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All Journal Paediatrica Indonesiana Jurnal Kebidanan dan Kesehatan
Cahya Dewi Satria, Cahya Dewi
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Health Professions Medicine & Pharmacology Nursing Public Health

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Interleukin-6 and disease activity in childhood systemic lupus erythematosus Satria, Cahya Dewi; Kurniati, Nia; Muktiarti, Dina
Paediatrica Indonesiana Vol. 63 No. 6 (2023): November 2023
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi63.6.2023.456-63

Abstract

Background Systemic lupus erythematosus (SLE) is a complex disease with various manifestations. Interleukin-6 (IL-6) is a pleiotropic cytokine with a wide range of biological activities which plays an important role in immune regulation and inflammation. Serum level of IL-6 may be used as a parameter of disease activity, especially in pediatric SLE patients with mild disease activity or total remission with conflicting clinical manifestations and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) scores. Objective To identify the characteristics of serum IL-6 concentration in pediatric SLE with mild disease activities and total remission. Methods This case-control study was performed at the allergy-immunology outpatient clinic, Department of Child Health Dr. Cipto Mangunkusumo Hospital, Jakarta and Dr. Sardjito Hospital, Yogyakarta. Serum IL-6 concentration and disease activity were assessed in all pediatric SLE patients aged 1-18 years old. Disease activity was assessed with SLEDAI scores and serum level of IL-6 was measured by enzyme-linked immunosorbent assay. Results Among 60 subjects included in this study, 30 subjects with mild activities were in the case group and 30 subjects with total remissions were in the control group. There was no difference in serum IL-6 concentration between the case and control group (OR 0.483; 95%CI 0.041to 5.628; P=0.500). In this study, 2 subjects with urinary tract infection had high serum IL-6 concentrations. Conclusion There is no difference in serum IL-6 concentration between pediatric SLE patients with mild disease activities compared to total remissions.
Crusted Scabies dengan Infeksi Sekunder pada Lupus Eritematosus Sistemik Berat : Laporan Kasus Sabana, Manusama Hasan; Sumadiono; Satria, Cahya Dewi
Jurnal Kebidanan dan Kesehatan Vol. 2 No. 1 (2024)
Publisher : LPPM Akbid Surya Mandiri Bima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70683/jkk.v2i1.20

Abstract

Background: Crusted scabies is characterised by hyperkeratosis and crusting of the skin due to profuse proliferation of S. scabiei mites. Clinical manifestations arise due to altered host response to mite infestation, such as in systemic lupus erythematosus (SLE) patients with immunocompromised conditions. This study aims to review clinical data: This study is a case report relating to cases found in 2020. Case illustration: In this case, a 17-year-old girl was diagnosed with SLE nephritis since September 2020. The patient was treated with severe SLE protocol, namely high dose methylprednisolone followed by full dose orally and Mycophenolate Mofetil (MMF). The patient presented with complaints of a reddish rash with scabs on the face. Examination of skin abnormalities in the malar region found erosions covered with multiple scattered red-black crusts with a base of erythema patches, skin scrapings between fingers found mite bodies and eggs. Laboratory results showed anaemia, hyperuricaemia, elevated anti dsDNA, strong positive ANA IF. Urinalysis found proteinuria and glucosuria. Permethrin 1% was given once per week until clinical improvement. Cefepime antibiotic was given to treat secondary infection of scabies. The severe SLE protocol was continued. Conclusion: Severe manifestations of scabies infection in SLE patients are associated with immunocompromised conditions as well as immunosuppressive drug administration. Adequate scabies therapy and antibiotics for secondary infections are needed to prevent morbidity in patients with SLE.
Co-Authors Dina Muktiarti, Dina Nia Kurniati Sabana, Manusama Hasan Sumadiono