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Journal : Paediatrica Indonesiana

Occurence and risk factors of tuberculosis infection in orphanage children in Bali Clearesta, Kartika Eda; Mayangsari, Ayu Setyorini Mestika; Wati, Dyah Kanya; Purniti, Ni Putu Siadi; Suwarba, I Gusti Ngurah Made; Artana, I Wayan Dharma
Paediatrica Indonesiana Vol. 64 No. 2 (2024): March 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.2.2024.152-9

Abstract

Background Tuberculosis (TB) is an infectious disease that is still a common threat worldwide, especially in pediatric populations. TB transmission occurs particularly when the transmitter has no obvious manifestation of the disease. There is a higher incidence of TB infection in children than in the general population, especially in high risk populations such as children in orphanages. However, the incidence of TB infection in orphaned children in Indonesia, including Bali, is unknown. Objective To describe the incidence and risk factors for TB infection in children in orphanages in Bali. Methods This case-control study was conducted in 12 orphanages in Bali. Subjects were divided into a case group comprised of children with TB infection, and a control group comprised of those without TB infection. TB infection was diagnosed by positive tuberculin test without clinically confirmed TB. Results A total of 175 children were recruited as subjects. There were 49 (28.0%) children with TB infection. Bivariate analysis revealed significant associations between density, humidity, ventilation/room area ratio, and area of ??origin with TB infection. Multivariate analysis showed that ventilation/room area ratio and room humidity of ?73% were independently positive correlated with TB infection. Natural lighting and BCG scar were not significantly different between groups. Conclusion The occurence of TB infection in children residing in orphanages in Bali is high (28%). The risk factors identified independently are lower ventilation and higher room humidity.
Prevalence and factors associated with extrauterine growth restriction in premature infants Anggareni, Komang Tria; Sidiartha, I Gusti Lanang; Artana, I Wayan Dharma; Suwarba, I Gusti Ngurah Made; Hartawan, I Nyoman Budi; Gustawan, I Wayan
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.405-11

Abstract

Background Extrauterine growth restriction (EUGR) is common in preterm infants and has been shown to affect their neurodevelopment. Significant variability exists in the criteria used to define EUGR and a standard definition has not yet been established. Several factors associated with EUGR have been identified, yet EUGR remains a problem in preterm infants. There is still much to be explored regarding risk factors associated with EUGR. Objective To determine the prevalence and factors associated with EUGR in preterm infants. Methods This cross-sectional study included randomly selected premature infants (<37 weeks gestational age) who were admitted to levels II and III Neonatal Ward at Prof. Dr. I.G.N.G. Ngoerah Hospital from May 2022 to August 2023. Results Of 185 subjects, the prevalence of EUGR in preterm infants was 47% and there were significant associations between EUGR and birth weight <1500 g (PR 8.814; 95%CI: 3.943 to 19.7; P=0.000), small for gestational age/SGA (PR 28.95; 95%CI: 3.79 to 220.1; P=0.000), neonatal sepsis (PR 4.29; 95%CI: 2.21 to 8.31; P=0.000), hyaline membrane disease/HMD (PR 2.12; 95%CI: 1.16 to 3.88; P=0.021), use of respiratory support (PR 2.57; 95%CI: 1.35 to 4.92; P=0.005), initiation of enteral nutrition at >48 hours (PR 2.23; 95%CI: 1.21 to 4.09; P=0.014) and length of stay/LOS >14 days (PR 8.11; 95%CI: 4.13 to 15.9; P=0.000). Multivariate analysis revealed birth weight <1500 g (aPR 5.14; 95%CI: 1.55 to 17.06; P=0.007), SGA (aPR 24.26; 95%CI: 2.64 to 222.6; P=0.005), presence of sepsis (aPR 2.35; 95%CI: 1.00 to 5.5; P=0.049), and length of hospital stay >14 days (aPR 4.93; 95%CI: 2.15 to 11.31; P=0.000) maintained positive significant associations with EUGR. Conclusion The prevalence of EUGR in preterm infants is 47%. Birth weight <1500 g, small for gestational age, sepsis, and length of stay >14 days are associated with EUGR in preterm infants.
Association of sepsis severity with serum ferritin in the pediatric intensive care unit Susanto, Yohanes; Wati, Dyah Kanya; Artana, I Wayan Dharma; Wati, Ketut Dewi Kumara; Widnyana, Anak Agung Ngurah Ketut Putra; Adnyana, I Gusti Agung Ngurah Sugitha
Paediatrica Indonesiana Vol. 65 No. 6 (2025): November 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background Sepsis remains a leading cause of pediatric intensive care unit (PICU) admissions in Indonesia. Serum ferritin is a potential biomarker for sepsis severity that requires validation. Objective To evaluate the association between serum ferritin and sepsis severity in children. Methods In this cross-sectional study, we consecutively enrolled children with sepsis (aged 1 month to 18 years) with lactate-excluded PELOD-2 scores of ≥7 admitted to the PICU of a tertiary referral hospital. Severe sepsis was defined as a PELOD-2 score of ≥11. Serum ferritin levels were measured at the time of PELOD-2 assessment. We determined the optimal ferritin cut-off point for severe sepsis by ROC analysis and performed bivariate and multivariate analyses to assess the association of ferritin level with sepsis severity. Results Among 74 subjects, 48.6% had severe sepsis. Serum ferritin concentration showed excellent discriminative power for severe vs. non-severe sepsis, with an area under curve (AUC) of 80% (95%CI 69.7-90.4%; P<0.001). The optimal serum ferritin cut-off level was 1,473.88 ng/mL, with a sensitivity of 80.6% and specificity of 78.9%. Severe sepsis was strongly correlated with elevated ferritin [bivariate prevalence ratio (PR) 3.8 (95%CI 2.0 to 8.2; P<0.001); adjusted PR 3.9 (95%CI 1.7 to 8.6; P=0.001)]. Conclusion Serum ferritin may serve as a biomarker for severe sepsis in children with good discriminative performance and may be useful for risk stratification of pediatric sepsis.