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Molecular Docking of the Interaction between Citrus amblycarpa Extract Contents and Inflammatory Proteins of Hepatic Steatosis Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Idhafi, Nasrul; Febriansyah, Muhammad; Budiarman, Andi Azizah Maulidia
Makara Journal of Science Vol. 28, No. 2
Publisher : UI Scholars Hub

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Abstract

Citrus amblycarpa possesses various pharmacological activities, such as antioxidant, anticancer, antitumor, hepatoprotective, anti-inflammatory, antidiabetic, antiviral, antibacterial, and antifungal. The main active compounds in C. amblycarpa (including gamma (γ)-aminobutyric acid [GABA], hesperidin, naringin, neoeriocitrin, poncirin, quercetin, and rutin) show potential to interact with the inflammatory proteins in hepatic steatosis (such as nuclear factor kappa beta [NF-kB], tumor necrosis alpha [TNF-alpha], interleukin-6 [IL-6], c-Jun NH2-terminal kinase [JNK], and adiponectin). Molecular docking simulations were performed using Swiss Dock (http://www.swissdock.ch/), and analysis and visualization were conducted using Discovery Studio 4.1. Rutin, poncirin, hesperidin, and neoeriocitrin exhibit high affinities to NF-κB, TNF-alpha, IL-6, and adiponectin proteins, respectively. Similar to curcumin–adiponectin complex interaction, neoeriocitrin–adiponectin interaction involves GLY 223, PRO41, and VAL93 residues. Thus, the most potent inhibitor of hepatic sterosis marker was neoeriocitrin.
STATUS GIZI PADA ANAK YANG MENDERITA DIARE AKUT DI RSD IDAMAN BANJARBARU ‘Azizah, Intan Nur; Ringoringo, Harapan Parlindungan; Panghiyangani, Roselina; Hidayah, Nurul; Rahmiati, Rahmiati
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11475

Abstract

Nutritional status is associated with the occurrence of acute diarrhea in children. Nutritional status is a description of the state of the body that is affected by food and nutrient intake. Acute diarrhea is defecation with a frequency of more than three times a day with the consistency of loose or liquid stools lasting less than 14 days. Examination of the nutritional status of toddlers can be obtained from anthropometric measurements. This study aims to describe the nutritional status of children with acute diarrhea at RSD Idaman Banjarbaru. This research is descriptive, a research conducted to provide an overview of the nutritional status of toddlers aged 0-60 months from October 2020 to September 2022. The sample of this study was 60 patients suffering from acute diarrhea with severe dehydration. The data used is secondary data from medical records. The results of this study showed that the nutritional status of weight for age was found for toddlers at very underweight 6.7% and toddlers underweight 28.3%, length/height for age found for short toddlers 8.3% and very short toddlers 3.3%, weight for length/height found toddlers with undernourishment 16.7% and toddlers with malnutrition 15.0%, and BMI/U found toddlers with malnutrition 21.7% and toddlers with malnutrition 16 .7%.
GAMBARAN KUALITAS TIDUR PADA PENDERITA HIPERTENSI DI PUSKESMAS 9 NOPEMBER BANJARMASIN PERIODE OKTOBER 2023 Mawarni, Khairida; Muttaqien, Fauzan; Kaidah, Siti; Darwis, Yulizar; Panghiyangani, Roselina
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13231

