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All Journal Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara
Sukma Sahreni
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Humanities Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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HUBUNGAN DIABETES MELITUS TIPE 2 DENGAN STROKE ISKEMIK PADA PASIEN POLIKLINIK SARAF DI RUMAH SAKIT BUDI KEMULIAAN KOTA BATAM TAHUN 2021 Indriasari Indriasari; Sukma Sahreni; Aditya Anugrah Fida Pratama
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 13 No 1 (2023): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v13i1.1153

Abstract

Latar Belakang: Stroke merupakan keadaan dimana ditemukan tanda klinis yang berkembang cepat berupa defisit neurologi fokal dan global, yang dapat memberat dan berlangsung lama selama 24 jam atau lebih dan dapat menyebabkan kematiaan tanpa penyebab lain yang jelas selain vaskuler. Diabetes Melitus tipe 2 merupakan salah satu faktor resiko untuk terjadinya stroke iskemik. Oleh sebab itu, penelitian ini bertujuan untuk melihat hubungan diabetes melitus tipe 2 dengan stroke iskemik. Metode: Penelitian ini merupakan penelitian observasional analitik dengan rancangan penelitian Case Control. Penelitian ini dilakukan di Poliklinik Saraf RSBK Batam Tahun 2021. Populasi kasus dalam penelitian ini adalah seluruh pasien Stroke Iskemik. Teknik pengambilan sampel yaitu Purposive Sampling dengan 60 kasus dan 60 control. Peneliti mengamati data rekam medik pasien, dan uji analisis data menggunakan chi-square. Hasil: Hasil analisis Hubungan Diabetes Melitus tipe 2 dengan Stroke Iskemik Pada Pasien Poliklinik Saraf di RSBK Batam Tahun 2021, dari 60 pasien stroke iskemik terdapat 45 pasien menderita diabetes melitus tipe 2 sedangkan dari 60 pasien tidak stroke iskemik terdapat 26 pasien menderita diabetes melitus tipe 2. Hasil uji chi-square diketahui adanya hubungan antara diabetes melitus tipe 2 dengan stroke iskemik dengan p value : 0,000 dimana nilai p <0,05 dan OR = 3,9. Simpulan: Berdasarkan hasil penelitian ini dapat disimpulkan bahwa terdapat Hubungan Diabetes Melitus tipe 2 dengan Stroke Iskemik Pada Pasien Poliklinik Saraf di Rumah Sakit Budi Kemuliaan Kota Batam Tahun 2021.
Pengaruh Esktrak Daun Krokot (Portulaca oleracea) Terhadap Kadar Malonialdehide (MDA) Pada Tikus Yang Diinduksi Aloksan Sukma Sahreni; Isramilda Isramilda; Rezha Irshadi Ashari
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 2 No. 1 (2023): April :Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v2i1.1920

Abstract

Background: Diabetes mellitus is a degenerative disease caused by the pancreas being damaged in production or insulin cannot work effectively. Portulaca Oleracea Leaf Extract can help reduce levels of Malondialdehyde. The purpose of this study was to analyze the effect of Portulaca Oleracea leaf extract on malondialdehyde levels in alloxan-induced rats as a diabetes model.Methods: There were 30 rats in this study divided into 5 groups, each group consisting of 6 rats. The negative control group was only given aquadest and standard rat feed, the positive group was induced with alloxan, the treatment group 1 was induced with alloxan and Portulaca Oleracea leaf extract at a dose 60 mg/200grBW, treatment group 2 was induced with alloxan and Portulaca Oleracea leaf extract at a dose 90 mg/200grBW and treatment group 3 was induced by alloxan and Portulaca Oleracea leaf extract at a dose 110 mg/200grBW rats. Analysis of the results used the One Way Anova test followed by Post Hoc LSD analysis to see differences between groups.Results: The results of One Way Anova test on Malondialdehyde levels showed that there was an effect after intervention of Portulaca Oleracea leaf extract among the five treatment groups p = 0.000. The results of Post Hoc LSD test showed that Portulaca Oleracea leaf extract had effective inhibits the formation of malondialdehyde activity at a dose of 90 mg/200grBB p = 0.145.Conclusion: It can be concluded that Portulaca Oleracea leaf extract can reduce Malondialdehyde levels.
Pengaruh Esktrak Daun Krokot (Portulaca Oleracea) Terhadap Kadar Gula Darah Pada Tikus Yang Diinduksi Aloksan Sukma Sahreni; Kasih Purwati; Dicky Pratama
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 1 No. 2 (2022): Oktober :Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v1i2.1923

