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All Journal Biology, Medicine, & Natural Product Chemistry Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Indonesian Journal of Natural Science Education Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Elfred Rinaldo Kasimo
Universitas Kadiri
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Physics Public Health Social Sciences

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EFEK PREVENTIF EKSTRAK DAUN KENTUT (Paederia foetida L.) TERHADAP KADAR INTERLEUKIN-6 PADA MENCIT MODEL SEPSIS YANG DIINDUKSI Escherichia coli Lisa Savitri; Elfred Rinaldo Kasimo
Indonesian Journal of Natural Science Education Vol 5, No 2 (2022): November
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/nse.v5i2.2778

Abstract

Sepsis adalah keadaan darurat medis yang menggambarkan respons imunologis sistemik tubuh dan perubahan nukleotida pada gen yang mengkodekan interleukin-6 (IL-6) yang menghasilkan polimorfisme sehingga meningkatkan faktor risiko kematian karena sepsis. Terapi berbasis imunoterapi yang ditargetkan sebagian besar belum terbukti efektivitasnya sejauh ini. Sehingga, diperlukan tindakan yang lebih mengarah pada tindakan preventif, salah satunya dengan daun kentut (Paederia foetida L.). Mencit yang telah diadaptasikan diberikan perlakuan selama 14 hari dengan variasi sebagai berikut: 1) kelompok mencit yang tidak diberikan sonde lambung (N), 2) kelompok mencit diberikan aquades, 3) kelompok mencit diberikan ciprofloxacin, 4) kelompok diberikan ekstrak daun kentut dengan dosis 100 mg/kgBB, 5) kelompokmencit diberikan ekstrak daun kentut dengan dosis 300 mg/kbBB, 6) kelompok mencit diberikan ekstrak daun kentut dengan dosis 500 mg/kgBB. Mencit yang telah diberikan perlakuan diinjeksi pada bagian peritoniumnya dengan E. coli dengan dosis 1x105 CFU/mL. Mencit setelah 24 jam pasca pemaparan polimikroba sepsis akan memperlihatkan kejadian apoptosis. Berdasarkan hasil ELISA didapatkan kadar IL-6 N sebesar 1625,83 pg/mL, K- sebesar 2656,17 pg/mL, K+ sebesar 2033,21 pg/mL, P1 sebesar 2272,67 pg/mL, P2 sebesar 2175,83 pg/mL, P3 sebesar  2064,83 pg/mL. Mekanisme antiinflamasi pada sepsis diduga disebabkan adanya kandungan saponin, flavonoid, dan minyak atsiri yang terdapat di dalam ekstrak daun kentut. Mekanisme antiinflamasi yang paling mungkin adalah diduga saponin mampu berinteraksi dengan banyak membran lipid, seperti fosfolipid yang merupakan prekursor prostaglandin dan mediator inflamasi lainnya.
PENGGALAKAN KEBIASAAN HIDUP BERSIH DAN SEHAT SEBAGAI UPAYA PENCEGAHAH PENYEBARAN COVID-19 DI KELURAHAN TAMANAN, KOTA KEDIRI Lisa Savitri; Elfred Rinaldo Kasimo; Rochmad Krissanjaya
Jurnal Abdimas Ilmiah Citra Bakti Vol 4 No 2 (2023)
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jailcb.v4i2.1598

Abstract

Wabah COVID-19 telah menjadi pandemi global yang memengaruhi banyak negara, termasuk Indonesia. Pemerintah dan lembaga kesehatan telah melaksanakan berbagai langkah untuk mencegah penyebaran COVID-19. Salah satu langkah penting adalah menggalakkan kebiasaan hidup bersih dan sehat sebagai upaya pencegahan penyebaran COVID-19 di kelurahan Tamanan, Kota Kediri. Pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat tentang kebiasaan hidup bersih dan sehat sebagai upaya pencegahan penyebaran COVID-19. Metode yang digunakan dalam pengabdian masyarakat ini adalah pendekatan partisipatif dengan melibatkan masyarakat secara aktif dalam pengumpulan data dan pelaksanaan kegiatan. Kegiatan yang dilakukan meliputi penyuluhan, demonstrasi, dan penyediaan fasilitas sanitasi. Aktivitas ini diikuti oleh 50 ibu rumah tangga selama 3 bulan, terdiri dari tiga kegiatan utama penyuluhan kesehatan tentang pola hidup bersih dan sehat untuk mencegah penularan COVID-19. Data untuk penilaian kebiasaan hidup sehat menggunakan instrumen kuesioner dan checklist sebelum dan sesudah pelatihan. Pengetahuan, sikap dan psikomotor ibu rumah tangga dalam penyebaran penularan COVID-19 setelah diberikan pelatihan kebiasaan hidup sehat selama 3 bulan mengalami peningkatan. Penilaian dilakukan dengan membandingkan hasil pre-test dan post-test pelatihan peserta. Setelah mengikuti pelatihan, sebagian besar kemampuan peserta masuk kategori tinggi pada aspek pengetahuan (76%), aspek sikap (82%) dan aspek aspek psikomotor (92%). Berdasarkan hasil pengabdian ini, dapat disimpulkan bahwa penggalakan kebiasaan hidup bersih dan sehat dapat menjadi upaya efektif dalam pencegahan penyebaran COVID-19 di kelurahan Tamanan, Kota Kediri.
PENGGALAKAN KEBIASAAN HIDUP BERSIH DAN SEHAT SEBAGAI UPAYA PENCEGAHAH PENYEBARAN COVID-19 DI KELURAHAN TAMANAN, KOTA KEDIRI Lisa Savitri; Elfred Rinaldo Kasimo; Rochmad Krissanjaya
Jurnal Abdimas Ilmiah Citra Bakti Vol. 4 No. 2 (2023)
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jailcb.v4i2.1598

