Claim Missing Document
Check
Articles

Found 3 Documents
Search

Potensi Ekstrak Etanol Biji Bunga Telang (C.ternatea L.) sebagai Agen Antihiperlipidaemia (Studi In Silico) Atik Kurniawati; Nur Rahman Nur Rahman; Dwipajati Dwipajati
Jurnal Penelitian Farmasi & Herbal Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i2.1121

Abstract

Hiperlipidemaemia didalam tubuh ditandai dengan meningkatnya kadar kolesterol didalam darah. Dibutuhkan hambatan kompetitif terhadap HMG-CoA reduktase.Senyawa dari tanaman herbal bunga telang (Clitorea ternatea L.) berpotensi sebagai agen antihiperlipidaemia. Tujuan penelitian ini adalah untuk mengetahui potensi biji bunga telang (C. ternatea L.) sebagai agen antihiperlipidemia melalui studi in silico. Persiapan ligand dengan reseptor menggunakan software YASARA. Moleculer docking menggunakan software PLANTS. Visualisasi menggunakan LigPlus dan PyMol. Reseptor yang digunakan adalah struktur kristal HMG-CoA reduktase dengan kode PDB 1HW9 dan ligand kontrol simvastatin.Hasil penelitian menunjukkan senyawa phloretin, trifolin dan trigonelline yang diprediksi memberikan efek antihiperlidemia berdasarkan studi in silico karena memiliki interaksi masing-masing secara berurutan yaitu phloretin (-64,05), trifolin (-59,24) dan trigonelline (-52,76). Residu asam amino yang berperan dalam ikatan ligand dengan reseptor adalah Asp 767, Tyr 761, Ala 768, Asn 771, Glu 801, Gln 770, Ser 774, Met 655, Ile 802, Gln 766.
Analisis Kandungan Gizi, Viskositas, Mutu Organoleptik dan Daya Terima Modisco III Dengan Substitusi Tempe dan Sari Wortel: Analysis of NutritionNutritional Content, Viscosity, Organoleptic, Qualuty and Acceptabiluty of Modisco Iii with Substitution if Tempe a d Carrot Extract Dwipajati Dwipajati; Endang Sutjiati; Arisa Rizqiyah
JURNAL GIZI DAN KESEHATAN Vol. 15 No. 2 (2023): JURNAL GIZI DAN KESEHATAN
Publisher : UNIVERSITAS NGUDI WALUYO

