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All Journal JSFK (Jurnal Sains Farmasi & Klinis) JPSCR : Journal of Pharmaceutical Science and Clinical Research Pharmaceutical Sciences and Research (PSR)
Sri Wulandah Fitriani, Sri Wulandah
Fakultas Farmasi Universitas Indonesia
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengaruh Pemberian Sari Buah Mengkudu (Morinda citrifolia Linn.) Terhadap Glibenklamid dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes Sari, Santi Purna; Munim, Abdul; Fitriani, Sri Wulandah
Majalah Ilmu Kefarmasian Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Drug interactions can occur in the use of two or more drugs simultaneously, including the use of synthetic drug with herbal medicine. Combination of glibenclamide with noni juice (Morinda citrifolia Linn.) often used by diabetic patient to decrease their blood glucose level. lhe aim of this research was to know the interaction between glibenclamide and noni juice administration on blood glucose level. This research used 24 Sprague-Dawley male rats which were divided into 6 groups. Before the experiment, the rats were first induced by alloxan, except group 1, which was the normal control. Group 2 was the control of diabetic without given any drugs. Group 3 and 4 were the control of glibenclamide (0.9 mg/200g body weight of rat) and of noni juice (2.5 ml/200g body weight of rat) respectively. Group 5 and 6 were the interaction test group which were given glibenclamide (0.9 mg/ 200 g body weight rat) and noni juice (2.5 ml or 5.0 ml/200 g body weight of rat) with an hour interval. The blood glucose level was measured by using spectrophotometer with o-toluidine as reagent. The result of this research shows that noni juice at a dose 5.0 ml/200 g body weight rat was able to increased the reduction of blood glucose levels by glibenclamide after two weeks administration
Medication Adherence, Glycemic Control and Quality of Life in Patients with Type 2 Diabetes Mellitus: a cross-sectional study Eliza, Delila; Syafhan, Nadia Farhanah; Andrajati, Retnosari; Fitriani, Sri Wulandah
JSFK (Jurnal Sains Farmasi & Klinis) Vol 10 No 1 (2023): J Sains Farm Klin 10(1), April 2023
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.10.1.21-27.2023

Abstract

Medication adherence is important in controlling blood sugar levels (HbA1c) in patients with Diabetes Mellitus (DM). Studies on the relationship between medication adherence and blood sugar control on the quality of life (QoL) in Type 2 DM patients are limited in Indonesia. This study aims to assess the relation between medication adherence with blood sugar control and the quality of life of Type 2 DM patients. This study used a cross-sectional design conducted at Universitas Indonesia Hospital. It used Medication Adherence questionnaires and EuroQoL 5D-5L questionnaires to assess patients’ medication adherence and quality of life. This study involved a total of 74 Type 2 DM patients with an average age of 57 ± 10.74 years. Medication adherence with good blood sugar control (HbA1c <7%) showed a significant relationship (p-value <0.05) with COR values of 3.74 (1.21 - 11.6) compared to non-adherent patients. But not on the QoL Index and VAS (Visual Analog Scale) values, where the value is lower in patients with high adherence and good blood sugar control. Factor asscociated with blood sugar controlled were comorbidites and medication adhrence while factor that associated with quality of life were comorbidities, ages, education and employment status
Adverse Drug Reactions, Treatment Adherence, and Treatment Outcomes in Drug-Resistant Tuberculosis Patients: A Single-center, Cross-sectional Study Syafhan, Nadia Farhanah; Rahmita, Galuh Zhafirah; Fitriani, Sri Wulandah
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 2 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i2.87515

Abstract

Drug-Resistant Tuberculosis (DRTB) is a significant global health issue due to its rapid transmission and high morbidity. The variety of medications used in DRTB treatment increases the risk of adverse drug reactions (ADRs), which can contribute to patient nonadherence and adversely affect treatment outcomes. This study aimed to describe the occurrence of ADRs, quantify medication adherence rates, and assess treatment outcomes among patients with drugresistant tuberculosis (DRTB). Furthermore, it sought to analyse the associations between ADRs, demographic and clinical variables, medication adherence, and the associations between ADRs and treatment outcomes. Using a cross-sectional design, this study utilized medical records data and the Tuberculosis Information System (SITB) of adult DRTB patients treated at Universitas Indonesia Hospital from April 1, 2022, to February 28, 2023. A total sampling method was employed to select the research participants. Of the 65 patients, 60 (95.24%) experienced ADRs, and the Medication Refill Adherence method indicated an 89.23% adherence rate. Two patients (3.08%) were classified as successful or cured during the data collection period. Chi-square tests revealed no significant relationship between ADRs and medication adherence (p = 0.373) or treatment outcomes (p = 0.120). All demographic and clinical factors (age, gender, comorbidities, treatment combinations, and potential drug interactions) also showed no significant relationships with adherence (p > 0.05). In contrast, treatment combinations showed significant relationships with treatment outcomes (p = 0.013). These findings highlight the importance of medicines optimisation strategies, including proactive ADR management and adherence support, to improve treatment outcomes in DRTB patients.
Co-Authors Abdul Munim Eliza, Delila Nadia Farhanah Syafhan Rahmita, Galuh Zhafirah Retnosari Andrajati Santi Purna Sari