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All Journal Statistika Indonesian Journal of Cardiology Jurnal Sains Dirgantara Indonesian Journal of Pharmacology and Therapy
Anwar Santoso
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Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology

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PREDIKSI MOF DAN LOF QUASI REAL TIME PADA SIRKIT KOMUNIKASI MANADO-SUMEDANG Habirun Habirun; Sity Rachyany; Anwar Santoso
STATISTIKA: Forum Teori dan Aplikasi Statistika Vol 4, No 2 (2004)
Publisher : Program Studi Statistika Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jstat.v4i2.881

Abstract

Model prediksi frekuensi komunikasi radio HF (High Frequency) telah banyak dilakukan penelitian terutama yang ditelitiadalah model prediksi MUF (Maximum Usable Frequency) dan LUF (Lowest Useble Frequency) jangka panjang denganberdasarkan median bulanan. Model prediksi MUF dan LUF ini dapat pula dikembangkan hingga model prediksi frekuensikomunikasi HF real time melalui MOF (Maximum Observed Frequency) dan LOF (Lowest Observed Frequency) padasirkit komunikasi dengan jarak tertentu. Sehubungan uraian di atas pada makalah ini dibahas pengembangan modelprediksi frekuensi komunikasi HF melalui model prediksi MOF dan LOF quasi real time yang digunakan pada sirkitkomunikasi Manado – Sumedang, menggunakan model rata-rata dan deviasi standar serta validasi model prediksididukung korelasi pola yang cukup memadai antara data pengamatan MOF dan LOF terhadap hasil prediksi. Dari analisisdata MOF dan LOF diperoleh bahwa prediksi MOF dan LOF quasi real time menggunakan model berbasis statistikberdasarkan model rata-rata, deviasi standar dan didukung autokorelasi yang cukup memadai dengan ditunjukkan masingmasingharga koefisien korelasi pola antara data pengamatan terhadap hasil prediksi sebesar 0,9840 dan 0,9987.
Improvement of exercise capacity after early phase II cardiac rehabilitation in patients who undergo rheumatic mitral valve surgery Ade Meidian Ambari; Budhi Setianto; Anwar Santoso; Basuni Radi; Bambang Dwiputra; Eliana Susilowati; Fadila Tulrahmi; Pieter A Doevendans; Maarten Jan Cramer
Jurnal Kardiologi Indonesia Vol 41 No 3 (2020): Indonesian Journal of Cardiology: July - September 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1038

Abstract

Background: Rheumatic heart disease still become a major concern in developing countries. Recent studies showed the benefits of early phase II cardiac rehabilitation (CR) on improving the exercise capacity but the evidence in patients after rheumatic mitral valve surgery due to rheumatic heart disease is limited. This study aims to investigate the effects of early phase II CR program on increasing exercise capacity in the rheumatic mitral valve surgery patients. Methods: This is a cohort retrospective study. A review of medical records identified 254 patients who underwent early phase II CR after rheumatic mitral valve surgery between July 2009 – June 2019. Effects of CR was assessed by 6 Minutes Walking Distance (6MWD) pre and post early phase II CR and peak oxygen uptake (VO2 peak) calculated by Cahallin formula. In this study, we observed and analyzed the increasing of 6MWD and VO2 peak. Results: Our findings showed that 6MWD and VO2 peak increased significantly in these patients after early phase II CR program (p = 0.001). Mean of 6MWD increased from 316.3 ± 71.7 meters to 378.6 ± 60.3 meters and VO2 peak increased from 7.7 ±2.4 mL/kg/min to 8.9 ± 2.2 mL/kg/min. The mean difference of 6MWD was 62.3 meters and VO2 peak was 1.2 mL/kg/min. There was a strong correlation between VO2 peak and 6MWD (r = 71%; R2 = 51%; p = 0.001). Conclusion: Early phase II CR in patients with Rheumatic Mitral Stenosis after mitral valve surgery improved the exercise capacity. Based on 6MWD, we can predict the value of VO2 peak patients with rheumatic mitral stenosis surgery patients. Keywords: Cardiac rehabilitation, rheumatic mitral stenosis, 6MWD, VO2 peak
PERBANDINGN PENGARUH BADAI GEOMAGNET TERHADAP TEC IONOSFER DI ATAS MANADO, PONTIANAK DAN BANDUNG (Studi Kasus : 17 Maret dan 23 Juni 2015) (Comparisson of Geomagnetic Storm Effect on Ionospheric TEC over Manado, Pontianak dan Bandung Case study: 17 March Sri Ekawati; Anwar Santoso
Jurnal Sains Dirgantara Vol 16, No 2 (2019)
Publisher : Lembaga Penerbangan dan Antariksa Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1376.301 KB) | DOI: 10.30536/j.jsd.2018.v16.a3031

