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Decreased osteoblasts and increased osteoclasts in rats after coal dust exposure Akbar, Izaak Zoelkarnain; Kania, Nia; Setiawan, Bambang; Nurdiana, Nurdiana; Widodo, M. Aris
Universa Medicina Vol 30, No 2 (2011)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2011.v30.73-79

Bone remodeling is a physiological process of cortical and trabecular bone reconstruction, with initial bone resorption, by osteoclasts and concurrent bone formation by osteoblasts. Oxidative stress due to coal dust exposure is not only found in the lungs, but also in the circulation or systemically. The aim of this study was to determine the effect of oxidative stress from coal dust exposure on the number of osteoblasts and osteoclasts in rats. In this experimental study, four groups were evaluated: control; coal dust exposure at 6.25 mg/m3 for 28 days; coal dust exposure at 12.5 mg/m3 for 28 days; coal dust exposure at 25 mg/m3 for 28 days (all exposures were given daily for one hour). Circulatory oxidative stress was measured by malondialdehyde level. Osteoblast and osteoclast numbers were counted by light microscopic examination of distal femoral cross-sections stained with hematoxylin eosin. This study showed that malondialdehyde levels were significantly increased in coal dust exposure groups, in comparison with the control group (p<0.05). There were also significantly decreased numbers of osteoblasts (p<0.05) and significantly increased numbers of osteoclasts (p<0.05) numbers in coal dust exposure groups, as compared with the control group. No correlations were found between malondialdehyde levels (oxidative stress) and respective numbers of osteoblasts and osteoclasts in all coal dust exposure groups (p>0.05). Coal dust exposure increased malondialdehyde level and osteoclast numbers, and decreased osteoblast numbers, but no correlation was found between oxidative stress (caused by coal dust exposure) and osteoblast and osteoclast numbers.

Analisis faktor-faktor yang berhubungan dengan pemanfaatan pelayanan pos bina terpadu penyakit tidak menular Sari, Ni Putu Sri Wulan; Akbar, Izaak Zoelkarnain; Panghiyangani, Roselina; Musafaah, Musafaah; Shadiqi, Muhammad Abdan
Holistik Jurnal Kesehatan Vol. 18 No. 12 (2025): Volume 18 Nomor 12
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v18i12.628

