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All Journal The Indonesian Biomedical Journal Amerta Nutrition
IRMA RAHAYU LATARISSA, IRMA RAHAYU
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Other

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Membangun Kekebalan Tubuh: Pengetahuan tentang Peran Prebiotik dan Probiotik dalam Kesehatan Anak: Crafting Paediatric Immunity: The Science of Prebiotic, Probiotic, and Synbiotic Roles in Child Health Sutanto, Luciana Budiati; Dilantika, Charisma; Pratiwi, Dessy; Latarissa, Irma Rahayu
Amerta Nutrition Vol. 9 No. 4 (2025): AMERTA NUTRITION (Bilingual Edition)
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v9i4.2025.747-766

Abstract

Background: The gut microbiota affects Children's immune system, which interacts with the immune system to support a healthy body. Prebiotics and probiotics, alongside their combination in the form of synbiotics, have demonstrated significant potential for enhancing immune health in children. Objectives: This article aims to review the role of prebiotics, probiotics, and synbiotics in supporting pediatric immune health by discusses their mechanisms of action, clinical evidence of benefits, and their impact on infection risk reduction, gut health enhancement, and improved vaccine effectiveness. Methods: A comprehensive literature review was conducted by utilizing recent studies and clinical trials on the effects of prebiotics, probiotics, and synbiotics on paediatric immune health. Discussions: Prebiotics, probiotics, and synbiotics play a crucial role in supporting paediatric immune health by optimizing gut microbiota balance and facilitating the production of beneficial metabolites, such as short-chain fatty acids (SCFAs), which subsequently strengthen gut barrier function and modulate immune responses.  Prebiotics provide essential nutrients for beneficial bacteria, probiotics directly interact with immune cells, and synbiotics synergistically combine these benefits, demonstrating effectiveness in reducing infections, enhancing vaccine responses, and preventing allergies. Clinical studies highlight their potential to improve gastrointestinal health, reduce inflammation, and strengthen immunity, emphasizing their importance as safe and effective interventions for children's health. Conclusions: Prebiotics, probiotics, and synbiotics demonstrate significant potential in supporting children's immune health through mechanisms that improve gut microbiota balance and enhance immune function. Despite encouraging findings, additional research is essential to determine optimal dosages, long-term safety, and individualized strategies for their clinical application.
The Impact of Organoid to Assembloid Technology in Biomedical Research Meiliana, Anna; Chouw, Angliana; Askandar, Retina Shyallala; Woran, Blessari Tesalonika; Latarissa, Irma Rahayu; Wijaya, Andi
The Indonesian Biomedical Journal Vol 18, No 2 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i2.4052

Abstract

Organoids, three-dimensional, self-organized structures derived from pluripotent or adult stem cells, have revolutionized biomedical research by overcoming the inherent limitations of traditional 2D cultures and animal models. This review traces the evolution of organoid technology from initial studies to the contemporary "assembloid" phase, examining systemic inter-organ communication. The primary discovery of this review resides in the shift from descriptive modelling to a functional "Comparative Paradigm." A major perspective addressed is the transition from exclusively descriptive modelling to a functional 'Comparative Paradigm.' By merging developmental biology with bioengineering, a systematic framework is created to discover the most clinically relevant models, employing patient-derived 'avatars' to enhance personalized medicine and and high-throughput drug discovery. Ultimately, this review provides a systematic framework for identifying the most clinically applicable models by integrating developmental biology and bioengineering. The lack of vascularization, embryonic immaturity, and batch-to-batch repeatability issues remain major technical obstacles despite their potential. Finally, we explore potential future approaches in bioengineering, including the incorporation of 3D bioprinting, AI-driven imaging, and microfluidics (organ-on-a-chip). Organoid technology is a key component of next-generation medicine because it bridges the gap between "bench and bedside," providing previously unattainable insights into human biology and illness.KEYWORDS: organoids, stem cells, disease modeling, bioengineering, personalized medicine, assembloids, regenerative medicine; organ-on-a-chip, translational manufacturing
Co-Authors ANDI WIJAYA Angliana Chouw, Angliana Anna Meiliana Askandar, Retina Shyallala Dilantika, Charisma Luciana Budiati Sutanto Pratiwi, Dessy Woran, Blessari Tesalonika