Abstract

Abstract: Hypertension is when systolic blood pressure ≥ 140 mmHg and/or diastolic blood pressure ≥ 90 mmHg. Symptoms that patients often experience headaches, shortness of breath, dizziness, stiff neck, and nocturia which disrupt sleep and impact sleep quality, which will affect control of the development of hypertension. The aim of this research was to determine the description of sleep quality in hypertensive patients at the 9 November Banjarmasin Community Health Center for the October 2023 period. The research method used descriptive observational with a cross-sectional approach with a purposive sampling technique of 93 respondents. Data were collected using structured interviews using the Pittsburgh Sleep Quality Index (PSQI) questionnaire, if a score ≤ 5 was good and a score > 5 was bad. Based on research conducted, it was found that of all respondents (93), there were 7 respondents (7.5%) who had good sleep quality and 86 respondents (92.5%) who had poor sleep quality.  Keywords: hypertension, sleep quality, pittsburgh sleep quality index (PSQI). Abstrak: Hipertensi adalah ketika tekanan darah sistolik  ≥ 140 mmHg dan/atau tekanan darah diastol ≥ 90 mmHg. Gejala yang sering dialami sakit kepala, sesak napas, pusing, kaku tengkuk, dan nokturia yang mengganggu tidur dan berdampak pada kualitas tidur dimana hal tersebut akan memengaruhi pengendalian terhadap perkembangan hipertensi. Tujuan dari penelitian ini untuk mengetahui gambaran kualitas tidur pada penderita hipertensi di Puskesmas 9 Nopember Banjarmasin Periode Oktober 2023. Metode penelitian menggunakan observasional deskriptif dengan pendekatan cross-sectional dengan Teknik purposive sampling sebanyak 93 responden. Pengambilan data dengan wawancara terstruktur menggunakan kuesioner Pittsburgh Sleep Quality Index (PSQI), jika skor ≤ 5 baik dan skor > 5 buruk. Berdasarkan penelitian yang dilakukan, didapatkan dari keseluruhan responden (93), terdapat 7 responden (7,5%) memiliki kualitas tidur baik dan 86 responden (92,5%) yang memiliki kualitas tidur buruk. Kata-kata kunci: hipertensi, kualitas tidur, pittsburgh sleep quality indeks (PSQI)
TINGKAT PEMAHAMAN MALPRAKTIK MAHASISWA FAKULTAS KEDOKTERAN SEMESTER AKHIR ANGKATAN 2019 Uyun, Andi Quratul; Nirmalasari, Nila; Husairi, Ahmad; Aflanie, Iwan; Panghiyangani, Roselina
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11443

Abstract

Malpractice is not only limited to the health profession but can also occur in other professions. Medical malpractice can be committed by doctors, nurses, midwives or other health workers whose actions deviate from medical standards.The problem of malpractice in health services today is being interesting topic for many people among various groups. It is proved by the many malpractice cases handled by the Honorary Council of Indonesian Medical Discipline (MKDKI). One of the reasons lies on the lack of communication between doctors or medical personnel and patients. One of the purposes of this research is to measure the level of understanding of doctor candidates about malpractice so that it is easier to follow up on it. his research used observation research method by taking data from medical students 2019 who are in the final semester to determine the students’ level of malpractice understanding. The sample of this research were decided by using purposive sampling in non-probability sampling technique. The results showed that there are 8 students (13%) in the high level,47 students (78%) in moderate level and 5 students (8%) in deficient level of malpractice understanding in the final semester students of medicine faculty at University of Lambung Mangkurat.
HUBUNGAN INTRAVESICAL PROSTATIC PROTRUSION DENGAN Q MAX UROFLOWMETRI Al-fath, Muhammad Fauzan; Sutapa, Hendra; Istiana, Istiana; Rahman, Eka Yudha; Panghiyangani, Roselina
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11458

Abstract

Benign prostatic hyperplasia (BPH) is a benign tumor that is often found in men. IPP is a protrusion of the prostate starting from the neck of the bladder into the cavity of the bladder which results in a ball valve mechanism in the neck of the bladder thereby disrupting the flow of urine past the neck of the bladder. Uroflowmetry test is the simplest test to measuring the amount of urine that is urinated divided by the duration of micturition (ml/second). This research aims to analyze the relationship between IPP and q max of uroflowmetry measurements in BPH patients with LUTS at Ulin General Hospital, Banjarmasin. This research is analytic observational with cross sectional method. The research subjects were BPH patients at Ulin General Hospital, Banjarmasin who met the inclusion and exclusion criteria. The independent variable is Intravesical Prostatic Protrusion. The dependent variable is the results of the Uroflowmetry q max examination. Data analysis used Spearman's rank correlation test. The results showed that the average size of enlarged prostate was 8.623 ± 5.694 mm and the average q max uroflowmetry was 9.945 ± 4.238 ml/second. Conclusion In this study p = 0.029 indicating that there is an adequate correlation and has a negative relationship between Intravesical Prostatic Protrusion and q max uroflowmetry. The higher the Intravesical Prostatic Protrusion measurement, the lower the q max uroflowmetry.
GAMBARAN KUALITAS TIDUR PADA PASIEN PENYAKIT JANTUNG ISKEMIK DI RSUD ULIN BANJARMASIN PERIODE OKTOBER-NOVEMBER 2023 Septerini, Ditha Detiana; Muttaqien, Fauzan; Kaidah, Siti; Darwis, Yulizar; Panghiyangani, Roselina
Homeostasis Vol 7, No 2 (2024)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v7i2.13217

