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All Journal Majalah Kedokteran Bandung Althea Medical Journal Paediatrica Indonesiana Archives of Pediatric Gastroenterology, Hepatology, and Nutrition
Aris Primadi, Aris
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Health Professions Medicine & Pharmacology

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Association between Intrauterine Growth Restriction and Pregnancy Hypertension Febrina, Nada Ardilla Dwiayu; Primadi, Aris; Lestari, Bony Wiem
Althea Medical Journal Vol 3, No 2 (2016)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (116.602 KB)

Abstract

Background: Intrauterine Growth Restriction (IUGR) certainly poses health problems that leads to increase mortality and can cause mental and physiological disturbances to the infants. Reduced organ perfusion is one of the etiologies of IUGR which is caused by placenta obstruction. This happens because of pregnancy hypertension as a risk factor. Furthermore, educational level, employment status, parity, and anemia are also its risk factors. The objective of this study was to analyze the prevalence of IUGR and association between IUGR and pregnancy hypertension.Methods: A case control design was performed using medical records from Neonatology Department of Child Health at Dr. Hasan Sadikin General Hospital Bandung in 2012. Subjects were taken from 149 medical records of the mother who had IUGR and 149 normal birth weight infant information about the characteristics of the mothers and the infants. The data were collected and analyzed by calculating the Odds ratio (OR).Results: The prevalence of IUGR at Dr. Hasan Sadikin General Hospital in 2012 was 149 cases (4.69%). There was association between pregnancy hypertension and IUGR with OR=1.72, 95% CI (1.044–2.836).Conclusions: Pregnancy hypertension is one of the risks that generates IUGR. [AMJ.2016;3(2):212–5] DOI: 10.15850/amj.v3n2.791
Gestational Age Conformity between New Ballard Score and Last Menstrual Period in Newborn with Respiratory Distress Syndrome Sakinah, Wulan Dwi; Primadi, Aris; Prajitno, Ihrul Prianza
Althea Medical Journal Vol 3, No 3 (2016)
Publisher : Althea Medical Journal

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Background: Gestational age is required to determine diagnosis and optimal management of newborns. The gold standard for gestational age determination is the first day of last menstrual period (LMP). However, not all mothers remember their LMP. Another method for gestational age determination after birth is the New Ballard Score (NBS). This method measures gestational age using two main components, namely neorumuscular and physical maturity. In premature infants, surfactant deficiency leads to hypoxia which eventually leads to neuromuscular disorders. This situation may cause younger gestational age estimation when using NBS. The objective of this study was to analyze the conformity between NBS and LMP in determining gestational age in newborns with respiratory distress syndrome (RDS).Methods: A cross-sectional study was conducted on 35 newborns with RDS that were recorded in 2012 database in Dr. Hasan Sadikin General Hospital Bandung. Data on the date of birth, LMP, NBS soon after birth, sex, birth weight, type of delivery and diagnosis were collected and analyzed statistically using Wilcoxon test.Results: The study showed that there was a significant difference (p<0.05) between gestational age determination done using NBS soon after birth and LMP in newborns with RDS.Conclusions: Gestational age determination based on NBS soon after birth does not conform the LMP in newborns with RDS. [AMJ.2016;3(3):401–4]DOI: 10.15850/amj.v3n3.888
Antimicrobial Sensitivity of Neonatal Bacterial Sepsis Iswandari, Nadya; Primadi, Aris; Sudigdoadi, Sunarjati
Althea Medical Journal Vol 4, No 2 (2017)
Publisher : Althea Medical Journal

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.214 KB) | DOI: 10.15850/amj.v4n2.1072