Abstract

ABSTRACT The largest geomagnetic storms of solar cycle 24 so far occurred on March 17, 2015 (Dst index reached -223 nT) and on June 23, 2015 (Dst index reached -204 nT). Geomagnetic storm is one of major space weather event sourced from Coronal mass Ejection (CME) of the Sun that affected the ionosphere layer. Total Electron Content (TEC) in the ionosphere is very vulnerable affected by changes of system electrical currents in the magnetosphere due to the geomagnetic storm. An extreme enhancement of TEC called positive ionospheric storms otherwise an extreme depression of TEC called negative ionospheric storms. The research objective of this paper was to determine the effect of the geomagnetic storms on enhancement and depression ionospheric TEC over Manado, Pontianak dan Bandung. This research also examines the solar wind plasma condition and CME as a drivers of this geomagnetic storm.  TEC data obtained from GPS Ionospheric scintillation and TEC Monitor (GISTM) in Manado (1.48o U;124.85o E) Pontianak (-0.03o S; 109.33o E) and Bandung (-6.90o S; 107.60o E). The TEC data is converted into data Vertical TEC (VTEC) then compared with the data median VTEC during geomagnetic quiet days (qVTEC). The results showed that there was a negative ionospheric storms affected by geomagnetic storm due date of March 17, 2015 with a deviation of VTEC (dVTEC) reached -71.41%. In contrast, there was a positive ionospheric storm affected by geomagnetic storm due date of June 23, 2015 with deviation VTEC (dVTEC) reached 53.82%. The mechanism of the significant enhancement and depression VTEC caused by ionospheric electrodynamics processes. Keywords: geomagnetic storm, Dst-Index, Ionosphere, TEC ABSTRAK Badai Geomagnet yang terbesar pada siklus Matahari ke-24 sampai saat ini adalah peristiwa badai geomagnet pada tanggal 17 Maret 2015 (indeks Dst mencapai -223nT) dan 23 Juni 2015 (indeks Dst mencapai -204 nT). Badai geomagnetik merupakan bagian dari cuaca antariksa yang bersumber dari Corronal Mass Ejection (CME) Matahari yang mempengaruhi lapisan ionosfer. Total Electron Content (TEC) di ionosfer sangat rentan dipengaruhi oleh perubahan sistem arus listrik di magnetosfer akibat terjadinya badai geomagnet. Peningkatan TEC yang ekstrim dinamakan badai ionosfer positif sebaliknya penurunan TEC yang ekstrim dinamakan badai ionosfer negatif. Tujuan penelitian pada makalah ini adalah mengetahui pengaruh badai geomagnet tersebut terhadap peningkatan dan penurunan TEC ionosfer diatas Manado, Pontianak dan Bandung. Penelitian ini juga meninjau kondisi plasma angin surya dan CME sebagai sumber penggerak badai geomagnetik ini. Data TEC diperoleh dari GPS Ionospheric Scintillation and TEC Monitor (GISTM) di Manado (1,48o LU; 124,85o LS); Pontianak (0,03oLS;109,33oBT) dan Bandung (-6,90o LS; 107,60o BT). Peristiwa badai Geomagnetic storm yang dianalisis adalah peristiwa badai geomagnet kategori kuat yang berlangsung pada tanggal 17 Maret 2015 (indeks Dst mencapai -223nT) dan 23 Juni 2015 (indeks Dst mencapai -204 nT). Data TEC tersebut dikonversi menjadi data Vertical TEC (VTEC) kemudian dibandingkan dengan data median VTEC pada saat hari tenang geomagnet (qVTEC). Hasil menunjukkan terjadi badai ionosfer negatif diakibatkan badai geomagnet tanggal 17 Maret 2015 dengan deviasi VTEC (dVTEC) data Pontianak mencapai -71,41%. Sebaliknya, terjadi badai ionosfer positif diakibatkan badai geomagnet tanggal 23 Juni 2015 dengan deviasi VTEC (dVTEC) mencapai 53,82%. Mekanisme terjadinya peningkatan dan penurunan VTEC yang siginifikan tersebut disebabkan oleh proses elektrodinamika di ionosfer. Kata kunci: Badai geomagnet, Indeks Dst, Ionosfer, TEC
ESTIMASI BADAI GEOMAGNET BERDASARKAN PERILAKU PARAMETER ANGIN SURYA DAN MEDAN MAGNET ANTARPLANET SEBELUM BADAI GEOMAGNET (THE ESTIMATION OF GEOMAGNETIC STORM BASED ON SOLAR WIND PARAMETERS AND INTERPLANETARY MAGNETIC FIELD BEHAVIOR BEFORE GEOMAGNETIC STOR Anwar Santoso; Mamat Rahimat; Rasdewita Kesumaningrum; Siska Filawati
Jurnal Sains Dirgantara Vol 14, No 2 (2016)
Publisher : Lembaga Penerbangan dan Antariksa Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (891.58 KB) | DOI: 10.30536/j.jsd.2016.v14.a2327

