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All Journal E-Jurnal Medika Udayana JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) Medical and Health Science Journal Warmadewa Minesterium Medical Journal
Suka Astini, Dewa Ayu Agung Alit
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Biochemistry, Genetics & Molecular Biology Education Health Professions Library & Information Science Medicine & Pharmacology Public Health Social Sciences

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THE EFFECT OF NOISE EXPOSURE ON THE AVERAGE NUMBER OF TEMPORAL LOBUS NEURONS IN ADULT WISTAR RATS Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gde; Witari, Ni Putu Diah; Sumadewi, Komang Trisna; Prima Dewi, A.A.A Asri; Anthony Kerans, Fransiscus Fiano; Kurniawati, Ida
E-Jurnal Medika Udayana Vol 13 No 07 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i07.P09

Abstract

Noise is defined as unwanted and disruptive sound, considered an environmental stressor and disturbance. Noise encompasses many aspects of modern communities, including work environments. The damaging effects of noise primarily result from the unrestricted production of free radicals into the auditory organs. Exposure to noise causes various health problems, such as hearing impairment, sleep disturbances, and interference with individual performance. Reactive oxygen species (ROS), also known as free oxygen radicals, are normal by-products of cellular aerobic metabolism. These unstable molecules can damage cellular lipids, proteins, and nucleic acids in DNA if the antioxidant balance is disrupted. Acute and chronic exposure to loud noise generates excessive free radicals and disrupts extra-auditory organs such as the nervous, endocrine, and cardiovascular systems. The purpose of this study is to analyze the relationship between noise exposure and the number of neurons in the temporal lobes of Wistar rats. The research design used is a laboratory experimental design, specifically a pure experimental design, implemented with the randomized posttest-only control group design. The research sample consists of 30 male Wistar rats randomized into 2 groups, control and treatment. The treatment group is exposed to 95dB noise for 4 hours per day for 14 days. The rats are then euthanized, and their brain tissue is fixed with 10% neutral buffered formalin. Assessment is performed using Hematoxylin Eosin staining, and analysis is conducted blindly on the average number of neurons in the rat's temporal lobes. Data is subjected to normality testing using the Shapiro-Wilk test and analyzed using independent t-tests for parametric comparison. The results show a significant difference in the mean number of neurons in the temporal lobes between rats exposed to noise and the control group (p <0.005). The conclusion of this study is that noise affects neuron cells in the temporal lobes. Keywords : noise, temporal lobe, neurons.
EVALUATING THE EFFECTIVENESS OF ANATOMY AND HISTOLOGY PRACTICUM DURING COVID-19 PANDEMIC AT FAKULTAS KEDOKTERAN DAN ILMU KESEHATAN UNIVERSITAS WARMADEWA Evayanti, Luh Gde; Sumadewi, Komang Trisna; Witari, Ni Putu Diah; Suka Astini, Dewa Ayu Agung Alit; Kerans, Fransiscus Fiano Anthony; Dewi, A.A.Ayu Asri Prima; Ekayani, Ni Wayan Diana
E-Jurnal Medika Udayana Vol 13 No 6 (2024): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2024.V13.i06.P11

Abstract

The implementation of anatomy and histology practical sessions at Fakultas Kedokteran dan Ilmu Kesehatan (FKIK) Universitas Warmadewa during the Covid-19 pandemic still has many variations. This difference in implementation will have an influence on the achievement of student learning. This research aims to evaluate the knowledge of anatomy and histology among students by giving asynchronous learning, pre-test, post-test and practicum exam. This study using cross-sectional approach. 124 participants are 3th semester students whose active status at FKIK Universitas Warmadewa. The primary data were collected directly from practical sessions and practicum exam. The pre-test and post-test data were analyzed using paired-T test (p<0.05). The post-test and practicum exam were analyzed using Spearman rho (p<0.05). In anatomical practicum, there is an increase in post-test scores when compared to pre-test although not significant (p = 0.119). Anatomical practicum exam results have a meaningful positive correlation with post-tests (p = 0.013, r = 0.22). In histological practicum there was a significant increase in post-test scores when compared to pre-tests (p = 0.013), although practicum exam results were not significantly correlated with post-test (p = 0.410). Based on this study, improvements are needed related to technical of anatomical and histological practicums, as well as provisions related to practicums so that activities are structured
Pemberdayaan Kader Posyandu Dalam Stimulasi Perkembangan Bayi Melalui Baby Gym di Banjar Tandang Tri Buana, Desa Batur Tengah, Kintamani Sumadewi, Komang Trisna; Asri Prima Dewi, Anak Agung Ayu; Anthony Kerans, Fransiscus Fiano; Diah Witari, Ni Putu; Suka Astini, Dewa Ayu Agung Alit; Evayanti, Luh Gede; Kurniawati, Ida
Warmadewa Minesterium Medical Journal Vol. 3 No. 3 (2024): September 2024
Publisher : Warmadewa University Press

