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Miladiarsi
Universitas Megarezky, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Neuroscience Veterinary

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Prevalence of CTX-M Gene as an ESBL Marker in Clinical Klebsiella pneumoniae Isolates Arafah Nurfadillah; Wahdaniar; Ummu Syauqah Al Musyahadah; Nur Insani Amir; Ade Irma; Miladiarsi; Tenri Ayu Adri
Journal of Health Sciences and Medical Development Vol. 2 No. 01 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i01.164

Abstract

Klebsiella pneumonia is a bacteria that causes many negative impacts on health, primarily due to its tendency to develop antibiotic resistance. This research aims to identify the prevalence of the CTX-M gene as an ESBL marker of the Clinical Isolate of K. pneumoniae of Wahidin Sudirohusodo General Hospital. The samples consisted of 50 Clinic isolates of K. pneumoniae which fulfilled the inclusion and exclusion criteria. The research procedure consisted of DNA extraction, amplification, and agarose gel electrophoresis. The research results indicate that 38 samples (76%) are positive for the CTX-M gene, while 12 samples (24%) are negative or not found CTX-M gene. Thus, the prevalence of the CTX-M gene in K. pneumoniae resistant to beta-lactam antibiotics in Wahidin Sudirohusodo General Hospital is relatively high.
Antibacterial Activity Test of Moringa Leaf Ethanol Extract Ointment of Moringa oleifera Lamk. on Staphylococcus aureus Bacteria Miladiarsi; Nasrawati Basir; Nurlindasari; Wahdaniar; Ade Irma
Journal of Health Sciences and Medical Development Vol. 2 No. 01 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i01.222

Abstract

Staphylococcus aureus is gram-positive bacteria and can cause infections and disorders of the skin. This study aims to determine the physical stability of ointment preparations containing ethanol extract from Moringa leaves based on variations in concentration and antibacterial activity against Staphylococcus aureus. This research is a laboratory experiment with the stages of making an ointment from the ethanol extract of Moringa leaves and testing its antibacterial activity against Staphylococcus aureus. Data analysis using One-Way ANOVA. The results of the research on moringa leaf ethanol extract ointment preparations were physically and chemically stable through organoleptic testing, homogeneity, dispersion, viscosity, and pH by including a cycling test. Antibacterial activity test showed that moringa leaf ointment had antibacterial activity against Staphylococcus aureus with the diameter of the inhibition zone each extract concentration of 15% (16.1mm), 20% extract concentration (17.3mm), 25% extract concentration (18.1mm) in inhibiting bacteria staphylococcus aureus. Ethanol extract ointment preparations with each concentration have a strong category of inhibition against the Staphylococcus aureus bacteria.
Co-Authors Ade Irma Arafah Nurfadillah Nasrawati Basir Nur Insani Amir Nurlindasari Tenri Ayu Adri Ummu Syauqah Al Musyahadah W, Wahdaniar