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All Journal Jurnal Respirologi Indonesia Pharmaceutical Sciences and Research (PSR) Makara Journal of Health Research Eduvest - Journal of Universal Studies Holistik Jurnal Kesehatan
Santi Purna Sari
Universitas Indonesia
Aerospace Engineering Computer Science & IT Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Pengembangan Metode Induksi Tukak Lambung Saputri, Fadlina Chany; Sari, Santi Purna; Munim, Abdul
Majalah Ilmu Kefarmasian Vol. 5, No. 2
Publisher : UI Scholars Hub

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Scientific evaluation on pharmacological activity of medicinal herbs required repro-ducible and valid method-induced ulcer models in animal. In this study, the method of antiulcerogenic effect was investigated using several inducers. The male white Sprague-Dawley rats divided into five groups which were orally administrated water, indomethacin (48 mg/kg bw), aspirin-HCl (150 mg/kg bw), 96% ethanol (1 ml/200 g bw), and 80% ethanol (1 ml/200 g bw), respectively. The result of this study showed that the group was induced with 80% ethanol demonstrated the highest ulcer index. Histological examination of the stomach showed abnormality of mucosa cells on the aspirin-HCl, 96% ethanol, and 80% ethanol-induced gastric ulcer model in rats.
Uji Efek Antiartritis Ekstrak Etanol 80% Kulit Buah Delima Merah (Punica granatum L) Terhadap Udem Pada Telapak Kaki Tikus Putih Jantan yang diinduksi oleh Complete Freund’s Adjuvant Sari, Rusmalita Pebriana; Amin, Juheini; Sari, Santi Purna
Majalah Ilmu Kefarmasian Vol. 7, No. 1
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Rheumatoid arthritis is a chronic inflammatory disease that can degrade the quality of patient survival. Conventional treatments of this disease have potentially dangerous side effects. Therefore, many patients are turning to alternative medicine using medicinal herbs, one of which is the fruit of Punica granatum L. The aim of this research was to determine antiarthritis effect of 80% ethanolic extract of Punica granatum L. fruit peel which had been given orally on 17-30th day based on decreased edema volume and percentage indexes of arthritis. The method was adjuvant induced arthritis by using the complete freund’s adjuvant 0,1 mL by subplantar and allowed to arthritis until day 16. The animals test were used 33 male rats of Sprague Dawley strain that were divided into six groups: normal control, positive control, negative control, and three groups had received suspension of 80% ethanolic extract of Punica granatum L. fruit peel in 0,5% CMC at doses 20, 40, and 80 mg/200 g body weight. The Edema volume was measured by pletismometer on days 17, 20, 23, 26, 29, 31 and indexes of arthritis determined on days 17 and 31. The Results showed that they were not significant difference in the decreased edema volume and the percentage indexes of arthritis, although the percentage inhibition of edema elevated with increasing dose.
Efek Hepatoprotektif Infus Daun Sukun (Artocarpus altilis (Park) Fsb) Terhadap Kerusakan Hati Tikus yang Diinduksi dengan Karbon Tetraklorida K.J, Wahyu Atmaja; Sari, Santi Purna; Azizahwati, Azizahwati
Majalah Ilmu Kefarmasian Vol. 7, No. 2
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Breadfruit leaves (Artocarpus altilis (Park.) Fsb.) are used as traditional medicine in treatment of liver diseases. This study aimed to figure out the hepatoprotective effect of breadfruit leaves infusion in carbon tetrachloride-induced liver damage in male albino rats. The study used 25 male albino rats of Sprague-Dawley strain, which were divided randomly into five groups. Group I (normal control group) and group II (carbon tetrachloride-induced control group) only received 0,5% carboxymethylcellulose (CMC) solution. Group III-V received different dose of breadfruit leaves infusion for seven days respectively, which were 13,5 g/kgBW (dose 1), 27 g/kg BW (dose 2) and 54 g/kg BW (dose 3). On 7th day, all groups, excepted the normal group, were induced by 0,4 ml/kgBW dose of carbon tetrachloride perorally two hours after the last breadfruit leaves infusion given. Parameters of liver damage were estimated by measuring the activity of plasma alanine aminotransferase (ALT), the concentration of lipid peroxide in liver, and the concentration of lipid peroxide in plasma. The results of ANOVA (p<0,05) demonstrated that breadfruit leaves infusion at a dose of 54 g/kgBW (dose 3) consumed for seven days respectively before 0,4 ml/kgBW dose of carbon tetrachloride-induced had hepatoprotective effect estimated by the activity of plasma ALT and the concentration of lipid peroxide in liver.
Pengaruh Pemberian Infusa Herba Sambiloto (Andrographis paniculata Nees) Terhadap Glibenklamid Dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes Sari, Santi Purna; Azizahwati, Azizahwati; Ratimanjari, Diandra Andina
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Many diabetics perform self-medication with antidiabetic herbs and synthetic drugs with the aim to obtain a synergistic or additive effects without informing their primary physician, such as the use of creat and glibenclamide. This research was carried out to know the impact of creat herb infusion on glibenclamide in bwering blood glucose levels on diabetic male albino rats. This study used 24 male Sparague-Lawley rats, which are divided into 6 groups, normal control and diabetic control were given 0,5% CMC solution I ml/200 g bw of rat, glibenclamide control were given glibenclamide suspension 0,9 mg/200 g bw of rat, creat control were given creat herb infusion 50 mg/200 g bw of rat, and 2 interaction groups were given creat herb infusion in 2 variant doses (50 and 100 mg/ 200 g bw of rat) and glibenclamide suspension 0,9 mg/200 g bw of rat, each of them were administrated orally. All of groups were induced with alloxan 32 mg/ 200 g bw of rat except normal control. Blood glucose was measured by 0-toluidine method at 2 hours and 4 hours after administration. The result showed that the creat herb infusion at 100 mg/200 g bw gave significant impact on glibenclamide in lowering blood glucose levels week after administration.
