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All Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Jurnal Teknologi Laboratorium Medik Borneo
Muhammad Fahmi Aminuddin
ITKES Wiyata Husada Samarinda
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Korelasi Feritin dengan Sitokin Proinflamasi pada Pasien Talasemia Beta Di Kota Samarinda Kalimantan Timur Muhammad Fahmi Aminuddin; Anton Budhi Darmawan; Lantip Rujito
Majalah Kedokteran Indonesia Vol 72 No 2 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.2-2022-608

Abstract

Introduction: Ferritin is a routine parameter used in the evaluation of iron overload in thalassemia patients. Excess iron causes the formation of ROS, resulting in an oxidative reaction that triggers inflammation. This study aims to determine the correlation of ferritin levels with proinflammatory cytokines in beta thalassemia. Methods: A cross-sectional analytical study was conducted on 33 beta thalassemia patients who received routine blood transfusions at I.A. Moeis Samarinda. Spearman rank correlation test was used to determine the correlation between ferritin and TNF-α and IL-6. Results: The results of this study showed that there was no relationship between ferritin and TNF- (p=0.580) and IL-6 (p=0.924). Meanwhile, there was a significant relationship between TNF- and IL-6 (p less than 0.0001) which had a strong positive correlation (r=0.621). Conclusion: This study showed that there was no correlation between ferritin levels with TNF-α and IL-6. Meanwhile, proinflammatory cytokines showed a correlation between TNF-α and IL-6 in thalassemia patients in Samarinda City.
Evaluasi Kualitas Pemeriksaan Liquor Cerebrospinalis pada Tahap Pra-Analitik, Analitik, dan Pasca-Analitik di Laboratorium Patologi Klinik: Quality Evaluation of Cerebrospinal Fluid Examination at the Pre-Analytical, Analytical, and Post-Analytical Stages in the Clinical Pathology Laboratory Rinda Aulia Utami; Muhammad Fahmi Aminuddin; Maya Tamara Mawardani; Devi Imelia; La Ode Marsudi
Jurnal Teknologi Laboratorium Medik Borneo Vol. 5 No. 2 (2025): Jurnal Teknologi Laboratorium Medik Borneo
Publisher : Institut Teknologi Kesehatan dan Sains Wiyata Husada Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35728/jutelmo.v5i2.2197

Abstract

Background: Cerebro Spinalis Fluid (CSF) examination can help establish a diagnosis of diseases affecting the central nervous system, including meningitis, increased WBC count, polymorphonuclear ions, and mononuclear ions. Color and clarity examinations are interrelated, and can also detect increased protein in the fluid. Purpose : To determine and observe the techniques and steps of CSF examination. Procedure: Observations were conducted on January 6th – February 6th, 2025 at the Clinical Pathology Laboratory of Abdoel Wahab Sjahranie Regional Hospital, Samarinda. Methods: This type of research is quantitative and uses descriptive analytical methods. Results: This observation obtained 15 samples, the quality of examination at the pre-analytical, analytical, and post-analytical stages was generally good. All samples were accepted and processed according to procedure at the pre-analytical stage. At the analytical stage, protein testing showed 40% positive and 60% negative results with a predominance of mononuclear cells, and no discrepancies were found between parameters. At the post-analytical stage, recording and reporting of results were carried out accurately according to procedure. Conclusion: The CSF examination system in the laboratory has met the basic principles of quality control, but still requires regular evaluation and monitoring to maintain and improve service quality.
Evaluasi Kinerja Pemeriksaan Kolesterol Berdasarkan Pemantapan Mutu Internal di Laboratorium Klinik Pratama Kota Samarinda: Performance Evaluation of Cholesterol Examination Based on Internal Quality Control at Pratama Clinical Laboratory in Samarinda City Muhammad Fahmi Aminuddin; Hendrikus Fabianus
Jurnal Teknologi Laboratorium Medik Borneo Vol. 6 No. 1 (2026): Jurnal Teknologi Laboratorium Medik Borneo
Publisher : Institut Teknologi Kesehatan dan Sains Wiyata Husada Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35728/fd6n0n14

Abstract

Pemeriksaan kolesterol merupakan pengujian laboratorium dengan tingkat permintaan yang tinggi, tercatat sebanyak 497 pemeriksaan pada bulan Mei hingga Agustus 2023 di Laboratorium Klinik Pratama di Kota Samarinda. Pelaksanaan pemantapan mutu internal sangat penting untuk menjamin hasil laboratorium yang presisi dan akurat agar penatalaksanaan klinis pasien tepat sasaran. Penelitian ini bertujuan untuk mengevaluasi kinerja analitik pemeriksaan kolesterol melalui analisis akurasi, presisi, serta evaluasi grafik Levey-Jennings menggunakan aturan Westgard Multirule. Desain penelitian ini adalah deskriptif kuantitatif dengan menggunakan data sekunder hasil kontrol kualitas harian parameter kolesterol (level low dan high) pada instrumen otomatis Mindray BS-240 periode Mei–Agustus 2023. Hasil penelitian menunjukkan bahwa nilai akurasi (bias) berada pada rentang yang baik pada bulan Mei hingga Juni, namun pada bulan Juli nilai melebihi batas maksimal (±4,1%) pada level low sebesar -6,12%. Nilai presisi menunjukkan hasil yang baik, ditandai dengan tidak adanya nilai Koefisien Variasi (KV) yang melebihi batas maksimal (±6%) secara berturut-turut selama periode pengamatan. Evaluasi grafik Levey-Jennings menemukan adanya status peringatan dengan pelanggaran aturan 12s pada bulan Mei dan Juni, serta pelanggaran aturan 41s dan 10x pada bulan Juli yang mengindikasikan terjadinya kesalahan sistematik. Pada bulan Agustus, grafik kembali normal dan tidak ditemukan pelanggaran. Kesimpulan dari penelitian ini menunjukkan bahwa tingkat presisi pemeriksaan sangat stabil, namun sempat terjadi penyimpangan akurasi akibat kesalahan sistematik pada bulan Juli yang membutuhkan tindakan korektif sebelum akhirnya berhasil distabilkan kembali pada bulan Agustus
Co-Authors Anton Budhi Darmawan Devi Imelia Hendrikus Fabianus La Ode Marsudi Lantip Rujito Maya Tamara Mawardani Rinda Aulia Utami