Background: Non-communicable diseases (NCDs) continue to increase and become a global health problem, including in Indonesia. Integrated development post for non-communicable diseases was developed to detect and control NCD risk factors early. However, the utilization of community health center Cempaka Banjarbaru has decreased, from 12.18% in 2022 to 10.17% in 2023 and is still far from the 70% target. Low utilization of non-communicable disease integrated service centers can increase non-communicable disease rates and burden community health center budgets, as well as affect the achievement of minimum service standards (MSS). Purpose: To analyze the factors associated with the utilization of integrated development post for non-communicable diseases services. Method: This study used a quantitative approach with a cross-sectional design. The population of this study were people aged 18-59 years in the community health center Cempaka Banjarbaru working area. The sample was taken using stratified random sampling technique with a total of 110 respondents. Data collection was done through distributing questionnaires that had been tested for validity and reliability. Data were analyzed using univariate analysis, bivariate using chi-square test, and multivariate using multiple logistic regression test. Results: The chi-square test showed that the knowledge variable had a p value = 0.0001 (<0.05) and PR = 1.851, employment status p value = 0.014 (<0.05) and PR = 1.580, distance traveled had a p value = 1.000 (>0.05) and PR = 1.012, family support had a p value = 0.0001 (<0.05) and PR = 2.847, and ease of obtaining information had a p value = 0.0001 (<0.05) and PR = 1.655. This means that there is a relationship between knowledge, employment status, family support, and ease of obtaining information with the utilization of integrated service center for non-communicable diseases services. However, the travel distance variable was not associated with the utilization of integrated service center for non-communicable diseases services. Based on multiple linear regression tests, the family support variable is the most dominant variable associated with the utilization of integrated service center for non-communicable diseases services with an EXP B value of 34,108. Conclusion: This study showed that knowledge, employment status, family support, and ease of obtaining information were associated with the utilization of integrated service center for non-communicable diseases, with family support as the dominant factor. Meanwhile, travel distance was not associated with the utilization of integrated service center for non-communicable diseases. Suggestion: The community is expected to make more use of an integrated service center for non-communicable diseases, while the community health center needs to organize regular counseling, with various media to increase understanding about health. Keywords: Integrated Development Post; Non-communicable Diseases (NCDs); Risk Factors; Services. Pendahuluan: Penyakit tidak menular (PTM) terus meningkat dan menjadi masalah kesehatan global, termasuk di Indonesia. Posbindu PTM dikembangkan untuk mendeteksi dini dan mengendalikan faktor risiko PTM. Namun, pemanfaatan di Puskesmas Rawat Inap Cempaka Banjarbaru mengalami penurunan, yaitu 12.18% pada 2022 menjadi 10.17% pada 2023 dan masih jauh dari target 70%. Rendahnya pemanfaatan posbindu PTM dapat meningkatkan angka penyakit tidak menular dan membebani anggaran kesehatan puskesmas, serta memengaruhi capaian standar pelayanan minimal (SPM). Tujuan: Untuk menganalisis faktor-faktor yang berhubungan dengan pemanfaatan pelayanan pos bina terpadu penyakit tidak menular. Metode: Penelitian kuantitatif dengan desain cross sectional. Populasi penelitian ini adalah berusia 18-59 tahun di wilayah kerja Puskesmas Rawat Inap Cempaka. Sampel diambil dengan teknik stratified random sampling dengan jumlah responden sebanyak 110. Pengumpulan data melalui penyebaran kuesioner yang telah diuji validitas dan reliabilitasnya. Analisis data menggunakan analisis univariat, bivariat menggunakan uji chi-square, dan multivariat menggunakan uji regresi logistik berganda. Hasil: Uji chi-square menunjukkan variabel pengetahuan memiliki nilai p= 0.0001 (< 0.05) dan PR = 1.851, status pekerjaan nilai p = 0.014 (< 0.05) dan PR = 1.580, jarak tempuh memiliki nilai p = 1.000 (> 0.05) dan PR = 1.012, dukungan keluarga memiliki nilai p = 0.0001 (< 0.05) dan PR = 2.847, serta kemudahan memperoleh informasi memiliki nilai p = 0.0001 (< 0.05) dan PR = 1.655. Hal ini menunjukkan adanya hubungan antara pengetahuan, status pekerjaan, dukungan keluarga, dan kemudahan memperoleh informasi dengan pemanfaatan pelayanan Posbindu PTM. Namun, variabel jarak tempuh tidak berhubungan dengan pemanfaatan posbindu PTM tersebut. Berdasarkan uji regresi linier berganda, variabel dukungan keluarga menjadi variabel yang paling dominan berkaitan dengan pemanfaatan pelayanan posbindu PTM dengan nilai EXP B sebesar 34.108. Simpulan: Pengetahuan, status pekerjaan, dukungan keluarga, dan kemudahan memperoleh informasi berhubungan dengan pemanfaatan posbindu PTM, dengan dukungan keluarga sebagai faktor dominan. Sementara itu, jarak tempuh tidak berhubungan dengan pemanfaatan posbindu PTM. Saran: Masyarakat diharapkan dapat lebih memanfaatkan posbindu PTM, sementara puskesmas perlu menyelenggarakan penyuluhan berkala, dengan berbagai media untuk meningkatkan pemahaman tentang kesehatan. Kata Kunci: Faktor Risiko; Pelayanan; Penyakit Tidak Menular (PTM); Pos Pembinaan Terpadu (Posbindu).

Determinan Penerimaan Pengguna dan Kesiapan Organisasi Pada Implementasi Sistem Informasi Kesehatan Berbasis Model Utaut-Toe Scoping Review Pramitasari, Maulida; Febriana, Silvia Kristanti Tri; Husaini, Husaini; Akbar, Izaak Zoelkarnain; Shadiqi, Muhammad Abdan
Malahayati Nursing Journal Vol 7, No 11 (2025): Volume 7 Nomor 11 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v7i11.23071