Pengaruh Pemberian Sari Buah Mengkudu (Morinda citrifolia Linn.) Terhadap Glibenklamid dalam Menurunkan Kadar Glukosa Darah Tikus Putih Jantan yang Dibuat Diabetes Sari, Santi Purna; Munim, Abdul; Fitriani, Sri Wulandah
Majalah Ilmu Kefarmasian Vol. 9, No. 1
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Drug interactions can occur in the use of two or more drugs simultaneously, including the use of synthetic drug with herbal medicine. Combination of glibenclamide with noni juice (Morinda citrifolia Linn.) often used by diabetic patient to decrease their blood glucose level. lhe aim of this research was to know the interaction between glibenclamide and noni juice administration on blood glucose level. This research used 24 Sprague-Dawley male rats which were divided into 6 groups. Before the experiment, the rats were first induced by alloxan, except group 1, which was the normal control. Group 2 was the control of diabetic without given any drugs. Group 3 and 4 were the control of glibenclamide (0.9 mg/200g body weight of rat) and of noni juice (2.5 ml/200g body weight of rat) respectively. Group 5 and 6 were the interaction test group which were given glibenclamide (0.9 mg/ 200 g body weight rat) and noni juice (2.5 ml or 5.0 ml/200 g body weight of rat) with an hour interval. The blood glucose level was measured by using spectrophotometer with o-toluidine as reagent. The result of this research shows that noni juice at a dose 5.0 ml/200 g body weight rat was able to increased the reduction of blood glucose levels by glibenclamide after two weeks administration
Toksisitas Ekstrak Etanol Mangifera foetida L. sebagai Pengkelat Besi Ditinjau dari LD50 dan Komponen Sel Darah Wahyuni, Tri; Sari, Santi Purna; Estuningtyas, Ari; Freisleben, HJ
Pharmaceutical Sciences and Research Vol. 2, No. 3
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Ethanolic extract of bacang mango leaves (Mangifera foetida L.) decreased iron concentration in blood Sprague dawley rats that had been induced iron overload. The aim of this experiment was to determine acute toxicity (LD50) value of ethanolic extract of M.foetida by weil method and its effect to blood component. This study was conducted by employing a complete random design using 25 male and 25 female mice of DDY strain which devided into 5 groups. The first group until fourth group were administered ethanolic extract of M.foetida with dose variation which suspension in aquadest orally. The fifth group was control that administered aquadest. The LD50 was determined by the total of death on all group. LD50 value of the extract showed no death in the biggest doses (13.013 g/kg). The examination was continued with measured blood count (erythrocites, trombocytes, leukocytes, and haemoglobin concentration). It was shown that the extract at dose 1.626; 3.253; 6.506 and 13.013 g/kg unchanged the blood count measurement.
Indonesian health professions students’ perceptions toward an interprofessional education program: Findings after five years of implementation Sari, Santi Purna; Soemantri, Diantha; Ayubi, Dian; Martha, Evi; Handiyani, Hanny; Findyartini, Ardi
Makara Journal of Health Research
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Background: The Interprofessional Education (IPE) program is important for preparing health professions students to provide future interprofessional collaborative practice. The Universitas Indonesia Health Sciences Cluster has been implementing the IPE program since 2013. A comprehensive evaluation is required following the implementation of the IPE program. The aim of the study was to evaluate the IPE course based on perceptions of undergraduate students at the Universitas Indonesia from 2013 to 2017. Methods: A mixed-methods study utilizing a semi-structured questionnaire was conducted with first year students following the completion of the first stage of the IPE course. A total of 2355 students (56.35%) from the 2013–2017 academic years completed the questionnaire. Results: The results showed that students’ perceptions of the IPE course improved each year on the domains of clear and relevant learning objectives, student-centered teaching methods, staff support, and supporting infrastructures. However, some room for improvement was identified, such as the need for tutors to have a more neutral attitude toward every student despite their background differences. Conclusion: The IPE course has been well perceived by students because of its comprehensive instructional design and principles of IPE that are implemented in the curriculum. The continuous cycles of improvement to maintain the quality of the IPE program will remain a challenge.
Medication Adherence among Drug-Resistant Tuberculosis (DR-TB) Patients at Universitas Indonesia Hospital Harahap, Daimah Wirdatus Sanaun; Andrajati, Retnosari; Sari, Santi Purna; Handayani, Diah
Jurnal Respirologi Indonesia Vol 44, No 3 (2024)
Publisher : Perhimpunan Dokter Paru Indonesia (PDPI)/The Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/jri.v44i3.775

