Article Per Year (5 Year)
p-Index From 2021 - 2026
0.817
P-Index
This Author published in this journals
All Journal Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Pharmacy and Natural Product Medical Sains : Jurnal Ilmiah Kefarmasian
Endang Diyah Ikasari
Sekolah Tinggi Ilmu Farmasi Yayasan Pharmasi Semarang
Medicine & Pharmacology

Published : 4 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 4 Documents
Search

 1 
FORMULASI DAN OPTIMASI KADAR HYDROXYPROPYL METHYLCELLULOSE K100M DAN POLYVINYL ACETATE DALAM SEDIAAN PATCH TRANSDERMAL PROPRANOLOL HCl: FORMULATION AND OPTIMIZATION OF HYDROXYPROPYL METHYLCELLULOSE K100M DAN POLYVINYL ACETATE CONCENTRATIONS IN TRANSDERMAL PATCH PROPRANOLOL HCl Sukma Ayu Ilkhawati; Endang Diyah Ikasari; Erwin Indriyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.671

Abstract

Propranolol hidroklorida merupakan penghambat reseptor beta-1 yang digunakan untukterapi angina, aritmia jantung, dan hipertensi. Penggunaannya secara oral memiliki beberapamasalah seperti mengalami first pass effect, indeks terapi sempit, dan rasa yang pahit.Kekurangan tersebut bisa diatasi dengan memformulasikannya sebagai sediaan transdermalberupa patch. Komponen yang digunakan dalam patch transdermal adalah kombinasipolimer hidrofilik yaitu HPMC K100M dan PVA. Optimasi dilakukan dengan SimplexLattice Design agar diperoleh formula optimal yang menghasilkan patch transdermalpropranolol HCl dengan karakteristik fisik dan daya penetrasi terbaik. Penelitian inibertujuan mengetahui pengaruh konsentrasi HPMC K100M dan PVA pada karakteristiksediaan patch dan daya penetrasi sediaan patch propranolol HCl serta mencari konsentrasioptimal. Optimasi perbandingan konsentrasi HPMC K100M dan PVA ditentukanmenggunakan Design Expert 11.0.1 dengan metode Simplex Lattice Design untuk 8 formulauji. Masing-masing formula diuji karakteristik fisik meliputi pH, keseragaman bobot,ketahanan lipat, ketebalan serta uji daya penetrasi sehingga diperoleh formula optimalkemudian dilakukan validasi dengan SPSS melalui one sample t-test. Hasil penelitianmenunjukkan ada pengaruh kombinasi HPMC K100M dan PVA pada karakteristik fisik dandaya penetrasi sediaan patch propranolol HCl. Formula optimum sediaan berdasarkanDesign Expert 11.0.1 yang menghasilkan sediaan dengan karakteristik fisik dan dayapenetrasi paling baik yakni konsentrasi HPMC K100M 6,13% dan PVA 2,37%. Kata kunci : patch, propranolol hidroklorida, HPMC K100M, Simplex Lattice Design, PVA
FORMULASI DAN OPTIMASI KADAR HYDROXYPROPYL METHYLCELLULOSE K100M DAN POLYVINYL ACETATE DALAM SEDIAAN PATCH TRANSDERMAL PROPRANOLOL HCl: FORMULATION AND OPTIMIZATION OF HYDROXYPROPYL METHYLCELLULOSE K100M DAN POLYVINYL ACETATE CONCENTRATIONS IN TRANSDERMAL PATCH PROPRANOLOL HCl Sukma Ayu Ilkhawati; Endang Diyah Ikasari; Erwin Indriyanti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.671

