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All Journal Jurnal Biogenerasi BIO-CONS: Jurnal Biologi dan Konservasi
Leni Widiarti, Leni
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Agriculture, Biological Sciences & Forestry Decision Sciences, Operations Research & Management Education Energy Languange, Linguistic, Communication & Media Other

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PENGARUH PEMBERIAN EKSTRAK ETANOL BUAH AREN (Arenga pinnata Merr.) TERHADAP KADAR KREATININ, UREUM DAN HISTOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) Awaliah Sifa, Nurharija; Febriani, Husnarika; Widiarti, Leni
Jurnal Biogenerasi Vol. 10 No. 2 (2025): Volume 10 no 2 periode februari - september 2025 ( continues)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v10i2.5637

Abstract

One substance that produces radical compounds is carbon tetrachloride (CCl4). As a solvent, insecticide, coolant, stain remover, and soap, carbon tetrachloride is widely used. Direct skin contact, ingestion, inhalation, and eye contact are ways this material enters the body. The antioxidants found in palm fruit (Arenga pinnata Merr.) can help protect against damage caused by free radicals. This study aims to determine how giving ethanol extract of palm fruit (Arenga pinnata Merr.) to white rats (Rattus norvegicus L.) affects creatinine, urea levels and kidney histology when exposed to carbon tetrachloride (CCl4).This study used a completely randomized design with 20 mice divided into 5 treatment groups. Negative controls were given food, drink and 1 ml/kg BW olive oil, positive controls were given 1 ml/kg BW carbon tetrachloride and olive oil with a ratio of 1:3. Treatments 1, 2 and 3 were given carbon tetrachloride 1ml/kg BW and olive oil with a ratio of 1:3 and given ethanol extract of palm fruit at different doses (P1= 90 mg/kg BW, P2= 180 mg/kg BW, P3= 360 mg/kg BW) for 16 days. The results obtained include that ethanol extract of palm fruit has a very significant effect on creatinine, urea and kidney histology. The optimal dose of palm fruit ethanol extract to improve kidney is a 360 mg/kg BW.
Pengaruh Pemberian Ekstrak Daun Salam (Syzygium polyanthum) terhadap Ginjal Tikus Putih (Rattus norvegicus L.) yang Diinduksi Kadmium Klorida (CdCl2) Rismayani, Fanya Audi; Syukriah, Syukriah; Widiarti, Leni
BIO-CONS : Jurnal Biologi dan Konservasi Vol. 7 No. 1 (2025): BIO-CONS: Jurnal Biologi dan Konservasi
Publisher : PROGRAM STUDI PENDIDIKAN BIOLOGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31537/biocons.v7i1.2218

Abstract

Kadmium merupakan logam berat yang jika terpapar secara berlebihan dapat menyebabkan nefroksisitas yang ditandai dengan penurunan fungsi ginjal akibat stres oksidatif yang dipicu oleh radikal bebas. Daun salam diketahui mengandung senyawa antioksidan seperti flavonoid dan tanin yang berperan dalam menangkal radikal bebas. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak daun salam (Syzygium polyanthum) terhadap morfologi, indeks organ ginjal, kadar kreatinin dan kadar ureum ginjal pada tikus yang diinduksi CdCl2. Penelitian ini menggunakan RAL dengan 20 ekor tikus dibagi menjadi 5 kelompok perlakuan, Kontrol Negatif : makan dan minum, Kontrol Positif : CdCl2 40 mg/kg BB, Perlakuan 1 : CdCl2 40 mg/kg BB + ekstrak daun salam 200 mg/kg BB, Perlakuan 2 : CdCl2 40 mg/kg BB + ekstrak daun salam 300 mg/kg BB dan Perlakuan 3 CdCl2 40 mg/kg BB + ekstrak daun salam 400 mg/kg BB. Tahapan dalam penelitian ini meliputi skrining fitokimia, uji aktivitas antioksidan, pengamatan morfologi, perhitungan indeks berat organ pemeriksaan kadar kreatinin dan ureum ginjal tikus putih. Analisis data menggunakan uji one way ANOVA dan dilanjutkan dengan uji Duncan. Hasil penelitian yang didapatkan diantaranya, daun salam tidak berpengaruh terhadap morfologi ginjal, namun daun salam berpengaruh dalam menurunkan rata-rata indeks organ ginjal dengan yaitu pada dosis ekstrak 300 mg/kg BB, serta berpengaruh dalam menurunkan kadar kreatinin dan ureum pada tikus putih yang diinduksi kadmium klorida dengan dosis ekstrak daun salam yang optimal yaitu pada dosis 400 mg/kg BB.
PENGARUH PEMBERIAN EKSTRAK ETANOL BUAH AREN (Arenga pinnata Merr.) TERHADAP KADAR KREATININ, UREUM DAN HISTOLOGI GINJAL TIKUS PUTIH (Rattus norvegicus L.) YANG DIINDUKSI KARBON TETRAKLORIDA (CCl4) Awaliah Sifa, Nurharija; Febriani, Husnarika; Widiarti, Leni
Jurnal Biogenerasi Vol. 10 No. 2 (2025): Volume 10 no 2 periode februari - september 2025 ( continues)
Publisher : Universitas Cokroaminoto Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30605/biogenerasi.v10i2.5637

Abstract

One substance that produces radical compounds is carbon tetrachloride (CCl4). As a solvent, insecticide, coolant, stain remover, and soap, carbon tetrachloride is widely used. Direct skin contact, ingestion, inhalation, and eye contact are ways this material enters the body. The antioxidants found in palm fruit (Arenga pinnata Merr.) can help protect against damage caused by free radicals. This study aims to determine how giving ethanol extract of palm fruit (Arenga pinnata Merr.) to white rats (Rattus norvegicus L.) affects creatinine, urea levels and kidney histology when exposed to carbon tetrachloride (CCl4).This study used a completely randomized design with 20 mice divided into 5 treatment groups. Negative controls were given food, drink and 1 ml/kg BW olive oil, positive controls were given 1 ml/kg BW carbon tetrachloride and olive oil with a ratio of 1:3. Treatments 1, 2 and 3 were given carbon tetrachloride 1ml/kg BW and olive oil with a ratio of 1:3 and given ethanol extract of palm fruit at different doses (P1= 90 mg/kg BW, P2= 180 mg/kg BW, P3= 360 mg/kg BW) for 16 days. The results obtained include that ethanol extract of palm fruit has a very significant effect on creatinine, urea and kidney histology. The optimal dose of palm fruit ethanol extract to improve kidney is a 360 mg/kg BW.
Co-Authors Awaliah Sifa, Nurharija Husnarika Febriani, Husnarika Rismayani, Fanya Audi Syukriah Syukriah, Syukriah