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Case Reports on Severe Antituberculosis-Drug Induced Hepatotoxicity in Tuberculosis Patients: The Post-Incidence Therapy Nasrawati Basir; Yulia Yusrini Djabir; Arif Santoso
Nusantara Medical Science Journal Volume 5 No. 1 Januari - Juni 2020
Publisher : Faculty of Medicine, Hasanuddin University.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/nmsj.v5i1.13450

Introduction: The first-line regimen for tuberculosis (TB) treatment comprises Isoniazid, Rifampicin, Pyrazinamide, and Ethambutol. However, these drugs are known to potentially cause hepatotoxicity. This study aimed to evaluate hepatotoxicity incidence in patients during intensive phase of anti-tuberculosis treatment focusing on post-incidence therapy. Methods: The study involved pulmonary TB patients who were admitted to the National Lung Health Center due to hepatotoxicity after receiving fixed-dose combination of antituberculosis drugs (FDC-AT) in September-October 2019. Drug-related hepatotoxicity is defined as an increase in serum alanine aminotransferase (ALT) or aspartate aminotransferase (AST) levels greater than 2.5 times of the normal upper limit (ULN) with an increase in bilirubin level. Results: There were 8 patients admitted to the center due to hepatotoxicity, 4 of them experienced grade 3 (severe) hepatotoxicity, during which the ALT, AST, bilirubin levels increased 5-10 times of the ULN. The post-hepatotoxicity treatment includes the cessation of FDC-AT treatment followed by hepatoprotective supplements. Following two weeks of treatments, the biomarker levels of two out of four patients went back to normal and the AT therapy was resumed. Meanwhile, the other two patients continued to receive the hepatoprotective therapy for up to 8 weeks. However, when the treatment failed to bring the transaminase level back to normal, a different AT regimen was prescribed. Conclusions: The cessation of FDC-AT and the use of hepatoprotective supplements for two to eight weeks were able to alleviate the AT-induced severe hepatotoxicity. A close monitoring of liver biomarkers is warranted to prevent the incidence of hepatotoxicity in patients receiving antituberculosis

Antibacterial Activity Test of Moringa Leaf Ethanol Extract Ointment of Moringa oleifera Lamk. on Staphylococcus aureus Bacteria Miladiarsi; Nasrawati Basir; Nurlindasari; Wahdaniar; Ade Irma
Journal of Health Sciences and Medical Development Vol. 2 No. 01 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i01.222

Staphylococcus aureus is gram-positive bacteria and can cause infections and disorders of the skin. This study aims to determine the physical stability of ointment preparations containing ethanol extract from Moringa leaves based on variations in concentration and antibacterial activity against Staphylococcus aureus. This research is a laboratory experiment with the stages of making an ointment from the ethanol extract of Moringa leaves and testing its antibacterial activity against Staphylococcus aureus. Data analysis using One-Way ANOVA. The results of the research on moringa leaf ethanol extract ointment preparations were physically and chemically stable through organoleptic testing, homogeneity, dispersion, viscosity, and pH by including a cycling test. Antibacterial activity test showed that moringa leaf ointment had antibacterial activity against Staphylococcus aureus with the diameter of the inhibition zone each extract concentration of 15% (16.1mm), 20% extract concentration (17.3mm), 25% extract concentration (18.1mm) in inhibiting bacteria staphylococcus aureus. Ethanol extract ointment preparations with each concentration have a strong category of inhibition against the Staphylococcus aureus bacteria.

Development and Physical Stability Test of Salak Fruit Peel Extract Mouthwash as a Plaque Preventative Nasrawati Basir; Nurfiddin Farid; Sriyanty Sadsyam; Andi Ulfiana Utari; Andi Bibit Utari Rahayu
Journal of Health Sciences and Medical Development Vol. 2 No. 02 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i02.262

The study aims to investigate the formulation and physical stability of salak peel extract mouthwash as a plaque preventer. Salak is a plant from Indonesia with medicinal properties, and its peel is a waste product that contains nutritional values such as protein, carbohydrates, water and low fat. The method used in this study is an experimental laboratory method. The salak peel was extracted through maceration of 96% ethanol and formulated into mouthwash with different concentrations of 5%, 10%, and 15%. The stability of the formulation was tested through organoleptic, pH, specific density, viscosity and clarity tests. The results showed no difference before and after the cycling test in organoleptic, pH, specific density, viscosity, and clarity tests, indicating the physical stability of the formulation.