Abstract

Space weather research is the principal activity at the Space Science Center, Lapan to learn characteristics and generator source of the space weather so that can mitigate its the impact on the Earth's environment as mandated in Law No. 21 Year 2013. One of them is the phenomenon of geomagnetic storms. Geomagnetic storms caused by the entry of solar wind together with the IMF Bz that leads to the south. The behavior of the solar wind parameters together with the IMF Bz before geomagnetic storms can determine the formation of geomagnetic storms that caused it. In spite that, by the solar wind parameters and IMF Bz behavior before geomagnetic storm can be estimated its intensity through the equation Dst * = 1.599 * Ptotal - 34.48. The result of this equation is obtained that the Dst minimum deviation between the raw data and the output of this equation to the geomagnetic storm events on March 17, 2013 is about of -2.51 nT or 1.9% and on the geomagnetic storm events on February 19, 2014 is about of 2.77 nT or 2, 5%. Thus, the equation Dst * = 1.599 * Ptotal - 34.48 is very good for the estimation of geomagnetic storms.
ANALISIS PENGARUH PENETRASI MEDAN LISTRIK LINTANG TINGGI KE LINTANG RENDAH TERHADAP IONOSFER SAAT BADAI GEOMAGNET (ANALYSIS OF THE ELECTRIC FIELD PENETRATION EFFECT FROM HIGH TO LOW LATITUDES ON THE IONOSPHERE DURING GEOMAGNETIC STORM) Anwar Santoso; Dadang Nurmali; Mira Juangsih; Iyus Edi Rusnadi; Sri Ekawati; Anton Winarko; Siska Filawati
Jurnal Sains Dirgantara Vol 14, No 2 (2017)
Publisher : Lembaga Penerbangan dan Antariksa Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (151.831 KB) | DOI: 10.30536/j.jsd.2017.v14.a2368

