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All Journal Farmaka IDJP (Indonesian Journal of Pharmaceutics) SRIWIJAYA JOURNAL OF MEDICINE AJAD : Jurnal Pengabdian kepada Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Abdimas Ilmiah Citra Bakti
RIZKA KHOIRUNNISA GUNTINA, RIZKA KHOIRUNNISA
Universitas Jenderal Achmad Yani
Arts Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Public Health

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DETEKSI BAKTERI VIBRIO CHOLERAE RIZKA KHOIRUNNISA GUNTINA; sri Agung Fitri Kusuma
Farmaka Vol 15, No 1 (2017): Suplemen
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (359.874 KB) | DOI: 10.24198/jf.v15i1.12913

Abstract

V. cholerae dapat menyebabkan penyakit diare kolera. Penyakit ini disebabkan oleh enterotoksin yang dihasilkan oleh V. cholerae. V. cholerae banyak ditemukan pada permukaan air yang telah terkontaminasi oleh tinja yang mengandung bakteri V. cholerae. Deteksi V. cholerae dilakukan dengan beberapa cara diantaranya dengan metode konvensional menggunakan uji biokimia, uji serologi, strip test, co-agglutination test, dan dark field test serta metode molekuler menggunakan polymerase chain reaction (PCR). Sampel yang digunakan berasal dari sampel cair (lingkungan sekitar) dan hasil kultur bakteri. Dari seluruh metode yang dapat digunakan, dapat disimpulkan bahwa metode deteksi bakteri V. cholerae dengan menggunakan strip test adalah yang paling efektif dan akurat.V. cholerae dapat menyebabkan penyakit diare kolera. Penyakit ini disebabkan oleh enterotoksin yang dihasilkan oleh V. cholerae. V. cholerae banyak ditemukan pada permukaan air yang telah terkontaminasi oleh tinja yang mengandung bakteri V. cholerae. Deteksi V. cholerae dilakukan dengan beberapa cara diantaranya dengan metode konvensional menggunakan uji biokimia, uji serologi, strip test, co-agglutination test, dan dark field test serta metode molekuler menggunakan polymerase chain reaction (PCR). Sampel yang digunakan berasal dari sampel cair (lingkungan sekitar) dan hasil kultur bakteri. Dari seluruh metode yang dapat digunakan, dapat disimpulkan bahwa metode deteksi bakteri V. cholerae dengan menggunakan strip test adalah yang paling efektif dan akurat.
Mini Review : Sedem System as a Tool to Characterize Excipients in Solid Dosage Form Iyan Sopyan; Rizka Guntina Khairunisa
Indonesian Journal of Pharmaceutics Vol 3, Issue 1, Jan - April 2021
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v3i1.34038

Abstract

SeDem System is a new system that can be applied in solid dosage form preformulation studies of medicines. It have parameters to evaluates critical quality attributes of materials that have an impact on final drug product’s quality. SeDeM studies could be used as a method for identifying the best excipient and calculating the maximum amount of excipient required for formulation. SeDeM method can , providing formulation with the lowest amount of excipients as it combines the Active Pharmaceutical Ingredients (API) with only one excipient and the standard formula of lubricants, thus avoiding the used of unnecessary excipients, such as diluents, binders and agglutinants. The information given by the SeDeM system contributes to a quality by drug design development.Keywords: SeDeM System, Excipients
Peningkatan Kualitas Produk Paguyuban Jamu Manunggal Kota Cimahi Melalui Standardisasi Bahan Baku Fahrauk Faramayuda; Ari Sri Windyaswari; Ridwan Ilyas; Dhimas Ariya Wibiksana; Nursafira Khairunnisa Ismail; Reyhan Adriana Deris; Rifaz Muhammad Sukma; Tzazkia Febriyana Akbar; Chandani Nurul Hafizah; Rizka Khoirunnisa Guntina
AJAD : Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 2 (2023): AUGUST 2023
Publisher : Lembaga Mitra Solusi Teknologi Informasi (L-MSTI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59431/ajad.v3i2.185

