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The difference of matrix metalloproteinase-9 level in saliva between myofascial pain and disc displacement of temporomandibular joint disorders Rafni, Elita; Y., Yanwirasti; Darwin, Eriyati; Rikmasari, Rasmi
Padjadjaran Journal of Dentistry Vol 29, No 2 (2017): July
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Introduction: Saliva is the type of liquid which contains enzyme, hormone, antibody, constituent microbe, and cytokines. Matrix metalloproteinase-9 (MMP-9) is one kind of proteolysis cellular enzyme in saliva that has a role in inflammation. Saliva is very easy to take and noninvasive treatment, proved efficient for early diagnosis. The purpose of this research was to study the difference MMP-9 level in saliva patient with temporomandibular joint disorders between myofascial pain and disc displacement. Methods: Cross sectional comparative study. The research was carried out at the Prosthodontics Clinic of Arifin Achmad Pekanbaru Hospital and at Biomedical Laboratory of Faculty of Medicine, Universitas Andalas Padang, Indonesia. The saliva samples were taken from 37 myofascial pain patients and 37 disc displacement patients. MMP-9 levels were examined by the Elisa and the data result was analyzed using the t-test. Result: The average value of MMP-9 level of disc displacement was 650.98Â±384.94 pg/mL and myofascial pain was 168.70Â±41.24 pg/mL. There was a significant difference on MMP-9 level in saliva between myofascial pain and disc displacement (p<0.05). Conclusion: The MMP-9 level in saliva of patients with disc displacement of temporomandibular joint disorders was higher than patients with myofascial pain.

PERBEDAAN KADAR INTERLEUKIN-1Î² SALIVA ANTARA PENDERITA MYOFASCIAL PAIN DENGAN DISC DISPLACEMENT SENDI TEMPOROMANDIBULA Rafni, Elita; Yanwirasti, Yanwirasti; Darwin, Eriyati; Rikmasari, Rasmi
Dentika: Dental Journal Vol. 19 No. 1 (2016): Dentika Dental Journal
Publisher : TALENTA

Gangguan sendi temporomandibula dapat terjadi karena peradangan neurogenik yang banyak melibatkan sitokin. Pada penderita gangguan sendi temporomandibula dengan keluhan nyeri ditemukan adanya substansi algogenik prostaglandin dan lukotrien sebagai mediator nyeri dan inflamasi. Prostaglandin berasal dari asam arakidonat yang berubah menjadi PGE2 karena aktivitas Cox2 yang diinduksi oleh sitokin IL-1Î². Saliva merupakan cairan yang mengandung hormon, antibodi, konstituent mikroba, dan sitokin seperti yang terdapat dalam darah. Penelitian ini dilakukan untuk melihat perbedaan kadar IL-1Î² pada penderita myofascial pain dan disc displacement sendi temporomandibula. Penelitian ini menggunakan metode cross sectional comparative. Variabel dependen dan independen diperiksa secara bersamaan. Penelitian ini dilakukan di Poliklinik Prostodonsia Rumah Sakit Arifin Ahmad Pekanbaru dan Laboratorium Biomedik Fakultas Kedokteran Universitas Andalas Padang. Pemeriksaan sampel saliva dilakukan pada 37 penderita myofascial pain dan 37 penderita disc displacement. Kadar IL-1Î² diperiksa dengan Elisa dan data dianalisis dengan t test. Berdasarkan uji statistik Kolmogorov Smirnov ditemukan bahwa data terdistribusi normal baik pada kelompok gender (p =0,772) maupun kelompok umur (p =1,000). Rerata nilai kadar IL-1Î² penderita myofascial pain adalah 0,22 Â± 0,18 nm/L dan penderita disc displacement adalah 0,57 Â± 0,45 nm/L. Hasil analisis t-test menunjukkan terdapat perbedaan kadar IL-1Î² saliva yang signifikan antara penderita myofascial pain dan disc displacement p =0,01 (p<0,05). Sebagai kesimpulan bahwa kadar IL-1Î² lebih tinggi pada disc displacement dibandingkan myofascial pain.

Bakteri Penyebab Gingivitis dan Sensitivitas Antibiotik Pada Pasien Diabetes Melitus Endriani, Rita; Rafni, Elita; Nabila, Hanifah Farah; Berlianti, Monica Putri; Alhadi, Dio Arif
Jurnal Ilmu Kedokteran Vol 18, No 2 (2024): Jurnal Ilmu Kedokteran
Publisher : Fakultas Kedokteran Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26891/JIK.v18i2.2024.144-149

