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Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse Alvilusia, Alvilusia; Fauzi, Amir; Azhari, Azhari; Wresnindyatsih, Wresnindyatsih; Saleh, Irsan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and Gynecology Dr. Mohammad Hoesin hospital Palembang. The study was conducted since December 1st, 2014 until July 31st, 2015. The sample was from the sacrouterine ligament and immunohistochemical examination was conducted to see the expression of TGF-β1 and tropoelastin. Result: Of the 30 subjects obtained, the expression of TGF-β1 was on 30 subjects consisting of 18 (60%) for weak expression and 12 (40%) for strong expression. Meanwhile, the strong tropoelastin expression was on 18 subjects (60%) and weak tropoelastin expression on 12 subjects (40%). There was a positive correlation between TGF-β1 and tropoelastin expression with moderate correlation (p=0.014; r=0.44). Conclusion: There is a positive correlation between the TGF-β1 and tropoelastin expression of sacrouterine ligament in uterine prolapse with moderate correlation. [Indones J Obstet Gynecol 2016; 4-2: 70-74] Keywords: transforming Growth Factor Beta 1, tropoelastin, uterine prolapse

Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse Alvilusia, Alvilusia; Fauzi, Amir; Azhari, Azhari; Wresnindyatsih, Wresnindyatsih; Saleh, Irsan
Indonesian Journal of Obstetrics and Gynecology Volume. 4, No. 2, April 2016
Publisher : Indonesian Socety of Obstetrics and Gynecology

Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and Gynecology Dr. Mohammad Hoesin hospital Palembang. The study was conducted since December 1st, 2014 until July 31st, 2015. The sample was from the sacrouterine ligament and immunohistochemical examination was conducted to see the expression of TGF-β1 and tropoelastin. Result: Of the 30 subjects obtained, the expression of TGF-β1 was on 30 subjects consisting of 18 (60%) for weak expression and 12 (40%) for strong expression. Meanwhile, the strong tropoelastin expression was on 18 subjects (60%) and weak tropoelastin expression on 12 subjects (40%). There was a positive correlation between TGF-β1 and tropoelastin expression with moderate correlation (p=0.014; r=0.44). Conclusion: There is a positive correlation between the TGF-β1 and tropoelastin expression of sacrouterine ligament in uterine prolapse with moderate correlation. [Indones J Obstet Gynecol 2016; 4-2: 70-74] Keywords: transforming Growth Factor Beta 1, tropoelastin, uterine prolapse

Penyuluhan dan deteksi dini kanker serviks menggunakan teknik sitologi Pap Smear konvensional Maulani, Heni; Kartika, Ika; Murti, Krisna; Wresnindyatsih, Wresnindyatsih
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 3 No 1 (2022): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V3I1.71

Cervical cancer is still the second biggest cause of mortality in women in Indonesia. Pap Smear cytology can detect precancerous lesions as precursor lesions early. Every married woman should have a Pap Smear examination done on a regular basis. If precancerous lesions are discovered, they must be treated immediately so that they do not proceed to cervical cancer. Counseling and Pap Smear Examination will be used to carry out the activity, which is aimed at all married women. The goal of this activity is to raise public awareness about the necessity of early cervical cancer screening and Pap Smear examination for early diagnosis of cervical precancerous lesions. Pre-test and post-test assessments were used to establish the degree of knowledge of participants. Counseling and examination activities was place four times in September-October 2021, at the Gandus Health Center and the practice of midwife Hj. Nani. This community service has attracted 130 counseling participants. Participants' understanding of the importance of early identification of cervical cancer increased from a score of 75.57 to 89.28 as a result of the pretest and post-test counseling outcomes. According to the Pap Smear diagnostic results, the majority of patients had non-specific chronic cervicitis, which was classified as Negative for Intraepithelial Lesion or Malignancy (NILM). Cervical cancer can be prevented with counseling and early detection.

Correlation between Poly ADP Ribose Polymerase (PARP) expression with Chemotherapy Response in Ovarian Carcinoma Yuniarti, Ria; Wresnindyatsih, Wresnindyatsih; Rusminan, Suly Auline; Bahar, Erial
Majalah Patologi Indonesia Vol. 35 No. 1 (2026): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v35i1.661

Background Germline mutations in BRCA1 and BRCA2 are high risk factors for ovarian and breast cancer. The risk of ovarian cancer in BRCA1 mutation carriers is 16-68% and 11-30% in BRCA2 mutation carriers.1,2 The enzyme poly ADP ribose polymerase (PARP) plays an important role in DNA damage repair and genome stability and cancer cells change its regulation as a way for tumor cells to survive cell death due to chemotherapeutic agents.3,4 Positive PARP expression is associated with high-grade tumors. advanced stage and is an indicator of aggressive disease. The aim of this study was to examine the relationship between PARP expression and the response to chemotherapy in ovarian carcinoma. Methods A cross sectional study was conducted using 34 samples of paraffin blocks and slides of ovarian carcinoma from oophorectomy and biopsy of patients registered at the Anatomical Pathology Department Faculty of Medicine Sriwijaya University/Dr. Mohammad Hoesin Hospital Palembang for the period January 2019 to December 2021. Each sample was stained by PARP monoclonal antibody. Qualitative interpretation by assessing semi-quantitatively, namely assessing the area/proportion (P) and intensity (I) of the polished, the score is obtained by multiplying the area by the intensity, the results are grouped into 2, score 0-4 was a weak expression, score 6 was a strong expression. Analysis of the relationship between PARP expression and response to chemotherapy was performed using Chi-square test and Spearmann correlation. Results Chi-square test showed that there was a significant relation PARP expression with chemotherapy response, age, CA 125 levels post chemotherapy and stage with p values were 0.008, 0.005, 0.020 dan 0.006 respectively. There was no relation between PARP expression with histopathology subtype with p values was 0.053. Conclusion There is a significant correlation between PARP expression with chemotherapy response, age, CA 125 levels post chemotherapy and stage in ovarian carcinoma

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