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Meliantha Tandiono, Meliantha
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Neuroscience

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BRAIN NEURON REGENERATION IN POST-STROKE REHABILITATION TREATMENT USING GRAPE PEEL AND SEED EXTRACT (Vitis vinifera) IN INDUCING ERK1 / 2 PATHWAY Lie, Zanella Yolanda; Tandiono, Meliantha; Pricillia, Lucy; Lukito, Astrid Nandikasari; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (643.65 KB) | DOI: 10.21776/ub.mnj.2016.002.01.4

Abstract

Background. Ischemic stroke can cause hypoxia in brain tissue and damage the neuron. The defense ability and plasticity is activated by ERK1/2 pathway. Grape peel and seed extract (Vitis vinifera can induce release neurotrophic factor that contribute in ERK1/2 pathway mechanism.Objective. To prove that grape peel and seed extract can regenerate neuron in anatomical and functional view.Methods. This research use true experimental design with sample in this research is 20 male 8-10 weeks old wistar strain rats which are induced stroke by internal and external carotid artery occlusion method.Results. The repairment is monitored from four parameters, namely cylinder test score, ladder rung walking test score, extensive infarct volume, and number of damaged neuron. Conclusion. The result is 50mg/KgBW is effective in repairing neuron. It is seen from the result of improvement in four parameters explained above.
Co-Authors Astrid Nandikasari Lukito, Astrid Nandikasari Cakra Parindra Gasmara, Cakra Parindra Lucy Pricillia, Lucy Zanella Yolanda Lie, Zanella Yolanda