Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

2.304

P-Index

This Author published in this journals

All Journal Media Ilmu Keolahragaan Indonesia Majalah Kedokteran Nusantara The Journal Of Medical School Indonesian Journal of Medicine Sumatera Medical Journal Jurnal Keperawatan Priority Journal of Telenursing (JOTING) Indonesian Journal of Global Health research Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) The Journal of Society Medicine (JSOCMED) Jurnal Penyakit Dalam Indonesia

Santi Syafril, Santi

Unknown Affiliation

Author-ID : 601620

Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 14 Documents Claim Missing Document

Claim Missing Document

Articles

1 2

Efektifitas Kombinasi Ekstrak Sambiloto (Andrographis paniculata (burm.f.) nees) dan Daun Salam (Syzygium polyanthum (wight) walp) terhadap Kadar hs-CRP pada Pasien Dislipidemia Yulindaa, Wina; Lindarto, Dharma; Syafril, Santi
Majalah Kedokteran Nusantara The Journal Of Medical School Vol 50, No 3 (2017): The Journal of Medical School
Publisher : Fakultas Kedokteran USU

Show Abstract | Download Original | Original Source | Check in Google Scholar

Introduction Dyslipidemia is risk factor of cardiovascular disease and significantly correlated with increased hs-CRP concentration. Simvastatin, a sintetic antidyslipidemic drug, decreases hs- CRP concentration. But long term use of sintetic drug may cause side effects, so that phytopharmaca is preferably to be consumed. Combination sambiloto extract and salam could decrease proinflammatory cytokines, cholesterol, and triglyceride. Aim of this study was to compare the effect of combination sambiloto extract and salam with simvastatin on hs-CRP concentration in dyslipidemic patientsMethods This clinical trial use prospective design. Treated group (n = 15) and control group (n = 15) were selected by double blind random sampling. Before and after 30 days therapy, blood sample was taken. Data was analysed with SPSS, p < 0.05 was considered significant.Results There was significant decrease of hs-CRP before and after 30 days therapy in treated group ((3.02 Â± 3.13 vs 1.67 + 1.37) mg/dL; p = 0.005); meanwhile insignificant decrease was there in control group ((2.78 Â± 1.97 vs 2.25 Â± 2.32) mg/dL; p = 0.285). hs-CRP decrease of treated group was bigger than in control group, but statistically insignificant ((1.35 Â± 2.37 vs 0.53 Â± 1.96) mg/dL; p = 0.089 mg/dL).Conclusion Combination sambiloto extract (Andrographis paniculata) and salam (Syzygium polyanthum) 2 x 150 mg for 30 days decreased hs-CRP concentration lower than simvastatin 1 x 20 mg, but statistically insignificant.Keywords : hs-CRP, Andrographis paniculata and Syzygium polyanthum, dyslipidemia

Comparison Pai-1 Level in Type 2 Diabetes Mellitus with and Without Diabetic Foot Ulcer Sholat, Alfi Dewi; Gatot, Dairion; Handayani, Savina; Mardia, Andri Iskandar; Syafril, Santi
Sumatera Medical Journal Vol. 1 No. 1 (2018): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

In type 2 diabetes mellitus, there are changes in hemostasis components, including overexpression of PAI-1. By these facts, the authors are interested in conducting the study of PAI-1 level in diabetic patients with and without foot ulcer. Methods: The sample of this research was collected cross-sectionally on 20 type 2 diabetic patients with foot ulcer and 20 without foot ulcer. Blood samples were taken to measure serum PAI-1 level, complete blood count and hemostasis screening test. Results: Statistical analysis showed there are significant differences in hemoglobin, trombosit, Fibrinogen and D-dimer levels in the ulcer and non-ulcer groups but no significant difference in PAI-1 level. Conclusions: No higher PAI – 1 level were found in diabetic foot ulcer group than those without diabetic foot ulcer. There was no significant difference between PAI-1 level and grade of diabetic foot ulcer.