Antioxidant Evaluation of Facial Toner Formulations Containing Ethyl Acetate Fraction from Garcinia Mangostana L. Fruit using ABTS 2,2'-Azinobis 3-ethyl benzothiazoline 6-sulphonic Acid Method Sriyanty Sadsyam; Nielma Auliah; Wa Ode Wisna Anto Uko; Nasrawati Basir; Andi Ulfiana Utari
Journal of Health Sciences and Medical Development Vol. 2 No. 02 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i02.266

The mangosteen fruit is rich in polyphenols, particularly xanthones, which have potent antioxidant effects. Given the various effects of facial toners and the growing demand for natural skincare products, mangosteen rind may serve as an alternative ingredient in facial toner formulations. This laboratory experimental study aimed to assess the antioxidant activity of facial toner preparations containing the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) using the ABTS method at different concentrations (0.2%, 0.4%, and 0.6%). Four facial toner formulas were formulated, with Formula 1 being the control formula without any active substance and Formulas 2-4 containing the ethyl acetate fraction of mangosteen rind at different concentrations. The prepared formulas underwent physical and chemical stability tests, including organoleptic, homogeneity, pH, viscosity, and humidity tests, before and after six cycles of cycling. The antioxidant activity of the formulas was also evaluated using the ABTS method. The results showed no significant difference (p>0.05) in the organoleptic, viscosity, pH, and humidity tests before and after cycling. Formula 3 showed significant (p<0.05) antioxidant activity compared to the other formulas. Therefore, it can be concluded that the ethyl acetate fraction of mangosteen rind (Garcinia mangostana L.) can be formulated into a facial toner with potent antioxidant activity.

Antioxidant Effectiveness Test on The Formulation of Combination Facial Soap Ingredients of Ethanol Extract Lemon Peel Citrus limon and Forest Honey Apis dorsata Sriyanty Sadsyam; Nasrawati Basir; Arafah Nurfadillah; Nurhikmah Awaluddin; Selviana
NSMRJ: Nusantara Scientific Medical Research Journal Vol. 2 No. 01 (2023): NSMRJ: Nusantara Scientific Medical Research Journal
Publisher : Nusantara Scientific Medical

Citrus limon and Apis dorsata are claimed to have several active compounds namely: alkaloids, flavonoids, tannins and saponins. These compounds are known to have antioxidant activity in preventing skin damage due to free radicals and preventing premature aging. In this study, Citrus limon and Apis dorsata were formulated into facial soap ingredients. The purpose of this study was to find out whether the ethanol extract formulation in the lemon peel and the Apis dorsata forest honey has the effectiveness of antioxidants in preventing the free radicals. This research was an experimental study with physical and chemical evaluation of ingredients. The DPPH test was used to determine the antioxidant activity of the ingredients. This research used three types of formulation of Ethanol Ethanol Extract Formulation were lemon and honey forest, they were : FI (5%: 2%); FII (5%: 3%) and FIII (5%: 4%). The results of the DPPH test respectively were FI 6,16; FII 5,53 and FIII 4.39. The ingredients of Facial Soap Combination of Ethanol Extract Lemon Feel and Apis dorsata had the best antioxidant and antioxidant energy in Formula III with concentration of 5%: 4%

AKTIVITAS ANTIBAKTERI HASIL FRAKSINASI EKSTRAK DAUN BOGENVIL (Bougainvillea spectabilis W.) TERHADAP BAKTERI Streptococcus mutans ATTC 25175 DENGAN METODE KLT BIOAUTOGRAFI: ANTIBACTERIAL ACTIVITY RESULTS OF EXTRACINATION BOGENVIL LEAF (Bougainvillea spectabilis W.) AGAINST Streptococcus mutans ATTC 25175 BACTERIA WITH METHODS TLC BIOAUTOGRAPHY Asti Vebriyanti Asjur; Chikita Inaku; Muhammad Akmal A. Sukara; Nasrawati Basir; Deolindo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.611

