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Cabe Jawa (Piper retrofractum Vahl.) : PENGGUNAAN TRADISIONAL, FITOKIMIA dan AKTIVITAS FARMAKOLOGI Piper retrofractum Vahl. : Traditional Uses, Phytochemical and Pharmacological Activities Fahrauk Faramayuda; Sufyan Zainul Arifin; Akhirul Kahfi Syam; Elfahmi Elfahmi
Perspektif Vol 20, No 1 (2021): Juni 2021
Publisher : Puslitbang Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/psp.v20n1.2021.26-34

ABSTRAK Cabe jawa (Piper retrofractum Vahl.) adalah tanaman daerah tropis asli Indonesia yang dijumpai juga di negara Asia Tenggara seperti Thailand dan Malaysia, dan sejak dahulu telah digunakan secara turun-temurun sebagai bahan tambahan makanan ataupun obat tradisional. Secara tradisional di masyarakat, buah cabe jawa dapat digunakan dalam ramuan untuk mengobati demam, perut kembung, mulas, muntah, mengatasi gangguan pencernaan, merangsang nafsu makan, dan lemah syahwat. Akarnya sering digunakan untuk mengobati sakit gigi, luka dan kejang, serta bagian daunnya digunakan juga untuk obat kumur. Beberapa penelitian menyebutkan aktivitas farmakologi cabe Jawa memiliki efek afrodisiaka, antipiretik, antihiperurisemia, antikanker, dan antimikroba. Pengujian klinis terhadap cabe jawa telah dilakukan dan potensial dikembangkan menjadi obat tradisional golongan fitofarmaka. Cabe jawa memiliki aktivitas sebagai imunostimulan, lebih tinggi dibandingkan dengan kelompok imunostimulan fitofarmaka. Cabe jawa mempunyai potensi sebagai anti-photoaging, aktivitas antituberkular, antiproliferasi, aktivitas larvasida, dan aktivitas sitotoksik. Studi fitokimia senyawa metabolit sekunder utama yang terkandung dalam cabe jawa antara lain beberapa jenis alkaloid seperti piperine, pipernonaline, guineensine, piperoctadecalidine, minyak atsiri buah cabe jawa mengandung tiga komponen utama yaitu yaitu β-caryophyllene (17%), pentadecane (17,8%) dan β- bisabollene (11,2%) . Selain senyawa utama tersebut, terdapat senyawa baru pada buah cabe jawa, diantaranya; senyawa amida, amida glikosida, fenilpropanoid glikosida, dan alkaloid. Sebagai afrodisiaka bagian yang digunakan adalah buahnya dan senyawa piperin yang diduga bertanggung jawab terhadap aktivitas tersebut. Piperin merupakan senyawa utama dan zat berkhasiat yang terkandung dalam buah cabe jawa dan berfungsi sebagai penurun demam, mengurangi rasa sakit, antioksidan, mengurangi peradangan, antitumor, dan sebagai imunomodulator. Berdasarkan aktifitas farmakologi yang baik dari cabe jawa maka studi atau penelitian-penelitian pada tanaman ini harus terus dilakukan seperti pengembangan formulasi dan upaya perbanyakan tanaman karena populasi cabe jawa jumlahnya terbatas. Media terbaik dalam induksi kalus tanaman cabe jawa adalah Murrashige Skoog (MS) yang ditambah 6-Benzil Amino Purin (BAP) dan Naphtalene Acetic Acid (NAA).ABSTRACT Piper retrofractum vahl. is a tropical plant native to Indonesia which is also found in Southeast Asian countries such as Thailand and Malaysia, and has been used for generations as a food additive or traditional medicine. Traditionally in the community, P. retrofractum fruit can be used in potions to treat fever, flatulence, heartburn, vomiting, overcome digestive disorders, stimulate appetite, and impotence. The roots are often used to treat toothaches, wounds, and seizures, and the leaves are also used for mouthwash. Several studies have stated that the pharmacological activity of P. retrofractum has aphrodisiac, antipyretic, anticancer, and antimicrobial effects. Clinical testing on P. retrofractum has been carried out and has the potential to be developed into a traditional medicine of the phytopharmaceutical class. P. retrofractum has activity as an immunostimulant, which is higher than the phytopharmaceutical immunostimulant group. P. retrofractum has potential as anti-photoaging, antitubercular, antiproliferative, larvicidal activity, and cytotoxic activity. Phytochemical studies of the main secondary metabolites contained in P. rectofractum include several types of alkaloids such as piperine, pipernonaline, guineensine, piperoctadecalidine, fruit essential oils. Javanese chili contains three main components, namely-caryophyllene (17%), pentadecane (17.8%) and -bisabollene (11.2%). In addition to these main compounds, there are new compounds in P. retrofractum fruit, including; amide compounds, amide glucosides, phenylpropanoid glucosides, and alkaloids. As an aphrodisiac, the part used is the fruit and the piperine compound which is thought to be responsible for this activity. Piperine is the main compound and efficacious substance contained in P. retrofractum fruit and functions as a fever reducer, pain reliever, antioxidant, reducing inflammation, antitumor, and immunomodulator. Based on the good pharmacological activity of P. retrofractum , studies or researches on this plant must continue to be carried out such as formulation development and plant propagation efforts because the population of P. retrofractum is limited. The best medium for callus induction of cabe jawa was Murashige Skoog (MS) with 6-Benzyl Amino Purine (BAP) and Naphtalene acetic (NAA) added.