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35473/jgk.v15i2.422

Abstract

Enteral formula is feeding to patients with good digestive conditions but it is difficult to take in enough food to meet their oral nutrient requirements. One of the enteral formulas that can be given to malnourished toddlers is modisco. Modisco is a formula of high-energy and protein drinks for malnourished children from the stabilization to rehabilitation phase. Modisco III modifications can be provided by adding local foodstuffs that can be reached by the community, cheap and easy to get such as soy tempe which contains high protein, and carrot juice which helps supplement the source of vitamins, iron, and potassium. Knowing the nutritional value, viscosity, organoleptic quality, and acceptability of enteral formulas. This study used the true experimental method and Complete Randomized Design (RAL) with three comparison treatments tempe : carrot juice, namely formula P1 (40:60), formula P2 (30:70), and formula P3 (20:80). The tests carried out are calculating nutritional value empirically, viscosity testing with dinamic methods, organoleptic quality tests and acceptability with hedonic methods. The test data are presented in descriptive and tabulation form. The energy density in each formula is different, namely P1 (1.51 kcal/ml), P2 (1.39 kcal/ml), and P3 (1.33 kcal/ml). The viscosity in the enteral blenderized formula is by the optimum viscosity of 3.5 – 10 cP. Most of the panelists stated the P1, P2, and P3 formulas have a slightly orange color, slightly fragrant in flavor, watery in texture, and have a sweet taste. The acceptability test found that the P1 formula with an achievement score of 77.50% was most preferred both in terms of color, aroma, texture, and taste. The P1 formula is the most preferred and has nutritional value and viscosity according to the requirements of the enteral formula.    ABSTRAK Formula enteral merupakan pemberian makan kepada pasien dengan kondisi pencernaan yang masih baik namun sulit untuk mengasup makanan yang cukup untuk memenuhi kebutuhan zat gizi secara oral. Salah satu formula enteral yang dapat diberikan kepada anak gizi buruk yaitu modisco. Modisco merupakan formula minuman tinggi energi dan protein untuk anak gizi buruk dari fase stabilisasi hingga rehabilitasi. Modifikasi modisco III dapat diberikan dengan menambahkan bahan pangan lokal yang dapat dijangkau oleh masyarakat, murah dan mudah didapat seperti tempe kedelai yang mengandung tinggi protein dan sari wortel yang membantu melengkapi sumber vitamin, zat besi dan kalium. Mengetahui nilai gizi, viskositas, mutu organoleptik dan daya terima formula enteral. Penelitian ini menggunakan metode true experimental dan Rancangan Acak Lengkap (RAL) dengan tiga perlakuan perbandingan tempe : sari wortel yaitu formula P1 (40:60), formula P2 (30:70) dan formula P3 (20:80). Uji yang dilakukan yaitu menghitung nilai gizi secara empiris, uji viskositas dengan metode dinamis, uji mutu organoleptik dan daya terima dengan metode hedonik. Data uji tersebut disajikan dalam bentuk deskriptif dan tabulasi. Densitas energi pada setiap formula berbeda-beda, yaitu P1 (1,51 kkal/ml), P2 (1,39 kkal/ml), dan P3 (1,33 kkal/ml). Viskositas pada formula enteral blenderized sudah sesuai dengan viskositas optimum yaitu 3,5 – 10 cP. Sebagian besar panelis menyatakan formula P1, P2 dan P3 memiliki warna agak jingga, beraroma agak harum, bertekstur encer dan memiliki rasa manis. Uji daya terima mendapatkan hasil bahwa formula P1 dengan skor pencapaian 77,50% paling disukai baik dari aspek warna, aroma, tekstur dan rasa. Formula P1 menjadi formula paling disukai dan memiliki nilai gizi dan viskositas sesuai dengan syarat formula enteral. 
Pengaruh pemberian ekstrak daun manisrejo terhadap perubahan kadar SGOT dan SGPT kelinci pedaging Nur Rahman; Gebby Putri Nurhaida; Dwipajati Dwipajati
Jurnal SAGO Gizi dan Kesehatan Vol 5, No 2 (2024): April
Publisher : Poltekkes Kemenkes Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30867/gikes.v5i2.1419

Abstract

Background: Manisrejo leaves (Vaccinium Varingifolium) contain flavonoids, steroids, tannins and triterpenoids. flavonoid are antioxidant compounds which are believed to have the ability to bind active oxygen radicals, superoxide and hydroxyl radicals through a single electron transfer. The properties of flavonoids besides protecting the effects of ROS on cells can also inhibit the formation of ROS and can reduce levels SGOT and SGPT. In conditions of liver disorders there is an increase in liver enzymes that cause changes in SGOT and SGPT levels. Antioxidant compounds can overcome liver damage caused by free radicals.Objectives: Analyzed the effect of giving Manisrejo leaf extract to changes in body weight and SGOT SGPT levels in broiler rabbits.Method: This research is a type of laboratoryan experimental research conductedstudy on meat rabbits by giving Manisrejo leaf extract to analyze changes in body weight and SGOT SGPT levels of meat rabbits. The research was carried out in May – June 2023 at the Chemistry Laboratory of the Health Polytechnic, Malang Ministry of Health, Malang in May-June 2023 Health Polytechnic. The samples used in the research were 30 meat rabbits. Research data includes the rabbit's body weight taken throughby weighing and SGOT SGPT data obtained through laboratory testing using kinetic methods before and after the intervention. Analysis of research data to test the normality of the data uses the Shapiro Wilk test, then if the data is normal, use the One Way ANOVA statistical test, if the distribution is not normal, use the Kruskal Wallis Test at a confidence level of 95%.Results: There is an increase in rabbit body weight before and after intervention with a p value of 0,001 which indicates that there is a significant difference between rabbit body weight before and after intervention. Statistical test results p value 0,198 which indicates there is no significant difference between the administration of manisrejo leaf extract at the SGOT level and p value 0,180 which indicates there is no significant difference between the administration of manisrejo leaf extract at the SGPT level.Conclusion: There is no effect of giving Manisrejo leaf extract on changes in SGOT and SGPT levels in broiler rabbits.KeywordsBroiler Rabbit, Manisrejo Leaf Extract, SGOT, SGPT