Abstract

Background: Diabetes mellitus (DM) is a degenerative disease caused by damage to the pancreas in production or insulin cannot work effectively. Purslane Leaf Extract (Portulaca Oleracea) can help lower blood sugar levels. The purpose of this study was to analyze the effect of purslane leaf extract (Portulaca Oleracea) on blood sugar levels in alloxan-induced rats as a diabetes model.Methods: The rats in this study were 30 rats divided into 5 groups, each group consisting of 6 rats. The negative control group was only given aquadest and standard rat feed, while the other group was induced with 35 mg/200gBW of alloxan. The positive group was treated with standard rat diet, treatment group 1 was given purslane leaf extract at a dose of 60 mg/200grBB, treatment group 2 was given purslane leaf extract at a dose of 90 mg/200grBB and treatment group 3 was given purslane leaf extract at a dose of 110 mg/200grBW rats. Analysis of the results used the Kruskall Wallis test followed by Post Hoc Mann Whitney analysis. Results: The results of the Kruskal Wallis test on blood sugar levels showed that there was an effect after administration of purslane leaf extract among the five treatment groups p= 0.000 (p<0.05). The results of the Mann Whitney test showed that purslane leaf extract had effective antidiabetic at a dose 60 mg/200grBB p= 0.011 (p<0.05).Conclusion: Based on the results of this study, it can be concluded that purslane leaf extract can reduce blood sugar levels.
PENGARUH EKSTRAK DAUN KEMANGI (Ocimum sanctum) TERHADAP KADAR KREATININ TIKUS PUTIH (Rattus norvegicus strain wistar) YANG DIINDUKSI MONOSODIUM GLUTAMATE (MSG) Sukma Sahreni; Hanny Mindasari; Siti Nurfitri Anugrah Bintani
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 14 No 2 (2024): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v14i2.1535

Abstract

Background: Acute Kidney Injury (AKI) is defined as a sudden impairment of kidney function. The main indicator of the severity of AKI is an increase in creatinine levels. One substance that can cause oxidative stress and damage the kidney system is Monosodium glutamate (MSG). MSG at a dose of 4,8g/kgBB was proven to cause damage to the kidneys of mice. Flavonoids found in plants function as natural antioxidants with their ability to ward off free radical molecules. One of these plants is basil leaves (Ocimum sanctum). The aim of this research was to determine the effect of basil leaf extract on creatinine levels in white mice induced by Monosodium glutamate (MSG). Methods: The rats in this study totaled 25, divided into 5 groups: negative control (received aquadest and standard rat feed), positive control (received MSG at 4.8g/kg body weight for 14 days), and three treatment groups (MSG + basil leaf extract at doses of 700 mg/kg body weight, 1,050 mg/kg body weight, and 1,400 mg/kg body weight for 10 days). Data analysis was conducted using One Way Anova followed by Post Hoc Tamhane test. Results: The results of the One Way Anova test on creatinine levels showed that there was an effect after administering basil leaf extract among the five treatment groups, p = 0.000. The results of the Post Hoc Tamhane test showed that basil leaf extract had the activity of inhibiting the formation of creatinine levels which was effective at a dose of 1,050 mg/kgBW p = 0.011. Conclusion: Based on the research results, it can be concluded that basil leaf extract can reduce creatinine levels induced by Monosodium glutamate (MSG). Keywords: Basil Leaf Extract, Creatinine, Monosodium glutamate, Acute Kidney Injury
UJI EFEKTIVITAS ANTIBAKTERIEKSTRAK JAHE MERAH (Zingiber Officinale Var. rubrum) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus Aureus SECARA IN VITRO Isramilda; Sukma Sahreni; Salamatun Nisa
Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam Vol 14 No 3 (2024): Zona Kedokteran: Program Studi Pendidikan Dokter Universitas Batam
Publisher : Universitas Batam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37776/zked.v14i3.1546