Abstract

Background: Appropriate treatment on neonatal bacterial sepsis is important based on the exact etiology to prevent bacterial resistance, but bacterial identification using blood cultures requires a considerable time. The newest data of various bacteria and their sensitivity can be used to assist empirical antibiotics usage. This study was conducted to identify bacterial profile that caused neonatal sepsis and their sensitivity to antibiotics at Dr. Hasan Sadikin General Hospital Bandung..Methods: A total of 275 neonatal sepsis cases and 288 blood cultures results were collected from a database provided by Dr. Hasan Sadikin General Hospital Bandung during the period of July 2011 toDecember 2012 (three semesters).  Etiology of the bacteria and antimicrobial sensitivity profile data were taken from positive bacteria results. Then, these variables were processed using the descriptive method and classified by semesterResult: The most common bacteria that caused neonatal sepsis in the second semester 2011 is Serratia marescens, the first semester 2012 was Enterobacter aerogenes and in the second semester 2012 was Burkholderia cepacia. The most sensitive antibiotics were piperacillin tazobactam, cefepime, meropenem and amikacin in all three semesters, gentamycin in the second semester 2011 and 2012, and amoxicillin clavulanic in the second semester 2012.Conclusions: Bacterial and antimicrobial sensitivity profile is varied in every semester.Keywords: Antimicrobial sensitivity profile, bacterial profile, neonatal sepsisDOI: 10.15850/amj.v4n2.1072
Unusual Lifespan of Edwards' Syndrome in COVID-19 Era Suryaningrat, Filla Reviyani; Hudayari, Devatri; Amalda Ediwan, Natasha; Rita Mardhiya, Wan; Aprilia Kadi, Fiva; Primadi, Aris; Yuniati, Tetty
Majalah Kedokteran Bandung Vol 56, No 3 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3230

Abstract

Edwards' syndrome is caused by an extra chromosome on the 18th chromosome. Patients with this diagnosis have median survival of only 3-14.5 days, with the majority of infants with full trisomy 18 type die before or shortly after they are born. There is only supportive treatment available for Edwards’ syndrome. During the COVID-19 pandemic, providing health services was challenging, leading to less than optimum treatments added by patients’ reluctance to visit healthcare facilities due to the fear of COVID-19 transmission. This case study presented an infant with Edwards’ syndrome with major malformation. The patient had several organ problems, was admitted to the NICU, and continued with home care for monitoring for 6 months. Patient then died at 9 months of age. Maintaining the best quality of life for this patient was very challenging for parents and healthcare providers. Since the management for this type of sydnome is more palliative, good education, information, and psychosocial supports for the parents are needed to prepare them with the worst conditions, which was especially more challenging during the COVID-19 pandemic.
Hematology scoring model to predict sepsis in preterm neonates Suryani, Yani Dewi; Yuniati, Tetty; Kadi, Fiva Aprilia; Primadi, Aris
Paediatrica Indonesiana Vol. 64 No. 5 (2024): September 2024
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi64.5.2024.389-97

Abstract

Background Neonatal sepsis is a major cause of neonatal morbidity and mortality, especially in developing countries. Atypical clinical symptoms lead to delays in diagnosis and treatment. Scoring a combination of routine hematology parameters may be able to predict the occurrence of sepsis in preterm neonates. Objective To formulate a new model for neonatal sepsis scoring from various complete blood count parameters to predict sepsis in preterm neonates. Methods This analytical cross sectional study using secondary data from the Registry of the Neonatology Division was conducted at the RSUP Dr. Hasan Sadikin, Bandung, West Java. Subjects were neonates diagnosed with sepsis, of gestational age 28–36 weeks, who were born at the RSUP Dr. Hasan Sadikin from January to December 2021. Laboratory results of patients who met the inclusion criteria were recorded. Subjects were divided into either proven sepsis and probable sepsis groups, based on blood culture results. Results Of 112 subjects, 35.7% had proven sepsis and 64.3% probable sepsis. In the proven sepsis group, 52.5% of subjects were male, median birth weight was 1,490 grams, median gestational age was 32 weeks, 90% were small for gestational age, and 60% were delivered normally. Multivariable analysis by multiple logistic regression revealed that the parameters associated with the incidence of neonatal sepsis were c-reactive protein (CRP) > 0.18 mg/dL (score 6), hematocrit <40% (score 4), platelet-to-lymphocyte ratio (PLR) < 19.623 (score 4); monocyte-lymphocyte ratio (MLR) < 0.461 (score 2); and mean platelet volume (MPV) value >10 (score 2). Score >8 had a sensitivity of 85% and specificity of 70.8%, with area under the ROC curve of 0.865 (P<0.001). Scoring accuracy was 75.8%, with a positive predictive value of 61.8%, a negative predictive value of 89.5%, and Kappa index of 51.5% with moderate agreement. Conclusion A hematological score >8 can be used as a predictor of sepsis in preterm neonates.
A Case Study on Neurological Outcome in Persistent Neonatal Hypoglycemia in Upper Middle-Income Country Primadi, Aris; Yuniati, Tetty; Aprilia Kadi, Fiva; Reviyani Suryaningrat, Filla; Hudayari, Devatri; Ediwan, Natasha Amalda
Majalah Kedokteran Bandung Vol 56, No 4 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3350

