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All Journal Journal of Community Empowerment for Health Indonesian Journal of Pharmacology and Therapy
Lukman Ade Chandra
Department Of Pharmacology And Therapy, Faculty Of Medicine, Public Health And Nursing, Universitas Gadjah Mada, Yogyakarta
Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Pneumonia Related Deaths in Sleman Based on Verbal Autopsy: an Observational Study Stephanie Audrey Handrianto; Beta Ahlam Gizela; Djayanti Sari; Lukman Ade Chandra
Journal of Community Empowerment for Health Vol 6, No 3 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.83510

Abstract

Pneumonia has long been and remains one of the leading causes of death, especially among children and the elderly. Until this study was released, only the Jakarta province fulfilled the national target of pneumonia case findings. Thus, it is important to determine the characteristics and prevalence of pneumonia-related deaths in Sleman District based on verbal autopsy. This cross-sectional study used secondary data from Sleman HDSS cycles 1 to 7. The subject of this study was a person aged over 28 days who passed away due to pneumonia between 2015 and 2022 and met the criteria for sample inclusion. Fisher’s exact and Pearson’s chi-square tests were used to analyze the data. The number of subjects who died due to pneumonia was 65 subjects (33,3%), and the number of subjects who died due to other causes was 130 (66,7%). The prevalence of those who died due to pneumonia was lower than non-pneumonia death for all of the predetermined risk factors, including elderly age, male sex, low education level, high occupational risk, smoking history, alcohol consumption, asthma history, COPD history, stroke history, tuberculosis history, hospitalization history, and very thin or malnourished body with sex, occupational status & type, and nutritional status being statistically significant. The prevalence of pneumonia-related deaths in the Sleman HDSS VA population is 33,3%, with some risk factors that may affect it.
Safety monitoring of chloroquine and hydroxychloroquine in COVID-19 patients in Indonesia on QT prolongation: hospital based monitoring study Jarir At Thobari; Togi Junice Hutadjulu; Tri Asti Isnariani; Umi Sa'adatun Nikmah; Lukman Ade Chandra; Pompini Agustina Sitompul; Anggoro Budi Hartopo; Rizki Amalia Gumilang; Luhur Pribadi; Deva Bachtiar; Anwar Santoso
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.7148

Abstract

Chloroquine (CQ) and Hydroxychloroquine (HCQ) are the challenging drugs used for COVID-19. Several studies show its beneficial, however, both medications can prolong the QTc interval and increase the risk of patients for torsades de pointes and death. The Tisdale score is identified to have successfully predicted the at-risk population of side effects of these drugs. This study aim to evaluate the QT prolongation caused by the administration of chloroquine and hydroxychloroquine in COVID-19 patients and the association with the treatment outcomes based on their Tisdale score. We conducted an observational study on 213 hospitalized patients with confirmed or suspect COVID-19 in 6 referral hospitals in Indonesia. All baseline demographic such as age and gender, RT-PCR test result, severity of disease, history of cardiovascular disease (myocardial infarction, heart failure, hypertension), serum kalium level at baseline, and the use of medication associated with risk QTc interval prolongation were collected. The Tisdale risk score was used for predicting high-risk patients for QT corrected (QTc) interval prolongation. Out of 213 patients who were treated with CQ/HCQ, there were 60 (28.2%) patients had QTc interval prolongation, included 43 patients (20.2%) who had normal QTc interval at baseline and at the end of treatment had prolong interval; or 17 patients (8.0%) who had QTc interval more than 470 msec at baseline and QTc interval prolongation was worsen at the end of treatment. Several factors, including age more than 50 years, COVID-19 confirm PCR, and had comorbidity heart failure, were statistically significant associated with QTc interval prolongation. The high-risk score of Tisdale score have increased risk significantly on QTc interval prolongation (RR: 2.15, 95%CI 1.07-4.32) and associated with risk of death (RR: 3.50, 95%CI 1.34-9.13) compared to low-risk score. Our findings showed that the treatment of CQ/HCQ in COVID-19 patients is associated with QTc prolongation. The Tisdale score can be used as a valuable tool to predict the COVID-19 patients’ outcome after treatment of these QTc-prolonging drugs.
Early drug-induced hepatotoxicity in newly diagnosed HIV-positive patients on ARV therapy: A retrospective follow-up study of liver function profiles Chandra, Lukman Ade; Subronto, Yanri Wijayanti; Thobari, Jarir At
Indonesian Journal of Pharmacology and Therapy Vol 4 No 2 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.7817