Abstract

The activity of the community of herbal medicine manunggal in Cimahi city, as the main partner, is to guide the processing of traditional medicines and the herbal medicine business. The proposing team held an initial meeting and socialization for members of the Jamu Manunggal community in the city of Cimahi on December 25, 2021, regarding counseling on planting, post-harvest processing, and the benefits of the cat's whiskers plant. From the results of these activities, several problems were identified: the raw materials for traditional medicines in the Jamu Manunggal Association needed to be better standardized. This activity aims to improve the quality of traditional medicinal products through standardization. The results of the drying shrinkage testing of the five medicinal raw materials met the standards in the Indonesian Herbal Pharmacopoeia. In testing the water-soluble ash content, the levels obtained were not too large illustrating the potential for minor contamination of traditional medicinal raw materials. The general conclusion is that the raw materials for traditional medicine in the Jamu Manunggal Association of Cimahi City have good quality.
ANALYSIS OF NON-SPECIFIC STANDARDIZED PARAMETERS ON KUMIS KUCING LEAVES (Orthosiphon aristatus (Blume) Miq.) PURPLE VARIETY Fahrauk Faramayuda; Soraya Riyanti; Totik Sri Mariani; Rizka Khoirunnisa Guntina; Winda Nur Halimah
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.977

Abstract

 One of the plants in Indonesia that can be used as a medicine is the purple variety of cat's whiskers (Orthosiphon aristatus (Blume) Miq.). This study aims to examine the quality and safety of the purple variety of Cat’s Whiskers as a raw material for traditional medicine so that it meets the requirements of being free from heavy metal, microbial, and aflatoxin contamination. The results of setting the standardization parameters on the dry material of cat’s whiskers leaves obtained drying losses, water content, total ash content, and acid insoluble ash content, respectively 8.45 ± 0.68%; 6.67 ± 1.15 %; 8.70 ± 0.09 %; 1.31 ± 0.16 %. The results of testing for the heavy metals lead (Pb) and mercury (Hg) on ??dry material and extracts were £ 0.0001 mg/kg. The results of testing the levels of microbial contamination in dry material and extracts obtained total bacteria 1.45x101 and 2.35x101 Cfu/gr, respectively. Test results for aflatoxin contamination on the dry material of Cat’s Whiskers leaves B1, B2, G1, G2 and total aflatoxin £ 0.50 ?g/kg and total aflatoxin £ 2 ?g/kg, respectively. The dried material and leaf extract of the purple variety of cat’s whiskers that were tested met the requirements stated in the regulation of the Food and Drug Supervisory Agency number 32 of 2019 about traditional medicines' safety and quality requirements.
EFFECT OF EXTRACTION METHOD ON ANTIOXIDANT ACTIVITY OF PALM PALM LEAVES (Elaeis guineensis Jacq.) Fahrauk Faramayuda; Ari Sri Windyaswari; Yeni Karlina; Muhamad Raihan Maulana; Rizka Khoirunnisa Guntina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.994

Abstract

Oil palm (Elaeis guineensis Jacq.) is a plant that is native to Africa and South America. This plant can grow well in tropical areas, such as Indonesia. Indonesia is currently one of the largest producers of palm oil worldwide. As the area of palm oil plantations increases, the potential for waste from this plant continues to increase. The potential for palm oil leaf waste production in Indonesia is 658 kg dry matter/hectare/year. Palm oil leaf waste has been widely processed into organic fertilizers and animal feeds. This plant has the potential to be developed into a source of traditional medicinal ingredients. Based on the abundant sources of palm oil leaves and their pharmacological potential, palm oil leaves can be used as a source of raw materials for traditional medicine. This study aimed to compare the antioxidant activities of oil palm leaf extracts obtained by maceration and reflux to determine which extraction method produces the best antioxidant activity. Extraction was carried out using 70% ethanol solvent by maceration and reflux. The results of the phytochemical screening showed that oil palm leaves contain flavonoids, polyphenols, saponins, quinones, steroid-triterpenoids, and monoterpene-sesquiterpenes. Antioxidant activity using a UV-Visible spectrophotometer with DPPH free radicals showed that the extract obtained by maceration and reflux methods had IC50 values of 46.61 ± 1.76 ug/mL and 55.21 ± 2.91 ug/mL respectively. Therefore, extraction by maceration produces a better antioxidant activity.  Keywords: Palm leaves; Traditional medicine; Extraction; Active compound stability; Antioxidant
Activity Assay and Determination of Active Larvicidal Compounds from Cat's Whiskers (Orthosiphon aristatus Blume miq.) Guntina, Rizka Khoirunnisa; Riyanti, Soraya; Faramayuda, Fahrauk
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.375

