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All Journal Buletin Udayana Mengabdi Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease WMJ (Warmadewa Medical Journal) WICAKSANA: Jurnal Lingkungan dan Pembangunan ISM (Intisari Sains Medis) : Jurnal Kedokteran Jurnal Kesehatan Indonesia Narra J Aesculapius Medical Journal Hang Tuah Medical Journal Community Services Journal (CSJ) Surabaya Biomedical Journal RESLAJ: Religion Education Social Laa Roiba Journal

Sri Masyeni, Dewa Ayu Putri

Universitas Warmadewa

Author-ID : 4055416

Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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PEMBERDAYAAN KELOMPOK PKK BANJAR LEBAH DESA SUMERTA SEBAGAI KADER SADAR GIZI DALAM MENJAGA SISTEM IMUN TUBUH UNTUK MENGHADAPI PANDEMI COVID-19 Anak Agung Gede Indraningrat; Made Dharmesti Wijaya; Dewa Ayu Putri Sri Masyeni
Buletin Udayana Mengabdi Vol 19 No 3 (2020): Buletin Udayana Mengabdi
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (565.837 KB)

Good and sufficient nutritional intakes are prerequisite to build a strong immune system against infectious diseases especially during the pandemic of COVID-19 that spread out widely since the early year of 2020. Currently socialization about COVID-19 have been emphasized on the preventive aspects such as washing hand with soap properly, using face mask and applying social distancing. However, these preventive aspects have not much focused on nutritional aspects. In order to build awareness of society on good nutritional intakes, this community service focused to build a group of cadres in collaboration with the women group (PKK) of Banjar Lebah Desa Sumerta Denpasar. The method of socialization was conducted via face to face meeting by still applying health protocols such as using face mask, washing hand with soap and physical distancing. Evaluation of the community service activity showed that cadres have displayed significant understanding about good nutritional intakes as indicated by increasing of post-test grades to 35% compared to the initial pre-test grades. These cadres were also successfully made yoghurt as the example of nutritional foods that can be consumed daily. In the future, these cadres were expected to actively socializing the importance of good nutritional intakes for their neighbourhood especially during the pandemic of COVID-19. Keywords: COVID-19, nutritional awarness, pandemic

Correlation of miR-150, hsa-let-7e, and miR-146a and gene expression of IL-6, IL-8, IP-10, and MIP-1β during dengue virus infection Sri Masyeni; Kuntaman Kuntaman; Aryati Aryati; Muchlis AU Sofro; Usman Hadi; Gondo Mastutik; Windu Purnomo; Agus Santosa; Benediktus Yohan; Erni Juwita Nelwan; R. Tedjo Sasmono
Narra J Vol. 1 No. 1 (2021): April 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i1.31

Growing evidence suggests that microRNAs (miRNAs) play a pivotal role in viral infection. The objective of this study was to assess the association between the expression of miR-150, hsa-let-7e, and miR-146a on cytokine expression during dengue infection. Dengue virus (DENV) strain SJN-006, a serotype 2 DENV strain of the Cosmopolitan genotype, isolated in Bali, Indonesia, was used to infect peripheral blood mononuclear cells (PBMCs) isolated from healthy individuals. The relative gene expressions of miR-150, hsa-let-7e, and miR-146a as well as the gene expression of cytokines (IL-6, IL-8, IP-10, and MIP-1β) were determined using quantitative real time - polymerase chain reaction (qRT-PCR) at 6, 12 and 24 hours post infection (hpi). Correlations between the microRNAs and cytokines were analyzed by means of causality tests. Our data suggests that miR-150 and hsa-let-7e were significantly higher in infected-PBMCs after 12 hpi compared to the uninfected-PBMCs (p<0.05). The causality tests demonstrated that miR-150 and hsa-let-7e were negatively correlated with IL-8 expression, meanwhile miR-146a was the contrast. DENV infection was negatively and positively correlated with miR-150 and hsa-let-7e, respectively, after 24 hpi. In conclusion, our data demonstrates the vital role of miR-150, hsa-let-7e, and miR-146a in regulating IL-8 expression with possible different pathways.

