Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal JURNAL FARMASIMED (JFM) Jurnal Katalisator
Febriyenti F.
Fakultas Farmasi Universitas Andalas
Agriculture, Biological Sciences & Forestry Chemistry Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
FORMULASI KRIM TABIR SURYA DARI FRAKSI TERPURIFIKASI HERBA Elephantopus mollis Kunth Verawati; Almahdy; Febriyenti; Deddi Prima Putra
JURNAL KATALISATOR Vol. 7 No. 1 (2022): Jurnal Katalisator Volume 7 Nomor 1, April 2022
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (404.448 KB) | DOI: 10.22216/katalisator.v7i1.956

Abstract

Elephantopus mollis Kunth merupakan tumbuhan obat tradisional yang kaya akan komponen polifenol seperti derivat asam kafeat, kaempferol dan rutin yang dapat berperan sebagai tabir surya organik. Penelitian ini bertujuan untuk mengevaluasi potensi tabir surya dari sediaan krim yang mengandung fraksi terpurifikasi dari E. mollis. Fraksi terpurifikasi E. mollis diperoleh melalui serangkaian prosedur ekstraksi dan pemisahan secara kromatografi pada herba E. mollis. Fraksi terpurifikasi yang kaya akan polifenol kemudian diformula menjadi sediaan krimtipe M/A dan dilakukan pengujian stabilitas fisik dan uji penetrasi dengan metode difusi Franz. Aktivitas tabir surya dievaluasi secara invitro menggunakan spektrofotometer UV-Vis. Hasil penelitian menunjukkan bahwa krim fraksi terpurifikasi E. mollis stabil secara fisik pada pengamatan selama 6 minggu dan dapat berpenetrasi dengan baik dimana peningkatan laju penetrasi linier terhadap waktu. Penentuan nilai SPF menunjukkan bahwa sediaan krim fraksi terpurifikasi ini memberikan perlindungan Ultra terhadap sinar UV dengan nilai SPF 17,55. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa fraksi terpurifikasi dari E. mollis memiliki potensi yang sangat bagus untuk dikembangkan sebagai sediaan tabir surya.
Isolation and Structural Analysis of Active Antioxidant Phenolic Compounds from Elephantopus mollis Kunth Verawati Verawati; Almahdy Almahdy; Febriyenti Febriyenti; Deddi Prima Putra
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/a2hcyr24

Abstract

Elephantopus mollis is a common weed found in West Sumatra, known for its diverse traditional uses and rich phytochemical content. This study aimed to isolate phenolic compounds and evaluate the antioxidant activity of the polar extract of E. mollis herb. The polar extract was obtained through successive extraction using solvents of increasing polarity. Separation of the polar extract was carried out using Amberlite XAD-4 resin chromatography with methanol and water eluents, followed by isolation through silica gel column chromatography using a step-gradient polarity elution system. The separation and isolation processes were monitored by thin-layer chromatography (TLC). Total phenolic content was determined by the Folin–Ciocalteu method, while antioxidant activity was assessed using the DPPH radical scavenging assay. Structural identification of the isolated compound was performed using UV-Vis, IR, NMR, and LC-MS spectroscopic techniques. Subfraction D of the polar extract exhibited a high phenolic content of 618.06 ± 3.38 mg GAE /g. From subfraction D, a phenolic compound designated D3a was isolated as a yellowish-white powder (95.30 mg) with an Rf value of 0.64, producing a dark blue color upon reaction with 10% FeCl₃. The antioxidant activity of compound D3a was classified as very strong, with an IC₅₀ value of 12.42 ppm. Based on physicochemical characterization, compound D3a was identified as caffeic acid with a molecular formula of C₉H₈O₄ and a molecular weight of 180.049.
Co-Authors Almahdy Almahdy Almahdy Deddi Prima Putra Verawati