Abstract

The influence of geomagnetic storms on the ionosphere in the equatorial and low latitudes can be either rising or falling value of the value foF2 with the different response delay time. The difference in response is one of them allegedly influenced by the modification of Equatorial Electrojet (EEJ) generated by the penetration of high latitude electric field towards the low latitude electric field and the equator. Therefore, this paper analyzes the influence of the high latitude penetration of electric current to the low latitude electric current towards the ionosphere response to Indonesia's current geomagnetic storms using the data foF2 BPAA Sumedang (SMD; 6,910 S; 106,830E geographic coordinates or 16,550 S; 179,950 E magnetic coordinates) and data from the Biak geomagnetic field station (BIK; 1,080 S; 136,050 E geographic coordinates or  9,730 S; 207,390 E magnetic coordinates) in 2000-2001. The result showed that the injection of the electric field of the high latitudes to lower latitudes causing foF2 BPAA Sumedang to be disturbed. Onset of the foF2 disturbance in BPAA Sumedang started coincide with EEJ(HBIK-HDRW) and reached its minimum point with a time delay between 0 to 4 hours before and after Dst index reached the minimum point. For a delay time of 0 to 4 hours after the Dst index reached the minimum point, the results were in accordance with the research results from the prior research. However, for the time difference of between 0 to 4 hours before the Dst index reached the minimum point, the results differ from their results. AbstrakPengaruh badai geomagnet terhadap ionosfer di ekuator dan lintang rendah berupa naiknya nilai foF2 atau turunnya nilai foF2 dengan waktu tunda respon berbeda-beda. Perbedaan respon tersebut salah satunya diduga dipengaruhi oleh modifikasi Equatorial electrojet (EEJ) yang dihasilkan oleh penetrasi medan listrik lintang tinggi sampai daerah lintang rendah dan ekuator. Oleh karena itu, dalam makalah ini dilakukan analisis pengaruh penetrasi arus listrik lintang tinggi ke lintang rendah terhadap ionosfer saat badai geomagnet menggunakan data foF2 dari Balai Pengamatan Antariksa dan Atmosfer (BPAA) Sumedang (SMD; 6,910 LS; 106,830 BT koordinat geografis atau 16,550 LS; 179,950 BT koordinat magnet) dan data medan geomagnet dari stasiun Biak (BIK; 1,080 LS; 136,050 BT koordinat geografis atau 9,730 LS; 207,390 BT koordinat magnet) tahun 2000-2001. Hasilnya diperoleh bahwa penetrasi medan listrik dari lintang tinggi ke lintang lebih rendah Indonesia menyebabkan foF2 BPAA Sumedang terganggu. Onset gangguan foF2 BPAA Sumedang mulai terjadi bertepatan dengan EEJ(HBIK-HDRW) mencapai titik minimumnya dengan jeda waktu antara 0 sampai 4 jam sebelum dan sesudah indeks Dst mencapai minimum. Untuk beda waktu 0 sampai 4 jam sesudah indeks Dst mencapai minimum, hasilnya bersesuaian dengan hasil penelitian peneliti sebelumnya. Namun, untuk beda waktu 0 sampai 4 jam sebelum indeks Dst mencapai minimum, hasilnya merupakan temuan berbeda dari hasil mereka.
ANALISIS RESPON MEDAN GEOMAGNET ANTARA STASIUN DI EKUATOR MAGNET DAN STASIUN BIAK SAAT BADAI GEOMAGNET PADA MERIDIAN MAGNET 210⁰ MM Anwar Santoso
Jurnal Sains Dirgantara Vol 13, No 2 (2016)
Publisher : Lembaga Penerbangan dan Antariksa Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1130.121 KB) | DOI: 10.30536/j.jsd.2016.v13.a2937

Abstract

Geomagnetic storm is a geomagnetic disturbance that occurs globally. Until now believed that the greatest impact of geomagnetic storms occurred in the high latitudes and decreases with decreasing latitude to the equator. However, based on the data component of the geomagnetic field H obtained CPMN other phenomena, that is H minimum of Onagawa station (31,15o LU; 212,63o BT magnetic coordinates) is smaller than the H minimum at Biak station (9,73o latitude; 207,39o BT magnetic coordinates) during geomagnetic storms on July 15, 2000. This reality is different from what was believed to be on top. To ensure this, then done the analysis of the geomagnetic field H component response based on the latitude using the geomagnetic field data from Biak station and stations around 210o MM for the whole event a strong geomagnetic storms (Dst <-100 nT) during 1995-2001. Results of the analysis showed that the response time of geomagnetic field geomagnetic storm in Biak is greater than at the magnetic equator (YAP) with an difference average of H is 59,27 nT. EEJ and CEJ pattern in the EEJ region (10o S to 10o N magnetic coordinate) shown could effected to the response of geomagnetic geomagnetic. The most important to note that if the geomagnetic response in Indonesia higher than in the geomagnetic equator (YAP) then the occurrence probability of GIC in Indonesia is higher.ABSTRAK Badai geomagnet merupakan gangguan geomagnet yang terjadi secara global. Sampai saat ini dipercaya bahwa dampak terbesar badai geomagnet terjadi di lintang tinggi dan semakin menurun dengan menurunnya lintang sampai di ekuator. Namun, berdasarkan olah data komponen H medan geomagnet dari CPMN diperoleh fenomena lain yaitu H minimum dari stasiun Onagawa (31,15⁰ LU; 212,63⁰ BT koordinat magnet) lebih kecil dari H minimum Balai Penjejakan dan Kendali Wahana Antariksa (BPKWA) Biak (9,73⁰ LS; 207,39⁰ BT koordinat magnet) saat badai geomagnet 15 Juli 2000. Kenyataan ini berbeda dari apa yang telah dipercayai di atas. Untuk memastikan hal ini maka dilakukan analisis respon komponen H medan geomagnet berdasarkan lintang menggunakan data komponen H medan geomagnet dari BPKWA Biak dan stasiun di sekitar 210⁰ MM untuk seluruh kejadian badai geomagnet kuat (Dst < -100 nT) selama 1995-2001. Hasil analisis diperoleh bahwa respon medan geomagnet saat badai geomagnet di Biak lebih besar dari pada di ekuator magnet (YAP) dengan rata-rata selisih ∆H-nya 59,27 nT. EEJ dan CEJ di daerah EEJ (10⁰ LU sampai 10⁰ LS magnet) terbukti mempengaruhi respon geomagnet. Hal terpenting yang perlu diperhatikan dari hasil ini adalah bahwa jika respon geomagnet di Indonesia lebih tinggi dibandingkan di daerah ekuator geomagnet (YAP) maka potensi kemunculan GIC juga lebih besar terjadi di Indonesia.
Safety monitoring of chloroquine and hydroxychloroquine in COVID-19 patients in Indonesia on QT prolongation: hospital based monitoring study Jarir At Thobari; Togi Junice Hutadjulu; Tri Asti Isnariani; Umi Sa'adatun Nikmah; Lukman Ade Chandra; Pompini Agustina Sitompul; Anggoro Budi Hartopo; Rizki Amalia Gumilang; Luhur Pribadi; Deva Bachtiar; Anwar Santoso
Indonesian Journal of Pharmacology and Therapy Vol 4 No 1 (2023)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.7148