Persistence of long COVID symptoms in COVID-19 survivors worldwide and its potential pathogenesis - A systematic review and meta-analysis Marhami Fahriani; Muhammad Ilmawan; Jonny K. Fajar; Helnida A. Maliga; Andri Frediansyah; Sri Masyeni; Hanifah Yusuf; Firzan Nainu; Francesco Rosiello; Salin Sirinam; Synat Keam; Youdiil Ophinni
Narra J Vol. 1 No. 2 (2021): August 2021
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narraj.v1i2.36

The study sought to determine the prevalence of persistent long COVID symptoms such as anxiety, depression, dizziness, chest pain, sleep difficulty, palpitations, weight loss, and hair loss among coronavirus disease 2019 (COVID-19) survivors worldwide and to discuss the potential pathogeneses. Potential studies were searched in three databases (PubMed, Scopus, and Web of Science) as of January 30, 2021. Data on study characteristics, patient characteristics during the follow-up, the number of patients with persistent long COVID symptoms and total COVID-19 survivors were collected according to PRISMA guidelines. To assess the quality of studies, the Newcastle-Ottawa scale was used. The estimated prevalence of each long COVID symptom and the association between COVID-19 severity and the occurrence of prolonged symptoms was assessed, if appropriate. The global prevalence of prolonged anxiety was 15.76% (95%CI: 6.36%, 25.15%). Chest pain persisted in 10.36% (239/3,224) of COVID-19 patients (95%CI: 4.92%, 15.80%). Prolonged depression was found in 24 of 548 COVID-19 survivors with an estimated prevalence of 4.32% (95%CI: 2.62%, 6.03%) and dizziness was presented in 4.83% (118/2,219, 95%CI: 1.50%, 8.16%) after recovery. Hair loss was complained by 527 of 2,251 recovered patients (cumulative prevalence of 24.76%, 95%CI: 19.60%, 29.91%), while weight loss was identified in 37 cases among 452 COVID-19 survivors (8.19%, 95%CI: 5.66%, 10.71%). Prolonged palpitation was experienced by 19.38% (211/1,926) survivors with 95%CI: 2.40%, 41.16%. Sleep difficulty was found in 541 of 2,622 COVID-19 survivors (17.87%, 95%CI: 7.55%, 28.20%). The association between COVID-19 severity and the occurrence of persistent long COVID symptoms was not analyzed due to the lack of data. In conclusion, persistent psychological symptoms are frequently reported among COVID-19 survivors. Follow-up studies with a longer duration and larger population are warranted to assess the extent of prolonged symptoms and the quality of life of COVID-19 survivors. Despite various potential pathogeneses that have been hypothesized, a definitive mechanism is yet to be addressed.

Titer disparity of anti-Spike receptor binding domain SARS-CoV-2 antibody between vaccinated and naturally infected individuals Dewa P. Surawan; Duwi Sumohadi; Anak AG. Budhitresna; Putri P. Lestari; Kartika Dewi; Wasudewa Wikananda; Retenra P. Suwari; Md. Rabiul Islam; Haypheng Te; Ali A. Rabaan; Sri Masyeni
Narra J Vol. 2 No. 1 (2022): April 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i1.71