Abstract

Wabah COVID-19 telah menjadi pandemi global yang memengaruhi banyak negara, termasuk Indonesia. Pemerintah dan lembaga kesehatan telah melaksanakan berbagai langkah untuk mencegah penyebaran COVID-19. Salah satu langkah penting adalah menggalakkan kebiasaan hidup bersih dan sehat sebagai upaya pencegahan penyebaran COVID-19 di kelurahan Tamanan, Kota Kediri. Pengabdian masyarakat ini bertujuan untuk meningkatkan pemahaman masyarakat tentang kebiasaan hidup bersih dan sehat sebagai upaya pencegahan penyebaran COVID-19. Metode yang digunakan dalam pengabdian masyarakat ini adalah pendekatan partisipatif dengan melibatkan masyarakat secara aktif dalam pengumpulan data dan pelaksanaan kegiatan. Kegiatan yang dilakukan meliputi penyuluhan, demonstrasi, dan penyediaan fasilitas sanitasi. Aktivitas ini diikuti oleh 50 ibu rumah tangga selama 3 bulan, terdiri dari tiga kegiatan utama penyuluhan kesehatan tentang pola hidup bersih dan sehat untuk mencegah penularan COVID-19. Data untuk penilaian kebiasaan hidup sehat menggunakan instrumen kuesioner dan checklist sebelum dan sesudah pelatihan. Pengetahuan, sikap dan psikomotor ibu rumah tangga dalam penyebaran penularan COVID-19 setelah diberikan pelatihan kebiasaan hidup sehat selama 3 bulan mengalami peningkatan. Penilaian dilakukan dengan membandingkan hasil pre-test dan post-test pelatihan peserta. Setelah mengikuti pelatihan, sebagian besar kemampuan peserta masuk kategori tinggi pada aspek pengetahuan (76%), aspek sikap (82%) dan aspek aspek psikomotor (92%). Berdasarkan hasil pengabdian ini, dapat disimpulkan bahwa penggalakan kebiasaan hidup bersih dan sehat dapat menjadi upaya efektif dalam pencegahan penyebaran COVID-19 di kelurahan Tamanan, Kota Kediri.
Isolation and Identification of Dermatophytes from Toenails and Interdigital Spaces of Students Using Czapek Yeast Extract Agar Lisa Savitri; Kharisul Ihsan; Rochmad Krissanjaya; Elfred Rinaldo Kasimo; Novirma Yanti; Mochamad Hanif Hilmi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.795-798

Abstract

Dermatophytosis remains a common superficial fungal infection affecting nails and interdigital spaces, with Trichophyton rubrum and T. mentagrophytes as the predominant etiologic agents. The recent emergence of terbinafine-resistant T. indotineae has raised new challenges in diagnosis and treatment. Although Sabouraud Dextrose Agar is the conventional medium for fungal culture, alternative media such as Czapek Yeast Extract Agar (CYA) may provide additional advantages for dermatophyte isolation and morphological identification. This study aimed to isolate and identify dermatophytes from toenails and interdigital spaces of university students using CYA medium and to evaluate its applicability in dermatophyte culture. A cross-sectional descriptive study was conducted among 100 university students aged 18–24 years. Specimens were collected from toenails (n = 60) and interdigital spaces (n = 40). Direct microscopy was performed using 20% KOH preparation. Samples were cultured on CYA supplemented with chloramphenicol and cycloheximide, and incubated at 28 ± 2 °C for up to 21 days. Fungal isolates were identified based on macroscopic and microscopic morphology. Data were analyzed descriptively, and associations were tested using the chi-square test. Fungal elements were detected in 65% of samples by KOH examination, and dermatophyte growth was confirmed in 52% of cultures. The most frequently isolated species were T. rubrum (28%) and T. mentagrophytes (18%). Notably, T. indotineae was detected in 5% of samples. No significant difference was found between toenail and interdigital isolates (p = 0.26). Dermatophytes are prevalent among university students, with T. rubrum as the dominant species. The detection of T. indotineae highlights its emerging role in young populations. CYA proved effective for dermatophyte isolation and may serve as an alternative culture medium in academic and diagnostic laboratories.
Onychomycosis in Students: An Overview of Nail Care Practices and Personal Hygiene Lisa Savitri; Kharisul Ihsan; Rochmad Krissanjaya; Elfred Rinaldo Kasimo; Novirma Yanti; Mochamad Hanif Hilmi
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1015-1019