Gingivitis is an inflammation of the gingiva caused by plaque and poor oral hygiene, including in patients with long-term diabetes mellitus and uncontrolled blood glucose. Gingivitis is caused by various bacteria such as Streptococcus sp, Staphylococcus aureus, Enterococcus faecalis, Streptococcus pneumoniae, Streptococcus pyogenes, Neisseria meningitidis and also the Enterobacteriaceae family, Haemophilus influenzae and Actinomycetes. Management of infection with antibiotics, especially beta-lactam class. The study aimed to determine the characteristics of the research subjects, the type of bacteria, and their sensitivity to the bacteria that cause gingivitis in diabetes mellitus (DM) patients. The research was a cross-sectional descriptive study at the internal medicine polyclinic at Arifin Achmad Hospital, Riau Province, and the Microbiology Laboratory of Medical Faculty, Universitas Riau. The research sample was a gingivitis plaque swab in DM patients who signed an informed consent. Samples were cultured, identified, and tested for antibiotic sensitivity. The results of the study obtained 34 samples with characteristics aged 33-67 years, most of them were women, high school education/equivalent, civil servants/army/police/retired. Most aerobic bacteria Klebsiella sp. The highest sensitivity to levofloxacin, amikacin, ciprofloxacin, trimethoprim-sulfamethoxazole, and meropenem, the lowest sensitivity to amoxicillin, ceftazidim, and amoxicillin-clavulanic acid.

Bacterial profile and antibiotic sensitivity in silk sutures following odontectomy Endriani, Rita; Rafni, Elita; Prakoso, Agung; Prima, Wahyu; Hadi, Farhan; Alni, Azzahra Dwi; Dwideta, Vezi Adina
Dental Journal (Majalah Kedokteran Gigi) Vol. 58 No. 2 (2025): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v58.i2.p128-134

Background: Impacted teeth, hindered from erupting normally due to space constraints, obstruction by neighboring teeth, or an abnormal eruption pathway, often necessitate surgical intervention known as odontectomy. Silk sutures are commonly used in this procedure, yet they may serve as sites for bacterial colonization, potentially leading to infection. Following odontectomy, antibiotics are typically prescribed. Purpose: This study aims to identify the bacterial profile adhering to silk sutures and analyze antibiotic sensitivity patterns in patients undergoing odontectomy. Methods: A descriptive study employing consecutive sampling of patients after odontectomy was conducted between May and November 2021 at Arifin Achmad General Hospital, Riau Province, Indonesia. Sutures were removed within 14 days of surgery, after which the silk was identified and subjected to antibiotic sensitivity testing using the Kirby–Bauer method. Results: Of the bacteria detected in the silk sutures, 53.7% were Gram positive, including Streptococcus sp. (33.3%) and Staphylococcus aureus (13%), and 46.3% were Gram negative, such as Enterobacter sp. (20.4%) and Klebsiella sp. (16.7%). Among the multi-resistant strains, methicillin-resistant S. aureus (MRSA) accounted for 57.1%. The Gram-positive bacteria exhibited the highest sensitivity to levofloxacin, whereas the Gram-negative bacteria showed sensitivity to ceftazidime, levofloxacin, and meropenem. Conclusion: The most dominant Gram-positive bacteria were Streptococcus sp. and S. aureus, whereas the most dominant Gram-negative bacteria were Enterobacter sp. and Klebsiella sp. Levofloxacin, ceftazidime, and meropenem emerged as the most effective antibiotics following odontectomy. Multidrug-resistant bacteria, exemplified by MRSA, were identified within the oral cavity.

The difference of matrix metalloproteinase-9 level in saliva between myofascial pain and disc displacement of temporomandibular joint disorders Rafni, Elita; Y., Yanwirasti; Darwin, Eriyati; Rikmasari, Rasmi
Padjadjaran Journal of Dentistry Vol 29, No 2 (2017): July 2017
Publisher : Universitas Padjadjaran

Introduction: Saliva is the type of liquid which contains enzyme, hormone, antibody, constituent microbe, and cytokines. Matrix metalloproteinase-9 (MMP-9) is one kind of proteolysis cellular enzyme in saliva that has a role in inflammation. Saliva is very easy to take and noninvasive treatment, proved efficient for early diagnosis. The purpose of this research was to study the difference MMP-9 level in saliva patient with temporomandibular joint disorders between myofascial pain and disc displacement. Methods: Cross sectional comparative study. The research was carried out at the Prosthodontics Clinic of Arifin Achmad Pekanbaru Hospital and at Biomedical Laboratory of Faculty of Medicine, Universitas Andalas Padang, Indonesia. The saliva samples were taken from 37 myofascial pain patients and 37 disc displacement patients. MMP-9 levels were examined by the Elisa and the data result was analyzed using the t-test. Result: The average value of MMP-9 level of disc displacement was 650.98±384.94 pg/mL and myofascial pain was 168.70±41.24 pg/mL. There was a significant difference on MMP-9 level in saliva between myofascial pain and disc displacement (p<0.05). Conclusion: The MMP-9 level in saliva of patients with disc displacement of temporomandibular joint disorders was higher than patients with myofascial pain.

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