In conjunction with other health promotion strategies, vaccination of coronavirus disease 2019 (COVID-19) is a strategy to alleviate the burden of infection. The aim of this study was to determine the differences in antibody response strength between individuals who received COVID-19 vaccination and those who had a natural infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted among post-natural confirmed COVID-19 infection and immunized people in Bali, Indonesia. The vaccination was using Sinovac-CoronaVac with two-weeks interval between the two vaccine doses. To measure the level of anti-Spike receptor binding domain (SRBD) of SARS-CoV-2 antibody, we used Roche electro-chemiluminescence immunoassay (ECLIA) platform. Blood samples were obtained before and 28 days after first immunization in the vaccinated group, as well as two weeks after hospital discharge in the confirmed COVID-19 patients based on real-time reverse transcription polymerase chain reaction (RT-PCR). A total of 58 confirmed COVID-19 patients and 60 vaccinated individuals were included. On the 28th day after the initial vaccination, the seroconversion rate among vaccinated individuals was 91.67%. The mean titer of anti-SRBD SARS-CoV-2 antibody among vaccinated participants was 63.62±82.57 IU/mL (ranged between 0 IU/mL and 250 IU/mL). The mean titer among naturally infected group was 188.47±94.57 IU/mL (ranged between 4.25 IU/mL to 250 IU/mL) regardless the severity of COVID-19. Our data suggested that the titer of anti-SRBD SARS-CoV-2 antibody was significantly higher in naturally infected individuals compared to those who received COVID-19 vaccination (p<0.001). These data suggest that not all individuals vaccinated with Sinovac COVID-19 had protective level of anti-SRBD SARS-CoV-2 antibody and booster dose of heterologous vaccine maybe required.

PEMBERDAYAAN KELOMPOK IBU PKK DI DESA KERTA KECAMATAN PAYANGAN KABUPATEN GIANYAR BALI SEBAGAI PEMBANTU JUMANTIK UNTUK MENCEGAH INFEKSI DEMAM BERDARAH DENGUE Sri Masyeni; A.A.G Indraningrat; P.A Suryanditha; Agus Santosa
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 4 No. 1 (2020)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Demam berdarah dengue (DBD) yang terjadi akibat infeksi virus Dengue merupakan penyakit yang mewabah tiap tahunnya di Bali dan Indonesia pada umumnya. Upaya menekan laju DBD khususnya melalui eradikasi vektor pembawa virus yaitu nyamuk Aedes aegypti perlu terus dilakukan dengan melibatkan peran serta masyarakat secara langsung. Penyuluhan mengenai DBD terhadap kelompok ibu PKK di Desa Kerta, Kecamatan Payangan, Kabupaten Gianyar, Provinsi Bali telah dilaksanakan dengan hasil yang memuaskan. Metode yang digunakan adalah presentasi dan diskusi melalui tatap muka. Hasil penyuluhan menunjukkan peningkatan pemahaman ibu-ibu PKK terhadap DBD dan upaya pencegahannya. Sebagai tindak lanjut kegiatan pengabdian ini, tim pembantu Jumantik dari anggota PKK Desa Kerta, Kecamatan Payangan telah dibentuk. Tim ini diharapkan berperan aktif dalam memonitoring dan meminimalisir tempat berkembang biak jentik nyamuk Aedes aegypti, serta secara aktif mensosialisasikan pencegahan DBD di lingkungan tempat tinggal mereka.

PEMBERDAYAAN KELOMPOK MASYARAKAT SEBAGAI PENGAWAS MINUM OBAT PASIEN GAGAL GINJAL KRONIS DI RS SANJIWANI D. G. A Budiyasa; Dewa Nyoman Sadguna; D. A. P Niti Widari; Sri Masyeni
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 5 No. 2 (2021)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wicaksana.5.2.2021.65-69