Salat Dhuha Improves Blood Pressure: A Randomized Controlled Trial Boy, Elman; Lelo, Aznan; Tarigan, Amira Permatasari; Machrina, Yetty; Yusni, Yusni; Harahap, Juliandi; Sembiring, Rosita Juwita; Syafril, Santi; Sumartiningsih, Sri
Media Ilmu Keolahragaan Indonesia Vol 11, No 2 (2021): December 2021
Publisher : Universitas Negeri Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/miki.v11i2.34225

The prevalence of hypertension increases with age, more than 1 in every two elderly has hypertension, dominated by women. The primary prevention of hypertension is a worldwide public health concern. Salat dhuha is a moderate-intensity physical activity. Salat 2 movement cycles demonstrated improved systolic and diastolic blood pressure in adults. Our study purpose was to assess the effect of 2 and 8 movement cycles (rakaat) of salat dhuha to improve systolic and diastolic blood pressure in healthy Muslim elderly women. Muslim elderly women in a government senior residence (aged 60-74 years) participated in a 6 weeks controlled trial. We completed formal physical, clinical, and blood assessments before admission. Participants with hypertension history were excluded. The participants were randomized into 2 groups. The intervention group performed 8 rakaat of salat dhuha (n=13) and the control group performed 2 rakaat of salat dhuha (n=13). Two participants were dropped out of this study. At baseline and at the end of 6 weeks, a blood pressure examination is recorded. Parametric and nonparametric methods were used to analyze the data. The baseline characteristics of the two groups of participants were homogeneous. Compared to the control, the 8 rakaat of salat dhuha achieved a significant reduction in systolic and diastolic blood pressure (P0.05) at the end of the 6-weeks period. The findings show that salat dhuha has significant potential to improve blood pressure.

Kolesterol Total dan Kolesterol LDL terhadap hsCRP pada Pasien COVID-19 Berat Irawaty, Noni; Syafril, Santi; Loesnihari, Ricke
Journal of Telenursing (JOTING) Vol 5 No 2 (2023): Journal of Telenursing (JOTING)
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/joting.v5i2.7251

This study aims to examine the relationship between total LDL cholesterol and hsCRP in severe COVID-19 patients at the H. Adam Malik Hospital, Medan. The research method used was a cross-sectional retrospective study. The research results showed a negative correlation between Total Cholesterol and LDL Cholesterol and hsCRP in severe COVID-19 patients. In conclusion, a decrease in Total Cholesterol and LDL Cholesterol levels was found in severe COVID-19 patients. Increased hsCRP levels were found in severe COVID-19 patients. The demographic characteristics of the research subjects were dominated by male patients. The most common comorbidity found is Diabetes Mellitus Type 2, followed by hypertension. Keywords: Severe COVID-19, hsCRP, LDL Cholesterol, Total Cholesterol

Effect of Glycemic Parameters on Mortality of Type 2 Diabetes Mellitus Patients with COVID-19 Infection in Haji Adam Malik Hospital Medan Pangaribuan, Jessica Patricia; Syafril, Santi; Lubis, Dian Anindita; Isnanta, Rahmad; Rey, Imelda
Journal of Society Medicine Vol. 2 No. 8 (2023): August
Publisher : CoinReads Media Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47353/jsocmed.v2i8.81

Introduction: Diabetes Mellitus Type 2 (DM T2) is a major health problem, especially in people in developing countries. DM T2 is the most frequently reported comorbid disease in patients with COVID-19. The relationship between DM T2 and poorer outcome in COVID-19 infection is thought to be because hyperglycemia and chronic inflammation impair control of viremia and inflammation by weakening the immune response. This research aim to determine the effect of glycemic parameters on the mortality of DM T2 patients with COVID-19. Method: This research is a descriptive analytic study with a retrospective design which was carried out at the H. Adam Malik General Hospital in Medan. The data obtained was analyzed statistically and said to be statistically significant if p <0.05. Results: Based on the results of the study, there were significant differences in the values of inflammatory markers such as leukocytes, neutrophils, NLR, PCT, LDH, D-dimer, ferritin, SGOT, urea and creatinine in the severity of COVID-19 patients and there were significant differences in the mean fasting blood sugar, blood sugar 2PP, in moderate, severe and critical COVID-19 patients. Conclusion: Glycemic parameters in patients who died were worse than patients who recovered, although the statistical results were not significantly different.

