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All Journal JBIO: jurnal biosains (the journal of biosciences) Jurnal Florea
Adriana Yulinda Dumaria Lumban Gaol
Universitas Negeri Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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THE EFFECT OF ETHANOL EXTRACT OF PIRDOT (Saurauria vulcani) ON HEMATOLOGICAL PROFILE AND KEAP1-NRF2 INHIBITION OF WHITE RATS INDUCED RHODAMINE B Adriana Yulinda Dumaria Lumban Gaol; Erlintan Sinaga; Rosinta Febryanti Simamora; Feimmy Ruth Pratiwi Sipahutar; Hudson Sidabutar
JBIO: jurnal biosains (the journal of biosciences) Vol 9, No 1 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i1.44136

Abstract

The study was designed to evaluate the hematological effect of ethanol extract of Pirdot (Saurauia vulcani) (EES) in white rats induce rhodamine B and predict interaction of bioactive compound Pirdot to bind active site Keap1-Nrf2. Twenty- four Male Wistar rats (100-200 g) divided into four groups. Group P1 served as group control is administered with CMC 0.5%; group P2 is treated with Rhodamine B 750 mg/kg BW, Group KP1 administered EES 500 mg/kg BW; and Group KP2 is treated with EES 500 mg/kg BW+ Rhodamine B 750 mg/kg BW. Hematological parameters were assessed. The results revealed that red blood cell (RBC), white blood cell (WBC), thrombocyte count, and hemoglobin concentration (Hb) in rats induced Rhodamine B significantly lower than the control group. However, EES could improve the value of hematological profile. Our finding demonstrated that EES normalizes the value of hematological parameters in rats induce Rhodamine B. Moreover, beta-amyrin, pomolic acid and maslinic acid from Pirdot had good binding affinity to Keap1-Nrf2
Comparison of Activities and Learning Outcomes Using PjBL and PBL on the Circulatory System Material at State Senior High School Sarah Pardede; Adriana Yulinda Dumaria Lumban Gaol
Florea : Jurnal Biologi dan Pembelajarannya Vol. 13 No. 3 (2026)
Publisher : UNIVERSITAS PGRI MADIUN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25273/florea.v13i3.23859

Abstract

This study aims to determine the comparison of learning activity and learning outcomes of students taught using Project Based Learning (PjBL) and Problem Based Learning (PBL) models on circulatory system material at Senior High School 12 Medan. This research is a quasi-experimental study with a non-equivalent control group design. The population in this study consisted of all students in grade XI Science at SMAN 12 Medan, comprising 7 classes with a total of 251 students. Sample determination was conducted using purposive sampling technique, namely class XI F5 as the PjBL class and class XI F7 as the PBL class, each consisting of 30 students. Data collection used multiple-choice and essay tests to measure cognitive learning outcomes and observation sheets to measure student learning activity. Based on the research results, the posttest score for the PjBL class was 80.3 and the PBL class was 75.5. The percentage of learning activity in the PjBL class was 74% and the PBL class was 68.31%, both categorized as good. The results of the t-test analysis (independent sample t-test) showed a sig (2-tailed) value of 0.000 < 0.05, which means Ha was accepted and Ho was rejected. It can be concluded that the learning activity and learning outcomes of students taught using the PjBL model were higher compared to the PBL model on circulatory system material.
Co-Authors Erlintan Sinaga Feimmy Ruth Pratiwi Sipahutar Hudson Sidabutar Rosinta Febryanti Simamora Sarah Pardede