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All Journal JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Berkala Ilmiah Kimia Farmasi
Feri Setiadi
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Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Medicine & Pharmacology Other

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In Vitro Evaluation of Antidiabetic and Anti-Inflammatory Activities of Five Selected Syzygium Leaves Ethanolic Extract as Alpha-Glucosidase Inhibitors and Anti-denaturation of Bovine Serum Albumin (BSA) Meiliza Ekayanti; Feri Setiadi; Siti Aminah; Alam Almaaz Afandi
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.83-92

Abstract

Background: Diabetes mellitus (DM) has become a major health problem worldwide, with a continuous increase in mortality due to complications caused by hyperglycemia. Chronic hyperglycemia is often associated with inflammation due to increased production of free radicals. Objective: This study’s main objective is to assess antidiabetic and anti-inflammatory properties in vitro of five particular Syzygium leaves extract (S. cumini, S.aqueum, S. malaccense, S. polyanthum, and S. aromaticum) using alpha-glucosidase and Bovine Serum Albumin (BSA).  Methods: The five of selected Szygium leaves were macerated by using ethanol 96%, each extract was assessed in vitro for antidiabetic activity by analyzing the inhibitory of alpha-glucosidase using acarbose as strandard, and anti-inflammatory activity by analyzing the inhibitory denaturation of BSA Heat-induced and BSA induced by 2,2-diphenyl-1-picrylhydrazine (DPPH) with Sodium diclofenac as standard. Results: The IC50 of α-glucosidase inhibition was 76.235 µg/mL (strong) for S. malaccense and 0.241 µg/mL (very strong) for the acarbose standard. The greater IC50 of antidenaturation of BSA with heat-induced was S. polyanthum (95.7 µg/mL) and sodium diclofenac standard (59.25 µg/mL) both were strong inhibitor. Along with greater anti-denaturation of BSA, DPPH-induced S. malaccense (90.320 µg/mL) and sodium diclofenac standard (43.301 µg/mL), both of which are strong inhibitors. Conclusion: The ethanol extract of Syzygium leaves has the potential to be developed as an antidiabetic and anti-inflammatory herbal medicine, particularly S. malaccense and S. polyanthum leaf extracts, which provided greater activity in this study.
Development of Blush On Powder Formulation using Beetroot Extract (Beta vulgaris L.) as Natural Colorant: Pengembangan Formulasi Blush On Powder menggunakan Ekstrak Umbi Bit (Beta vulgaris L.) sebagai Pewarna Alami Feronika Evma Rahayu; Evi Sri Maulidi Risalah; Aluwi Nirwanasari; Ing Mayfa Situmorang; Feri Setiadi
Berkala Ilmiah Kimia Farmasi Vol. 12 No. 2 (2025): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikfar.v12i2.75812

Abstract

Research on the development of natural dyes using beetroot (Beta vulgaris L.) has been investigated. Beetroot extract was obtained using the maceration method and then characterized through phytochemical screening tests, TLC (Thin Layer Chromatography), FT-IR (Fourier Transform Infrared), and XRD (X-ray Diffraction). The extract was developed as an active ingredient in a blush on powder formulation. The formulation was evaluated through organoleptic testing, homogeneity, pH, and spreadability tests, as well as stability testing using the freeze and thaw method. The results showed that the beetroot extract yield was 4.64%, containing secondary metabolites in the form of alkaloids, flavonoids, saponins, tannins, and terpenoids, with an Rf value of 0.54, the presence of chemical structures in the form of O-H, C-H, C-H, and R-CH=CH-R, and an amorphous form. Formulation was carried out by varying the beetroot extract to F1 (2%), F2 (5%), and F3 (8%) and control F0. Based on organoleptic testing, the formulations showed light brown color for F1, brown for F2, and dark brown for F3, homogeneous, pH in the range of 6.56-6.94, and spreading power in the range of 5-7 cm. The stability test showed a normality test >0.05, indicating that the formulation was normally distributed. The homogeneity test >0.05 showed no significant differences between the formulations. The one-way ANOVA test p<0.05 showed that the formulation had an effect on the pH value, while the post hoc Tukey HSD test p<0.05 showed no significant differences between the formulations.   Keywords: Beetroot, TLC, FT-IR, XRD, Blush On, Natural Colorant
Co-Authors Alam Almaaz Afandi Aluwi Nirwanasari Evi Sri Maulidi Risalah Feronika Evma Rahayu Ing Mayfa Situmorang Meiliza Ekayanti SITI AMINAH