The Relationship Between Lipoprotein (A) And Lipid Profile In Patients Treated With Bay Leaf Extract [Syzygium Polyanthum (Wight) Walp] In Patients Dyslipidemia Prianwari, Catur; Syafril, Santi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 4 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Background: Increased Lp(a) accelerates atherosclerosis by means of cholesterol deposits in tunica. The purpose of the study was to assess the relationship of decreased Lp(a) with lipid profile in patients with dyslipidemia given bay leaf extract [syzygium polyanthum (Wight) Walp] treatment. Method: Thirty subjects were divided into 2 groups: group I received salam leaf extract therapy 2 x 200 mg and group II received salam leaf extract therapy 2 x 300 mg per day capsules for 30 days randomly selected and double blind. Examination of Lp(a), total cholesterol, LDL-C, HDL-C and TG before and after research. The manufacture of bay leaf extract is done by maseration, the extraction process using ethanol 70%, then the extract is inserted in the capsule. Result: In groups I and II there were significant differences in variable Lp(a) and lipid profiles after treatment except HDL-C. There is a significant correlation between Lp(a) and LDL at salam leaf extract therapy doses of 2x200 mg per day. Conclusion: Decrease in Lp(a) is significantly correlated with decreased LDL-C. Salam leaf extract therapy can predict decreased cardiovascular risk in patients with dyslipidemia.

Correlation Between Adiponectin Receptor with Indices of Glucose Homeostasis and Mediators Of Insulin Sensitivity in Type 2 Diabetic Rats Treated With Puguntano (Curanga felterrae Lour.) Leaf Extract Lindarto, Dharma; Ihsan, Brama; Syafril, Santi; Saragih, Awaluddin
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 2 No. 4 (2020): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

ABSTRACT Objective: Adiponectin receptors (AdipoR) regulates metabolism and has anti-inflammatory and insulin-sensitizing effects. We aimed to determine the relationships between AdipoR with parameters of glucose homeostasis (FPG, insulin, and HOMA-IR), and insulin sensitivity (PPAR-γ and p38MAPK) in T2DM rats treated with puguntano (Curanga felterrae Lour.) leaf extract. Methods: T2DM was induced in Wistar rats aged 8–10 weeks and weighing 180–200 g by high-fat diet (HFD) feeding and low-dose streptozotocin (30mg/kg.bw) administration. The rats were then allocated randomly to a treatment group and a control group (n=24 each). The treatment group was orally administered puguntano leaf extract (200 mg/kg.bb) once daily for 10 days. Subsequently, FPG and plasma insulin were measured, and HOMA-IR was calculated. Results: There was significantly difference between treatment group and control group on AdipoR and parameter of glucose homeostasis (FPG, Insulin, HOMA-IR) and insulin sensitivity (PPAR-γ, p38MAPK (all, p<0.01). In both groups, there were no significantly correlations between of AdipoR with all parameter of glucose homeostasis and insulin sensitivity except PPAR-ϒ (p <0.003) across the entire cohort of rats. Conclusion: Our data suggest that puguntano could improve glucose homeostasis, insulin sensitivity and molecular mediators of insulin sensitivity. There were no significantly correlated between improvement of AdipoR with glucose homeostasis and molecular mediators of insulin sensitivity in T2DM.

The Relationship Between Body Mass Index and Inflammatory Parameters in HIV Patients Treated with Antiretrovirals Theresia, Lydia; Lindarto, Dharma; Syafril, Santi; Kembaren, Tambar
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 1 (2021): Journal of Endocrinology, Tropical Medicine, and Infectiouse Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Antiretroviral administration affects weight gain and inflammation in HIV patients. The purpose of the study was to assess the relationship of body mass index with inflamation parameters in HIV patients who ARV therapy. In 40 HIV patients (stage III-IV) treated with ARV (FDC 87%, Durival Efaviren 7.5%, Tenofovir, Huviral, Aluvia 2.5%, and Tenofovir, Huviral, Neviral 2.5%) conducted observational analytics with crosssectional design. CD4 examination was carried out flowcytometrically, BMI measured by formula weight (kg) divided by height squared (m2), waist circumference (WC) measured by ribbon between costae arcus and anterior superior iliac spine, albumin measurement with Brom Cresol Green (BCG) method. There is a significant correlation between BMI with WC and CD4 (r=0.61, p<0.001 and r=0.38, p<0.001, respectively). There is no correlation between BMI and duration of ARV treatment, albumin and leptin. ARV treatment in HIV patients will affect weight and inflammatory markers.

