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All Journal The Indonesian Biomedical Journal Molecular and Cellular Biomedical Sciences (MCBS)
Siska Darmayanti, Siska
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Biochemistry, Genetics & Molecular Biology Dentistry Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Is Stem Cell a Curer or an Obstruction? Darmayanti, Siska; Triana, Rina; Chouw, Angliana; Dewi, Nurrani Mustika
Molecular and Cellular Biomedical Sciences Vol 1, No 1 (2017)
Publisher : Cell and BioPharmaceutical Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21705/mcbs.v1i1.12

Abstract

Stem cell research and therapy are progressing these days dramatically. Stem cell therapy holds enormous treatment potential for many diseases which currently have no or limited therapeutic options. Unfortunately, this potential also comes with side-effects. In this review, the positive and negative effects of regulation of stem cells will be explained. Stem cells are undifferentiated cells which able to develop into many different cells of types in the body during early life and growth. There are five types of stem cells: embryonic stem cells, induced pluripotent stem cells, somatic stem cells, fetal stem cells and mesenchymal stem cells. Stem cell transplantation is one form of stem cell therapy, it comes with different techniques sourced, and those are autologous and allogeneic transplantation stem cells. In an autologous transplant, a patients blood-forming stem cells are collected, meanwhile, in an allogeneic transplant, target cells are replaced with new stem cells obtained from a donor or donated umbilical cord blood. Its abilities to maintain the phenotype, self-renewing and differentiate itself into specialized cells, give rise to stem cell as an innovation for the treatment of various diseases. In the clinical setting, stem cells are being explored for different conditions, such as in tissue repair and regeneration and autoimmune diseases therapy. But along with its benefit, stem cell therapy also holds some harm. It is known that the treatment using stem cell for curing and rehabilitation has the risk of tumor formation.Keywords: stem cell, therapy, transplantation, tumorigenic, mesenchymal stem cell, allogeneic
Tempeh Smoothie Consumption Reduces Triglyceride Levels and Body Mass Index of Menopausal Women Adawiyah, Asyifa Robiatul; Kridawati, Atik; Hadisaputra, Sugeng; Indrawati, Lili; Apriyan, Nur; Darmayanti, Siska
The Indonesian Biomedical Journal Vol 17, No 6 (2025)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v17i6.3876

Abstract

BACKGROUND: To reduce the risk of dyslipidemia, increasing the consumption of fiber-rich foods, such tempeh, is necessary. Tempeh contains abundant isoflavones that support lipid metabolism and vascular function, prompting researchers to develop methods for producing tempeh with more practical consumption compared to conventional tempeh. In current study, tempeh smoothie was produced and its effects on body composition and lipid profiles in menopausal women was evaluated.METHODS: A quasi-experimental study was conducted including 16 menopause women as subjects. The tempeh smoothie was prepared using tempeh blended with water until smooth and creamy. The tempeh smoothie was consumed by the subjects five times a week for six weeks, and then the subjects’ body composition and lipid profiles were measured before and after the intervention.RESULTS: There were some improvements in subjects’ body composition, specifically in muscle mass, and a few subjects shifted their body mass index (BMI) status from obesity to overweight. However, these changes were not statistically significant. Even though the consumption of tempeh smoothie did not improve total cholesterol level, which increased by 12.31 mg/dL); low-density lipoprotein (LDL) cholesterol, which increased by 32.81 mg/dL; and high-density lipoprotein HDL cholesterol, which decreased by 5.12 mg/dL; however, it is significantly reduced triglyceride levels by 75.00 mg/dL from baseline to post-intervention.CONCLUSION: Consuming tempeh smoothie regularly shows a trend towards BMI reduction and a slight improvement in muscle mass among menopausal women. This consumption also significantly lowers the triglyceride levels, indicating that it might be potential in preventing dyslipidemia in menopausal women.KEYWORDS: tempeh smoothie, menopausal women, body composition, lipid profile
Co-Authors Adawiyah, Asyifa Robiatul Angliana Chouw, Angliana Apriyan, Nur Hadisaputra, Sugeng kridawati, atik Lili Indrawati Nurrani Mustika Dewi, Nurrani Mustika Rina Triana, Rina