pasien Gagal Ginjal Kronis yang Menjalani Hemodialisis Reguler di RSUD Sanjiwani Gianyar Dewa Gde Agung Wikananda Besang; Anak Agung Gede Budhitresna; Putu Arya Suryandhita
Aesculapius Medical Journal Vol 3 No 1 (2023): February
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.3.1.2023.81-85

One of the most often seen condition in Chronic Kidney Failure patients that undergo regular hemodialysis is decreasing nutritional status with the length of time these patients underwent therapy. This study aims to determine the relationship between the duration of undergoing hemodialysis and nutritional status of chronic kidney failure patients undergoing regular hemodialysis at the Sanjiwani Hospital, Gianyar. This study uses analytical method and a cross-sectional approach. Data was taken at Sanjiwani Hospital, Gianyar with a medical record data recording form. The sample were patients that underwent hemodialysis regularly at hemodialysis unit of the Sanjiwani Hospital Gianyar using a criterion that had been chosen using the sampling technique, which is purposive sampling. Chi-Square Test was used to assess the relationship of the variables. The results showed that most of the chronic kidney failure patients who underwent regular hemodialysis at the Sanjiwani Hospital, Gianyar, in this study underwent hemodialysis for less than 3 years, which is 52.2%. Chronic kidney failure patients who underwent regular hemodialysis at the Sanjiwani Hospital Gianyar in this study had a normal nutritional status of 40%, 26,7% patients are underweight, 20% patients are pre-obesity, 11,1% patients are obesity I, and 2,2% patients are obesity II. Chi-Square test result showed that there was a significant relationship between length of time undergoing hemodialysis and nutritional status of chronic kidney failure patients undergoing regular hemodialysis at the Sanjiwani Hospital, Gianyar (p = 0.011).

Hubungan Kadar Hb-A1c (Glikosilasi Hemoglobin) dengan Komplikasi Makrovaskular pada Penderita Diabetes Melitus tipe 2 di RSUD Sanjiwani Gianyar I Gede Ari Purnama Putra; Anak Agung Gede Budhitresna; Suka Astini
Aesculapius Medical Journal Vol 3 No 1 (2023): February
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/amj.3.1.2023.37-42

Several studies have stated that HbA1c levels are known to be associated with the incidence of macrovascular complications in patients with type 2 diabetes. Patients often have higher HbA1c levels than non-diabetic patients, so it is used as a way to test blood sugar control for patients with type 2 diabetes. 2 to prevent complications. This study was done to assess the relationship between HbA1c levels and macrovascular complications so that HbA1c levels can be used to predict the prognosis and the main controller in preventing macrovascular complications. Analytic method was used and the design was cross-sectional. The research was done at the Sanjiwani Hospital Gianyar with a total sample of 53 people. The results of the chi-square test showed that t a significant relationship was found between Glycosylated Hemoglobin (HbA1c) levels and the incidence of macrovascular complications with p value = 0.021 with HbA1c levels as a risk factor with POR value = 1.705. The conclusion was that there was a significant relationship between HbA1c levels and the occurrence of macrovascular complications in patients with type 2 diabetes.

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