Brown Tumor of Lower Right Limb in Patients With Primary Hyperparathyroidism: A Case Report Iqbal, Muhammad; Syafril, Santi
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 3 No. 4 (2021): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Background.Brown tumor of Hyperparathyroidism is a metabolic disorder that can affect the entire skeleton and reactive process due to bone resorption caused by primary or secondary hyperparathyroidism (HPT). Brown tumors can occur as solitary or multiple lesions in any bone, most often in the pelvis, ribs, clavicle, mandibula, and extremities. Here, we report the Brown tumor in the lower right limb in patients with primary HPT, and the literature is reviewed. Case presentation. Patients was women 30 years old had married and come with main complains of difficulty walking. This condition has been experienced by patients since diagnosis with lunb of tibia last 8 months and caused pain from hip to lower leg. On laboratory results, it showed elevated PTH 1.249 (normal 15-65) pg/dL, elevated phosphatase alkali 1156 (normal 40-150) u/dL, elevated Ca 10,8 (n:8,6 -10,3) mg/dL, phosphor 2,1 (3–4,5) mg/dL. Histology examination of tibia lump was a benign lesion of bone (Brown Tumor). Ultrasonography transabdominal result revealed kidney stones with bilateral renal pelvis dilation, nephrolithiasis non-obstructive was found with size 1 cm & left kidney cyst with size 0.6 cm. On Neck USG showed giant cyst lesion on parathyroid glands. Radiologist pelvic examination results showed bone metastasis disease. Head CT Scan examination concluded as suspect metastatic bone. Body bone scans examination showed pathological bone metastatic process. Conclusion. Brown tumor in right lower limb caused by primary HPT

RASIO MONOSIT LIMFOSIT SEBAGAI PREDIKTOR KEPARAHAN NEFROPATI DIABETIK PADA PASIEN DIABETES MELITUS TIPE 2 Bernando, Andri; Siregar, Jelita; Syafril, Santi
Jurnal Keperawatan Priority Vol. 6 No. 2 (2023)
Publisher : Universitas Prima Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34012/jukep.v6i2.4073

Diabetic nephropathy is a complication that often occurs in diabetics. In this disease, there is damage to the kidney filter, known as the glomerulus. Due to glomerular damage, diabetic nephropathy is closely related to the mechanism of inflammation. The Monocyte-Lymphocyte Ratio is a relatively new marker of inflammation. This study aims to explore the significance of the prediction of the Monocyte-Lymphocyte Ratio as a predictor of the severity of diabetic nephropathy in Type 2 Diabetes Mellitus (DMT2) patients at H. Adam Malik Hospital, Medan. The research was conducted using the cross-section method. This study took blood samples from 44 patients with type 2 diabetes mellitus with diabetic nephropathy, 22 patients with macroalbuminuria, and 22 patients with microalbuminuria. Then blood was drawn from the vein, and the Monocyte-Lymphocyte Ratio was assessed in all patients. In this study, the average MLR for all patients was 0.41±0.037. There was a significant difference between MLR values in diabetic nephropathy patients with macroalbuminuria compared to diabetic nephropathy patients with microalbuminuria (p<0.001). The optimal cut-off value of MLR in predicting diabetic nephropathy with macroalbuminuria and microalbuminuria was 0.37 with a specificity of 81.8% and a sensitivity of 81.8%. The MLR value in type 2 diabetic patients with diabetic nephropathy can be used as a prognostic factor for the incidence of microalbuminuria and macroalbuminuria.

Co-Authors Awaluddin Saragih Aznan Lelo Bernando, Andri Dairion Gatot, Dairion dharma Lindarto, dharma ELMAN BOY Ginting, Almaycano Handayani, Savina Harahap, Juliandi Ihsan, Brama Imelda Rey Irawaty, Noni Kembaren, Tambar Lubis, Dian Anindita Mardia, Andri Iskandar Merlin, Asri Pangaribuan, Jessica Patricia Prianwari, Catur Rahma, Hadiyatur Rahmad Isnanta, Rahmad Ratna Akbari Ganie, Ratna Akbari Ricke Loesnihari Sanusi, Muhammad Arif Sembiring, Rosita Juwita Sholat, Alfi Dewi Siregar, Dewi Indah Sari Siregar, Jelita Situmorang, Immanuel Sri Sumartiningsih Sugeng, Santoso Tarigan, Amira Permatasari Theresia, Lydia Yetty Machrina Yulindaa, Wina Yusni Yusni

Title

Found 14 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 14 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 14 Documents
Search