Abstract

Chloroquine (CQ) and Hydroxychloroquine (HCQ) are the challenging drugs used for COVID-19. Several studies show its beneficial, however, both medications can prolong the QTc interval and increase the risk of patients for torsades de pointes and death. The Tisdale score is identified to have successfully predicted the at-risk population of side effects of these drugs. This study aim to evaluate the QT prolongation caused by the administration of chloroquine and hydroxychloroquine in COVID-19 patients and the association with the treatment outcomes based on their Tisdale score. We conducted an observational study on 213 hospitalized patients with confirmed or suspect COVID-19 in 6 referral hospitals in Indonesia. All baseline demographic such as age and gender, RT-PCR test result, severity of disease, history of cardiovascular disease (myocardial infarction, heart failure, hypertension), serum kalium level at baseline, and the use of medication associated with risk QTc interval prolongation were collected. The Tisdale risk score was used for predicting high-risk patients for QT corrected (QTc) interval prolongation. Out of 213 patients who were treated with CQ/HCQ, there were 60 (28.2%) patients had QTc interval prolongation, included 43 patients (20.2%) who had normal QTc interval at baseline and at the end of treatment had prolong interval; or 17 patients (8.0%) who had QTc interval more than 470 msec at baseline and QTc interval prolongation was worsen at the end of treatment. Several factors, including age more than 50 years, COVID-19 confirm PCR, and had comorbidity heart failure, were statistically significant associated with QTc interval prolongation. The high-risk score of Tisdale score have increased risk significantly on QTc interval prolongation (RR: 2.15, 95%CI 1.07-4.32) and associated with risk of death (RR: 3.50, 95%CI 1.34-9.13) compared to low-risk score. Our findings showed that the treatment of CQ/HCQ in COVID-19 patients is associated with QTc prolongation. The Tisdale score can be used as a valuable tool to predict the COVID-19 patients’ outcome after treatment of these QTc-prolonging drugs.
Co-Authors Ade Meidian Ambari Anggoro Budi Hartopo Anton Winarko Bambang Dwiputra Basuni Radi Dadang Nurmali Deva Bachtiar Eliana Susilowati Fadila Tulrahmi FitriaNugraha Aini Habirun Habirun Indah Nur Chomsy Iyus Edi Rusnadi Jarir At Thobari Luhur Pribadi Lukman Ade Chandra Maarten Jan Cramer Mamat Rahimat Mira Juangsih Muhammad Ridwan Pieter A Doevendans Pompini Agustina Sitompul Rasdewita Kesumaningrum Rizki Amalia Gumilang Siska Filawati Sity Rachyany Solly Aryza Sri Ekawati Sri Ekawati Teuku Heriansyah Titin Andri Wihastuti Togi Junice Hutadjulu Tri Asti Isnariani Umi Sa'adatun Nikmah