Izaak Zoelkarnain Akbar, Izaak Zoelkarnain
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Decreased osteoblasts and increased osteoclasts in rats after coal dust exposure Akbar, Izaak Zoelkarnain; Kania, Nia; Setiawan, Bambang; Nurdiana, Nurdiana; Widodo, M. Aris
Universa Medicina Vol 30, No 2 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.73-79

Abstract

Bone remodeling is a physiological process of cortical and trabecular bone reconstruction, with initial bone resorption, by osteoclasts and concurrent bone formation by osteoblasts. Oxidative stress due to coal dust exposure is not only found in the lungs, but also in the circulation or systemically. The aim of this study was to determine the effect of oxidative stress from coal dust exposure on the number of osteoblasts and osteoclasts in rats. In this experimental study, four groups were evaluated: control; coal dust exposure at 6.25 mg/m3 for 28 days; coal dust exposure at 12.5 mg/m3 for 28 days; coal dust exposure at 25 mg/m3 for 28 days (all exposures were given daily for one hour). Circulatory oxidative stress was measured by malondialdehyde level. Osteoblast and osteoclast numbers were counted by light microscopic examination of distal femoral cross-sections stained with hematoxylin eosin. This study showed that malondialdehyde levels were significantly increased in coal dust exposure groups, in comparison with the control group (p<0.05). There were also significantly decreased numbers of osteoblasts (p<0.05) and significantly increased numbers of osteoclasts (p<0.05) numbers in coal dust exposure groups, as compared with the control group. No correlations were found between malondialdehyde levels (oxidative stress) and respective numbers of osteoblasts and osteoclasts in all coal dust exposure groups (p>0.05). Coal dust exposure increased malondialdehyde level and osteoclast numbers, and decreased osteoblast numbers, but no correlation was found between oxidative stress (caused by coal dust exposure) and osteoblast and osteoclast numbers.
Analisis faktor-faktor yang berhubungan dengan pemanfaatan pelayanan pos bina terpadu penyakit tidak menular Sari, Ni Putu Sri Wulan; Akbar, Izaak Zoelkarnain; Panghiyangani, Roselina; Musafaah, Musafaah; Shadiqi, Muhammad Abdan
Holistik Jurnal Kesehatan Vol. 18 No. 12 (2025): Volume 18 Nomor 12
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v18i12.628