Daun Bogenvil (Bougainvillea spectabilis W.) adalah tanaman hias yang sangat bermanfaat karena memiliki kandungan senyawa yang bersifat antibakteri. Kandungan tersebut yang akan digunakan untuk menghambat pertumbuhan bakteri. Karies gigi merupakan penyakit infeksi pada jaringan keras gigi yang disebabkan oleh bakteri khususnya bakteri Streptococcus mutans ATTC 25175 dimana mengubah polisakarida yang melekat pada permukaan gigi menjadi asam dan terjadi kehilangan mineral sehingga permukaan gigi rusak. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri hasil fraksinasi ekstrak daun bogenvil (Bougainvillea spectabilis W.) dengan mengetahui zona hambat yang diperoleh menggunakan metode Kromatografi Lapis Tipis Bioautografi. KLT bioautografi merupakan metode untuk mengidentifkasi senyawa yang bersifat antibakteri dengan memanfaatkan kromatografi lapis tipis. Pengujian aktivitas antibakteri menggunakan lempeng kromatogram hasil elusi dengan pelarut n-butanol : asam asetat : air pada berbandingan 4 : 1 : 5 sebanyak tiga kali perlakuan. Hasil uji aktivitas antibakteri dari fraksi air, n-heksan dan etil asetat daun bogenvil (Bougainvillea spectabilis W.) diperoleh zona hambat tiap perlakuan yaitu pada perlakuan replikasi 1 fraksi air, n- heksan dan etil asetat dengan rerata zona hambat 5,1 mm, 4,2 mm dan 4,4 mm perlakuan replikasi 2 fraksi air, n- heksan dan etil asetat rerata zona hambat 4,93 mm, 3,86 mm dan 3,38 mm dan pada perlakuan replikasi 3 fraksi air, n- heksan dan etil asetat dengan rerata zona hambat 5,06 mm, 4,0 mm dan 4,13 mm. Dari penelitian ini dapat disimpulkan bahwa fraksi air daun bogenvil (Bougainvillea spectabilis W.). ...

AKTIVITAS ANTIBAKTERI HASIL FRAKSINASI EKSTRAK DAUN BOGENVIL (Bougainvillea spectabilis W.) TERHADAP BAKTERI Streptococcus mutans ATTC 25175 DENGAN METODE KLT BIOAUTOGRAFI: ANTIBACTERIAL ACTIVITY RESULTS OF EXTRACINATION BOGENVIL LEAF (Bougainvillea spectabilis W.) AGAINST Streptococcus mutans ATTC 25175 BACTERIA WITH METHODS TLC BIOAUTOGRAPHY Asti Vebriyanti Asjur; Chikita Inaku; Muhammad Akmal A. Sukara; Nasrawati Basir; Deolindo
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.611

Daun Bogenvil (Bougainvillea spectabilis W.) adalah tanaman hias yang sangat bermanfaat karena memiliki kandungan senyawa yang bersifat antibakteri. Kandungan tersebut yang akan digunakan untuk menghambat pertumbuhan bakteri. Karies gigi merupakan penyakit infeksi pada jaringan keras gigi yang disebabkan oleh bakteri khususnya bakteri Streptococcus mutans ATTC 25175 dimana mengubah polisakarida yang melekat pada permukaan gigi menjadi asam dan terjadi kehilangan mineral sehingga permukaan gigi rusak. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri hasil fraksinasi ekstrak daun bogenvil (Bougainvillea spectabilis W.) dengan mengetahui zona hambat yang diperoleh menggunakan metode Kromatografi Lapis Tipis Bioautografi. KLT bioautografi merupakan metode untuk mengidentifkasi senyawa yang bersifat antibakteri dengan memanfaatkan kromatografi lapis tipis. Pengujian aktivitas antibakteri menggunakan lempeng kromatogram hasil elusi dengan pelarut n-butanol : asam asetat : air pada berbandingan 4 : 1 : 5 sebanyak tiga kali perlakuan. Hasil uji aktivitas antibakteri dari fraksi air, n-heksan dan etil asetat daun bogenvil (Bougainvillea spectabilis W.) diperoleh zona hambat tiap perlakuan yaitu pada perlakuan replikasi 1 fraksi air, n- heksan dan etil asetat dengan rerata zona hambat 5,1 mm, 4,2 mm dan 4,4 mm perlakuan replikasi 2 fraksi air, n- heksan dan etil asetat rerata zona hambat 4,93 mm, 3,86 mm dan 3,38 mm dan pada perlakuan replikasi 3 fraksi air, n- heksan dan etil asetat dengan rerata zona hambat 5,06 mm, 4,0 mm dan 4,13 mm. Dari penelitian ini dapat disimpulkan bahwa fraksi air daun bogenvil (Bougainvillea spectabilis W.). ...