Abstract

Abstract: The imbalance between oxygen supply and demand in the myocardium leads to ischemic heart disease. Patient symptoms, especially chest pain, can affect patient's sleep quality. Sleep quality is defined as feeling satisfied, fresh, feeling fit, and not showing drowsiness so it will not cause daytime dysfunction. Patients with poor sleep quality is linked to an increased chance of myocardial infarction, heart-related surgery, and possibly even death. This study is a descriptive observational study using a cross-sectional design which aims to determine the quality of sleep in patients with ischemic heart disease. Data was taken through interviews using of PSQI questionnaire. Samples were collected using a purposive sampling technique from 97 patients with ischemic heart disease at Ulin General Hospital Banjarmasin. Result showed that 79.4% of ischemic heart disease patients at Ulin General Hospital Banjarmasin had poor sleep quality, 45.4% of patients were 51-60 years, 79.2% of male, and 93.5% experienced chest pain as a symptom that are often perceived. Keywords: sleep quality, ischemic heart disease, PSQI Abstrak: Penyakit jantung iskemik (PJI) merupakan penyakit yang terjadi akibat ketidakseimbangan pasokan dan kebutuhan oksigen dalam miokardium. Keluhan pasien terutama nyeri pada bagian dada dapat mempengaruhi kualitas tidur. Kualitas tidur didefinisikan sebagai rasa puas, segar, bugar serta tidak menunjukkan kantuk sehingga hal tersebut tidak akan mengganggu aktivitas sehari-hari. Kualitas tidur pasien yang buruk dapat berkaitan dengan peningkatan resiko terjadinya kejadian infark miokard, operasi yang berhubungan dengan jantung, bahkan kematian. Penelitian ini merupakan penelitian observasional deskriptif dengan desain cross-sectional yang bertujuan untuk mengetahui kualitas tidur pada pasien penyakit jantung iskemik. Pengambilan data pada penelitian ini melalui wawancara dan pengisian kuesioner PSQI. Pengambilan sampel menggunakan teknik purposive sampling dengan jumlah sampel 97 orang. Hasil penelitian menunjukkan bahwa 79,4% pasien penyakit jantung iskemik di RSUD Ulin Banjarmasin memiliki kualitas tidur yang buruk. Sebesar 45,4% responden berada pada rentang usia 51-60 tahun, 79,2% berjenis kelamin laki-laki dan 93,5% mengalami nyeri dada sebagai gejala yang sering dirasakan. Kata-kata kunci: kualitas tidur, penyakit jantung iskemik, kuesioner PSQI
TINGKAT PENGETAHUAN ORANG TUA TENTANG PENDIDIKAN SEKSUAL DINI PADA ANAK DI TK HARAPAN BANGSA BANJARMASIN Feodora, Anisha Nanda; Nirmalasari, Nila; Husairi, Ahmad; Aflanie, Iwan; Panghiyangani, Roselina
Homeostasis Vol 6, No 3 (2023)
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/ht.v6i3.11446

