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All Journal The Indonesian Biomedical Journal Universa Medicina Majalah Kedokteran Nusantara The Journal Of Medical School Buletin Farmatera Sumatera Medical Journal Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED)
Dairion Gatot, Dairion
Division Of Hematology Oncology Medic, Department Of Internal Medicine, Faculty Of Medicine, University Of Sumatera Utara Medan
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Journal : Majalah Kedokteran Nusantara The Journal Of Medical School

 1 
Perbandingan status koagulasi penderita stroke iskemik dengan non stroke Zainal Abdi; Rusli Dhanu; Savita Handayani; Dairion Gatot
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 45, No 2 (2012): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Abstract

Background: Thrombosis is one of causes increasing morbidity, disablement,and mortality in ischemic stroke’s patient. The basic mechanism of thrombosis is hypercoagulation state, so by finding it earlier can prevent and reduce thrombosis that cause ischemic stroke.Objective: This study to asses the event of hypercoagulation between ischemic stroke’s patient and non stroke. Methods: A total of 21 subjects with ischemic stroke’s patient and 21 subjects with non stroke entered into the study. All participants were examined for hemostatic parameters included prothrombin time (PT), INR, activated partial thromboplastin Time (aPTT), Fibrinogen, D-dimer. To compare the result of hemostatic both of groups were used t independent test if the distribution was normal or used Mann Whitney test if the distribution wasn’t normal. The result would be significant if P <0.05. Result: According to characteristic of population, it was found some variables significantly, included systolic blood pressure, diastolic blood pressure, INR, aPTT ratio and D-dimer. Hypercoagulation in ischemic stroke group was found 47.6% (n=10) and non hypercoagulation group was 52.4% (n=11) , but in non stroke group, hypercoagulation was found about 23.8% (n=5) and non hypercoagulation was 76.2% (n=16). According to statistical analysis there wasn’t significant hypercoagulation between ischemic stroke’s patient and non stroke (P >0.05).Conclusion: There isn’t significant hypercoagulation between ischemic stroke group with non stroke group. Keywords: ischemic stroke; hemostatic measurement; hypercoagulation; thrombosis
Korelasi antara interleukin-6 dengan responawal terapi eritropoietin pada pasien hemodialisis reguler Vally Ramayanda; Dairion Gatot; Savita Handayani; Syafrizal Nasution
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 2 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introuction:In hemodialysis patients conditionsinflammation can play a main role in causing hiporesponsif erythropoietin therapy. Interleukin - 6 (IL-6) was a predictor of mortality that is more powerful than other inflammatory markers.To determine correlation between Interleukin-6 with respon Erythropoirtin Stimulating Agent (ESA) which assessed based on changes of hemoglobin level before and after ESA treatment to regular hemodialysis patients.Methods: The cohort study of experimental methods of measurement data pre and post test from December 2014 to Mei 2016with 50 hemodialysis patients do a complete blood count, interleukin - 6 and iron profiles before and 1 month after the intervention. Patients were given injections of Recombinant Human Erythropoietin(rHuEPO) for 1 month subcutaneously at a dose of 2,000-4,000 each time the hemodialysis procedure. Kolmogorov-Smirnov test was used to determine the distribution of the data. Spearman assess the association between interleukin - 6 with an increase hemoglobin before and after be given erythropoietin therapy.Results : The mean levels of IL - 6 was 20.24 pg/mL and the mean increase in hemoglobin after erythropoietin administration of 0.56 mg/dL. Found a significant negative correlation (r = -0.287 ; p = 0.043) between IL - 6 and increased hemoglobin level, the higher the levels of IL-6, then the increase of hemoglobin level after erythropoietin administration will be lower than expected. Conclusion : In our trial, we found a negative correlation between Interleukin-6 with hiporesponsifity erythropoietin in reguler hemodialysis patientsKeywords : erythropoietin, inflammation, IL-6, hemodialysis, hemoglobin
Korelasi short form-36 dengan skala eastern cooperative oncology group dalam menilai kualitas hidup pada pasien limfoma non hodgkin yang mendapat kemoterapi regimen cyclophosphamide, doxorubicin, vincristine, dan prednisone Dika Iyona Sinulingga; Savita Handayani; Dairion Gatot
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 47, No 1 (2014): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction : Health-related quality of life’s (HRQOL) assessment has become a vital tool. In this study, we analyze two generic instruments ECOG Scale and SF-36 in NHL patients receiving CHOP chemotherapy. This study intends to find out the the correlation between SF-36 and ECOG scale in NHL patients receiving CHOP chemotherapy.Method : Cross sectional research was conducted from October 2012 up to December 2013. Samples were selected consecutively to NHL patients. SF-36 and ECOG scale was assessed after CHOP chemotherapy cycle 6.Results : There were 21 patients of NHL, 12 male, 9 female, age 20 – 64 years old, mean 47.95 (SD 10.85). The range score of SF-36: 23.9 – 95.9, mean 75,3 (SD 17.93). The range scale of ECOG 0 – 4, mean 0.81 (SD 1.12). By using Spearman correlation, we found a significant correlation between SF-36 and ECOG scale (r = - 0.744, p = 0.0001). SF-36 showed good diagnostic performance to predict good ECOG scale with cut-off •'3d 54.66, with sensitivity 94.7%, specificity 100%, PPV 100%, NPV 66.67%, LR (+) ~, LR (-) 0.05, accuracy 95.23%, and AUC 98.7% (95% CI: 0% - 100%; p = 0.027).Conclusion : SF-36 correlates with ECOG scale and has a very good diagnostic in predicting ECOG scale.Key word : SF-36; ECOG scale; Quality of life; Non Hodgkin Lymphoma; CHOP chemotherapy
Hubungan jumlah trombosit dengan fungsi trombosit pada pasien penyakit ginjal kronis tahap akhir pre-hemodialisis Ahsan Tanio Daulay; Savita Handayani; Dairion Gatot
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 1 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

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Introduction : Renal failure is condition where kidney cannot fitter blood waste and toxins adequately. One of complication is bleeding diathesis causes insufficiency of platelet function, coagulation cascade or fibrinolysis system activation. Method :Analytic observaiional research from September-Dece mber 2014 to 31 pre-dialyzed subject.Conclusion :Nocorrelation among high serum creatinine and urea with platelet count. bleeding lime,and platelet aggregation. Nocorrelation between platelet count and function (bleeding time and platelet aggregation).Result : Of 31 subject, mean of c;ge 50.71(S0=10.91) years old; Platelet 250,548 (SD=98,268)fmm3 with thrombocytopenia 19.4% case; bleeding time 4.77 (SD=3.03) minutes;with prolong bleeding time 19.4% case and 3.2% of it is thrombocytooe nia; hypoaggregation, 19.4%case. No significant correlation between platelet count and platelet function;among serum creatinine with platelet count and function;and urea with platelet count and functions. Key Words :chronicrenaldisease; platelet; platelet aggregation
Co-Authors Ahsan Tanio Daulay Alfajri, Muhammad Jailani Alfajri dharma Lindarto, dharma Dika Iyona Sinulingga Handayani, Savina Lubis, Heny Syahrini Mardia, Andri Iskandar Mardia, Andri Iskandar Mardiya Sari Rusli Dhanu Santi Syafril Santi Syafril, Santi Savita Handayani Savita Handayani Sholat, Alfi Dewi Syafrizal Nasution Syahrini Lubis, Henni tantri, Anita Vally Ramayanda Zainal Abdi