Abstract

Background: Non-communicable diseases (NCDs) continue to increase and become a global health problem, including in Indonesia. Integrated development post for non-communicable diseases was developed to detect and control NCD risk factors early. However, the utilization of community health center Cempaka Banjarbaru has decreased, from 12.18% in 2022 to 10.17% in 2023 and is still far from the 70% target. Low utilization of non-communicable disease integrated service centers can increase non-communicable disease rates and burden community health center budgets, as well as affect the achievement of minimum service standards (MSS). Purpose: To analyze the factors associated with the utilization of integrated development post for non-communicable diseases services.   Method: This study used a quantitative approach with a cross-sectional design. The population of this study were people aged 18-59 years in the community health center Cempaka Banjarbaru working area. The sample was taken using stratified random sampling technique with a total of 110 respondents. Data collection was done through distributing questionnaires that had been tested for validity and reliability. Data were analyzed using univariate analysis, bivariate using chi-square test, and multivariate using multiple logistic regression test. Results: The chi-square test showed that the knowledge variable had a p value = 0.0001 (<0.05) and PR = 1.851, employment status p value = 0.014 (<0.05) and PR = 1.580, distance traveled had a p value = 1.000 (>0.05) and PR = 1.012, family support had a p value = 0.0001 (<0.05) and PR = 2.847, and ease of obtaining information had a p value = 0.0001 (<0.05) and PR = 1.655. This means that there is a relationship between knowledge, employment status, family support, and ease of obtaining information with the utilization of integrated service center for non-communicable diseases services. However, the travel distance variable was not associated with the utilization of integrated service center for non-communicable diseases services. Based on multiple linear regression tests, the family support variable is the most dominant variable associated with the utilization of integrated service center for non-communicable diseases services with an EXP B value of 34,108. Conclusion: This study showed that knowledge, employment status, family support, and ease of obtaining information were associated with the utilization of integrated service center for non-communicable diseases, with family support as the dominant factor. Meanwhile, travel distance was not associated with the utilization of integrated service center for non-communicable diseases. Suggestion: The community is expected to make more use of an integrated service center for non-communicable diseases, while the community health center needs to organize regular counseling, with various media to increase understanding about health.   Keywords: Integrated Development Post; Non-communicable Diseases (NCDs); Risk Factors; Services.   Pendahuluan: Penyakit tidak menular (PTM) terus meningkat dan menjadi masalah kesehatan global, termasuk di Indonesia.  Posbindu PTM dikembangkan untuk mendeteksi dini dan mengendalikan faktor risiko PTM. Namun, pemanfaatan di Puskesmas Rawat Inap Cempaka Banjarbaru mengalami penurunan, yaitu 12.18% pada 2022 menjadi 10.17% pada 2023 dan masih jauh dari target 70%. Rendahnya pemanfaatan posbindu PTM dapat meningkatkan angka penyakit tidak menular dan membebani anggaran kesehatan puskesmas, serta memengaruhi capaian standar pelayanan minimal (SPM). Tujuan: Untuk menganalisis faktor-faktor yang berhubungan dengan pemanfaatan pelayanan pos bina terpadu penyakit tidak menular. Metode: Penelitian kuantitatif dengan desain cross sectional. Populasi penelitian ini adalah berusia 18-59 tahun di wilayah kerja Puskesmas Rawat Inap Cempaka. Sampel diambil dengan teknik stratified random sampling dengan jumlah responden sebanyak 110. Pengumpulan data melalui penyebaran kuesioner yang telah diuji validitas dan reliabilitasnya. Analisis data menggunakan analisis univariat, bivariat menggunakan uji chi-square, dan multivariat menggunakan uji regresi logistik berganda. Hasil: Uji chi-square menunjukkan variabel pengetahuan memiliki nilai p= 0.0001 (< 0.05) dan PR = 1.851, status pekerjaan nilai p = 0.014 (< 0.05) dan PR = 1.580, jarak tempuh memiliki nilai p = 1.000 (> 0.05) dan PR = 1.012, dukungan keluarga memiliki nilai p = 0.0001 (< 0.05) dan PR = 2.847, serta kemudahan memperoleh informasi memiliki nilai p = 0.0001 (< 0.05) dan PR = 1.655. Hal ini menunjukkan adanya hubungan antara pengetahuan, status pekerjaan, dukungan keluarga, dan kemudahan memperoleh informasi dengan pemanfaatan pelayanan Posbindu PTM. Namun, variabel jarak tempuh tidak berhubungan dengan pemanfaatan posbindu PTM tersebut. Berdasarkan uji regresi linier berganda, variabel dukungan keluarga menjadi variabel yang paling dominan berkaitan dengan pemanfaatan pelayanan posbindu PTM dengan nilai EXP B sebesar 34.108. Simpulan: Pengetahuan, status pekerjaan, dukungan keluarga, dan kemudahan memperoleh informasi berhubungan dengan pemanfaatan posbindu PTM, dengan dukungan keluarga sebagai faktor dominan. Sementara itu, jarak tempuh tidak berhubungan dengan pemanfaatan posbindu PTM. Saran: Masyarakat diharapkan dapat lebih memanfaatkan posbindu PTM, sementara puskesmas perlu menyelenggarakan penyuluhan berkala, dengan berbagai media untuk meningkatkan pemahaman tentang kesehatan.   Kata Kunci: Faktor Risiko; Pelayanan; Penyakit Tidak Menular (PTM); Pos Pembinaan Terpadu (Posbindu).
Meta Analisis: Pengaruh Kualitas Pelayanan dan Harga Terhadap Kepuasan Pasien di Fasilitas Kesehatan Salsabila, Nur’aien Istiqayani; Akbar, Izaak Zoelkarnain; Ilmi, Bahrul; Suhartono, Eko; Noor, Meitria Syahadatina
MAHESA : Malahayati Health Student Journal Vol 6, No 4 (2026): Volume 6 Nomor 4 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i4.21571

