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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya SRIWIJAYA JOURNAL OF MEDICINE Majalah Patologi Indonesia Jurnal Pengabdian Masyarakat: Humanity and Medicine
Heni Maulani, Heni
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

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Korelasi Antara Overekspresi p53 Dengan Derajat Histopatologi Dan Stadium Klinis Karsinoma Ovarium Lahmuddin, Tati; Maulani, Heni; Musa, Zulkarnain; Saleh, Irsan
JURNAL KEDOKTERAN DAN KESEHATAN Vol 2, No 3 (2015): Oktober 2015
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Karsinoma ovarium adalah keganasan yang berasal dari sel-sel epitelial di ovarium, terbanyak keenam pada wanita di dunia. Di RS Umum Dr. Mohammad Hoesin Palembang, insiden karsinoma ovarium menempati urutan ketiga keganasan terbanyak pada wanita setelah karsinoma payudara dan leher rahim. Gen TP53 mensintesis protein p53 yang bila inaktif dapat mempengaruhi derajat histopatologi dan stadium klinik. Penelitian ini bertujuan mengetahui korelasi antara overekspresi p53 dengan derajat histopatologi dan stadium klinik karsinoma ovarium.  Penelitian dilakukan secara analitik observasional, pendekatan potong lintang di sentra diagnostik laboratorium Patologi Anatomi RS Umum Dr. Mohammad Hoesin Palembang. Sampel berjumlah 32 kasus, diambil dari arsip rekam medik periode 1 Januari 2012 sampai 30 Juni 2015, dipulas dengan antibodi monoklonal p53. Hasil penelitian menemukan frekuensi karsinoma ovarium derajat rendah sebanyak 65,6% dan derajat tinggi sebanyak 34,4%. Tipe histopatologi terbanyak adalah karsinoma serosa derajat tinggi (25%) dan karsinoma musinus (25%). Frekuensi karsinoma ovarium stadium lanjut (53,1%) lebih banyak dari stadium awal (46,9%).  Frekuensi overekspresi p53 pada karsinoma ovarium 43,8%. Tidak ada korelasi bermakna antara overekspresi p53 dengan derajat histopatologi (p=0,1) dan stadium klinis karsinoma ovarium (p=0,6). Terdapat korelasi bermakna antara derajat histopatologi dan stadium klinik (p=0,00, r=0,46)
Korelasi Ekspresi CD47 terhadap Faktor-Faktor Klinikopatologi pada Karsinoma Ovarium: - Fitrianti, Fitrianti; Maulani, Heni; Aspitriani, Aspitriani
Sriwijaya Journal of Medicine Vol. 3 No. 1 (2020): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Ovarian carcinoma is the fourth most common cause of death in gynecological malignancies. CD47 is asurface protein widely expressed on many benign and malignant cells, including ovarian carcinoma. This study wasaimed to identifythe correlation between CD47 expression with clinicopathological factors inovarian carcinoma.Case series studies was undertaken started on January 1, 2016 to October 31, 2019 at Department of Anatomic Pathology Faculty of Medicine Sriwijaya University/Mohammad Hoesin Hospital, Palembang. Fifty cases, consisting of LGSC, HGSC, MC, EC, CCC, each 10 cases were selected. The slides were stained with anti-CD47 antibody. The correlation of expression of anti CD47 protein with ages, clinical stages and CA125 serumwere analysed byGamma test. The correlation of expression of anti CD47 protein with histopathologic subtypes and chemotherapeuticresponses were analyzed using Contingency test.There was no significantcorrelation between CD47 expression with ages (p=0.130), histopathological subtypes (p=0,956), FIGO clinical stages (p=0.459), CA125 serum level (p=0.366) and chemotherapeutic response (p=0.129).Althoughthere was no significant correlation between CD47 expression and clinicopathological characteristics,atendency that the higher expression CD47 will be followed by the younger age groups, higher clinical stagesand higher CA125 serum was observed.
Penyuluhan dan deteksi dini kanker serviks menggunakan teknik sitologi Pap Smear konvensional Maulani, Heni; Kartika, Ika; Murti, Krisna; Wresnindyatsih, Wresnindyatsih
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 3 No 1 (2022): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V3I1.71

