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All Journal Jurnal Farmasi Indonesia
Dhigna Luthfiyani Citra Pradana
Pharmacology and Clinical Pharmacy Department, Medical Faculty, Universitas Pembangunan Nasional Veteran Jakarta
Medicine & Pharmacology

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The relationship of secretory phospholipase A2 type IIA levels with glomerulus filtration rate in type 2 DM patients Nadifa Kartika Dewi; Mila Citrawati; Dhigna Luthfiyani; Harli Amir Mahmudji
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (378.923 KB) | DOI: 10.35617/jfionline.v12i1.51

Abstract

Phospholipase/sPLA2 type IIA is a mediator that connects the pathogenesis of diabetes and its complications. Diabetic nephropathy is the most frequent microvascular complication, with albumin urine and changes in glomerular filtration rate. This study aimed to discover the relation between sPLA2 type IIA levels in diabetic patients with glomerular filtration rate (GFR). This study used the crossectional method in 62 samples in RSJ. Prof. Dr. Soerojo Magelang. Sampling was done by total sampling, and medical records were used as an instrument. This research was conducted in patients with sPLA2 type IIA levels and had complete laboratory examination data in 2016. The results showed that the level of sPLA2 type IIA was very high in diabetic patients, and GFR was below standard. Pearson correlation analysis showed no significant correlation between type IIA sPLA2 and GFR (p=0.318), with a positive but weak correlation (r=0.129) with the diabetic duration of 8 years. Pearson correlation analysis was conducted in 21 samples in which GFR values were ≤60 (p=0.0712), resulting in a negative direction (r=-0.086) with a diabetes duration of 11 years. It was shown that diabetic patients with increased levels of sPLA2 type IIA and more extended periods of diabetes would affect the decrease in GFR value.
Monitoring efek samping obat antituberkulosis fase intensif dan lanjutan pasien dewasa tuberkulosis di RSUD Kota Bandung Siti Thannisa Aisiyah Gumanti; Dhigna L. C. P.; Via Rifkia
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 12 No. 1 (2020): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (362.707 KB) | DOI: 10.35617/jfionline.v12i1.52

Abstract

Tuberculosis is an infectious disease caused by the bacterium Mycobacterium tuberculosis which can be transmitted through sputum splashes. The use of antituberculosis drugs can cause a variety of side effects depending on the duration of TB treatment. Based on TB treatment conditions that have a long duration of drug administration and many types of drugs, there will be a high risk of side effects or toxicity. The purpose of this study was to determine the description of side effects arising from TB drugs at the Bandung City Hospital and the factors causing the incidence of side effects during TB treatment. This research method the author uses a descriptive observational method with a cross sectional approach. The sampling technique uses purposive sampling based on inclusion criteria with a minimum sample of 34 and excursion criteria for TB patients with sepsis complications. The results of the comparative test obtained a p-value of 0.549 > 0.05 which showed that there was no significant difference between the side effects of the drug that arose in new patients and relapse patients.
Co-Authors Harli Amir Mahmudji Mila Citrawati Nadifa Kartika Dewi Siti Thannisa Aisiyah Gumanti Via Rifkia