Identification Secondary Metabolites From Callus Piper retrofractum Vahl Fahrauk Faramayuda; Jaka Permana; Akhirul Kahfi Syam; Elfahmi Elfahmi
Elkawnie: Journal of Islamic Science and Technology Vol 7, No 1 (2021)
Publisher : Universitas Islam Negeri Ar-Raniry Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22373/ekw.v7i1.8630

Abstract: Javanese chili (Piper retrofractum Vahl) is a traditional medicinal plant originating from Indonesia and has many pharmacological activities, one of which is often used as a base for aphrodisiac herbal medicine. The population of P. retrofractum is limited, so it is necessary to design secondary metabolite production and propagation efforts using plant tissue culture techniques. The materials used in this study were explants of P. retrofractum leaves that were induced in Murashige and Skoog (MS) media and the ratio of growth regulators 2.4-dichlorophenoxyacetis acid (2,4-D): Benzyl Amino Purine (BAP) 0.5: 0.5. The results showed that the callus of P. retrofractum was formed in the growth regulator 2.4D: BAP (0.5: 0.5). TLC and spectrophotometry identified the secondary metabolite content of callus. Secondary metabolite analysis using the thin layer chromatography (TLC) method using the mobile phase ethyl acetate: n-hexane (7: 3) showed a terpenoid compound indicated by purple spots on the visual appearance after spraying 10% spotting vanillin. Identification using infrared spectrophotometry shows functional groups -CH, C = O, C = C, -CH2, and -CH3, characteristic of terpenoid compounds. Based on TLC data and spectrophotometry, callus P. retrofractum is thought to contain terpenoid compounds. This study's results are expected to be the basis for developing secondary metabolite production in P. retrofractum with cell suspension culture and P. retrofractum propagation by micropropagation.Abstrak: Cabai Jawa (Piper retrofractum Vahl) merupakan tanaman obat tradisional yang berasal dari Indonesia dan banyak memiliki aktivitas farmakologis salah satunya sering digunakan sebagai bahan dasar jamu afrodisiaka. Populasi tanaman cabai Jawa terbatas maka perlu dirancang upaya produksi metabolit sekunder dan upaya perbanyakan tanaman cabai Jawa salah satunya menggunakan teknik kultur jaringan tanaman. Bahan yang digunakan pada penelitian ini adalah eksplan daun tanaman cabai Jawa yang diinduksi pada media Murashige and Skoog (MS) dan perbandingan zat pengatur tumbuh 2.4-dichlorophenoxyacetis acid (2,4-D) : Benzyl Amino Purine (BAP) 0,5 : 0,5. Hasil penelitian menunjukkan bahwa kalus cabai Jawa terbentuk dalam zat pengatur tumbuh 2,4D: BAP (0,5: 0,5). Kandungan metabolit sekunder dari kalus diidentifikasi dengan KLT dan spektrofotometri. Analisis metabolit sekunder menggunakan metode kromatografi lapis tipis (KLT) menggunakan fasa gerak etil asetat: n-heksana (7: 3) menunjukkan adanya senyawa terpenoid yang ditunjukkan dengan adanya bercak ungu pada penampakan visual setelah disemprotkan spotting vanilin 10%. Hasil Identifikasi menggunakan spektrofotometri UV-Vis menunjukkan isolat mempunyai panjang gelombang maksimum 272,6 nm. Identifikasi menggunakan spektrofotometri inframerah menunjukkan adanya gugus fungsi -CH, C = O, C = C, -CH2, dan -CH3 yang merupakan ciri khas senyawa terpenoid . Berdasarkan data KLT dan spektrofotometri kalus cabai Jawa diduga mengandung senyawa terpenoid. Hasil penelitian ini diharapkan dapat menjadi dasar pemgembangan produksi metabolit sekunder dalam tanaman cabai Jawa dengan kultur suspensi sel dan perbanyakan tanaman cabai Jawa dengan mikropropagasi.