Abstract

Cervical cancer is still the second biggest cause of mortality in women in Indonesia. Pap Smear cytology can detect precancerous lesions as precursor lesions early. Every married woman should have a Pap Smear examination done on a regular basis. If precancerous lesions are discovered, they must be treated immediately so that they do not proceed to cervical cancer. Counseling and Pap Smear Examination will be used to carry out the activity, which is aimed at all married women. The goal of this activity is to raise public awareness about the necessity of early cervical cancer screening and Pap Smear examination for early diagnosis of cervical precancerous lesions. Pre-test and post-test assessments were used to establish the degree of knowledge of participants. Counseling and examination activities was place four times in September-October 2021, at the Gandus Health Center and the practice of midwife Hj. Nani. This community service has attracted 130 counseling participants. Participants' understanding of the importance of early identification of cervical cancer increased from a score of 75.57 to 89.28 as a result of the pretest and post-test counseling outcomes. According to the Pap Smear diagnostic results, the majority of patients had non-specific chronic cervicitis, which was classified as Negative for Intraepithelial Lesion or Malignancy (NILM). Cervical cancer can be prevented with counseling and early detection.
Penyuluhan kesehatan tentang kesadaran terhadap risiko tumor pada usia remaja Kurniawaty, Nyiayu Fauziah; Maulani, Heni; Farida, Aida
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 4 No 3 (2023): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V4I3.103

Abstract

Any lump that is not normally there is called a tumor. Tumors are divided into two types, namely benign and malignant. Benign tumors generally do not cause death. Meanwhile, what is called a malignant tumor indicates a tumor that can invade the surrounding tissue, is able to move to other parts of the body and generally has a high mortality rate. In 2018 there were 18.1 million new cases with a death rate of 9.6 million deaths. 47 out of 100,000 teenagers have cancer. Cancer can be prevented by avoiding exposure to risk factors for malignancy such as radiation and chemicals. In addition, early detection plays an important role in reducing morbidity and mortality. There are still many cases that come to health workers at an advanced stage which have a worse prognosis when compared to diseases detected at an early stage. In this activity, we have explained several types of lumps that often affect teenagers and how to respond to them. The activity was coordinated by the staff of the Anatomic Pathology Section of the Faculty of Medicine, Sriwijaya University in collaboration with the Prabumulih City Government. At the end of the activity, the participants understood more about the importance of awareness of the risk of tumors in their teens.
Hubungan Tingkat Ekspresi Fibroblast Activation Protein (FAP) Terhadap Faktor Klinikopatologi Karsinoma Tiroid Papiler Herlina; Maulani, Heni; Apriyani, Nursanti
Majalah Patologi Indonesia Vol. 30 No. 3, September 2021
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v30i3.478

Abstract

BackgroundPapillary thyroid carcinoma is the most common subtype among thyroid cancers. The interaction between cancer cells and tumormicroenvironment plays roles in cancer proliferation and invasiveness. One of important components of tumor microenvironmentthat could stimulate tumor proliferation and invasiveness is activated fibroblast, known as carcinoma associated fibroblasts (CAFs).The aim of this research is to analysed FAP expression is associated with clinicopathologic characteristics.MethodsThis retrospective descriptive observational study with serial cases design was conducted in 40 samples of the paraffin blocks oftissues registered in Department of Anantomical Pathology Faculty of Medicine University of Sriwijaya/Dr. Moh. Hoesin PalembangHospital from January 1st, 2017 to October 31st, 2019. All samples were immunostained with FAP antibody. The expressions of FAPwere evaluated in accordance with the results of the previous study. Statistical test was performed by using Chi-square andSpearman-rho statistical test. Statistical analysis was performed by using SPSS version 23.0.ResultsOur data indicated that patients who were ≥45 years old (21 cases; 52.5%), women (31 cases; 77.5%) suffered from this cancer themost. The stromal type found in ten classic, follicular, solid and columnar variance were pauci (25 cases; 62.6%), desmoplastic (8cases;20%), sclerosis (5 cases; 12.5%) and inflammatory (2 cases; 5%). The expression of FAP in tumor stroma has a significantcorrelation with histopathology subtypes (p=0.028) and stromal type (p=0.000).ConclusionFAP was expressed in tumor epithelial cells and fibroblast stromal tumour of papillary thyroid carcinoma. FAP expression in stromaltumor between histopathologic subtype and stromal type showed significant correlation
Co-Authors Apriyani, Nursanti Aspitriani Fitrianti Fitrianti, Fitrianti Herlina Ika Kartika Jayawarsa, A.A. Ketut Krisna Murti Kurniawaty, Nyiayu Fauziah Muhammad Irsan Saleh Tati Lahmuddin, Tati Wresnindyatsih Wresnindyatsih, Wresnindyatsih Zulkarnain Musa, Zulkarnain