Abstract

Latar Belakang : Staphylococcus aureus merupakan bakteri patogen oportunistik yang dapat ditemukan di permukaan kulit dan permukaan mukosa di beberapa organ manusia. Jahe merah (Zingiber officinale. var rubrum) mengandung senyawa Flavonoid, Fenol, Terponoid, dan Minyak astiri yang dapat menghambat pertumbuhan bakteri. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak jahe merah dengan konsentrasi 60%, 80%, dan 100% terhadap pertumbuhan bakteri Staphylococcus aureus. Metode : Penelitian ini adalah penelitian eksperimental menggunakan rancangan secara acak dengan tes dan kelompok kontrol (The Randomized Posttest Only Control Group Design). Ekstrak jahe merah diperoleh melalui metode maserasi yang direndam pelarut etanol 95%. Untuk mengetahui efektivitas ekstrak jahe merah terhadap pertumbuhan bakteri Staphylococcus aureus dilakukan uji in vitro dengan metode difusi cakram. Hasil : Hasil uji efektivitas ekstrak jahe merah terhadap Staphylococcus aureus menunjukkan adanya zona bening di sekitar kertas cakram yang menandakan terhambatnya pertumbuhan bakteri dengan konsentrasi yang paling efektif adalah 80%. Kesimpulan : Berdasarkan hasil penelitian ini diketahui bahwa Ekstrak jahe merah efektif dalam menghambat pertumbuhan Staphylococcus aureus. Kata kunci : Uji Efektivitas Antibakteri, Jahe Merah (Zingiber Officinale Var. rubrum), Pertumbuhan Bakteri Staphylococcus aureus.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN SINGKONG (MANIHOT ESCULENTA) TERHADAP PERTUMBUHAN STAPHYLOCOCCUS AUREUS DAN ESCHERICHIA COLI Sukma Sahreni; Isramilda; Miftahuliah Rohima Sururi
Ibnu Sina: Jurnal Kedokteran dan Kesehatan - Fakultas Kedokteran Universitas Islam Sumatera Utara Vol. 19 No. 1 (2020): Januari 2020
Publisher : Faculty of Medicine Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (105.916 KB) | DOI: 10.30743/ibnusina.v19i1.11

Abstract

Daun singkong (Manihot esculenta) merupakan salah satu bahan alam yang dimanfaatkan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun singkong (Manihot esculenta) terhadap S. aureus dan E. coli. Penelitian ini merupakan penelitian dengan desain post test only control group. Ekstrak etanol daun singkong dibuat dengan metode ekstraksi maserasi. Sampel terdiri dari 5 kelompok perlakuan yaitu ekstrak etanol daun singkong konsentrasi 75%, 80%, 85%, kontrol positif (Chloramphenicol) dan kontrol negatif (DMSO). Hasil pengamatan akan dianalisis menggunakan analisis varians (ANOVA). Ekstrak etanol daun singkong (Manihot esculenta) menghasilkan zona bening disekitar cakram yang diartikan adanya daya hambat dengan mengukur diameternya, Hasil uji Oneway pada S. aureus dan E. coli menunjukkan nilai signifikan 0,000 (<0,05) dan kemudian dilanjutkan dengan uji LSD menunjukan adanya perbedaan signifikan pada setiap kelompok perlakuan. Berdasarkan hasil penelitian ini dapat disinpulkan bahwa ekstrak etanol daun singkong (Manihot esculenta) dapat menghambat pertumbuhan bakteri S. aureus dan E. coli.
Co-Authors Aditya Anugrah Fida Pratama Dicky Pratama Hanny Mindasari Indriasari Indriasari Isramilda, Isramilda Kasih Purwati Miftahuliah Rohima Sururi Rezha Irshadi Ashari Salamatun Nisa Siti Nurfitri Anugrah Bintani