ISOLASI DARI 8-HIDROKSI-6,7-DIMETHOKSI KUMARIN DAN TOKSISITAS BATANG JARAK TINTIR (Jatropha multifida L.) MENGGUNAKAN BRINE SHRIMP LETHALITY TEST (BSLT) Akhirul Kahfi Syam; Muhamad Insanu; Komar Ruslan Wirasutisna
Majalah Obat Tradisional Vol 22, No 1 (2017)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Jatropha multifida L. (jarak tintir) was a shrub, annual, and had ± 2 m high. Empirically jarak tintir sap was used as traditional medicine by Indonesian people for a long time. Only limited studies were conducted regarding its chemical compound. It was reported that multifidone (diterpenoid compound from the stem) had an activity against cancer cells in vitro. This study aimed to test the toxicity of various extracts (n-hexane, ethyl acetate, and methanol) with Brine Shrimp Lethality Test (BSLT) of Jatropha multifida L. stem. A Fraxidin (8-hidroxy-6,7-dimethoxy coumarin) has been isolated from ethyl acetate fraction based on highest cytotoxic with LC50 value 3.69 µg/mL. The isolated compound was elucidated to gain chemical structure base on spectroscopic data (UV-Vis Spectrofotometric, IR Spectrofotometric, and NMR). Toxicity of fraxidin was tested on BSLT and showed no potential activity with LC50 value > 500 μg/mL.

Cabe Jawa (Piper retrofractum Vahl.) : PENGGUNAAN TRADISIONAL, FITOKIMIA dan AKTIVITAS FARMAKOLOGI Piper retrofractum Vahl. : Traditional Uses, Phytochemical and Pharmacological Activities Fahrauk Faramayuda; Sufyan Zainul Arifin; Akhirul Kahfi Syam; Elfahmi Elfahmi
Perspektif Vol 20, No 1 (2021): Juni 2021
Publisher : Puslitbang Perkebunan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21082/psp.v20n1.2021.26-34