Abstract

Based on the results of interviews conducted with the parents of the seven students at Harapan Bangsa Kindergarten Banjarnasin, the four students already knew what sexual violence was, but had never provided education to their children because it was still considered taboo by children of their age. There are those who think that their children's education from school is sufficient, and there are also those who have provided education to their children about sexual violence. The purpose of this study is to know the level of knowledge of parents about awareness of the interests of early sexual education in children in Harapan Bangsa Banjarmasin Kindergarten. The research method used is observational, with data collection of parents of kindergarten students. The population used in this study was all parents of kindergarten students in Banjarmasin, The study sample was part of the population that was the subject of enelitian which was considered representative of the entire population using total sampling. The subjects of the study were all parents of 30 students of Harapan Bangsa Kindergarten in North Banjarmasin District who met the inclusion and exclusion criteria. The results showed that the level of parental knowledge of early sexual education in children in Harapan Bangsa Banjarmasin Kindergarten was 6 people (20%) good, 21 people (70%) were quite good, and 3 people (10%) were less.
The Dynamics of Adolescent Sexuality: A Comprehensive Study Jannah, Raudhatul; Budinurdjaja, Pribakti; Febriana, Silvia Kristanti Tri; Arifin, Syamsul; Panghiyangani, Roselina
Grimsa Journal of Science Engineering and Technology Vol. 2 No. 1 (2024): April 2024
Publisher : Graha Primera Saintifika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61975/gjset.v2i1.27

Abstract

Adolescent sexual behavior is all adolescent behavior that is driven by sexual desire. One of the impacts of risky sexual behavior is STIs in the form of AIDS. Banjarbaru City is one of the cities with the highest prevalence rate of AIDS sufferers aged 15-19 years, namely 28.57%. The aim of this research is to analyze the influence of knowledge, attitudes, parenting patterns and spiritual beliefs on adolescent sexual behavior through intention in Banjarbaru City. This research uses cross sectional. There are 200 samples using the Cluster Proportional Random Sampling technique. The instrument uses a questionnaire. Dependent variable: adolescent sexual behavior. Independent variables: knowledge, attitudes, parenting patterns and spiritual beliefs. Intermediary variable: intention. Analysis uses path analysis. The research results show the p-value of the direct effect on sexual behavior, knowledge variables (p=0.016), parenting patterns (p=0.004) and spiritual beliefs (p=0.005), attitudes (p=0.305). Simultaneously the p-value of all independent variables on sexual behavior (p=0.014). Taken together in the indirect effect, intention was not a significant mediating variable (p=0.159>0.05). The conclusion of this research is that there is a direct effect between knowledge, parenting patterns and spiritual beliefs and there is no direct effect between attitudes towards sexual behavior. Simultaneously, all independent variables have a direct effect on sexual behavior. The indirect effect of intention was not a significant mediation in this study.
Pengaruh Ekstrak Kulit Limau Kuit (Citrus Amblycarpa Hassk) Terhadap Perlemakan Hepar Tikus (Rattus Norvegicus) Yang Diberi Diet Tinggi Lemak Rosida, Lena; Pratiwi, Dewi Indah Noviana; Panghiyangani, Roselina; Utami, Juliyatin Putri; Maghfirah, Yolanda Sajjida; Amalia, Aysca Fakhira
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 10, No 2 (2023): AN-NADAA JURNAL KESEHATAN MASYARAKAT (DESEMBER)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v10i2.11053