Penyakit ginjal kronis (PGK) merupakan penyakit yang ditandai penurunan fungsi ginjal yang semakin progresif sehingga memerlukan bantuan berupa terapi pengganti mesin dialysis untuk menggantikan fungsi ginjal. Hemodialisis dengan mesin hemodialisis harus dilakukan secara rutin 2-3 kali seminggu dan berkesinambungan seumur hidup pasien. Selain hemodialisis atau cuci darah rutin, pasien PGK juga harus mengonsumsi obat dalam jumlah yang relatif banyak yang apabila tidak dikonsumsi secara rutin akan memicu kondisi akut yang mungkin akan memperburuk fungsi ginjal. Untuk mengantisipasi hal ini diperlukan bantuan keluarga terdekat untuk membantu mengawai pasien PGK untuk selalu mengonsumsi obat-obat sesuai dengan instruksi dokter. Kegiatan PKM ini bertujuan untuk membentuk kelompok Kader Siaga Minum Obat pada mitra yang akan memantau pasien mematuhi instruksi dokter. Kegiatan PKM dimulai dengan sosialisasi kegiatan, focus group discussion, pelaksanaan kegiatan serta evaluasi hasil kegiatan. Adapun outcome dari PKM ini adalah terdapat peningkatan pengetahuan mitra mengenai penyakit PGK, pencegahan perburukan serta peningkatan kualitas hidup pasien PGK sebesar 81% pada delapan mitra PKM. Output sementara, kegiatan dilakukan dengan observasi dan pengamatan frekuensi kejadian perburukan penyakit pada pasien sebagai hasil/peran dari fungsi kader Siaga Minum Obat.

Karakteristik Penderita dengan Infeksi Tuberkulosis di RSUD Sanjiwani Ni Kadek Kumara Aida; Dewa Ayu Putri Sri Masyeni; Rima Kusuma Ningrum
AMJ (Aesculapius Medical Journal) Vol. 2 No. 1 (2022): June
Publisher : Fakultas Ilmu Kedokteran dan Ilmu Kesehatan, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (366.039 KB)

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. The incidence of TB in Indonesia (WHO 2018) is the third highest. Meanwhile in Bali, TB cases are increasing by 5% every year. This research is a non-experimental descriptive observational study with a cross sectional design. There are 73 medical record samples (2019-2020) in this study. The results showed that the majority of TB patients were new cases, were of productive age with male gender. There are 34% of patients are active smokers and 13.7% of patients have a family history of tuberculosis infection. There are about 6 patients with anemia and 5 other patients have a history of diabetes. The OAT treatment period, the majority of patients complained of side effects of nausea (64.4%), and dizziness (47.9%) with a success rate of around 78.1%. This research still requires further analysis to find out the relationship between the variables studied.

Diagnosis dan tatalaksana rinosinusitis maksilaris odontogenik yang meluas sampai etmoid dan frontal: laporan kasus Agus Santosa; Nyoman Dian Permata Sari; Ida Bagus Semara Putra; Dewa Ayu Putu Sri Masyeni
Intisari Sains Medis Vol. 12 No. 3 (2021): (Available online: 1 December 2021)
Publisher : DiscoverSys Inc.