ABSTRACT Health Information Systems (HIS) play a crucial role in improving efficiency, service quality, and data-driven decision-making. However, their implementation still faces challenges such as low digital literacy and limited infrastructure. A deeper understanding of user acceptance and organizational readiness is essential for the success of digital transformation of health. This study aims to map the factors influencing user acceptance and organizational readiness in HIS implementation using the Unified Theory of Acceptance and Use of Technology (UTAUT) and the Technology-Organization-Environment (TOE) frameworks, as well as to identify research gaps in previous studies. A scoping review method was conducted following the PRISMA-ScR guidelines. Literature searches were performed through PubMed, ScienceDirect, and Google Scholar databases using international keywords based on MeSH and Indonesian terms. Article selection followed the PCC (Population, Concept, Context) framework. Out of 4,469 identified articles, 30 studies met the inclusion criteria and were analyzed. The literature mapping revealed that within the UTAUT framework, key determinants of user acceptance included performance expectancy (18 studies), effort expectancy (18), social influence (19), facilitating conditions (18), and behavioral intentions (16). Within the TOE framework, important influencing factors included technological compatibility (7 studies), technological infrastructure (7), management support (8), and government policy (7). Most studies employed a quantitative cross-sectional design, while organizational culture, external environment, and longitudinal approaches were rarely explored. Successful HIS implementation requires a holistic approach integrating individual acceptance (UTAUT) with organizational readiness and environmental support (TOE). Further studies with longitudinal designs, multi-location contexts, and qualitative or mixed methods are needed to deepen the understanding of non-technical factors determining the success of health digitalization. Keywords: Health Information System, User Acceptance, Organizational Readiness, Unified Theory of Acceptance and Use of Technology (UTAUT), Technology-Organization-Environment (TOE) ABSTRAK Sistem Informasi Kesehatan (SIK) berperan penting dalam meningkatkan efisiensi, mutu layanan, dan pengambilan keputusan berbasis data. Namun, implementasinya masih menghadapi tantangan seperti rendahnya literasi digital dan keterbatasan infrastruktur. Perlu adanya pemahaman lebih lanjut terkait faktor penerimaan pengguna dan kesiapan organisasi sebagai kunci keberhasilan transformasi digital di bidang kesehatan. Penelitian ini bertujuan memetakan faktor penerimaan pengguna dan kesiapan organisasi dalam implementasi SIK menggunakan kerangka Unified Theory of Acceptance and Use of Technology (UTAUT) dan Technology-Organization-Environment (TOE), serta mengidentifikasi kesenjangan penelitian. Metode scoping review dilakukan dengan mengikuti pedoman PRISMA-ScR. Pencarian literatur dilakukan melalui basis data PubMed, ScienceDirect, dan Google Scholar dengan kata kunci internasional berbasis MeSH serta istilah dalam Bahasa Indonesia. Seleksi artikel mengacu pada kerangka PCC (Population, Concept, Context). Dari 4.469 artikel, 30 studi memenuhi kriteria dan dianalisis. Pemetaan literatur menunjukkan bahwa dalam kerangka UTAUT, determinan utama penerimaan pengguna meliputi performance expectancy (18 studi), effort expectancy (18), social influence (19), facilitating conditions (18), dan behavioral intentions (16). Dalam kerangka TOE, faktor penting yang berpengaruh meliputi kompatibilitas teknologi (7 studi), infrastruktur teknologi (7), dukungan manajemen (8), dan kebijakan pemerintah (7). Sebagian besar penelitian bersifat kuantitatif dengan desain cross-sectional, sementara dimensi budaya organisasi, lingkungan eksternal, serta pendekatan longitudinal masih jarang dieksplorasi. Keberhasilan implementasi SIK memerlukan pendekatan holistik yang mengintegrasikan penerimaan individu (UTAUT) dengan kesiapan organisasi dan dukungan lingkungan (TOE). Diperlukan penelitian lanjutan dengan desain longitudinal, konteks multilokasi, serta pendekatan kualitatif atau campuran untuk memperdalam pemahaman terhadap faktor nonteknis yang menentukan keberhasilan digitalisasi kesehatan. Kata Kunci: Sistem Informasi Kesehatan; Penerimaan Pengguna, Kesiapan Organisasi, UTAUT, TOE.

Bibliometric Analysis of Research on Factors Affecting Service Quality and Physician Performance Marlina, Marlina; Aflanie, Iwan; Akbar, Izaak Zoelkarnain; Shadiqi, Muhammad Abdan; Lahdimawan, Ardik
Malahayati Nursing Journal Vol 6, No 9 (2024): Volume 6 Nomor 9 (2024)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mnj.v6i9.16648

ABSTRACTThis study analyzes the influence of various factors on service quality and doctor performance with a focus on aspects of additional employee income, adequacy of doctor personnel, facilities and infrastructure, competence, and communication. The background of this study is the importance of improving the quality of health services to achieve optimal patient satisfaction and effective physician performance. The purpose of this study is to identify trends, distribution, and relationships between these factors in the scientific literature, as well as identify research gaps that need to be further explored. The method used in this study is bibliometric analysis, with data collected from Google Scholar using the Publish or Perish application. The search period was limited to 2018 to 2024, and the keywords used included "quality of service," "performance," "doctors," "factors," "facilities and infrastructure," "income," "competence," and "communication." The data was analyzed using VOS viewer to visualize the keyword network and identify research trends.The results show that India and Indonesia are the biggest contributors with 10 and 5 publications respectively. Springer and Emerald were the most active publishers, with 9 and 8 publications respectively. The publication trend peaked in 2019 with 16 publications, and the citation analysis identified the article "Health care service delivery based on the Internet of things: A systematic and comprehensive study" as the most influential with 249citations. Network visualization revealed close relationships between keywords such as "doctor," "service quality," and "competence." The conclusion of this study is that although there are many studies that discuss factors affecting service quality and physician performance, there are still gaps that need to be further explored, especially regarding the influence of additional employee income, adequate physician staffing, and facilities and infrastructure. Filling these gaps will provide a more comprehensive understanding and help improve the overall quality of healthcare services.Keywords: Service Quality, Doctor Performance, Competence, Communication, Infrastructure.

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