Abstract

Propranolol hidroklorida merupakan penghambat reseptor beta-1 yang digunakan untukterapi angina, aritmia jantung, dan hipertensi. Penggunaannya secara oral memiliki beberapamasalah seperti mengalami first pass effect, indeks terapi sempit, dan rasa yang pahit.Kekurangan tersebut bisa diatasi dengan memformulasikannya sebagai sediaan transdermalberupa patch. Komponen yang digunakan dalam patch transdermal adalah kombinasipolimer hidrofilik yaitu HPMC K100M dan PVA. Optimasi dilakukan dengan SimplexLattice Design agar diperoleh formula optimal yang menghasilkan patch transdermalpropranolol HCl dengan karakteristik fisik dan daya penetrasi terbaik. Penelitian inibertujuan mengetahui pengaruh konsentrasi HPMC K100M dan PVA pada karakteristiksediaan patch dan daya penetrasi sediaan patch propranolol HCl serta mencari konsentrasioptimal. Optimasi perbandingan konsentrasi HPMC K100M dan PVA ditentukanmenggunakan Design Expert 11.0.1 dengan metode Simplex Lattice Design untuk 8 formulauji. Masing-masing formula diuji karakteristik fisik meliputi pH, keseragaman bobot,ketahanan lipat, ketebalan serta uji daya penetrasi sehingga diperoleh formula optimalkemudian dilakukan validasi dengan SPSS melalui one sample t-test. Hasil penelitianmenunjukkan ada pengaruh kombinasi HPMC K100M dan PVA pada karakteristik fisik dandaya penetrasi sediaan patch propranolol HCl. Formula optimum sediaan berdasarkanDesign Expert 11.0.1 yang menghasilkan sediaan dengan karakteristik fisik dan dayapenetrasi paling baik yakni konsentrasi HPMC K100M 6,13% dan PVA 2,37%. Kata kunci : patch, propranolol hidroklorida, HPMC K100M, Simplex Lattice Design, PVA
REVIEW: A STUDY ON THE USE OF GOTU KOLA EXTRACT (Centella asiatica (L.) Urb.) AS A TREATMENT FOR ACNE Endang Diyah Ikasari; Tris Harni Pebriani
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1010

Abstract

Acne is an inflammatory skin condition caused by sebaceous follicles and characterized by skin inflammation in the form of a buildup of bacteria and oil that clogs pores and causes acne. Centella asiatica (L.) Urb., often known as gotu kola, has antibacterial properties that inhibit Propionibacterium acnes, thereby reducing papules, pustules, and nodules. Antioxidants, asiatic acid, and madecassic acid found in gotu kola (Centella asiatica (L.) Urb.) can treat wounds. Skin damaged by acne can be repaired and rejuvenated with gotu kola antioxidants, which also help collagen formation more quickly in the skin. This research aims to examine the ability of gotu kola (Centella asiatica (L.) Urb.) extract to inhibit acne-causing bacteria (Propionibacterium acnes) resulting from a literature review. This research method is a literature review or literature review. Research journals that met the inclusion criteria (activity test results suppressing bacterial growth activity) were collected, and a journal summary was made. A summary of the research journals is included in the table sorted by the year of publication of the journal. Based on the results of a literature review carried out by researchers, Gotu kola can be extracted using the maceration method by soaking the plant material in an extraction solvent such as ethanol or water for a specified time. This process was used to remove the active components from the plant material. The inhibition zone formed was evaluated to determine the effectiveness of the extracts or preparations containing gotu kola extract in preventing bacterial growth ...
Comparative Potential of Cream Preparations As Tyrosinase Inhibition Between Ethanolic Extracts of Kepel Leaves (Stelechocarpus burahol (Blume) Hook f. & Thomson) and Pulasari Bark (Alyxia reinwardii Blume) Endang Dwi Wulansari; Endang Diyah Ikasari; Adilah Athtahirah; Dharu Fajar Dwikha Timronna
Indonesian Journal of Pharmacy and Natural Product Vol. 8 No. 02 (2025): Indonesian Journal of Pharmacy and Natural Product
Publisher : Universitas Ngudi Waluyo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/ijpnp.v8i02.4307

Abstract

The problem of skin hyperpigmentation due to excessive exposure to ultraviolet rays is a primary concern in the development of cosmetic preparations based on natural ingredients. The enzyme tyrosinase plays a crucial role in the melanin formation process, making it a key target in the formulation of skin-lightening agents. This study evaluated the potential of cream preparations containing ethanol extract of Kepel leaf (Stelechocarpus burahol) and pulasari bark (Alyxia reinwardii) as tyrosinase inhibitors. The extract is obtained through the maceration method using a 96% ethanol solvent and then formulated into a cream preparation with concentrations of 1.25% and 2.5%. Physical characteristics tests (viscosity, pH, dispersibility, adhesion, homogenity) and tyrosinase enzyme inhibition activity tests were performed in vitro using ELISA instruments or microplate readers. The results showed that increased concentration of the extract affected the physical properties of the preparation and increased inhibition ability against tyrosinase, but statistical tests showed insignificant differences in results. Formulations with a concentration of 2.5% showed the highest activity in inhibiting tyrosinase, with pulasari bark extract being more effective than kepel leaves. These findings strengthen the potential of both plants as active ingredients in natural-based skin lightening cosmetic products
Co-Authors Adilah Athtahirah Dharu Fajar Dwikha Timronna Endang Dwi Wulansari Erwin Indriyanti Sukma Ayu Ilkhawati Tris Harni Pebriani