Aktivitas Antimitosis dan Identifikasi Golongan Senyawa Aktif Ekstrak Daun Katuk (Sauropus androgynus L. Merr) terhadap Sel Telur Bulu Babi (Tripneustes gratilla Linn.) Doloking, Haeria; Ningsi, Surya; Nasrawati Basir
Jurnal Farmasi UIN Alauddin Makassar Vol 11 No 2 (2023): Jurnal Farmasi Edisi November
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jfuinam.v11i2.45721

Abstract Introduction: Katuk leaves (Sauropus androgynus L.Merr) are a plant that contains a variety of phytochemicals that have the potential to be developed as cancer drugs derived from natural ingredients. Objective: to determine the antimitotic activity of soluble and insoluble ethanol extracts of n-hexane of katuk leaves towards inhibiting cell division. sea urchin (Tripneustus gratilla Linn) eggs and determined the IC50 value of the n-hexane soluble and insoluble fractions, as well as identifying bioactive compounds in the most active Sauropus androgynus fraction. Methods: extraction using 96% ethanol solvent then partitioning using n-hexane solvent using liquid-solid technique. The extract obtained was then tested for its antimitotic effect using sea urchin egg cells. Results: The hexane insoluble extract had antimitotic activity with an IC50 of 0.79 μg/ml and the n-hexane soluble ethanol extract 16.46 μg/ml. Fractionation of the n-hexane insoluble ethanol extract using vacuum liquid chromatography produced 15 fractions which were further divided into subfractions A, B and C. Each subfraction had an IC50 of 2.63 μg/ml, 0.06 μg/ml and 3.98 μg/ml respectively. Conclusion: Fraction B showed the best activity with an inhibition value of 0.06 μg/ml. The results of the identification of bioactive compounds in fraction B showed the presence of phenol, flavonoid, triterpenoid, and steroid compounds. Keywords: cytotoxic, flavonoids, terpenoids, anti-cancer, subfraction

Uji aktivitas sediaan sabun mandi cair ekstrak etanol daun sukun (Artocarpus altilis) terhadap bakteri Staphylococcus aureus Basir, Nasrawati; Wahdaniar, Wahdaniar; Azmi, Nurul
Teknosains Vol 18 No 1 (2024): Januari-April
Publisher : Fakultas Sains dan Teknologi Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/teknosains.v18i1.43677

Staphylococcus aureus merupakan flora mikroba kulit yang dapat menyebabkan penyakit. Sabun mandi dapat mengurangi jumlah bakteri pada kulit dan merupakan surfaktan yang digunakan dengan air guna untuk membersihkan dan melindungi kulit. Selain dapat membersihkan kotoran, sabun juga dapat digunakan untuk menjaga kesehatan kulit dari bakteri. Penelitian ini merupakan eksperimental laboratorium yang bertujuan untuk melihat zona hambat bakteri Staphylococcus aureus. Metode yang digunakan pada penelitian ini adalah difusi sumuran untuk mengetahui diameter inhibisi atau zona hambat. Pengukuran diameter zona hambat menggunakan jangka sorong kemudian dikategorikan zona hambatnya. Hasil penelitian menunjukkan bahwa sabun mandi cair dapat menghambat bakteri S. aureus pada formula F1, F2, dan F3. Konsentrasi yang terbaik dalam menghambat bakteri S. aureus adalah F3 dengan luas zona hambat 20,8 mm diikuti oleh F2 19,3 mm dan F1 17,8 mm.

Exploring the Potent Anti-Hyperglycemic Properties of Red Betel Leaf Ethanol Extract Fraction on Male Wistar Rats Upi, Andi Ulfiana Utari; Aliah, Ahmad Irsyad; Hasniah; Basir, Nasrawati; Sadsyam, Sriyanty
Journal of Health Sciences and Medical Development Vol. 2 No. 03 (2023): Journal of Health Sciences and Medical Development
Publisher : The Indonesian Institute of Science and Technology Research

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56741/hesmed.v2i03.267

Hyperglycemia is characterized by an increase in blood glucose levels exceeding 200 mg/dL, an initial symptom of diabetes mellitus. Hyperglycemia can be addressed through traditional treatment with Red Betel Leaf. Red betel leaf contains phytochemical compounds, including flavonoids. Flavonoid compounds in red betel leaves possess antioxidant properties. These antioxidants can scavenge hydroxyl radicals that damage the β cells of the pancreas, thereby maximizing insulin production. Empirically, the flavonoid content in red betel leaves has been shown to lower blood glucose levels and cure diabetes mellitus. An effectiveness test of the anti-hyperglycemic properties of the ethanol extract fraction of red betel leaf was conducted. This research aimed to determine the effectiveness of the ethanol extract fraction of red betel leaf on male white rats. The method employed in this study was laboratory experimentation. Fifteen rats were divided into five treatment groups: Group I, healthy control without treatment; Group II, negative control with Na.CMC administration; Group III, positive control with glibenclamide administration; Group IV, the polar group with polar extract suspension of red betel leaf administration; Group V, the nonpolar group with nonpolar extract suspension of red betel leaf administration. In conclusion, administering the polar fraction was more effective in reducing blood glucose levels than the nonpolar fraction.

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