Background: Sinusitis is an inflammatory process in the nasal mucosa, especially in the paranasal sinuses. Sinusitis problems are important and need special attention in cases of sinusitis that do not improve after being given conventional therapy. The purpose of this paper is to establish the diagnosis and management of odontogenic maxillary rhinosinusitis that extends to the ethmoid and frontal areas.Case presentation: A male patient, aged 22 years, came to the ENT clinic at Mangusada Hospital, Badung. Based on the history, physical examination, supporting examination in the form of CT-scan so that it was diagnosed as chronic rhinosinusitis et causa odontogenic which extends to the ethmoid and frontal. The treatment chosen was surgery in the form of Functional Endoscopic Sinus Surgery (FESS) and septorhinoplasty because in this case the patient had complications and did not respond to medical therapy. Postoperative evaluation, complaints of smelly mucus, nasal congestion and headache were not felt.Conclusion: The diagnosis of chronic rhinosinusitis et causa odontogenic which extends to the ethmoid and frontal based on CT-Scan and the treatment given to the patient in the form of FESS and septorhinoplasty. Latar belakang: Sinusitis merupakan proses inflamasi pada mukosa hidung, lebih khususnya pada sinus paranasal. Masalah sinusitis menjadi penting dan perlu perhatian khusus pada kasus sinusitis yang tidak membaik setelah diberikan terapi konvensional. Tujuan penulisan ini adalah untuk menegakkan diagnosis dan penatalaksan rinosinusitis maksilaris odontogenik yang meluas sampai etmoid dan frontal.Presentasi kasus: Seorang pasien laki-laki, berusia 22 tahun datang ke poli THT RS Mangusada, Badung. Berdasarkan anamnesis, pemeriksaan fisik, pemeriksaan penunjang berupa CT-scan sehingga didiagnosis sebagai rinosinusitis kronis et causa odontogenic yang meluas sampai etmoid dan frontal. Penatalaksanaan yang dipilih adalah pembedahan berupa Functional Endoscopic Sinus Surgery (FESS) dan septorhinoplasti, karena pada kasus ini pasien mengalami komplikasi dan tidak memberikan respon dengan terapi medikamentosa. Evaluasi pasca operasi, keluhan ingus berbau, hidung tersumbat dan nyeri kepala sudah tidak dirasakan.Kesimpulan: Diagnosis rinosinusitis kronis et causa odontogenic yang meluas sampai etmoid dan frontal berdasarkan dari CT-Scan dan tatalaksana yang diberikan pada pasien berupa FESS dan septorhinoplasti.

PEMBERDAYAAN KELOMPOK IBU PKK DI DESA RENON DALAM PENGELOLAAN DIIT DAN PEMANTAU MINUM OBAT PASIEN DIABETES Agus Santosa; D A P Niti Widari; K Irwan Setiawan; Vemi Hendrayani; Sri Masyeni
WICAKSANA: Jurnal Lingkungan dan Pembangunan Vol. 6 No. 2 (2022)
Publisher : Lembaga Penelitian, Universitas Warmadewa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22225/wicaksana.6.2.2022.47-52

Penyakit diabetes mellitus merupakan penyakit metabolik yang ditandai dengan peningkatan kadar gula darah yang diakibatkan oleh berbagai faktor seperti kerusakan sel beta pancreas atau penyakit autoimun yang menimbulkan kerusakan pancreas. Kadar gula darah yang berkepanjangan akan memicu kerusakan sel endotel yang dapat mengakibatkan komplikasi seperti penyakit ginjal kronis, penyakit jantung dan stroke yang akan memicu permasalahan yang lebih kompleks. Salah satu cara untuk memperlambat munculnya komplikasi diabetes adalah melalui pengontrolan gula darah melalui pengelolaan diit diabetes serta mengonsumsi obat secara rutin. Dukungan keluarga terdekat sangat dibutuhkan dalam membantu penderita diabetes dalam kontrol gula darah. Kegiatan pengabdian ini bertujuan untuk memberdayakan mitra, yaitu kelompok ibu di desa Renon supaya bisa berperan sebagai pengelola diit dan pemantau minum obat pasien diabetes. Kegiatan diawali dengan rapat koordinasi, focus group discussion untuk menemukan permasalahan prioritas mitra. Solusi untuk mitra adalah pemberdayaan kelompok ibu tersebut yang diawali dengan pre-tes untuk mengukur tingkat pengetahuan ibu mengenai diabetes, penyampaian materi, praktek mengatur diit diabetes serta mengawasi minum obat. Pemaparan materi dilakukan melalui peragaan pamphlet, poster serta video dan diakhiri dengan post-test. Out-put kegiatan diukur dari peningkatan pengetahuan mitra dari hasil pre dan post-test dimana ditemukan peningkatan pengetahuan mitra sebanyak 75%. Outcome akan diukur dari tercapainya kontrol gula darah pasien dan terhambatnya komplikasi diabetes.

