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All Journal Molecular and Cellular Biomedical Sciences (MCBS) World Nutrition Journal Journal Pharmacy of Tanjungpura
Rina Triana, Rina
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Is Stem Cell a Curer or an Obstruction? Darmayanti, Siska; Triana, Rina; Chouw, Angliana; Dewi, Nurrani Mustika
Molecular and Cellular Biomedical Sciences Vol 1, No 1 (2017)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v1i1.12

Abstract

Stem cell research and therapy are progressing these days dramatically. Stem cell therapy holds enormous treatment potential for many diseases which currently have no or limited therapeutic options. Unfortunately, this potential also comes with side-effects. In this review, the positive and negative effects of regulation of stem cells will be explained. Stem cells are undifferentiated cells which able to develop into many different cells of types in the body during early life and growth. There are five types of stem cells: embryonic stem cells, induced pluripotent stem cells, somatic stem cells, fetal stem cells and mesenchymal stem cells. Stem cell transplantation is one form of stem cell therapy, it comes with different techniques sourced, and those are autologous and allogeneic transplantation stem cells. In an autologous transplant, a patients blood-forming stem cells are collected, meanwhile, in an allogeneic transplant, target cells are replaced with new stem cells obtained from a donor or donated umbilical cord blood. Its abilities to maintain the phenotype, self-renewing and differentiate itself into specialized cells, give rise to stem cell as an innovation for the treatment of various diseases. In the clinical setting, stem cells are being explored for different conditions, such as in tissue repair and regeneration and autoimmune diseases therapy. But along with its benefit, stem cell therapy also holds some harm. It is known that the treatment using stem cell for curing and rehabilitation has the risk of tumor formation.Keywords: stem cell, therapy, transplantation, tumorigenic, mesenchymal stem cell, allogeneic
The role of MTHFR polymorphism on hyperhomocysteinemia and folic acid and vitamin B metabolism Triana, Rina
World Nutrition Journal Vol. 9 No. S1 (2025): Vol. 9 No. S1 (2025): Selected conference proceedings of the Nutri Symposium 2
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V09.S1.0010

Abstract

Non-communicable diseases (NCDs) remain a leading global health concern, with hyperhomocysteinemia recognized as a contributing metabolic disorder linked to cardiovascular disease, neurodegenerative conditions, and developmental anomalies. This presentation explores the pivotal role of methylenetetrahydrofolate reductase (MTHFR) polymorphisms—particularly C677T and A1298C variants—in disrupting homocysteine metabolism through impaired folate and vitamin B pathways.
HUBUNGAN PELAYANAN INFORMASI OBAT DENGAN TINGKAT KEPATUHAN PASIEN HIPERTENSI DI PUSKESMAS PAL TIGA PONTIANAK Triana, Rina
Journal Pharmacy Of Tanjungpura Vol 2, No 1 (2024): Oktober
Publisher : Universitas Tanjungpura

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Abstract

Hipertensi merupakan salah satu penyakit kronis yang dapat mengakibatkan morbiditas serta mortalitas. Salah satu pengendalian kasus hipertensi dapat dilakukan melalui pelayanan informasi obat (PIO). Penelitian ini bertujuan untuk menganalisis perubahan tingkat kepatuhan serta hubungan PIO dengan tingkat kepatuhan pasien hipertensi. Metode quasi experimental rancangan pretest-posttest control group dan teknik purposive sampling digunakan dalam penelitian ini. Sampel yang memenuhi kriteria inklusi didapatkan sebanyak 36 responden. Pengambilan data berasal dari pretest dan posttest menggunakan kuesioner ARMS. Data yang diperoleh dianalisis statistik menggunakan uji wilcoxon, mann-whitney, kendall’s tau-b, dan chi-square. Hasil penelitian ini adalah : (1) Karakteristik responden dominan ditemukan pada perempuan sebanyak 66,7%, usia ≥ 60 tahun sebanyak 75%, pekerjaan IRT sebanyak 38,9%, dan tingkat pendidikan SMA sebanyak 33,3%. (2) Tingkat kepatuhan pasien hipertensi setelah diberikan intervensi adalah kepatuhan rendah sebanyak 27,8% dan kepatuhan tinggi sebanyak 72,2%. (2) Hubungan antara PIO dengan tingkat kepatuhan pasien hipertensi didapatkan sebesar p = 0,031 (p 0,05) dan diperoleh koefisien korelasi sebesar 0, 423. Kesimpulan pada penelitian ini adalah terjadi perubahan tingkat kepatuhan rendah menjadi kepatuhan tinggi dan terdapat hubungan pelayanan informasi obat berupa leaflet dan video dengan tingkat kepatuhan pasien hipertensi di Puskesmas Pal Tiga Pontianak serta memiliki keeratan hubungan yang cukup dan berarah positif.
Co-Authors Angliana Chouw, Angliana Nurrani Mustika Dewi, Nurrani Mustika Siska Darmayanti, Siska