Abstract

In Indonesia, comprehensive management and monitoring of persistent neonatal hypoglycemia, is rarely reported. Despite the fact that there are studies highlighting the risk of neurodevelopmental disorders in neonates with hypoglycemia, there seems to be limited comprehensive case reports detailing both the early diagnosis and the long-term growth and development monitoring in these neonates. A unique case report of a 10-day-old male baby, born at a term weeks gestation via caesarean section, diagnosed with persistent hypoglycemia and suspect of hyperinsulinemia is presented in this study. At birth, the neonate exhibited hypoglycemia with a blood glucose level of 25 mg/dL, accompanied by a one-minute seizure characterized by upward gaze and stiffening of the extremities. The neonate cried after seizure and there was no loss of consciousness and was admitted to the NICU due to worsening respiratory distress. Based on the thoracic X-ray examination, he was diagnosed with transient tachypnea of newborn (TTN). Blood glucose levels were monitored every four hours, and tests for cortisol, thyroid and growth hormone and routine urinalysis were planned. Total parenteral nutrition (TPN) were given with intravenous antibiotics. At 6months of age, the infant was diagnosed with intellectual disability by the growth and development social pediatric unit. At 7 months, the infant  began undergoing physiotherapy. This case was followed for 7 months in total and the findings highlight the challenges in managing neonatal persistent hypoglycemia and the potential long-term developmental implications in neonates with early-life hypoglycemia, emphasizing the need for continual growth and development monitoring.
Umbilical Venous Catheter Position Evaluation in Hasan Sadikin General Hospital : Overview of the Time Required Suryaningrat, Filla Reviyani; Primadi, Aris; Kadi, Fiva Aprilia; Hudayari, Devatri; Ediwan, Natasha Amalda; Yuniati, Tetty
Archives of Pediatric Gastroenterology, Hepatology, and Nutrition Vol. 3 No. 2 (2024): APGHN Vol. 3 No. 2 May 2024
Publisher : The Indonesian Society of Pediatric Gastroenterology, Hepatology, and Nutrition

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58427/apghn.3.2.2024.8-14

Abstract

Background: An umbilical venous catheter (UVC) is one of the most frequently used access in neonates. In developed countries, bedside ultrasonography (USG) is used in assessing the position of the UVC catheter’s tip. However, this is difficult to be implemented in developing countries. In Indonesia, which categorized as a middle- income developing country, the evaluation of UVC mainly used chest radiographs. However, this procedure would take time. The delay in ascertaining UVC positioning through chest radiography among neonatologists in Indonesia remains unstudied, despite its potential on the clinical efficacy. Therefore, this study aimed to determine the time required for the installation of the UVC and the interval from the completion of UVC insertion until the release of the chest radiography result. Method: In this prospective observational cohort study, neonates requiring UVC access were examined in Dr. Hasan Sadikin Hospital in Bandung, West Java. Patients underwent anthropometric measurements and UVC installation. Duration required for UVC installation and the interval between the completion of UVC insertion and the release of the chest radiography result were documented. Descriptive data were shown in percentage, mean and standard deviation. Result: 127 neonates were studied. The average time taken for UVC insertion was 31 minutes and the average time taken from the completion of UVC insertion until the release of chest radiography results was 6 hours. Conclusion: The long wait for chest radiography results significantly delayed the administration of fluids, medications, and parenteral nutrition in this study. Therefore, we need alternative tools to evaluate the UVC location that can be used bedside right after the installation.
Co-Authors Amalda Ediwan, Natasha Aprilia Kadi, Fiva Bony Wiem Lestari, Bony Wiem Ediwan, Natasha Amalda Febrina, Nada Ardilla Dwiayu Fiva Aprilia Kadi Hudayari, Devatri Ihrul Prianza Prajitno Iswandari, Nadya Reviyani Suryaningrat, Filla Rita Mardhiya, Wan Sakinah, Wulan Dwi Sunarjati Sudigdoadi Suryani, Yani Dewi Suryaningrat, Filla Reviyani Tetty Yuniati