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Zanella Yolanda Lie, Zanella Yolanda
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Neuroscience

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BRAIN NEURON REGENERATION IN POST-STROKE REHABILITATION TREATMENT USING GRAPE PEEL AND SEED EXTRACT (Vitis vinifera) IN INDUCING ERK1 / 2 PATHWAY Lie, Zanella Yolanda; Tandiono, Meliantha; Pricillia, Lucy; Lukito, Astrid Nandikasari; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (643.65 KB) | DOI: 10.21776/ub.mnj.2016.002.01.4

Abstract

Background. Ischemic stroke can cause hypoxia in brain tissue and damage the neuron. The defense ability and plasticity is activated by ERK1/2 pathway. Grape peel and seed extract (Vitis vinifera can induce release neurotrophic factor that contribute in ERK1/2 pathway mechanism.Objective. To prove that grape peel and seed extract can regenerate neuron in anatomical and functional view.Methods. This research use true experimental design with sample in this research is 20 male 8-10 weeks old wistar strain rats which are induced stroke by internal and external carotid artery occlusion method.Results. The repairment is monitored from four parameters, namely cylinder test score, ladder rung walking test score, extensive infarct volume, and number of damaged neuron. Conclusion. The result is 50mg/KgBW is effective in repairing neuron. It is seen from the result of improvement in four parameters explained above.
GRAPE’S LEATHER AND SEED EXTRACT (VITIS VINIFERA) IMPROVING THE FUNCTION OF WISTAR RATS’ MOTOR (RATTUS NORVEGICUS) ISCHEMIC STROKE MODEL Indra, Muhamad Rasjad; Lie, Zanella Yolanda
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (524.299 KB) | DOI: 10.21776/ub.mnj.2017.003.01.2

Abstract

Background. Grape peel and seed extract (Vitis vinifera), that has resveratrol, is one of many antioxidants that can pass through blood brain barrier and can induce release neurotrophic factor that contribute in ERK 1/2 pathway mechanism in post stroke.Objective. To prove that grape peel and seed extract can regenerate neuron in brain functional.Methods. True experimental design with five groups in this research. The five groups are negative control, positive control, grape peel and seed extract 50mg/KgBW, 100mg/KgBW, and 200mg/KgBW. rats are given grape peel and seed extract in variable dose to know how extract’s effect in neuron repairment. The repairment is monitored from ladder rung walking test score.Results. Range average score ladder rung walking test post stroke dan post treatment group N, K, Ra, Rb, dan Rc, were 0 ± 0, 0.001028933 ± 0.011664445, 0.123214286 ± 0.019834983, 0.064744427 ± 0.024296721, 0.03781401 ± 0.006888803. Statistical test used Annova significantly p;0,001.Dose 50mg/KgBW is effective in repairing neuron.Conclusion. Grape’s leather and Seed extract 50 mg/kgBW can improve neuron regeneration on animal model.
Co-Authors Astrid Nandikasari Lukito, Astrid Nandikasari Cakra Parindra Gasmara, Cakra Parindra Lucy Pricillia, Lucy Meliantha Tandiono, Meliantha Muhamad Rasjad Indra