Abstract

Antiretroviral therapy (ART) is a primary therapeutic modality for managing individuals with Human Immunodeficiency Virus (HIV) infection, and its efficacy has been established. However, the safety profiles of ART need to be continually monitored, including early elevated liver function test (LFT) after antiretroviral (ARV) initiation. This study aimed to assess the incidence of abnormal LFT among HIV-positive patients receiving initial ARV and to identify factors associated with abnormal LFT. A retrospective cohort study without a control group summarised medical records from Dr Sardjito General Hospital, Yogyakarta between January 2014 and December 2021. The study subjects were adult HIV patients taking their first ARV and underwent follow-up visits for at least two weeks. Study outcomes were LFT levels, abnormal LFT, and factors associated with abnormal LFT during follow-up visits at 2 wk, 6 mo, and 12 mo. Univariate and multivariate analyses will be performed with a significance level of p<0.05. A total of 137 subjects with 203 visits were retrieved from medical records. The subjects' mean age was 33.4 years, predominantly male, younger, unmarried, in the early stage of HIV infection, and without comorbidities. The findings showed a significant increase in alanine transaminase (ALT) at all three follow-up visits: 2 wk (p=0.02), 6 mo (p=0.003), 12 mo (p=0.001) and an increase in aspartate aminotransferase (AST) after 6 mo (p=0.007) and 12 mo (p=0.04). Abnormal LFT levels (AST and/or ALT) were observed in 23.4% of patients after a normal baseline, with ALT increase being more common. Furthermore, homosexuality was identified as a significant independent factor associated with abnormal LFT (AOR=3.1; 95% CI 1.27-7.51; p=0.01). The findings indicate exceptionally elevated LFT levels and the occurrence of abnormal LFTs among HIV-positive patients initiating ARVs. The increase in abnormal LFTs was significantly associated with patients identifying as homosexual, where hepatitis co-infection may be a contributing factor. The limited study design and measured variables warrant further investigation.
The drive-through COVID-19 vaccination in Yogyakarta Chandra, Lukman Ade; Nirwati, Hera; Puspitasari, Ika; Dibtyanusa, Ajib; Sutono, Sutono; Achmad, Bayu Fandi; Kumara, Intan Fatah; Siswishanto, Rukmono
Journal of Community Empowerment for Health Vol 7, No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jcoemph.82335

Abstract

Introduction: COVID-19 vaccination is the government's priority to control viral transmission. Drive-through system provides quick means of product or service delivery; however, it has not been extensively adopted as a vaccination method. This study aims to describe the implementation of the drive-through COVID-19 vaccination conducted by the Faculty of Medicine, Public Health, and Nursing at Universitas Gadjah Mada in collaboration with several national and regional, governmental and non-governmental institutions. Methods: The drive-through vaccination involved online registration, data collecting, reporting, on-site dose preparation, injection, and post-vaccination monitoring while participants remained in their vehicles. The events were scheduled between July and September 2021 in either FK-KMK UGM Campus or Grha Sabha Pramana, UGM. These venues are on the inner property side of UGM, therefore is no disruption of public traffic. Participants who are eligible and receive an invitation may attend the immunization venue according to the schedule. Results: In ten vaccination events, 20,870 doses of the COVID-19 vaccine were administered. Most participants were young people, with slightly more women than men. The drive-through vaccination went relatively well and offered many benefits such as improving vaccine coverage, time efficiency, social distancing, and herd immunity. Yet, issues like mild Adverse events following immunization and an accumulation of vehicles occurred. Therefore, careful planning and risk anticipation are necessary. Conclusion: The drive-through vaccination generally provides rapid and safe vaccine delivery to large communities. This method could be an alternative to delivering mass vaccinations requiring rapid and extensive coverage.
Co-Authors Achmad, Bayu Fandi Anggoro Budi Hartopo Anwar Santoso Anwar Santoso Beta Ahlam Gizela Deva Bachtiar Deva Bachtiar Dibtyanusa, Ajib Djayanti Sari Gumilang, Rizki Amalia Hera Nirwati Ika Puspitasari Jarir At Thobari Jarir At Thobari Kumara, Intan Fatah Luhur Pribadi Luhur Pribadi Pompini Agustina Sitompul Pompini Agustina Sitompul Rizki Amalia Gumilang Rukmono Siswishanto Stephanie Audrey Handrianto Sutono Sutono Togi Junice Hutadjulu Togi Junice Hutadjulu Tri Asti Isnariani Tri Asti Isnariani Umi Sa'adatun Nikmah Umi Sa'adatun Nikmah Yanri Wijayanti Subronto