Abstract

Background: Drug-resistant tuberculosis (TB-DR) is a deadly disease caused by infectious agents. Indonesia is one of the countries with the highest drug-resistant tuberculosis (TB-DR) rates in the world. The prevalence of tuberculosis cases in Depok City between 2019-2022 showed an increase in cases every year. This study aims to measure the level of adherence of drug-resistant tuberculosis (TB-DR) patients to their treatment using the Eight-Item Morisky Medication Adherence Scale (MMAS-8) questionnaire.Methods: This study is an observational study using a cross-sectional study design, conducted from February 2024 to March 2024 at the University of Indonesia Hospital. Eighty-seven respondents participated in this study. Respondents completed the validated Indonesian version of the MMAS-8 questionnaire after signing informed consent forms.Results: The results of the study showed that 50.6% of respondents had low adherence levels, 47.1% had moderate adherence levels, and 2.3% had high adherence levels. The data was then statistically analyzed using the SPSS version 29 statistical package with Chi-Square analysis, which resulted in a significant correlation (P<0.05) between adherence levels and gender.Conclusion: There was a significant correlation between gender and respondent adherence. More than 50% of drug-resistant tuberculosis (TB-DR) patients at the University of Indonesia Hospital still have low adherence levels to their treatment.
Literature Review on the Appropriateness of Medication Prescription in Chronic Kidney Disease Patients: Focus on Antibiotic Use Oktamauri, Ariesa; Syafhan, Nadia Farhanah; Sari, Santi Purna
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.44784