Abstract

Onychomycosis is a common nail disorder caused by dermatophytes, yeasts, and non-dermatophyte molds, with increasing prevalence among young adults. Poor nail care and personal hygiene habits are essential predisposing factors that contribute to infection. Despite its clinical relevance, data on onychomycosis in student populations remain limited. A cross-sectional study was conducted among 150 undergraduate students from the Faculty of Health Sciences, aged 18–25 years. Nail specimens were collected from individuals presenting with suspected onychomycosis. Direct microscopy was performed using a 20% potassium hydroxide (KOH) preparation, and samples were cultured on Sabouraud Dextrose Agar supplemented with chloramphenicol and cycloheximide. Fungal isolates were identified based on macroscopic and microscopic characteristics. Sociodemographic data, nail care habits, and hygiene practices were collected through structured questionnaires. Data were analyzed descriptively, and associations were assessed using chi-square tests. Onychomycosis was confirmed in 27 students (18%). Dermatophytes were the most frequent isolates, with Trichophyton rubrum (9%) and T. mentagrophytes (5%) predominating, followed by Candida albicans (3%) and Aspergillus spp. (1%). Risk factors significantly associated with infection included irregular nail trimming (p = 0.01), sharing of nail clippers (p = 0.03), and prolonged use of closed footwear (p = 0.02). No significant associations were observed with gender or age. Onychomycosis is prevalent among university students, with dermatophytes as the leading causative agents. Inadequate nail care and poor hygiene practices play a critical role in the occurrence of diseases. Health education and preventive interventions should be prioritized to reduce infection rates in young adults. Further studies employing molecular methods are recommended to refine species identification and improve epidemiological insights.
The Influence of Strain Type and Female Age on the Receptivity of Female Drosophila melanogaster in Homogamous Crosses Lisa Savitri; Kharisul Ihsan; Rochmad Krissanjaya; Elfred Rinaldo Kasimo
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.937-941

Abstract

Drosophila melanogaster is a widely used model organism in genetic research due to its short life cycle and the presence of many genes homologous to those found in humans. It plays an important role in studies related to genetic inheritance, gene interaction, sex determination, and developmental genetics. One key aspect of its reproductive biology is female receptivity—the willingness of a female to accept mating—which is influenced by various internal and external factors. External factors include environmental conditions such as temperature and humidity, as well as male courtship signals like wing vibrations and chemical cues. Internal factors are mainly related to the female's sexual maturity and mating status. Generally, female receptivity increases with age after eclosion, reaches a peak, and gradually declines. This study investigates the impact of strain type and female age on receptivity in homogamous crosses of D. melanogaster, using two mutant strains: dp (with a wing mutation) and wa (with an eye color mutation). Receptivity was measured by the presence or absence of F1 offspring following crosses between males and females of the same strain, with females tested at different ages ranging from 10 to 60 hours after eclosion. The results indicate that strain type does not have a significant effect on female receptivity. In contrast, female age plays a clear role: individuals aged 30 years and older were more receptive and more likely to produce offspring. No significant interaction was found between strain type and age. These findings suggest that female receptivity in D. melanogaster is more strongly influenced by sexual maturity (as indicated by age) than by genetic differences between strains.
Academic Stress and Blood Glucose Levels: A Correlational Study Among Medical Laboratory Technology Students Lisa Savitri; Mochamad Hanif Hilmi; Elfred Rinaldo Kasimo; Rochmad Krissanjaya; Kharisul Ihsan
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.977-981