ABSTRAK Cabe jawa (Piper retrofractum Vahl.) adalah tanaman daerah tropis asli Indonesia yang dijumpai juga di negara Asia Tenggara seperti Thailand dan Malaysia, dan sejak dahulu telah digunakan secara turun-temurun sebagai bahan tambahan makanan ataupun obat tradisional. Secara tradisional di masyarakat, buah cabe jawa dapat digunakan dalam ramuan untuk mengobati demam, perut kembung, mulas, muntah, mengatasi gangguan pencernaan, merangsang nafsu makan, dan lemah syahwat. Akarnya sering digunakan untuk mengobati sakit gigi, luka dan kejang, serta bagian daunnya digunakan juga untuk obat kumur. Beberapa penelitian menyebutkan aktivitas farmakologi cabe Jawa memiliki efek afrodisiaka, antipiretik, antihiperurisemia, antikanker, dan antimikroba. Pengujian klinis terhadap cabe jawa telah dilakukan dan potensial dikembangkan menjadi obat tradisional golongan fitofarmaka. Cabe jawa memiliki aktivitas sebagai imunostimulan, lebih tinggi dibandingkan dengan kelompok imunostimulan fitofarmaka. Cabe jawa mempunyai potensi sebagai anti-photoaging, aktivitas antituberkular, antiproliferasi, aktivitas larvasida, dan aktivitas sitotoksik. Studi fitokimia senyawa metabolit sekunder utama yang terkandung dalam cabe jawa antara lain beberapa jenis alkaloid seperti piperine, pipernonaline, guineensine, piperoctadecalidine, minyak atsiri buah cabe jawa mengandung tiga komponen utama yaitu yaitu β-caryophyllene (17%), pentadecane (17,8%) dan β- bisabollene (11,2%) . Selain senyawa utama tersebut, terdapat senyawa baru pada buah cabe jawa, diantaranya; senyawa amida, amida glikosida, fenilpropanoid glikosida, dan alkaloid. Sebagai afrodisiaka bagian yang digunakan adalah buahnya dan senyawa piperin yang diduga bertanggung jawab terhadap aktivitas tersebut. Piperin merupakan senyawa utama dan zat berkhasiat yang terkandung dalam buah cabe jawa dan berfungsi sebagai penurun demam, mengurangi rasa sakit, antioksidan, mengurangi peradangan, antitumor, dan sebagai imunomodulator. Berdasarkan aktifitas farmakologi yang baik dari cabe jawa maka studi atau penelitian-penelitian pada tanaman ini harus terus dilakukan seperti pengembangan formulasi dan upaya perbanyakan tanaman karena populasi cabe jawa jumlahnya terbatas. Media terbaik dalam induksi kalus tanaman cabe jawa adalah Murrashige Skoog (MS) yang ditambah 6-Benzil Amino Purin (BAP) dan Naphtalene Acetic Acid (NAA).ABSTRACT Piper retrofractum vahl. is a tropical plant native to Indonesia which is also found in Southeast Asian countries such as Thailand and Malaysia, and has been used for generations as a food additive or traditional medicine. Traditionally in the community, P. retrofractum fruit can be used in potions to treat fever, flatulence, heartburn, vomiting, overcome digestive disorders, stimulate appetite, and impotence. The roots are often used to treat toothaches, wounds, and seizures, and the leaves are also used for mouthwash. Several studies have stated that the pharmacological activity of P. retrofractum has aphrodisiac, antipyretic, anticancer, and antimicrobial effects. Clinical testing on P. retrofractum has been carried out and has the potential to be developed into a traditional medicine of the phytopharmaceutical class. P. retrofractum has activity as an immunostimulant, which is higher than the phytopharmaceutical immunostimulant group. P. retrofractum has potential as anti-photoaging, antitubercular, antiproliferative, larvicidal activity, and cytotoxic activity. Phytochemical studies of the main secondary metabolites contained in P. rectofractum include several types of alkaloids such as piperine, pipernonaline, guineensine, piperoctadecalidine, fruit essential oils. Javanese chili contains three main components, namely-caryophyllene (17%), pentadecane (17.8%) and -bisabollene (11.2%). In addition to these main compounds, there are new compounds in P. retrofractum fruit, including; amide compounds, amide glucosides, phenylpropanoid glucosides, and alkaloids. As an aphrodisiac, the part used is the fruit and the piperine compound which is thought to be responsible for this activity. Piperine is the main compound and efficacious substance contained in P. retrofractum fruit and functions as a fever reducer, pain reliever, antioxidant, reducing inflammation, antitumor, and immunomodulator. Based on the good pharmacological activity of P. retrofractum , studies or researches on this plant must continue to be carried out such as formulation development and plant propagation efforts because the population of P. retrofractum is limited. The best medium for callus induction of cabe jawa was Murashige Skoog (MS) with 6-Benzyl Amino Purine (BAP) and Naphtalene acetic (NAA) added.

