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Cakra Parindra Gasmara, Cakra Parindra
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Neuroscience

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BRAIN NEURON REGENERATION IN POST-STROKE REHABILITATION TREATMENT USING GRAPE PEEL AND SEED EXTRACT (Vitis vinifera) IN INDUCING ERK1 / 2 PATHWAY Lie, Zanella Yolanda; Tandiono, Meliantha; Pricillia, Lucy; Lukito, Astrid Nandikasari; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (643.65 KB) | DOI: 10.21776/ub.mnj.2016.002.01.4

Abstract

Background. Ischemic stroke can cause hypoxia in brain tissue and damage the neuron. The defense ability and plasticity is activated by ERK1/2 pathway. Grape peel and seed extract (Vitis vinifera can induce release neurotrophic factor that contribute in ERK1/2 pathway mechanism.Objective. To prove that grape peel and seed extract can regenerate neuron in anatomical and functional view.Methods. This research use true experimental design with sample in this research is 20 male 8-10 weeks old wistar strain rats which are induced stroke by internal and external carotid artery occlusion method.Results. The repairment is monitored from four parameters, namely cylinder test score, ladder rung walking test score, extensive infarct volume, and number of damaged neuron. Conclusion. The result is 50mg/KgBW is effective in repairing neuron. It is seen from the result of improvement in four parameters explained above.
UCAO (UNILATERAL CEREBRAL ARTERY OCCLUSSION) METHOD INCREASES THE LEVEL OF MMP- 9 BRAIN TISSUE IN RATS MODEL OF ISCHEMIC STROKE Indra, Muhamad Rasjad; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (517.47 KB) | DOI: 10.21776/ub.mnj.2016.002.02.1

Abstract

Background. UCAO (Unilateral Cerebral Artery Occlusion) is a stroke induction method by ligating mice’s carotid artery for 45 minutes. Thus giving a hypoxic condition similar to stroke attacks to human. This method is less complicated and far more efficient. MMP-9 is a stroke marker which is assayed by ELISA from the blood of test animal.Objective. To prove UCAO method is capable to raise MMP-9 concentration in mice’s blood.Methods. This research was an experimental laboratory research with post-test only controlled group design. 8 male rats (8-10 weeks) were divided into 2 groups. A day after the treatment group had been induced to stroke, both group were tested to measure the MMP-9 blood concentration through ELISA.Results. In this research, UCAO method had increased MMP-9 blood concentration in treatment group, compared to the control group. It is proved by the statistic tests, Mann-Whitney and Kruskal-Wallis, which showed a significant increase in treatment group (p < 0.05).Conclusion. UCAO method is accepted as a method to create an ischemic stroke mice model.
Co-Authors Astrid Nandikasari Lukito, Astrid Nandikasari Lucy Pricillia, Lucy Meliantha Tandiono, Meliantha Muhamad Rasjad Indra Zanella Yolanda Lie, Zanella Yolanda