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Abstract

Gangguan perkembangan pada bayi dan anak menjadi perhatian pemerintah karena dampak yang dapat ditimbulkan. Gangguan perkembangan motorik banyak ditemukan pada bayi usia 3-5 bulan. Gangguan ini berupa keterlambatan perkembangan yang tidak sesuai dengan usianya. Kondisi ini terjadinya karena dipengaruhi oleh berbagai faktor, salah satunya rendahnya stimulus yang diberikan. Berdasarkan wawancara bersama kader Posyandu di Banjar Tandang Tribuana, Desa Batur Tengah, Kecamatan Kintamani, Kabupaten Bangli, didapatkan bahwa pemberian informasi mengenai perkembangan anak masih rendah, pelatihan mengenai pemberian stimulasi bayi dan anak juga masih jarang dilakukan, serta belum pernah dilakukan pelatihan mengenai baby gym. Melihat permasalahan tersebut, maka solusi yang dapat dilakukan antara lain memberikan edukasi mengenai tumbuh kembang serta stimulasi anak berdasarkan usia, dan pelatihan mengenai baby gym yang dapat membantu perkembangan bayi dan anak. Program ini bertujuan untuk meningkatkan pengetahuan mitra mengenai tumbuh kembang anak, stimulasi perkembangan sesuai usia, mengenali keterlambatan perkembangan serta meingkatkan keterampilan mitra dalam melakukan baby gym. Mellalui kegiatan ini didapatkan hasil berupa peningkatan pengetahuan mitra mengenai tumbuh kembang dan stimulasi anak sebesar 51.17%, peningkatan keterampilan mitra dalam memberikan stimulasi serta melalukan baby gym. Kehadiran peserta 100% dengan pastisipasi aktif melalui respon yang diberikan oleh peserta. Kesimpulannya, program ini terlaksana dengan lancar dan dapat memenuhi indikator keberhasilan program yang sudah ditetapkan oleh tim pengabdian.
The Relationship between Body Mass Index and Blood Pressure Control in Hypertension Patients at the Sukawati I Community Health Center, Gianyar Regency Tjahyadi, I Gede Ketut Deny Patmantha Putra; Budhitresna, Anak Agung Gede; Suka Astini, Dewa Ayu Agung Alit
Jurnal Ilmu Kesehatan dan Kesehatan Vol 8 No 02 (2024): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v8i02.4580

Abstract

Background: Being overweight or obese is one of the factors that cause an increase in blood pressure. The bigger a person's body, the more blood is needed to supply nutrients and oxygen to other tissues and muscles. Bali Province, especially Gianyar Regency, has a relatively high number of hypertension sufferers. The highest estimate of hypertension sufferers is in the working area of the Sukawati I Public Health Center, with a prevalence of 8.55% of the total in Gianyar Regency of 17.35%. This research aims to determine the relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Methods: The research design used was analytic observational with a crosssectional approach. The number of research subjects, namely 83 people, was taken by consecutive sampling technique. Data analysis will be carried out univariately and bivariate using the chi-square test method with a confidence level of 95% (p < 0.05). Results: The results of the univariate analysis showed that the majority of study subjects were aged 51-60 years (60.2%), were female (66.3%), most had normal BMI (66.3%), and 66.3% of subjects with hypertension were classified as have controlled blood control. Based on the results of statistical tests, a value of p = 0.003 (p < 0.05) was obtained, which indicated a significant relationship between body mass index and blood pressure control in hypertensive patients at the Sukawati I Public Health Center, Gianyar Regency. Conclusion: The results of this study indicate that the increasing BMI status of hypertensive patients will tend to have uncontrolled blood pressure.
Noise Exposure-Induced Functional Anatomical Changes: Impact on Superoxide Dismutase, Tumor Necrosis Factor-Alpha, and Adiponectin Suka Astini, Dewa Ayu Agung Alit; Luh Gde Evayanti; Sri Ratna Dewi
JURNAL KESEHATAN LINGKUNGAN Vol. 18 No. 1 (2026): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v18i1.2026.1-9

Abstract

Introduction: Environmental noise is a non-auditory stressor that can trigger inflammatory and oxidative responses in the body. Continuous noise exposure is associated with increased production of pro-inflammatory cytokines and reactive oxygen species (ROS). This can disrupt the body's cellular balance. This study aimed to determine the effects of chronic noise exposure on serum superoxide dismutase (SOD), tumor necrosis factor-alpha (TNF-α), and adiponectin levels in wistar rats. Methods: This study used a laboratory based experimental design, involving twenty-four adult male Wistar rats. The rats were randomly divided into two groups: a control group and a treatment group. The treatment group was exposed to 95 dB noise for four hours daily for 14 consecutive days, while the control group received no exposure. SOD, TNF-α, and adiponectin levels were determined using ELISA. The independent t-test was used for statistical analysis. Results and Discussion: TNF-α was significantly higher (p < 0.05) and adiponectin was significantly lower (p < 0.05) in the treatment group than in the control group. SOD levels did not differ significantly across groups (p > 0.05). Noise exposure causes metabolic and inflammatory disruptions, as evidenced by the rise in TNF-α and fall in adiponectin, but the SOD levels remain unchanged, suggesting a limited antioxidant response. Conclusion: An inflammatory response and decreased adiponectin were caused by noise exposure at 95 dB for 14 days, suggesting a possible risk of metabolic dysfunction. Nonetheless, the stability of SOD levels indicates that enzymatic antioxidant action is maintained in these circumstances.
Co-Authors Anak Agung Gede Budhitresna, Anak Agung Gede Anthony Kerans, Fransiscus Fiano Asri Prima Dewi, Anak Agung Ayu Dewi, A.A.Ayu Asri Prima Ekayani, Ni Wayan Diana Evayanti, Luh Gede Ida Kurniawati, Ida Kerans, Fransiscus Fiano Anthony Luh Gde Evayanti Ni Putu Diah Witari, Ni Putu Prima Dewi, A.A.A Asri Sri Ratna Dewi Sumadewi, Komang Trisna Tjahyadi, I Gede Ketut Deny Patmantha Putra Witari, Ni Putu Diah