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Erlintan Sinaga
Universitas Negeri Medan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology

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THE EFFECT OF ETHANOL EXTRACT OF PIRDOT (Saurauria vulcani) ON HEMATOLOGICAL PROFILE AND KEAP1-NRF2 INHIBITION OF WHITE RATS INDUCED RHODAMINE B Adriana Yulinda Dumaria Lumban Gaol; Erlintan Sinaga; Rosinta Febryanti Simamora; Feimmy Ruth Pratiwi Sipahutar; Hudson Sidabutar
JBIO: jurnal biosains (the journal of biosciences) Vol 9, No 1 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i1.44136

Abstract

The study was designed to evaluate the hematological effect of ethanol extract of Pirdot (Saurauia vulcani) (EES) in white rats induce rhodamine B and predict interaction of bioactive compound Pirdot to bind active site Keap1-Nrf2. Twenty- four Male Wistar rats (100-200 g) divided into four groups. Group P1 served as group control is administered with CMC 0.5%; group P2 is treated with Rhodamine B 750 mg/kg BW, Group KP1 administered EES 500 mg/kg BW; and Group KP2 is treated with EES 500 mg/kg BW+ Rhodamine B 750 mg/kg BW. Hematological parameters were assessed. The results revealed that red blood cell (RBC), white blood cell (WBC), thrombocyte count, and hemoglobin concentration (Hb) in rats induced Rhodamine B significantly lower than the control group. However, EES could improve the value of hematological profile. Our finding demonstrated that EES normalizes the value of hematological parameters in rats induce Rhodamine B. Moreover, beta-amyrin, pomolic acid and maslinic acid from Pirdot had good binding affinity to Keap1-Nrf2
IDENTIFYING THE POTENTIAL OF Saurauia vulcani Korth. LEAVES ON BLOOD GLUCOSE LEVEL, HISTOPATHOLOGY OF PANCREATIC AND SPLEEN IN RATS (Rattus norvegicus) INDUCED ALLOXAN – IN VIVO AND IN SILICO APPROACH Erlintan Sinaga; Uswatun Hasanah; Feimmy Ruth Pratiwi Sipahutar; Hudson Sidabutar; Melati Nugrahalia Sipahutar
JBIO: jurnal biosains (the journal of biosciences) Vol 9, No 2 (2023): JBIO : Jurnal Biosains (The Journal of Biosciences)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v9i2.53242

Abstract

Insulin resistance related to pancreatic islet and spleen was one of incidence for diabetes mellitus disease. Our study determined the potential antidiabetic of Pirdot leaves (Saurauia vulcani, Korth.) (EEP) through in vivo and in silico approach. The effect of Pirdot on blood glucose level and histopathological pancreatic and spleen was analyzed by in vivo. Thirty male Wistar rats were divided into five groups as follows. Group KN served as negative control and was orally given distilled water; group KP were only 5.04 mg/ kg alloxan administered; group P1 were administered 16.5 mg/kg EEP and 5.04 mg/kg alloxan; group P2 were administered 33 mg/kg EEP and 5.04 mg/kg alloxan; group P3 rats 66 mg/kg EEP and 5.04 mg/kg alloxan. A single dose of alloxan was given in rats diabetic at KP, P1, P2, and P3 group treatment. Furthermore, the protein-protein interaction (PPI) and molecular docking were used to predict the interaction between the crossed genes in diabetes mellitus (DM) with 6 active compounds of Pirdot through in silico approach. The results indicated that Saurauia vulcani significantly decreased blood glucose and improved the histopathological alteration of pancreatic islet and spleen in alloxan induced treated diabetic rats. Moreover, the network pharmacology demonstrated ten hub genes and three genes target such as GANC (α-glucosidase), DPP4, and PTPN1 (tyrosine phosphatase protein) contributed in DM signaling pathway. Finally, the molecular docking study showed that the bioactive compounds Pirdot have a good binding affinity to the active site of PTP1B and α-glucosidase protein when compared to acarbose as a control compound
Co-Authors Adriana Yulinda Dumaria Lumban Gaol Feimmy Ruth Pratiwi Sipahutar Feimmy Ruth Pratiwi Sipahutar Hudson Sidabutar Melati Nugrahalia Sipahutar Rosinta Febryanti Simamora Uswatun Hasanah