Retrospective Analysis on Antibiotic Resistance among Clinical Bacterial Isolates in the General Hospital Sanjiwani, Gianyar Bali Anak Agung Gede Indraningrat; Dewa Ayu Putri Sri Masyeni; I Made Sila Darmana
Jurnal Kesehatan Indonesia Vol 12 No 3 (2022): Juli 2022
Publisher : HB PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar

Resistensi antibiotik saat ini merupakan ancaman kesehatan global yang muncul akibat penggunaan antibiotik yang salah dan berlebihan sehingga meningkatkan angka mortalitas dan morbiditas. Informasi tentang resistensi antibiotik sangat penting untuk menentukan pengobatan yang ideal bagi pasien. Ketersedian data terkait resistensi antibiotika di Bali masih cukup rendah. Studi ini bertujuan untuk menganalisi profil kerentanan antibiotik pada isolat bakteri klinik di RSUD Sanjiwani Gianyar Bali menggunakan metode retrospektif tahun 2018. Data tersebut meliputi jenis antibiotik yang diuji, nama isolat bakteri klinis, sumber isolasi. dan profil resistensi antibiotik. Diantara 65 isolat bakteri klinis, ditemukan keragaman bakteri patogen yang tinggi dan dikelompokkan menjadi 22 spesies, dimana Escherichia coli, Klebsiela pneumoniae, Acinetobacter baumanii dan Staphylococcus aureus merupakan empat isolat dominan yang diidentifikasi. Paparan terhadap 17 jenis antibiotika menunjukkan bahwa isolat bakteri dominan resisten terhadap levofloxacin, ciprofloxacin, dan gentamycin. Sedangkan isolat dominan tersebut rentan terhadap meropenem, amikacyin dan ampicillin-sulbactam. Surveilans rutin untuk mengetahui profil resistensi antibiotik penting dilakukan dan direkomendasikan untuk menghasilkan antibiotikogram lokal sebagai pedoman untuk mengatasi infeksi patogen.

Co-Authors A. Maheraditya A.A.G Indraningrat AAG Indraningrat Agus Santosa Agus Santosa Agus Santosa Ali A. Rabaan Anak Agung Gede Budhitresna, Anak Agung Gede Anak Agung Gede Indraningrat Ananda Maheraditya Andri Frediansyah Aryati Aryati Benediktus Yohan D A P Niti Widari D. A. P Niti Widari D. A. P. N. Widari D. G. A Budiyasa Dewa Nyoman Sadguna Dewa P. Surawan Duwi Sumohadi ERLY SINTYA Erni Juwita Nelwan, Erni Juwita Firzan Nainu Francesco Rosiello Gondo Mastutik Gustu Rama Bhaskara Putra HANIFAH YUSUF Haypheng Te Helnida A. Maliga I Ketut Agus Indra Adhiputra I Komang Galih Vedanta Artana I Made Indra Wijaya I Made Sila Darmana Ida Bagus Semara Putra IG Rai Tirta Jonny K. Fajar K Irwan Setiawan Kadek Suryawan Kartika Dewi Kuntaman Kuntaman LUH VIDYA KENCANA S. ROBIN M. Indrawijaya Made Dharmesti Wijaya Made Dharmesti Wijaya Margyaningsih, Nur Ita Marhami Fahriani Marta Setiabudy Md. Rabiul Islam Muchlis AU Sofro Muhammad Amirul bin Abdul Rahman Muhammad Ilmawan Ni Kadek Kumara Aida NI MADE DHANISWARA PUTRI WIRAWAN Ni Wayan Widhidewi Nyoman Dian Permata Sari P.A Suryanditha PA Suryandhita Putri P. Lestari Putu Arya Suryanditha Putu Indah Budi Apsari R. Kartika R. Tedjo Sasmono Ratna Kartika Retenra P. Suwari Rima Kusuma Ningrum Salin Sirinam Sasmono, R. Tedjo SP Permana Lestari Synat Keam Usman Hadi Vemi Hendrayani Wasudewa Wikananda Windu Purnomo Yohan, Benediktus Youdiil Ophinni

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