KARAKTERISASI FARMAKOGNOSI DAUN FALOAK (Sterculia quadrifida R.Br): CHARACTERIZATION OF PHARMACOGNOSY OF FALOAC LEAVES (Sterculia quadrifida R.Br) Fahrauk Faramayuda; Julia Ratnawati; Akhirul Kahfi Syam
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 2 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i2.322

Faloak secara empiris digunakan sebagai antimikroba, megobati penyakit tifus, mengatasi gangguan pada hati, laksatif, dan antimalaria. Faloak merupakan salah satu tumbuhan yang secara empiris digunakan sebagai obat tradisional di Nusa Tenggara Timur. Selanjutnya dari hasil penelitian ini dapat digunakan untuk studi dan pengembangan aktivitas biologi ekstrak daun faloak menjadi produk farmasi. Ekstraksi menggunakan cara maserasi dengan pelarut etanol dan menghasilkan rendemen 8,84% b/b. Parameter standarisasi ekstrak menunjukkan bobot jenis ekstrak 0,7543 ± 0,0060 g/mL, kadar sari larut air 54 ± 1,15% b/b, sari larut etanol 88,48 ± 1,05% b/b, kadar abu total 10,47 ± 0,16% b / b, abu larut air 8,01 ± 0,99% b / b, abu tidak larut asam 0,39 ± 0,03% b/b. Ekstrak etanol daun faloak mengandung flavonoid, kuinon, polifenol, steroid-triterpenoid, dan monoterpen-sesquiterpen. Ekstrak dianalisis kandungan kimianya menggunakan kromatografi lapis tipis (KLT) dengan fase diam silica F254 dan menggunakan fasa gerak n-heksana: etil asetat (1:1), hasilnya terdapat bercak dengan Rf 0,21 memberi warna biru pada UV 365 nm dan bercak hitam berlatar hijau pada UV 254 nm. Total kandungan flavonoid pada ekstrak etanol daun faloak 5,31 ± 0,29% b / b dan total kandungan polifenol 1,79 ± 0,03% b / b. Dari hasil karakterisasi ini bisa menjadi dasar pemgembangan tanaman faloak menjadi bahan baku obat tradisional terstandar dan acuan untuk melakukan uji aktivitas farmakologi.

SOSIALISASI POTENSI TANAMAN KUMIS KUCING SEBAGAI IMUNOSTIMULAN YANG DAPAT DIGUNAKAN DIMASA PANDEMIK COVID-19 : PENJELASAN KHASIAT, PENANAMAN DAN PENGOLAHAN PASCA PANEN Faizal Hermanto; Akhirul kahfisyam; Suryani; Fahrauk Faramayuda
Jurnal Abditani Vol. 5 No. 2 (2022): Oktober
Publisher : FAKULTAS PERTANIAN UNIVERSITAS ALKHAIRAAT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/abditani.v5i2.152

Saat ini diseluruh dunia masih terjadi pandemi covid-19. Penyakit yang disebabkan oleh virus dalam proses penyembuhan pada umumnya mengandalkan kekuatan pertahanan tubuh, sehingga diperlukan suatu senyawa yang dapat meningkatkan kerja sistem imun atau lebih dikenal imunostimulan. Berdasarkan hasil penelitian banyak tanaman obat yang berkhasiat sebagai imunostimulan salah satunya kumis kucing atau nama laiannya Orthosiphon aristatus. Selama ini kumis kucing terkenal dan banyak digunakan sebagai diuretik serta peluruh batu ginjal. Masyarakat belum banyak yang tahu bahwa kumis kucing memiliki potensi sebagai imunostimulan. Oleh karena itu perlu dilakukan upaya sosialisasi dan pelatihan potensi tanaman kumis kucing sebagai imunostimulan meliupti penjelasan khasiat, penanaman dan pengolahan pasca panen. Sosialisasi dilakukan pada paguyuban jamu manunggal kota cimahi dan umumnya pada masyarakat melalui video. Dari hasil sosialisasi, pemahaman para peserta paguyuban jamu manunggal tentang potensi tanaman kumis kucing sebelum diberikan materi dan pelatihan adalah 44 % dan sesudah diberikan materi naik menjadi 100 %. Pada kegiatan ini dilakukan pemberian bibit tanaman kumis kucing hasil kultur in vitro, bibit ini merupakan pengembangan hasil penelitian di Fakultas Farmasi UNJANI. Sosialisasi harus terus dilakukan pada skala lebih besar melalui video edukasi yang dibagikan pada media sosial.

