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Noni Novisari Soeroso
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Health Professions Medicine & Pharmacology Public Health

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Deciphering the Coagulation Factors in Pulmonary Embolism Incident-Based Thorax Enhanced Chest CT in COVID-19 Patient Wan Betty Pratiwi; Noni Novisari Soeroso; Setia Putra Tarigan; Muntasir Abdullah; Rosita Juwita Sembiring; Azizah Ghanie Icksan; Netty Delvrita Lubis; Putri Chairani Eyanoer
Jurnal Respirasi Vol. 9 No. 2 (2023): May 2023
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v9-I.2.2023.93-100

Abstract

Introduction: Pulmonary embolism is associated with coagulopathy in COVID-19. It is one of the causes of death in COVID-19 cases and is often underdiagnosed in Indonesia because computed tomography-pulmonary angiography (CTPA) is not used as the gold standard. T Methods: This study used a prospective analytical design with a cross-sectional approach. The study participants were 45 COVID-19 patients admitted to Santa Elisabeth Hospital, Medan, from January to March 2021.  Patients were identified with moderate to severe degrees of COVID-19 and elevated D-dimer and subsequently instructed to undergo a thorax CT scan with IV contrast. The data was analyzed using dependent t-test statistical analysis. The p-value < 0.05 was noted as significant. Results: Moderate to severe coagulation factor values in COVID-19 patients with mean + SD PT, APTT, D-dimer, fibrinogen, and platelets were 14.11; 30.65; 1172.14; 423.56 and 215.822, respectively. In this study, 22 (48.9%) patients experienced a pulmonary embolism, while the other 23 (51.1%) did not. No significant correlation was found between all coagulation factors and embolism (p > 0.05). The mean + SD well score for pulmonary embolism was 0.23 + 0.57. Conclusion: Pulmonary embolism was detected in 22 patients (48.49%) with moderate to severe COVID-19 who developed hypercoagulation as indicated by the thorax CT scan with IV contrast. This case was quite common. In resource-constrained situations, a thorax CT scan with IV contrast may replace CTPA in diagnosing/detecting the presence of pulmonary embolism.
Assessment of Heavy Risk Factor Association with Lung Cancer Risk Using Questionnaire-Based Screening: A Cross-Sectional Study at Medan Johor Public Health Center, Medan, Indonesia Muhammad Azka Auliya; Noni Novisari Soeroso; Rina Amelia; Dina Arwina Dalimunthe; Darren Wan-Teck Lim
Jurnal Respirasi Vol. 12 No. 1 (2026): January 2026
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v12-I.1.2026.6-12

Abstract

Introduction: Lung cancer remains a major public health concern in Indonesia, characterized by high morbidity and mortality rates. Effective prevention and management strategies necessitate the accurate identification of lung cancer risk factors. The questionnaire was developed and validated as a screening tool to evaluate risk factors and generate lung cancer risk scores. This study aimed to assess the questionnaire’s utility for identifying lung cancer risk factors and categorizing risk levels among individuals at the Medan Johor Public Health Center, Medan, Indonesia. Methods: This study enrolled 180 subjects who met the inclusion criteria. These subjects were part of the population, specifically non-lung-cancer patients at the Medan Johor Public Health Center in Medan, Indonesia. A cross-sectional analytic design was used to examine the correlation between risk factors and risk levels. Results: Among 180 lung cancer patients screened, the tool classified most individuals into moderate- to high-risk strata and showed significant between-group differences for most risk factors (p<0.05). In addition, the Kenali Paru (NARU) screening tool is accessible, reproducible, and cost-effective, using a 14-item multiple-choice format (2-3 options per item) with weighted scoring that converts responses into a total risk score. Conclusion: The questionnaire demonstrates its effectiveness as a screening tool for identifying lung cancer risk factors and stratifying risk levels. Nevertheless, refinement is necessary to address its limitations, including the addition of tailored questions for sub-populations with specific comorbidities or health conditions.
Co-Authors Azizah Ghanie Icksan Darren Wan-Teck Lim Dina Arwina Dalimunthe Muhammad Azka Auliya Muntasir Abdullah Netty Delvrita Lubis Putri Chairani Eyanoer, Putri Chairani Rina Amelia Rosita Juwita Sembiring Tarigan, Setia Putra Wan Betty Pratiwi