Abstract

Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, often influenced by various physiological and psychological factors. One such factor is stress, particularly academic stress among university students. This study aims to explore the potential correlation between academic stress levels and random blood glucose levels among Medical Laboratory Technology (D.IV) students at Kadiri University. A cross-sectional, quantitative approach was used in this study. A total of 28 eligible students participated. Academic stress levels were assessed using the Perceived Sources of Academic Stress (PSAS) questionnaire, while random blood glucose levels were measured using spectrophotometric methods with glucose GOD FS reagents. Data were analyzed using the Pearson correlation test to determine the relationship between the two variables. The majority of students experienced moderate academic stress (71.43%), while the rest (28.57%) experienced high stress. No students reported low stress levels. Regarding blood glucose, 53.57% of participants had normal levels, and 46.43% had elevated levels. The Pearson correlation coefficient was 0.045 with a p-value of 0.819, indicating no statistically significant relationship between academic stress levels and blood glucose levels. Regression analysis also confirmed that while there was a slight positive trend (suggesting that higher stress may slightly raise glucose levels), the effect was negligible and not statistically significant. This study found no significant correlation between academic stress and random blood glucose levels among Medical Laboratory Technology students. Although stress may contribute to changes in glucose levels through hormonal mechanisms, other factors—such as diet, physical activity, and individual coping strategies—likely play a more substantial role. Interventions focusing on stress management, healthy lifestyle habits, and regular health monitoring are recommended to maintain both psychological well-being and metabolic health in students.
Laboratory Detection of Toenail Onychomycosis Using Malt Extract Agar in Students Lisa Savitri; Kharisul Ihsan; Elfred Rinaldo Kasimo
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1325-1330

Abstract

Onychomycosis is a common nail disorder caused by dermatophytes, non-dermatophyte molds, and yeasts. Despite being more prevalent in older adults, it is increasingly reported among younger populations, including university students, due to lifestyle factors and communal exposures. Rapid and accurate diagnosis is critical for effective management, but conventional methods remain limited in sensitivity. This study aimed to evaluate the prevalence and etiological profile of toenail onychomycosis among university students using potassium hydroxide (KOH) microscopy and Malt Extract Agar (MEA) culture. A total of 98 students with clinical signs of onychomycosis provided toenail specimens. Direct microscopy examination with 20% KOH was performed, followed by culture on MEA at 28–30 °C for up to 21 days. Fungal isolates were identified based on macroscopic and microscopic morphology. Statistical analysis assessed associations between clinical features and culture results. KOH microscopy detected fungal elements in 59.2% of specimens, while MEA culture yielded growth in 63.3%. When combined, the overall prevalence of confirmed onychomycosis was 71.4%. Trichophyton rubrum was the most frequent isolate (35.5% of positive cultures), followed by non-dermatophyte molds such as Aspergillus and Fusarium, and yeasts including Candida albicans and Candida parapsilosis. Nail thickening and discoloration were significantly associated with culture positivity (p < 0.05). Onychomycosis is prevalent among university students, with MEA culture providing superior diagnostic yield compared to KOH microscopy alone. The identification of non-dermatophyte molds and yeasts underscores the importance of comprehensive diagnostic strategies for guiding effective treatment. Future studies should combine culture and molecular methods to enhance detection accuracy and clarify the clinical significance of emerging pathogens.
Jumlah Neutrofil sebagai Penanda Inflamasi pada Diabetes Melitus Tipe 2 dengan dan tanpa Ulkus Aprilia Anjarwati; Elfred Rinaldo Kasimo; Dita Apriana Dwi Astuti
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 2 (2026): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i2.10194

Abstract

Type 2 diabetes mellitus causes chronic hyperglycemia, systemic inflammation, and immune dysfunction, which increase the risk of diabetic foot ulcers, amputation, and mortality. This study is urgent because the dominance of elevated neutrophil counts in T2DM patients with ulcers reflects an active inflammatory response that may worsen wound healing, while neutrophil testing is widely available in clinical pathology laboratories. The literature highlights the role of inflammation, cytokines, NLR, and complex biomarkers in diabetic complications; however, these indicators are often costly, less applicable in regional healthcare settings, and rarely compare ulcerated and non-ulcerated T2DM patients directly. This study addresses this gap by proposing absolute neutrophil count as a simple, quantitative, and categorical inflammatory indicator. The objective was to analyze differences in neutrophil counts between T2DM patients with and without ulcers at RSU Daha Husada Kediri using a comparative descriptive quantitative design involving 20 patients. The results showed that 80% of ulcerated T2DM patients had elevated neutrophil levels compared with 10% in the non-ulcer group, with a significantly higher mean neutrophil count (9.19 ± 2.56 vs 4.80 ± 1.32 ×10³/µL; p = 0.00012). In conclusion, increased neutrophil counts significantly distinguish the inflammatory status of T2DM patients with ulcers and represent a practical clinical marker for early screening of diabetic foot ulcer complications in regional hospitals.
Co-Authors Aprilia Anjarwati Dita Apriana Dwi Astuti Kharisul Ihsan Mochamad Hanif Hilmi Novirma Yanti Rochmad Krissanjaya savitri, Lisa