Abstract

The tropical climate of Indonesia presents a significant risk for the prevalence of various mosquito-borne diseases, particularly Dengue Hemorrhagic Fever (DHF), which has become a critical public health concern in recent years. The control of mosquito populations, specifically targeting larvae, is a strategic approach in managing the transmission of DHF. Traditional methods involving synthetic larvicidal agents, however, raise concerns regarding potential resistance among mosquito populations and adverse effects on human health. Consequently, there exists an urgent need for alternative solutions that are both effective and safe for human exposure. One promising avenue is the exploration of natural larvicidal agents sourced from local flora, such as the white-purple variety of cat's whiskers (Orthosiphon aristatus Blume miq.). This study investigates the larvicidal potential of this plant, focusing on its main secondary metabolites, namely flavonoids and phenolics, which are hypothesized to possess larvicidal activities. Conducted extensive larvicidal activity assaying on various extracts and fractions derived from the white-purple cat's whiskers. Notably, the ethyl acetate fraction demonstrated superior efficacy, evidenced by a calculated LC50 value of 737.71 ppm, underscoring its potential as a sustainable larvicidal agent. Subsequent analyzes of this active fraction revealed the presence of the compound sinensetin, which further validates the insecticidal application of this plant in controlling mosquito populations effectively. This research contributes to the paradigm shift toward natural alternatives in pest management, highlighting the importance of harnessing local biodiversity in the fight against vector-borne diseases.
PENYULUHAN DAN PELATIHAN BUDI DAYA KUMIS KUCING VARIETAS UNGU HASIL KULTUR JARINGAN PADA KELOMPOK TANI TUMBUH MANDIRI KOTA CIMAHI Fahrauk Faramayuda; Rizka Khoirunnisa Guntina; Mentari Suci Indah Lestari; Osama Al Hafiz; Putri Fatimatuz Zahro; Olva Nurnissa Krissakti; Nurul Wahdaniah Andi Wajuanna; Liquw Rontos; Zaza Nurahmadanti; Tety Lutfia; Defanie Sophi Nurfadhilah; Wayan Puspita Dewi
Jurnal Abdimas Ilmiah Citra Bakti Vol. 7 No. 3 (2026)
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jailcb.v7i3.7385

Abstract

Kelompok Tani Tumbuh Mandiri (TUMAN) Kota Cimahi merupakan kelompok tani binaan Perkumpulan Penyandang Disabilitas Indonesia (PPDI) Kota Cimahi yang sebagian besar anggotanya merupakan penyandang disabilitas dan bergerak dalam bidang pertanian, perikanan, serta usaha mikro, kecil, dan menengah (UMKM). Permasalahan mitra meliputi keterbatasan pengetahuan mengenai komoditas pertanian bernilai ekonomi tinggi, teknik budi daya dan pascapanen, serta diversifikasi produk untuk meningkatkan nilai tambah hasil pertanian. Kegiatan ini bertujuan meningkatkan pengetahuan dan keterampilan anggota TUMAN dalam mengenal potensi, membudidayakan, dan menangani pascapanen kumis kucing (Orthosiphon aristatus) varietas ungu hasil kultur jaringan. Kegiatan dilaksanakan di Balai Tani TUMAN, Kelurahan Citeureup, Kecamatan Cimahi Utara, Kota Cimahi, dengan melibatkan 10 peserta. Metode kegiatan meliputi penyuluhan melalui ceramah dan diskusi, demonstrasi dan praktik langsung penanaman bibit hasil kultur jaringan, pendampingan mengenai pemeliharaan dan pascapanen, serta evaluasi menggunakan pre-test dan post-test. Hasil evaluasi menunjukkan bahwa rata-rata nilai peserta meningkat dari 55,0 pada pre-test menjadi 90,0 pada post-test, atau meningkat sebesar 63,6%. Seluruh peserta (100%) mengalami peningkatan nilai setelah mengikuti kegiatan. Kegiatan ini menunjukkan bahwa penyuluhan dan pelatihan berbasis praktik dapat meningkatkan pengetahuan peserta mengenai budi daya kumis kucing varietas ungu hasil kultur jaringan serta memberikan alternatif diversifikasi komoditas bernilai tambah bagi TUMAN.
Co-Authors Ari Sri Windyaswari Chandani Nurul Hafizah Defanie Sophi Nurfadhilah Dhimas Ariya Wibiksana Fahrauk Faramayuda, Fahrauk Iyan Sopyan Liquw Rontos Mentari Suci Indah Lestari Muhamad Raihan Maulana Nursafira Khairunnisa Ismail Nurul Wahdaniah Andi Wajuanna Olva Nurnissa Krissakti Osama Al Hafiz Putri Fatimatuz Zahro Reyhan Adriana Deris Ridwan Ilyas Rifaz Muhammad Sukma Soraya Riyanti Soraya Riyanti, Soraya Sri Agung Fitri Kusuma, Sri Agung Tety Lutfia Totik Sri Mariani Tzazkia Febriyana Akbar Wayan Puspita Dewi Winda Nur Halimah Yeni Karlina Zaza Nurahmadanti