Effect of Media Variation on the Induction and Phytochemical Profile of Callus in Two Varieties of Cat's Whiskers (Orthosiphon aristatus Blume Miq) Fahrauk Faramayuda; Akhirul Kahfi Syam; Totik Sri Mariani; Elfahmi; Sukrasno
HAYATI Journal of Biosciences Vol. 30 No. 1 (2023): January 2023
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.30.1.159-170

The levels of rosmarinic acid and sinensetin in purple and white-purple varieties of Orthosiphon aristatus, cat's whiskers, can be increased using modified in vitro culture. This work focused on callus induction of the purple and white-purple variety of cat's whiskers grown on Gamborg (B5) and CHU (N6) with the addition of growth regulators 2,4-dichlorophenoxyacetis acid. Our observation suggested that the callus could grow within three weeks and produce rosmarinic acid and sinensetin. The level of sinensetin from various extraction methods is relatively low; in contrast, the rosmarinic acid from purple callus was detected at about 5% w/w, while the white-purple variety was around 2% w/w. The results of this study also provided new information on the basic media other than MS that can grow cat's whiskers callus while producing active compounds.

POTENSI KRIM ANTIOKSIDAN GETAH JARAK TINTIR (Jatropha mulfida L.) DALAM MENGHAMBAT ENZIM TIROSINASE SECARA IN SILICO SEBAGAI ALTERNATIF AGEN PEMUTIH Farah Salsabilla Saidah Azhar; Sheila Nur Hasanah; Renata Ananda Marthasedana; Meyra Pratami Dewilestari; Sri Restu Andriyani; Wulan Anggraeni; Dadan Suryasaputra; Akhirul Kahfi Syam; Hestiary Ratih
Jurnal Ilmiah Farmasi Farmasyifa Vol 6, No 1 (2023)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v6i1.10700

Getah Jarak Tintir (Jatropha multifida Linn.) yang berasal dari famili Euphorbiaceae diketahui memiliki kandungan fenolik dan flavonoid yang berpotensi sebagai antioksidan alami. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sebagai antioksidan, interaksi senyawa metabolit sekunder dalam getah jarak tintir dengan enzim tirosinase, dan mengaplikasikannya dalam bentuk sediaan. Metode pengujian antioksidan dilakukan dengan metode DPPH dan pengujian aktivitas inhibitor enzim tirosinase dilakukan dengan in silico metode molekular docking. Formulasi hand and body cream getah jarak tintir dibuat dalam tiga formula yaitu F0 (basis krim sebagai kontrol), F1 (basis krim dengan 100Ã—IC50 serbuk getah jarak tintir), F2 (basis krim dengan 200Ã—IC50 serbuk getah jarak tintir). Hasil penelitian menunjukkan bahwa senyawa yang mempunyai afinitas kuat dalam menghambat enzim tirosinase yaitu Multifidol dengan nilai âˆ†G sebesar -6,01 kkal/mol dan KI sebesar 39,37 nM. Hasil pengujian antioksidan dari hasil freeze drying serbuk getah jarak tintir menunjukkan nilai IC50 sebesar 8,33 Âµg/mL yang termasuk kategori sangat kuat. Persen inhibisi pada krim F1 (konsentrasi zat aktif 8,33 Âµg/mL) dan F2 (konsentrasi zat aktif 16,4 Âµg/mL) berturut-turut adalah 25,08% dan 50,57% yang termasuk kategori sangat kuat dan berpotensi sebagai alternatif krim pemutih.Â Kata kunci: Getah jarak tintir, molecular docking, krim, antioksidan, DPPH Â The sap of Jarak Tintir (Jatropha multifida Linn.) from the family Euphorbiaceae was known to contain phenolic and flavonoid compounds that have the potential as natural antioxidants. This study aimed to determine the content of metabolites as antioxidants, the interaction of secondary metabolites in Jatropha sap with tyrosinase enzymes, and to apply them in a dosage form. The antioxidant test method was carried out using the DPPH method and the tyrosinase enzyme inhibitory activity was tested using the molecular docking in silico method. The hand and body cream formulation of the sap was made in three formulas, namely F0 (cream base as control), F1 (cream base + 100Ã—IC50 of the sap powder), F2 (cream base + 200Ã—IC50 of the sap powder). The results showed that the compound that has a strong affinity to inhibit the tyrosinase enzyme is Multifidol with a âˆ†G value of -6.01 kcal/mol and a KI of 39.37 nM. The freeze-drying of the sap powder had the potential as an antioxidant with an IC50 value of 8.32 g/mL which was categorized as very strong activity. The percentage of inhibition in F1 cream (active substance concentration 8.32 g/mL) and F2 (active substance concentration 16.4 g/mL) were 25.08% and 50.57%, respectively, included in the very strong category and have potential to be alternative whitening cream.Â Keywords:Â Â the sap of Jarak tintir, molecular docking, cream, antioxidant, DPPH

