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Riski dwi utami
Departemen Fisiologi, Fakultas Kedokteran, Universitas Abdurrab, Kota Pekanbaru, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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Efektivitas Ekstrak Spirulina platensis terhadap Jumlah Fibroblas pada Tikus yang Dilakukan Insisi pada Kulitnya Riski dwi utami; olvaria misfa; Bimby Irenesia; deinike wanita marwan
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19268

Abstract

Fibroblasts play a role in the wound healing process. The active compound content of Spirulina sp. has fibroblastic activity. The use of extracts from S. platensis can play a role in the wound healing process. To analyze the effectiveness of Spirulina platensis extract on the number of fibroblasts in rats that were incised in their skin. This study used a randomized post test only control group design. Forty-eight male Wistar rats were skin incised and infected with S.aureus divided into 4 groups, namely the group given S.platensis extract at a dose of 500 mg/kgBW/day, a dose of 750 mg/kgBW/day, the negative control group was given saline solution and positive control group with diclofenac 20 mg/kgBW orally. The number of fibroblasts was counted on histopathological examination of the wound tissue on the 7th and 14th days covering 5 visual fields. Data analysis was carried out with a one way ANOVA test and continued with the LSD Post Hoc Test. The mean number of fibroblasts on the 7th day in the 500 mg/kgBW/day group, 750 mg/kgBW/day, positive control and negative control was 13.33 ± 3.615; 117.42±3.980; 9.58±2.417; and 4.00 ± 1.761 with p 0.001. The number of fibroblasts on the 14th day in the 500 mg/kgBW/day, 750 mg/kgBW/day group, positive control and negative control was 16.17 ± 3.251; 19.67±1.633; 12.17±2.137; and 8.33 ± 2.317 with p 0.001. The post hoc test found that the number of fibroblasts on day 7 significantly increased in the 500 mg/kgBB/day S. platensis group compared to the positive and negative control groups. While at a dose of 750 mg/kg/day, the number of fibroblasts was higher than the positive and negative control groups after 14 days of treatment.Administration of Spirulina platensis extract at doses of 500 and 750 mg/kg/day significantly increased the number of fibroblasts in the incision wounds of Wistar rats.
Efektivitas Gel Madu Hutan Akasia terhadap Jumlah Fibroblas pada Luka Sayat Tikus Putih (Rattus novergicus) Bimby Irenesia; puan sadila islami; riski dwi utami
Indonesian Journal of Pharmaceutical Education Vol 3, No 2 (2023): Mei-Agustus 2023
Publisher : Jurusan Farmasi Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/ijpe.v3i2.19872

Abstract

Cuts are wounds caused by sharp objects such as knives, swords, razors and glass. According to data from the Arifin Achmad Regional General Hospital, Riau Province, it was noted that the most common type of wound in sharp violence was a cut (66.7%). When a wound occurs, the wound healing process occurs, namely: inflammation, proliferation, and remodeling. During the proliferative phase, fibroblasts influence the reepithelialization process that closes the wound. Handling cuts using acacia honey because acacia honey in wound healing has anti-inflammatory, antibacterial and antioxidant activities. Knowing the effectiveness of acacia honey gel on the number of fibroblasts in white rat (Rattus novergicus) incision wounds. This type of research is an experimental study design with a randomized posttest only control group design that uses acacia honey on cuts in white rats (Rattus novergicus). There was no significant difference between each treatment group: 20% acacia honey gel, 60% acacia honey gel, 80% acacia honey gel, positive control (povidone iodine) and negative control (gel without honey). Giving acacia honey gel could not increase the number of fibroblasts in white rat (Rattus novergicus) incision wounds.
Co-Authors Bimby Irenesia Marwan, Deinike Wanita olvaria misfa puan sadila islami