Abstract

Chronic Kidney Disease (CKD) significantly impacts pharmacokinetics and pharmacodynamics, altering drug metabolism and excretion, thus increasing the risk of drug toxicity. CKD patients are more susceptible to infections, which contribute to significant morbidity and mortality. This underscores the importance of appropriate antimicrobials used in this population. This literature review explores recent findings on medication prescribing practices, dose adjustments, and factors affecting appropriateness, especially in antibiotic use for CKD patients. A comprehensive literature search was conducted using six databases to identify studies published from 2015 to 2024. Twenty-six studies were included. This literature review found that prevalence of inappropriate prescriptions in CKD patients ranges widely between 10% to 77.1% and from 30% to 34,9% specifically for antibiotic, with higher rates observed in outpatient settings compared to hospital environments. Antibiotics, antidiabetic agents, antihypertensive, nutraceuticals, and electrolytes are frequently inappropriately prescribed. Factors influencing inappropriate prescription include comorbidity, severity level of kidney disorder, age, and polypharmacy. The antibiotics most commonly prescribed inappropriately include cefazolin, meropenem, oral sulfamethoxazole-trimethoprim, nebulised colistin, vancomycin, and piperacillin-tazobactam. This study emphasizes the mixed and limited evidence regarding the clinical outcomes of antibiotics dose adjustments in CKD patients. While some studies suggest that antibiotics dose adjustments improve therapeutic outcomes and reduce adverse events, others show no significant impact. Further research is needed to understand the impact of this intervention, as these outcomes may be influenced by various factors. Enhanced education and collaboration between healthcare providers are critical to improving the accuracy of antibiotic prescriptions and ensuring patient safety in CKD management.
Challenges of Monitoring Blood Levels of Bedaquiline in Drug-Resistant Tuberculosis: A Narrative Review Isra, Nur; Sari, Santi Purna; Harahap, Yahdiana; Handayani, Raden Rara Diah
Eduvest - Journal of Universal Studies Vol. 5 No. 3 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i3.50267

Abstract

Bedaquiline, a second-line drug for drug-resistant tuberculosis (MDR-TB), is one of the latest generation drugs in the treatment of tuberculosis (TB). However, the challenge in determining the optimal dose and individual pharmacokinetic variability requires the implementation of Therapeutic Drug Monitoring (TDM). This article aims to evaluate the challenges of TDM bedaquiline through a narrative review of the current literature. Relevant articles were identified through computerized searches on PubMed and Google Scholar using a combination of keywords related to bedaquiline, pharmacokinetics, and TDM. Limited clinical data indicate a lack of standard exposure targets and reliable efficacy thresholds. Pharmacokinetic variability is influenced by factors such as age, weight, gender, genetics, comorbidities, and serum albumin. Technical challenges include the need for precise analytical methods and the accessibility of technology in clinical practice. The use of TDM for bedaquiline offers the potential to improve the efficacy of MDR-TB treatment, but more research is needed to address pharmacokinetic variability and develop standardized guidelines.
Co-Authors Abdul Munim Ardi Findyartini, Ardi Ari Estuningtyas, Ari Ariesa Oktamauri Diah Handayani Dian Ayubi Diandra Andina Ratimanjari, Diandra Andina Diantha Soemantri Dumiarsih, Suci Rizki Evi Martha Fadlina Chany S Fadlina Chany Saputri Farmasita Budiastuti, Rizky Handayani, Raden Rara Diah Hanny Handiyani Harahap, Daimah Wirdatus Sanaun HJ Freisleben, HJ Isra, Nur Juheini Amin K.J, Wahyu Atmaja MARIA BINTANG Nadia Farhanah Syafhan Nurhikmah, Rizky Retnosari Andrajati Sari, Rusmalita Pebriana Sri Wulandah Fitriani, Sri Wulandah tri wahyuni Yahdiana Harahap