Potency of Honje Hutan Flowers (Etlingera Hemisphaerica (Blume) R.M.Sm.) as Alpha-Glucosidase Inhibitor Soraya Riyanti; Nandi Agustian; Akhirul Kahfi Syam
Indonesian Journal of Pharmaceutical Science and Technology Vol 10, No 1 (2023)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v10i1.35453

The Pangandaran people process honje flowers into fresh drinks that are consumed for health. Theforest honje leaf extract provides antidiabetic activity at a dose of 0.39 mg/g BW can reduce bloodglucose levels by 36.16% has been reported. Limited scientific information from honje hutan flowers,it is necessary on its activity as an alpha-glucosidase inhibitor and study its chemical content. Theextraction process was macerated in 70% ethanol for 24 hours and the fractionation process wascarried out by liquid-liquid extraction method with n-hexane, ethyl acetate and water as solvents.Testing the activity of alpha-glucosidase inhibitors colorimetrically using the chromogenic substratep-nitrophenyl α-D-glucopyranoside, alpha-glucosidase enzymes derived from Saccharomycescerevisiae, measurement of absorption at a maximum wavelength of 401.3 nm and acarbose usedas a comparison drug alpha-glucosidase inhibitors. The results showed that the forest honje flowerscontain flavonoids, polyphenols, tannins, quinones, monoterpenoids, and sesquiterpenoids. IC50 valuesfor 70% ethanol extract, n-hexane, ethyl acetate, water and acarbose fractions were 136.79, 307.18,277.12, 66.18, and 14.63 g/mL respectively. The water fraction gave the best inhibitory activity againstalpha-glucosidase with an IC50 value of 66.18 g/mL.Keywords: Etlingera hemisphaerica (Blume) R.M.Sm, honje hutan flowers, alpha-glucosidaseinhibitor.

Traditional uses, phytochemistry, pharmacology activity and plant tissue culture of ficus carica l. (a mini review) Fahrauk Faramayuda; Sigid Pamungkas Wicaksono; Akhirul Kahfi Syam; Soraya Riyanti; Ari Sri Windyaswari; Yeni Karlina; Elfahmi Elfahmi
Riset Informasi Kesehatan Vol 11 No 1 (2022): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

Ficus carica L. or Figs plants are plants originating from the Middle East and the Mediterranean region, which then spread to various parts of the world through explorers who try to plant in various countries. Figs plants can grow in various habitats, including infertile rocky soils, forests, shrubs, and even hot dry soils. Figs plants have several varieties that can be distinguished from the shape of the stem, the shape of the leaves, and the fruit's color. Figs plants are widely used as traditional medicine for both leaves and fruit. Noted in several countries have used the Figs plant as one of the plants used for traditional medicine. Figs plants are widely used for antioxidants, anticancer, hepatoprotective, antidiabetic, antibacterial, antipyretic, antituberculosis, antispasmodic antiplatelet in several countries. Figs plants contain secondary metabolites of alkaloids, latexonins, phenols, and flavonoids. There is one method of multiplication of Figs plants that began to be widely used, namely plant tissue culture. Plant tissue culture is a method of propagation using tissue slices or parts of plants that are small and in aseptic conditions. Several studies have been obtained to trace figs plants by tissue culture methods using slices of leaves and shoots.

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