Abstract

ABSTRACT Health services provided to patients are closely related to the level of patient satisfaction who have received treatment from health workers. Health services are professional services provided by health workers to individuals or communities in the fields of promotive, preventive and curative aimed at improving optimal public health. To analyze the effect of service quality and price on patient satisfaction reviewed from a meta-analysis study. This study uses a retrospective observational study method (meta-analysis), meaning that researchers make a recapitulation of facts without conducting experimental manipulation. Data sources use secondary data obtained from previous studies online. The data collection procedure uses the Google Scholar database published in the last 1 year. Data were analyzed using Review Manager 5.4.1 (Revman 5.4.1). Of the 671 studies obtained according to the inclusion and exclusion criteria, 11 studies were obtained that could be continued into the review manager 5.4.1 analysis (Revman 5.4.1). The service quality variable uses 10 studies, and service price 4 studies. The results of the data analysis showed that there was an influence of service quality on patient satisfaction with a p value 0.00001 and a pooled odds ratio value of 1.40 with a 95% CI range (1.21-1.06). The results of the data analysis showed that there was an influence of service prices on patient satisfaction with p = 0.003, namely p 0.05 and a pooled odds ratio value of 1.48 with a 95% CI range (1.14-1.90). There is an influence of service quality and service prices on patient satisfaction through a meta-analysis study. Keywords: Service Quality, Service Prices, Patient Satisfaction.  ABSTRAK Pelayanan kesehatan yang diberikan kepada pasien sangat berkaitan erat dengan tingkat kepuasan pasien yang telah menerima perawatan dari tenaga kesehatan. Pelayanan kesehatan merupakan pelayanan profesional yang diberikan oleh tenaga kesehatan kepada perorangan atau masyarakat dibidang promotif, preventif dan kuratif yang ditujukan untuk meningkatkan derajat kesehatan masyarakat yang optimal. Menganalisis pengaruh kualitas pelayanan dan harga terhadap kepuasan pasien ditinjau dari studi meta analisis. Penelitian ini menggunakan metode studi observational retrospektif (meta analisis), dalam arti peneliti membuat rekapitulasi fakta tanpa melakukan manipulasieksperimental. Sumber data menggunakan data sekunder yang diperoleh dari penelitian-penelitian sebelumnya secaraonline. Prosedur pengumpulan data menggunakan database Google Scholar yang diterbitkan 1 tahun terakhir. Data dianalisis menggunakan Review Manager 5.4.1 (Revman 5.4.1). Dari 671 studi yang diperoleh sesuai kriteria inklusi dan eksklusi diperoleh sebanyak 11 studi yang dapat dilanjutkan kedalam analisis review manager 5.4.1 (Revman 5.4.1).Variabel kualitas pelayanan menggunakan 10 studi, dan harga jasa layanan 4 studi. Hasil analisis data menunjukkan adanya pengaruh kualitas pelayanan terhadap kepuasan pasien dengan nilai p0,00001 dan nilai pooled odds ratiosebesar 1,40 dengan rentang CI 95% (1,21-1,06). Hasil analisis data menunjukkan ada pengaruh harga jasa layanan dengan kepuasan pasien dengan p=0,003 yaitu p0,05 dan nilai pooled odds ratio sebesar 1,48 dengan rentang CI 95% (1,14-1,90). Ada pengaruh kualitas pelayanan dan harga jasa layanan terhadap kepuasan pasien melalui studi metaanalisis. Kata Kunci: Kualitas Pelayanan, Harga Jasa Layanan, Kepuasan Pasien.
Factors Influencing the Enhancement of Flexibility and Accountability in Financial Management Services under the BLUD Scheme at Community Health Ukas, Muhammad; Akbar, Izaak Zoelkarnain; Ilmi, Bahrul; Yunani, Ahmad; Erlyani, Neka
Journal La Medihealtico Vol. 7 No. 2 (2026): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v7i2.3224

Abstract

Transparent healthcare services has driven Community Health Centers (Puskesmas) to adopt the Financial Management Pattern of Regional Public Service Agencies (PPK-BLUD). This study aims to examine the factors influencing the flexibility and accountability of BLUD-based financial management within Community Health Centers in Kotabaru Regency. The research employs a literature review approach, utilizing content analysis of scholarly articles and relevant regulatory documents published within the last five years. The findings reveal that the effectiveness of BLUD implementation is predominantly shaped by four key determinants: the quality of human resources, regulatory frameworks, infrastructural capacity, and the structure of authority and governance