Abstract

Akumulasi trigliserida di hepar dapat terjadi akibat diet tinggi lemak yang berlebihan, sehingga dapat menginduksi terjadi inflamasi dan stres oksidatif di hepar. Perlemakan hepar secara histopatologis ditandai oleh adanya steatosis. Tanaman Limau Kuit (Citrus amblycarpa Hassk) sebagai tanaman lokal Kalimantan Selatan memiliki manfaat dalam menghambat pembentukan akumulasi lemak berlebihan karena kulit jeruk Limau Kuit mengandung alkaloid, saponin, triterpenoid, tanin, dan flavonoid. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian ekstrak kulit Limau Kuit (Citrus amblycarpa Hassk) terhadap perlemakan hepar tikus (Rattus norvegicus) yang diberi diet tinggi lemak. Metode penelitian adalah true experimental design dengan posttest with control group design dengan 6 kelompok, yaitu KI (diet standar + akuades, KII (diet tinggi lemak + akuades), KIII (diet tinggi lemak + orlistat), KIV (diet tinggi lemak + ekstrak kulit Limau Kuit 200 mg/KgBB), KV (diet tinggi lemak + ekstrak kulit Limau Kuit 300 mg/KgBB), dan KVI (diet tinggi lemak + ekstrak kulit Limau Kuit 400 mg/KgBB). Perlakuan diberikan selama 6 minggu. Perlemakan hepar dinilai dari jumlah sel hepar yang mengalami perlemakan pada 5 lapangan pandang dari sediaan histologis hepar yang diwarnai HE dan perbesaran 400 x. Uji statistik menggunakan Kruskal-Wallis test. Hasil penelitian menunjukkan rerata perlemakan hepar KI 38,83 + 35,63, KII 24,00 + 21,46, KIII 20,40 + 13,90, KIV 42,40 + 11,93, KV 19,60 + 12,50, KVI 30,50 + 14,80, dengan p = 0,447. Kesimpulan penelitian ini adalah tidak ada perbedaan yang bermakna dari pemberian ekstrak kulit Limau Kuit terhadap perlemakan tikus (Rattus norvegicus) yang diberi pakan tinggi lemak (p > 0,05).Keywords: Diet tinggi lemak; Kulit jeruk Limau Kuit; Perlemakan hepar; Rattus norvegicus; Steatosis.
Analisis Faktor Yang Berhubungan dengan Pemanfaatan Layanan poliklinik Pasien Rawat Jalan RSUD Brigjend. H. Hasan Basry Kandangan Nizwar, Muhammad; Arifin, Syamsul; Panghiyangani, Roselina; Husaini, Husaini; Nugroho, Adi
An-Nadaa: Jurnal Kesehatan Masyarakat (e-Journal) Vol 11, No 1 (2024): AN-NADAA JURNAL KESEHATAN MASYARAKAT (JUNI)
Publisher : Universitas Islam Kalimantan Muhammad Arsyad Al Banjari Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31602/ann.v11i1.13992

Abstract

Tingkat kunjungan pasien merupakan sebuah indikator kinerja untuk Rumah Sakit yang berbanding lurus dengan pendapatan. Pendapatan Rumah Sakit Umum Daerah (RSUD) Brigjend. H. Hasan Basry Kandangan memberikan kontribusi sebesar 11% terhadap pendapatan asli daerah pada tahun 2022 sehingga apabila  terjadi penurunan pendapatan RSUD) Brigjend. H. Hasan Basry Kandangan maka mengakibatkan pendapatan daerah turut mengalami penurunan. Mengetahui hubungan antara usia, jenis kelamin, dan fasilitas dengan pemanfatan pelayanan pada poliklinik rawat jalan. Studi ini bersifat observasional analitik dan menggunakan pendekatan cross-sectional dengan rumus slovin 92 sampel diambil dengan teknik purposive sampling. Penelitian menggunakan kuesioner. Variabel terikat: pemanfatan pelayanan pada poliklinik rawat jalan. Variabel bebas:Usia, jenis kelamin, dan fasilitas. Analisis bivariat menggunakan chi-square dan multivariat menggunakan regresi logistik berganda. Hasil penelitian menunjukkan terdapat hubungan antara usia(p=0,001), jenis kelamin(p=0,003), dan fasilitas(p=000) dengan pemanfatan pelayanan. Variabel fasilitas paling berhubungan dengan pemanfatan pelayanan pada poliklinik rawat jalan RSUD Brigjend. H Hasan Basry Kandangan. Terdapat hubungan antara usia, jenis kelamin, dan fasilitas dengan pemanfaatan layanan. Variabel yang paling berhubungan dengan pemanfaatan layanan poliklinik pasien rawat jalan RSUD Brigjend. H. Hasan Basry Kandangan adalah fasilitas.